K Bork

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint [Umbilical metastasis of a gallbladder carcinoma: "Sister Mary Joseph's nodule"]
    K Bork
    Klinik fur Dermatologie, Germany
    Dtsch Med Wochenschr 127:553-6. 2002
  2. ncbi request reprint Hereditary angioedema with normal C1 inhibitor activity including hereditary angioedema with coagulation factor XII gene mutations
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany
    Immunol Allergy Clin North Am 26:709-24. 2006
  3. ncbi request reprint Hereditary angioedema with normal C1 inhibitor: clinical symptoms and course
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Am J Med 120:987-92. 2007
  4. pmc Diagnosis and treatment of hereditary angioedema with normal C1 inhibitor
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Allergy Asthma Clin Immunol 6:15. 2010
  5. ncbi request reprint Current drugs in early development for hereditary angioedema: potential for effective treatment
    Konrad Bork
    Johannes Gutenberg University, Department of Dermatology, Langenbeckstr 1, 55131 Mainz, Germany 49 6131 17 7290 49 6131 17 6614
    Expert Opin Investig Drugs 23:887-91. 2014
  6. ncbi request reprint Hereditary angioedema with normal C1 inhibitor
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany Electronic address
    Immunol Allergy Clin North Am 33:457-70. 2013
  7. ncbi request reprint Angioedema
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany Electronic address
    Immunol Allergy Clin North Am 34:23-31. 2014
  8. doi request reprint Antihistamine-resistant angioedema in women with negative family history: estrogens and F12 gene mutations
    Konrad Bork
    Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany Electronic address
    Am J Med 126:1142.e9-14. 2013
  9. ncbi request reprint Fatal laryngeal attacks and mortality in hereditary angioedema due to C1-INH deficiency
    Konrad Bork
    Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    J Allergy Clin Immunol 130:692-7. 2012
  10. doi request reprint Current management options for hereditary angioedema
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Curr Allergy Asthma Rep 12:273-80. 2012

Collaborators

Detail Information

Publications45

  1. ncbi request reprint [Umbilical metastasis of a gallbladder carcinoma: "Sister Mary Joseph's nodule"]
    K Bork
    Klinik fur Dermatologie, Germany
    Dtsch Med Wochenschr 127:553-6. 2002
    ..The tumor was 1.5 cm in diameter. There were no other diseases in the patient's history. Physical examination was normal except the umbilical tumor...
  2. ncbi request reprint Hereditary angioedema with normal C1 inhibitor activity including hereditary angioedema with coagulation factor XII gene mutations
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany
    Immunol Allergy Clin North Am 26:709-24. 2006
    ..Recently, in some families mutations in the coagulation factor XII (Hageman factor) gene were detected in the affected women...
  3. ncbi request reprint Hereditary angioedema with normal C1 inhibitor: clinical symptoms and course
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Am J Med 120:987-92. 2007
    ..It was characterized by recurrent bouts of angioedema in various organs and normal C1 inhibitor and was observed mainly in women. Our aim was to conduct a detailed study of the clinical features of this condition...
  4. pmc Diagnosis and treatment of hereditary angioedema with normal C1 inhibitor
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Allergy Asthma Clin Immunol 6:15. 2010
    ..Recently, in some families mutations in the coagulation factor XII (Hageman factor) gene were detected in the affected persons...
  5. ncbi request reprint Current drugs in early development for hereditary angioedema: potential for effective treatment
    Konrad Bork
    Johannes Gutenberg University, Department of Dermatology, Langenbeckstr 1, 55131 Mainz, Germany 49 6131 17 7290 49 6131 17 6614
    Expert Opin Investig Drugs 23:887-91. 2014
    ..Attenuated androgens also may have problematic side effects, highlighting the need for new treatment options. ..
  6. ncbi request reprint Hereditary angioedema with normal C1 inhibitor
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany Electronic address
    Immunol Allergy Clin North Am 33:457-70. 2013
    ..In some families mutations in the coagulation factor XII (Hageman factor) gene were detected. ..
  7. ncbi request reprint Angioedema
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany Electronic address
    Immunol Allergy Clin North Am 34:23-31. 2014
    ..The article presents an overview of these groups and the role of the main mediators, and the clinical features of urticaria and angioedema. ..
