Martin Borggrefe

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Prevalence of supraventricular tachyarrhythmias in a cohort of 115 patients with Brugada syndrome
    Rainer Schimpf
    First Department of Medicine, Division of Cardiology, University Hospital Mannheim, Germany
    Ann Noninvasive Electrocardiol 13:266-9. 2008
  2. doi request reprint Randomized, double blind study of non-excitatory, cardiac contractility modulation electrical impulses for symptomatic heart failure
    Martin M Borggrefe
    I Medizinische Klinik, Klinikum Mannheim GmbH, Universitatsklinikum, Medizinische Fakultät Mannheim der Universität Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Eur Heart J 29:1019-28. 2008
  3. ncbi request reprint [Amiodarone or ICD in patients with cardiac insufficiency. SCD-HeFT Study]
    M Borggrefe
    I Medizinische Klinik, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim
    Internist (Berl) 47:89-91. 2006
  4. ncbi request reprint [Reduced pump function after myocardial infarct. Indication for defibrillator implantation? The MADIT II Study]
    M Borggrefe
    I Medizinische Klinik, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim
    Internist (Berl) 44:110-2. 2003
  5. pmc Short QT syndrome. Genotype-phenotype correlations
    Martin Borggrefe
    1st Department of Medicine Cardiology, University Hospital Mannheim, Faculty of Clinical Medicine of the University of Heidelberg, 68167 Mannheim, Germany
    J Electrocardiol 38:75-80. 2005
  6. ncbi request reprint Cardiovascular magnetic resonance findings in typical versus atypical forms of the acute apical ballooning syndrome (Takotsubo cardiomyopathy)
    Dariusch Haghi
    I Medical Department, University Hospital Mannheim, Mannheim, Germany
    Int J Cardiol 120:205-11. 2007
  7. ncbi request reprint Validation of the peak to mean pressure decrease ratio as a new method of assessing aortic stenosis using the Gorlin formula and the cardiovascular magnetic resonance-based hybrid method
    Dariusch Haghi
    Medical Department, University Hospital Mannheim, Mannheim, Germany
    Echocardiography 24:335-9. 2007
  8. pmc CMR findings in patients with hypertrophic cardiomyopathy and atrial fibrillation
    Theano Papavassiliu
    1st Department of Medicine Cardiology, University Hospital of Mannheim, Mannheim, Germany
    J Cardiovasc Magn Reson 11:34. 2009
  9. ncbi request reprint Recombinant human activated protein C upregulates the release of soluble fractalkine from human endothelial cells
    Martina Brueckmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Br J Haematol 133:550-7. 2006
  10. doi request reprint Midregional pro-atrial natriuretic peptide: a novel marker of myocardial fibrosis in patients with hypertrophic cardiomyopathy
    Elif Elmas
    1st Department of Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Int J Cardiovasc Imaging 27:547-56. 2011

Detail Information

Publications123 found, 100 shown here

  1. ncbi request reprint Prevalence of supraventricular tachyarrhythmias in a cohort of 115 patients with Brugada syndrome
    Rainer Schimpf
    First Department of Medicine, Division of Cardiology, University Hospital Mannheim, Germany
    Ann Noninvasive Electrocardiol 13:266-9. 2008
    ..Initial reports in small numbers of patients suggest an association between supraventricular tachycardias and Brugada syndrome with a prevalence varying between 13% and 40%...
  2. doi request reprint Randomized, double blind study of non-excitatory, cardiac contractility modulation electrical impulses for symptomatic heart failure
    Martin M Borggrefe
    I Medizinische Klinik, Klinikum Mannheim GmbH, Universitatsklinikum, Medizinische Fakultät Mannheim der Universität Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Eur Heart J 29:1019-28. 2008
    ..We performed a randomized, double blind, crossover study of cardiac contractility modulation (CCM) signals in heart failure patients...
  3. ncbi request reprint [Amiodarone or ICD in patients with cardiac insufficiency. SCD-HeFT Study]
    M Borggrefe
    I Medizinische Klinik, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim
    Internist (Berl) 47:89-91. 2006
  4. ncbi request reprint [Reduced pump function after myocardial infarct. Indication for defibrillator implantation? The MADIT II Study]
    M Borggrefe
    I Medizinische Klinik, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim
    Internist (Berl) 44:110-2. 2003
  5. pmc Short QT syndrome. Genotype-phenotype correlations
    Martin Borggrefe
    1st Department of Medicine Cardiology, University Hospital Mannheim, Faculty of Clinical Medicine of the University of Heidelberg, 68167 Mannheim, Germany
    J Electrocardiol 38:75-80. 2005
    ..It may serve as an adjunct to ICD therapy or as possible alternative treatment especially for children and newborns...
