Erawan Borkham-Kamphorst

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi request reprint The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Germany Electronic address
    Biochim Biophys Acta 1843:902-14. 2014
  2. doi request reprint Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Germany
    Biochim Biophys Acta 1832:660-73. 2013
  3. ncbi request reprint Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Aachen, Germany
    Liver Int 32:1342-53. 2012
  4. pmc CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, 52074, Aachen, Germany
    J Cell Commun Signal 6:11-25. 2012
  5. ncbi request reprint Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
    Lab Invest 84:766-77. 2004
  6. doi request reprint Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes
    Hacer Sahin
    Medical Department III and University Hospital Aachen, Aachen, Germany
    Hepatology 57:797-805. 2013
  7. ncbi request reprint The expression of CSRP2 encoding the LIM domain protein CRP2 is mediated by TGF-beta in smooth muscle and hepatic stellate cells
    Jens Herrmann
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Germany
    Biochem Biophys Res Commun 345:1526-35. 2006
  8. ncbi request reprint Pro-fibrogenic potential of PDGF-D in liver fibrosis
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, and Division of Nephrology, RWTH University Hospital Aachen, D 52074 Aachen, Germany
    J Hepatol 46:1064-74. 2007
  9. doi request reprint Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1β through nuclear factor-κB activation
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Aachen, Germany
    Liver Int 31:656-65. 2011
  10. doi request reprint Proteomic profiling in Lipocalin 2 deficient mice under normal and inflammatory conditions
    Kirsten Labbus
    Institute of Pathology, RWTH University Hospital Aachen, Germany
    J Proteomics 78:188-96. 2013

Collaborators

Detail Information

Publications22

  1. ncbi request reprint The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Germany Electronic address
    Biochim Biophys Acta 1843:902-14. 2014
    ..CCN1/CYR61 gene transfer into extracellular matrix-producing liver cells is therefore potentially beneficial in liver fibrotic therapy. ..
  2. doi request reprint Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Germany
    Biochim Biophys Acta 1832:660-73. 2013
    ..LCN2 levels provide no correlation to the degree of liver fibrosis but show significant positive correlation to inflammation instead...
  3. ncbi request reprint Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Aachen, Germany
    Liver Int 32:1342-53. 2012
    ..Recent studies have linked overexpression of CCN3/NOV to mitigate kidney fibrosis. This study aims to investigate CCN3/NOV overexpression in liver fibrogenesis in vivo...
  4. pmc CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, 52074, Aachen, Germany
    J Cell Commun Signal 6:11-25. 2012
    ..These results indicate the complexity of CCN actions that are far beyond the classic Yin/Yang interplay...
  5. ncbi request reprint Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
    Lab Invest 84:766-77. 2004
    ....
  6. doi request reprint Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes
    Hacer Sahin
    Medical Department III and University Hospital Aachen, Aachen, Germany
    Hepatology 57:797-805. 2013
    ..Accordingly, systemic application of CXCL10 led to TLR4-induced liver cell apoptosis in vivo...
  7. ncbi request reprint The expression of CSRP2 encoding the LIM domain protein CRP2 is mediated by TGF-beta in smooth muscle and hepatic stellate cells
    Jens Herrmann
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Germany
    Biochem Biophys Res Commun 345:1526-35. 2006
    ....
  8. ncbi request reprint Pro-fibrogenic potential of PDGF-D in liver fibrosis
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, and Division of Nephrology, RWTH University Hospital Aachen, D 52074 Aachen, Germany
    J Hepatol 46:1064-74. 2007
    ..We analyzed the expression of platelet-derived growth factor D (PDGF-D) in an experimental bile duct-ligated (BDL) rat model and assessed its biological function in cultured hepatic stellate cells (HSC) and myofibroblasts (MFB)...
  9. doi request reprint Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1β through nuclear factor-κB activation
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Aachen, Germany
    Liver Int 31:656-65. 2011
    ..Aims: In this study, we wanted to analyse the expression and regulation of LCN2 in models of acute and chronic experimental liver injury...
  10. doi request reprint Proteomic profiling in Lipocalin 2 deficient mice under normal and inflammatory conditions
    Kirsten Labbus
    Institute of Pathology, RWTH University Hospital Aachen, Germany
    J Proteomics 78:188-96. 2013
    ....
  11. doi request reprint Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling
    Steffen K Meurer
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
    Cell Signal 23:683-99. 2011
    ..In supernatants of respective cultures, we could detect the ectodomain of endoglin suggesting that shedding is a further key process involved in the regulation of this surface receptor...
  12. doi request reprint Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis
    Ina V Martin
    Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany
    Am J Pathol 182:107-17. 2013
    ..PDGF-C antagonism, therefore, may not be effective to treat liver fibrosis...
  13. doi request reprint Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
    J Hepatol 58:104-11. 2013
    ..FSAP is activated by damaged cells and its substrates include growth factors and hemostasis proteins...
  14. doi request reprint Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Aachen, Germany
    Lab Invest 88:1090-100. 2008
    ....
  15. ncbi request reprint Disruption of intermolecular disulfide bonds in PDGF-BB dimers by N-acetyl-L-cysteine does not prevent PDGF signaling in cultured hepatic stellate cells
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Germany
    Biochem Biophys Res Commun 338:1711-8. 2005
    ..Therefore, we conclude that the PDGF monomer is still active. The described antifibrotic effects are therefore mainly attributable to the structural impairment of TGF-beta signaling components reported previously...
  16. ncbi request reprint Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrogenesis
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Germany
    Biochem Biophys Res Commun 321:413-23. 2004
    ..The asPDGF mRNA also attenuates experimental liver fibrogenesis indicated by reduced levels of alpha-SMA and collagen type I expression...
  17. doi request reprint A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects
    Claudia R C van Roeyen
    Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany
    Am J Pathol 180:1979-90. 2012
    ..Manipulation of CCN3 may represent a novel approach to help repair glomerular endothelial damage and mesangioproliferative changes...
  18. ncbi request reprint Cryopreservation of hepatic stellate cells
    Svenja Neyzen
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Pauwelsstr 30, D 52074 Aachen, Germany
    J Hepatol 44:910-7. 2006
    ..Thus, there is a continuing need for developing methods allowing the exchange of HSC isolates between different laboratories. A practical solution to this problem is cryopreservation and banking of HSC...
  19. ncbi request reprint BMP-7 as antagonist of organ fibrosis
    Ralf Weiskirchen
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Germany
    Front Biosci (Landmark Ed) 14:4992-5012. 2009
    ....
  20. doi request reprint Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice
    Hacer Sahin
    Medical Department III, University Hospital Aachen, Aachen, Germany
    Hepatology 55:1610-9. 2012
    ..Accordingly, systemic administration of Cxcl9 led to a strong attenuation of neoangiogenesis and experimental liver fibrosis in vivo...
  21. pmc Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease
    Sorina Georgiana Boaru
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Pauwelsstr, 30, Aachen D 52074, Germany
    J Inflamm (Lond) 9:49. 2012
    ....
  22. ncbi request reprint Inhibitory effect of soluble PDGF-beta receptor in culture-activated hepatic stellate cells
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen D 52074, Germany
    Biochem Biophys Res Commun 317:451-62. 2004
    ..In summary, sPDGFRbeta clearly shows effective inhibitory properties in early HSC activation, suggesting potential therapeutic impact for anti-PDGF intervention in liver fibrogenesis...