  8. doi request reprint Antihistamine-resistant angioedema in women with negative family history: estrogens and F12 gene mutations
    Konrad Bork
    Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany Electronic address
    Am J Med 126:1142.e9-14. 2013
    ....
  9. ncbi request reprint Fatal laryngeal attacks and mortality in hereditary angioedema due to C1-INH deficiency
    Konrad Bork
    Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    J Allergy Clin Immunol 130:692-7. 2012
    ..Hereditary angioedema due to C1 inhibitor deficiency (HAE-C1-INH) is characterized by relapsing skin swellings, abdominal pain attacks, and, less frequently, potentially life-threatening laryngeal attacks...
  10. doi request reprint Current management options for hereditary angioedema
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Curr Allergy Asthma Rep 12:273-80. 2012
    ..The number of management options has increased considerably within the last few years, thus helping to diminish the burden of HAE...
  11. pmc HAE international home therapy consensus document
    Hilary J Longhurst
    Department of Immunology, Barts and The London NHS Trust, London, UK
    Allergy Asthma Clin Immunol 6:22. 2010
    ..It represents the opinion of the authors who have a wide range of expert experience in the management of HAE...
  12. pmc 2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema
    Tom Bowen
    Departments of Medicine and Paediatrics, University of Calgary, Calgary, Alberta, Canada
    Allergy Asthma Clin Immunol 6:24. 2010
    ....
  13. ncbi request reprint Treatment of acute edema attacks in hereditary angioedema with a bradykinin receptor-2 antagonist (Icatibant)
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Allergy Clin Immunol 119:1497-503. 2007
    ..In hereditary angioedema, bradykinin is assumed to be the most important mediator of edema formation...
  14. doi request reprint Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patients
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Ann Allergy Asthma Immunol 100:153-61. 2008
    ..Treatment with androgens prevents attacks for those with this condition...
  15. doi request reprint Kallikrein-kinin system and fibrinolysis in hereditary angioedema due to factor XII gene mutation Thr309Lys
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Blood Coagul Fibrinolysis 20:325-32. 2009
    ..Contrary to the results of a recently published study, no indication that the Thr309Lys mutation causes a 'gain-of-function' of FXIIa was observed in this investigation...
  16. doi request reprint Human pasteurized C1-inhibitor concentrate for the treatment of hereditary angioedema due to C1-inhibitor deficiency
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany
    Expert Rev Clin Immunol 7:723-33. 2011
    ..Prophylactic therapy with C1-inhibitor is also available. Future advances may improve morbidity and mortality associated with hereditary angioedema...
  17. ncbi request reprint Hereditary angioedema: increased number of attacks after frequent treatments with C1 inhibitor concentrate
    Konrad Bork
    Department of Dermatology, University Hospital Mainz, Mainz, Germany
    Am J Med 122:780-3. 2009
    ..This study investigated the course of disease in 3 women treated frequently with C1 inhibitor concentrate...
  18. ncbi request reprint Hereditary angioedema with normal c1 inhibition
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Curr Allergy Asthma Rep 9:280-5. 2009
    ..In some families, mutations in the coagulation factor XII (Hageman factor) gene were detected in the affected persons...
  19. doi request reprint Risk of laryngeal edema and facial swellings after tooth extraction in patients with hereditary angioedema with and without prophylaxis with C1 inhibitor concentrate: a retrospective study
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:58-64. 2011
    ..The aim of this study was to determine how many tooth extractions were followed by symptoms of HAE-C1-INH in patients with and without preoperative short-term prophylaxis with C1 inhibitor concentrate...
  20. ncbi request reprint Pasteurized C1 inhibitor concentrate in hereditary angioedema: pharmacology, safety, efficacy and future directions
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany
    Expert Rev Clin Immunol 4:13-20. 2008
    ..Pasteurized C1 inhibitor concentrates can also be used for prophylaxis of HAE, and are currently also being assessed for home therapy in this setting. Future advances may improve disease burden and mortality associated with HAE...
  21. pmc Recurrent angioedema and the threat of asphyxiation
    Konrad Bork
    Universitäts Hautklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Dtsch Arztebl Int 107:408-14. 2010
    ..Angioedema is a clinical sign that can be produced by a variety of diseases. Asphyxiation due to edematous obstruction of the upper airway is rare, but, for the affected patients, it is a permanent risk...