  6. ncbi request reprint Cardiovascular magnetic resonance findings in typical versus atypical forms of the acute apical ballooning syndrome (Takotsubo cardiomyopathy)
    Dariusch Haghi
    I Medical Department, University Hospital Mannheim, Mannheim, Germany
    Int J Cardiol 120:205-11. 2007
    ....
  7. ncbi request reprint Validation of the peak to mean pressure decrease ratio as a new method of assessing aortic stenosis using the Gorlin formula and the cardiovascular magnetic resonance-based hybrid method
    Dariusch Haghi
    Medical Department, University Hospital Mannheim, Mannheim, Germany
    Echocardiography 24:335-9. 2007
    ....
  8. pmc CMR findings in patients with hypertrophic cardiomyopathy and atrial fibrillation
    Theano Papavassiliu
    1st Department of Medicine Cardiology, University Hospital of Mannheim, Mannheim, Germany
    J Cardiovasc Magn Reson 11:34. 2009
    ....
  9. ncbi request reprint Recombinant human activated protein C upregulates the release of soluble fractalkine from human endothelial cells
    Martina Brueckmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Br J Haematol 133:550-7. 2006
    ..Further clinical trials are needed to confirm the in vivo relevance of these data...
  10. doi request reprint Midregional pro-atrial natriuretic peptide: a novel marker of myocardial fibrosis in patients with hypertrophic cardiomyopathy
    Elif Elmas
    1st Department of Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Int J Cardiovasc Imaging 27:547-56. 2011
    ..The results imply that MR-proANP serves as a novel marker of myocardial fibrosis assessed by LGE CMR in patients with HCM...
  11. doi request reprint Role of proinflammatory markers and NT-proBNP in patients with an implantable cardioverter-defibrillator and an electrical storm
    Florian Streitner
    1st Department of Medicine Cardiology, University Hospital of Mannheim, Faculty of Medicine of the University of Heidelberg, Mannheim, Germany
    Cytokine 47:166-72. 2009
    ....
  12. ncbi request reprint Coronary artery disease in takotsubo cardiomyopathy
    Dariusch Haghi
    I Medical Department, University Hospital Mannheim, Mannheim, Germany
    Circ J 71:1092-4. 2007
    ..Significant coronary artery disease (CAD) is generally considered as an exclusion criterion for the diagnosis of takotsubo cardiomyopathy (TC). However, this may not be justified in all cases, because TC and CAD may coincide...
  13. ncbi request reprint Endotoxin-induced effects on platelets and monocytes in an in vivo model of inflammation
    Thorsten Kälsch
    1st Department of Medicine, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Basic Res Cardiol 102:460-6. 2007
    ..The aim of this study was to investigate the direct and short-term effects of inflammation on platelet and monocyte activation with an in vivo model of endotoxemia in healthy volunteers...
  14. ncbi request reprint Enhanced expression of platelet CD40-ligand by in vitro lipopolysaccharide-challenge in patients with ventricular fibrillation complicating acute myocardial infarction
    Thorsten Kälsch
    Department of Cardiology, 1st Department of Medicine, University Hospital Mannheim, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Int J Cardiol 107:350-5. 2006
    ..A role of inflammatory stimulation on platelets as a potential risk factor for ventricular fibrillation during acute myocardial infarction has not been described yet...
  15. doi request reprint Platelet and monocyte activity markers and mediators of inflammation in Takotsubo cardiomyopathy
    Rainer Pirzer
    1st Department of Medicine Cardiology, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Heart Vessels 27:186-92. 2012
    ..Our results indicate that inflammatory mediators and platelet-activity markers contribute to the differences in the pathogenesis of MI and TC...
  16. pmc Electromechanical coupling in patients with the short QT syndrome: further insights into the mechanoelectrical hypothesis of the U wave
    Rainer Schimpf
    1st Department of Medicine Cardiology, University Hospital Mannheim, Mannheim, Germany
    Heart Rhythm 5:241-5. 2008
    ..It is not known whether abbreviation of cardiac repolarization alters mechanical function in SQTS. Controversies persist regarding whether the U wave is a purely electrical or mechanoelectrical phenomenon...