  22. doi request reprint Hereditary angioedema: long-term treatment with one or more injections of C1 inhibitor concentrate per week
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz, Germany
    Int Arch Allergy Immunol 154:81-8. 2011
    ..The objective of the present study was to assess the efficacy and safety of weekly long-term replacement treatment with one or more injections of plasma-derived C1-INH concentrate per week (WLTC) in patients with HAE-C1-INH...
  23. ncbi request reprint Hereditary angioedema with normal C1-inhibitor activity in women
    K Bork
    Department of Dermatology, University of Mainz, Germany
    Lancet 356:213-7. 2000
    ..We report an unusual variant of HAE with normal biochemical C1-inhibitor function, occurring only in women...
  24. ncbi request reprint Transfer of aciclovir from plasma to human breast milk
    K Bork
    Department of Dermatology, University of Mainz, Germany
    Arzneimittelforschung 50:656-8. 2000
    ..Thus, the higher aciclovir concentration in human breast milk is due to passive diffusion. No active transport mechanism is needed...
  25. ncbi request reprint Treatment of 193 episodes of laryngeal edema with C1 inhibitor concentrate in patients with hereditary angioedema
    K Bork
    Universitäts Hautklinik, Langenbeckstr 1, 55131 Mainz, Germany
    Arch Intern Med 161:714-8. 2001
    ..The clinical symptoms include skin swelling, abdominal pain, and life-threatening episodes of upper airway obstruction. We evaluated the efficacy of C1-INH concentrate for treating sudden airway compromise...
  26. ncbi request reprint Recurrent episodes of skin angioedema and severe attacks of abdominal pain induced by oral contraceptives or hormone replacement therapy
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Am J Med 114:294-8. 2003
    ..We investigated potential interactions between these medications and various types of recurrent angioedema in a large cohort of women...
  27. ncbi request reprint Clinical studies of sudden upper airway obstruction in patients with hereditary angioedema due to C1 esterase inhibitor deficiency
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Arch Intern Med 163:1229-35. 2003
    ..This study describes the age at which laryngeal edema first occurs, the time between onset and full development, and the effectiveness of therapy and prophylaxis...
  28. ncbi request reprint Laryngeal edema and death from asphyxiation after tooth extraction in four patients with hereditary angioedema
    Konrad Bork
    Universitäts Hautklinik, Mainz, Germany
    J Am Dent Assoc 134:1088-94. 2003
    ..Hereditary angioedema, or HAE, due to C1 inhibitor, or C1NH, deficiency has considerable implications for dental health care providers because dental surgery may trigger distressing and even life-threatening episodes...
  29. ncbi request reprint Sudden upper airway obstruction in patients with hereditary angioedema
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University of Mainz, Universitäts Hautklinik, Langenbeckstr 1, 55131 Mainz, Germany
    Transfus Apher Sci 29:235-8. 2003
    ..It is essential to instruct patients and their relatives about the first signs of laryngeal edemas and the necessary procedures to follow...
  30. ncbi request reprint Pruritus precipitated by hydroxyethyl starch: a review
    K Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Br J Dermatol 152:3-12. 2005
    ..Well-designed clinical outcome studies are needed to assess more fully the incidence, dose dependency and mechanisms of pruritus with particular HES solutions...
  31. ncbi request reprint Treatment with C1 inhibitor concentrate in abdominal pain attacks of patients with hereditary angioedema
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Transfusion 45:1774-84. 2005
    ..Abdominal edema attacks in patients with hereditary angioedema are often extremely painful, associated with vomiting and diarrhea, and have a high potential for causing recurrent disability of the patient...
  32. ncbi request reprint Hereditary angioedema: new findings concerning symptoms, affected organs, and course
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Am J Med 119:267-74. 2006
    ..Our aim was to examine a temporal and spatial pattern of the edema episodes by evaluating the long-term course of hereditary angioedema in order to establish a specific swelling pattern...
  33. ncbi request reprint Hereditary angioedema caused by missense mutations in the factor XII gene: clinical features, trigger factors, and therapy
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstr 1, Mainz 55131, Germany
    J Allergy Clin Immunol 124:129-34. 2009
    ..Hereditary angioedema caused by mutations in the factor XII gene is a recently described disease entity that occurs mainly in women. It differs from hereditary angioedema caused by C1 inhibitor deficiency...