  17. ncbi request reprint Influence of bag volume on reproducibility of inert gas rebreathing pulmonary blood flow measurements in patients with pulmonary diseases
    Joachim Saur
    1st Department of Medicine Cardiology, Angiology, Pneumology, Intensive Care, Universitatsmedizin Mannheim, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Lung 191:467-73. 2013
    ..However, elderly patients or those with severe pulmonary disease may be unable to rebreathe this volume entirely. We evaluated the effect of adapting V bag on the reproducibility of IGR...
  18. pmc Impact of shocks on mortality in patients with ischemic or dilated cardiomyopathy and defibrillators implanted for primary prevention
    Florian Streitner
    1st Department of Medicine Cardiology, University Medical Centre Mannheim, Mannheim, Germany
    PLoS ONE 8:e63911. 2013
    ..The purpose of this study was to compare the outcome after shocks in patients with ischemic cardiomyopathy (ICM) or DCM and defibrillators (ICD) implanted for primary prevention...
  19. doi request reprint Is arterial pulse contour analysis using Nexfin a new option in the noninvasive measurement of cardiac output?--A pilot study
    Frederik Trinkmann
    1st Department of Medicine Cardiology, Angiology, Pneumology, Intensive Care, Medical Faculty Mannheim, University of Heidelberg, Germany
    J Cardiothorac Vasc Anesth 27:283-7. 2013
    ..The aim of this study was to evaluate the accuracy and precision of pulse contour analysis (PCA) compared with cardiac magnetic resonance imaging (CMR)...
  20. ncbi request reprint Alimentary lipemia enhances procoagulatory effects of inflammation in patients with a history of acute myocardial infarction complicated by ventricular fibrillation
    Thorsten Kälsch
    1st Department of Medicine, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Int J Cardiol 123:131-7. 2008
    ..The role of acute alimentary lipemia and inflammation in the occurrence of ventricular arrhythmias in acute myocardial infarction has not been described yet...
  21. ncbi request reprint Prospective study of interleukin-6 and the risk of malignant ventricular tachyarrhythmia in ICD-recipients--a pilot study
    Florian Streitner
    1st Department of Medicine Cardiology, University Hospital of Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Cytokine 40:30-4. 2007
    ..We investigated the relationship between interleukin-6 (IL-6) and the risk of experiencing spontaneous ventricular tachyarrhythmia (VT/VF) in patients with an implantable cardioverter-defibrillator (ICD)...
  22. ncbi request reprint Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcification
    Jens J Kaden
    First Department of Medicine Cardiology, Angiology, and Pneumology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theordor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Mol Cell Cardiol 36:57-66. 2004
    ..Receptor Activator of Nuclear factor kappaB Ligand" (RANKL) and osteoprotegerin (OPG) are members of a cytokine system involved in bone turnover and vascular calcification. Their role in calcific AS is not known...
  23. doi request reprint Visual estimation of the extent of myocardial hyperenhancement on late gadolinium-enhanced CMR in patients with hypertrophic cardiomyopathy
    Christina Doesch
    1st Department of Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    Magn Reson Imaging 28:812-9. 2010
    ..The aim of our study was to investigate whether the determination of LGE in patients with HCM using a semiquantitative score based on the 17-segment model is feasible and has comparable accuracy to manual planimetry...
  24. doi request reprint Predictors of electrical storm recurrences in patients with implantable cardioverter-defibrillators
    Florian Streitner
    Department of Medicine Cardiology, University Medical Centre Mannheim, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    Europace 13:668-74. 2011
    ..To determine prevalence and predictors of electrical storm recurrences (ES-Rs) in patients with implantable cardioverter-defibrillators (ICDs) as electrical storms (ESs) represent serious clinical events carrying a high risk of mortality...
  25. ncbi request reprint Midregional pro-atrial natriuretic peptide is a useful indicator for the detection of impaired left ventricular function in patients with coronary artery disease
    Elif Elmas
    1st Department of Medicine, Medical Faculty Mannheim of the University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Int J Cardiol 128:244-9. 2008
    ....
  26. doi request reprint Response to intravenous ajmaline: a retrospective analysis of 677 ajmaline challenges
    Christian Veltmann
    11st Department of Medicine Cardiology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Europace 11:1345-52. 2009
    ..Challenge with intravenous ajmaline is used to unmask the diagnostic Brugada ECG. The aim of this study was to evaluate the safety of the test and to identify predictors for the response to an intravenous ajmaline challenge...