  34. doi request reprint A novel mutation in the coagulation factor 12 gene in subjects with hereditary angioedema and normal C1-inhibitor
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Clin Immunol 141:31-5. 2011
    ..Thr328Lys* and p.Thr328Arg* reported previously. Our findings confirm the association between F12 gene mutations modifying the proline-rich region of the FXII protein and hereditary angioedema with normal C1-inhibitor...
  35. ncbi request reprint [Achalasia in circumscribed scleroderma]
    I Gockel
    Klinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat Mainz
    Dtsch Med Wochenschr 131:1799-802. 2006
    ..His symptoms had increased markedly 6 months before presenting at our hospital and the patient had lost 15 kg of weight. 2 months ago, a percutaneous endoscopic gastrostomy (PEG) had been inserted at another hospital...
  36. ncbi request reprint Hereditary angio-oedema with normal C1 inhibitor in a family with affected women and men
    K Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Br J Dermatol 154:542-5. 2006
    ..Alternatively, our present observation of hereditary angio-oedema with normal C1 inhibitor affecting both sexes may represent a new disease entity, presumably with a different underlying defect...
  37. ncbi request reprint Symptoms, course, and complications of abdominal attacks in hereditary angioedema due to C1 inhibitor deficiency
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Am J Gastroenterol 101:619-27. 2006
    ..They are characterized by crampy pain, but may include vomiting, diarrhea, and other features. Detailed clinical data about the symptoms and course of abdominal attacks have not been reported...
  38. doi request reprint Treatment of skin swellings with C1-inhibitor concentrate in patients with hereditary angio-oedema
    K Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Allergy 63:751-7. 2008
    ..They may be painful and impact daily activities of patients. Detailed clinical data concerning the treatment of skin swellings by C1-INH concentrate have not been reported yet...
  39. ncbi request reprint Multifocal disseminated lipoatrophy secondary to intravenous corticosteroid administration in a patient with adrenal insufficiency
    Jürgen Bauerschmitz
    Department of Dermatology, University of Mainz, Germany
    J Am Acad Dermatol 46:S130-2. 2002
    ....
  40. ncbi request reprint Missense mutations in the coagulation factor XII (Hageman factor) gene in hereditary angioedema with normal C1 inhibitor
    Georg Dewald
    Institut d Immunologie et d Hématologie, Faculte de Medecine, Universite Louis Pasteur, 4 rue Kirschleger, 67085 Strasbourg Cedex, France
    Biochem Biophys Res Commun 343:1286-9. 2006
    ..The predicted structural and functional impact of the mutations, their absence in 145 healthy controls, and their co-segregation with the phenotype in five families provide strong support that they cause disease...
  41. pmc Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III
    Sven Cichon
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Am J Hum Genet 79:1098-104. 2006
    ..The results of our study represent an important step toward an understanding of the molecular processes involved in HAE type III and provide diagnostic and possibly new therapeutic opportunities...
  42. ncbi request reprint Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond
    Angelo Agostoni
    University of Milan, Italy
    J Allergy Clin Immunol 114:S51-131. 2004
    ..This supplement seeks to raise awareness and aid diagnosis of HAE, optimize treatment for all patients, and provide a platform for further research in this rare, partially understood disorder...
  43. ncbi request reprint Helicobacter pylori infection as a triggering factor of attacks in patients with hereditary angioedema
    Beata Visy
    Madarász Street Hospital of the Heim Pál Pediatric Hospital, Budapest, Hungary
    Helicobacter 12:251-7. 2007
    ..The present study aimed to reinvestigate the relationship between H. pylori infection and the attack rate in the framework of an international collaborative study...
  44. ncbi request reprint Canadian 2003 International Consensus Algorithm For the Diagnosis, Therapy, and Management of Hereditary Angioedema
    Tom Bowen
    Department of Medicine and Paeditrics, University of Calgary, Calgary, Alberta T2N 2T8, Canada
    J Allergy Clin Immunol 114:629-37. 2004
    ..Hopefully evidence to support approaches to the management of HAE will approach the level of meta-analysis of randomized controlled trials in the near future...
  45. ncbi request reprint Danazol-induced hepatocellular adenoma in patients with hereditary angio-oedema
    Konrad Bork
    J Hepatol 36:707-9. 2002