  27. ncbi request reprint Effects of alimentary lipemia and inflammation on platelet CD40-ligand
    Thorsten Kälsch
    1st Department of Medicine, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Thromb Res 120:703-8. 2007
    ..Our aim was to describe the role of postprandial lipemia and inflammatory stimulation on platelet and monocyte activation and CD40-ligand (CD40L) levels...
  28. ncbi request reprint [Chlamydia pneumoniae--a new risk factor for calcific aortic stenosis?]
    Jens J Kaden
    I Medizinische Klinik, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim
    Med Klin (Munich) 100:334-9. 2005
    ..Recent studies suggest that it is based on a chronic inflammatory process. The pathogenetic mechanisms, however, are unclear...
  29. pmc Alterations of leptin in the course of inflammation and severe sepsis
    Michael Behnes
    First Department of Medicine, University Medical Centre Mannheim UMM, Faculty of Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    BMC Infect Dis 12:217. 2012
    ....
  30. ncbi request reprint Extent of myocardial hyperenhancement on late gadolinium-enhanced cardiovascular magnetic resonance correlates with q waves in hypertrophic cardiomyopathy
    Theano Papavassiliu
    1st Department of Medicine, University Hospital of Mannheim, Faculty of Clinical Medicine of the University of Heidelberg, Mannheim, Germany
    J Cardiovasc Magn Reson 9:595-603. 2007
    ..The purpose of this prospective study was to evaluate the morphological basis of abnormal Q waves in hypertrophic cardiomyopathy (HCM) as assessed by CMR...
  31. ncbi request reprint A prospective study on spontaneous fluctuations between diagnostic and non-diagnostic ECGs in Brugada syndrome: implications for correct phenotyping and risk stratification
    Christian Veltmann
    First Department of Medicine, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Eur Heart J 27:2544-52. 2006
    ..The purpose of this study was to prospectively evaluate the spontaneous ECG changes between diagnostic and non-diagnostic ECG patterns in patients diagnosed with Brugada syndrome...
  32. doi request reprint Transforming growth factor beta 1 (TGF-beta 1) in atrial fibrillation and acute congestive heart failure
    Michael Behnes
    First Department of Medicine, University Medical Centre Mannheim, Medical Faculty of Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    Clin Res Cardiol 100:335-42. 2011
    ..Transforming growth factor beta 1 (TGF-beta 1) represents a central regulator of cardiac fibrosis. This study investigates serum levels of TGF-beta 1 in patients with AF and aCHF...
  33. ncbi request reprint Right ventricular involvement in Takotsubo cardiomyopathy
    Dariusch Haghi
    Medical Department, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, Mannheim 68167, Germany
    Eur Heart J 27:2433-9. 2006
    ..The aim of our study is to assess the incidence and clinical significance of right ventricular (RV) involvement in Takotsubo cardiomyopathy (TTC)...
  34. ncbi request reprint Coagulation activation and expression of CD40 ligand on platelets upon in vitro lipopolysaccharide-challenge in patients with unstable angina
    Thorsten Kälsch
    University Hospital Mannheim, 1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Int J Cardiol 111:217-23. 2006
    ..A role of inflammatory stimulation on coagulation time and expression of CD40 ligand on platelets in acute coronary syndromes has not been described yet...
  35. ncbi request reprint Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis
    Jens J Kaden
    1st Department of Medicine Cardiology, Angiology, and Pneumology, University Hospital of Mannheim, Germany
    J Heart Valve Dis 13:560-6. 2004
    ..Their pathogenetic role in calcific aortic stenosis is unknown...
  36. ncbi request reprint Recombinant human activated protein C upregulates cyclooxygenase-2 expression in endothelial cells via binding to endothelial cell protein C receptor and activation of protease-activated receptor-1
    Martina Brueckmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Thromb Haemost 93:743-50. 2005
    ....
  37. ncbi request reprint Prevalence of atherosclerosis of the coronary and extracranial cerebral arteries in patients undergoing aortic valve replacement for calcified stenosis
    Jens J Kaden
    1st Department of Medicine Cardiology, Angiology, and Pneumology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    J Heart Valve Dis 15:165-8. 2006
    ..The study aim was to investigate the coexistence of various atherosclerotic changes in patients with non-rheumatic calcific aortic valve stenosis (AS), since calcific AS shares various clinical risk factors with atherosclerosis...
  38. doi request reprint Effects of nicotinic acid on endothelial cells and platelets
    Ksenija Stach
    1st Department of Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    Cardiovasc Pathol 21:89-95. 2012
    ..The purpose of this study was to investigate possible protective effects of nicotinic acid in an in vitro endothelial cell model...
  39. ncbi request reprint Short QT syndrome
    Rainer Schimpf
    1st Department of Medicine Cardiology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Cardiovasc Res 67:357-66. 2005
    ..It may serve as an adjunct to ICD therapy or as a possible alternative treatment, especially for children and newborns...
  40. ncbi request reprint Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis
    Jens J Kaden
    1st Department of Medicine Cardiology, Angiology, Pneumology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Cardiovasc Pathol 14:80-7. 2005
    ....
  41. ncbi request reprint A hybrid approach for quantification of aortic valve stenosis using cardiac magnetic resonance imaging and echocardiography
    Dariusch Haghi
    Medical Department, University Hospital Mannheim, Mannheim, Germany
    J Cardiovasc Magn Reson 7:581-6. 2005
    ....
  42. doi request reprint Prevention of inappropriate ICD shocks in patients with Brugada syndrome
    Christian Veltmann
    1st Department of Medicine Cardiology, University Medical Centre Mannheim, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Clin Res Cardiol 99:37-44. 2010
    ..7-14.1%/year). Aim of the present study was to evaluate a single ventricular fibrillation (VF) detection zone with a high cut-off rate with respect to prevention of inappropriate ICD shock due to SVT and safety of this programming...
  43. ncbi request reprint Takotsubo cardiomyopathy (acute left ventricular apical ballooning syndrome) occurring in the intensive care unit
    Dariusch Haghi
    Medical Department, University Hospital Mannheim, 68167 Mannheim, Germany
    Intensive Care Med 32:1069-74. 2006
    ..The aim of our study was to assess clinical features of Takotsubo cardiomyopathy occurring in the intensive care unit...
  44. pmc Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG
    Christian Wolpert
    1st Department of Medicine Cardiology, University Hospital Mannheim, Mannheim, Germany
    J Cardiovasc Electrophysiol 16:54-8. 2005
    ..The principal aim of this study was to assess the efficacy of quinidine in suppressing IKr in vitro and in modulating the rate dependence of the QT interval in the "SQT1" form of the short QT syndrome...
  45. pmc Intravenous drug challenge using flecainide and ajmaline in patients with Brugada syndrome
    Christian Wolpert
    1st Department of Medicine Cardiology, University Hospital of Mannheim, Faculty of Clinical Medicine of the University of Heidelberg, Germany
    Heart Rhythm 2:254-60. 2005
    ..The purpose of this study was to compare the effect of intravenous flecainide and ajmaline with respect to their ability to induce or accentuate the typical ECG pattern of Brugada syndrome...
  46. ncbi request reprint In vivo effects of mutant HERG K+ channel inhibition by disopyramide in patients with a short QT-1 syndrome: a pilot study
    Rainer Schimpf
    First Department of Medicine Cardiology, University Hospital Mannheim, Mannheim, Germany
    J Cardiovasc Electrophysiol 18:1157-60. 2007
    ..The aim of the present study was to test the in vivo effects of disopyramide in patients with short QT-1 syndrome caused by a N588K mutation in HERG...
  47. ncbi request reprint Volumetric assessment of epicardial adipose tissue with cardiovascular magnetic resonance imaging
    Stephan Flüchter
    First Medical Department, University Hospital of Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Obesity (Silver Spring) 15:870-8. 2007
    ..In this prospective study, a new cardiovascular magnetic resonance imaging (CMR) method using the three-dimensional summation of slices method was introduced to assess the total amount of epicardial fat...
  48. ncbi request reprint Channelopathies: Brugada syndrome, long QT syndrome, short QT syndrome, and CPVT
    Rainer Schimpf
    Ist Department of Medicine Cardiology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Herz 34:281-8. 2009
    ..Competitive sports and vigorous exercise are contraindications in almost all patients. Even recreational exercise may have to be avoided in phenotypically overt patients or silent gene carriers depending on the underlying disease...
  49. ncbi request reprint Levels of oxidized low-density lipoproteins are increased in patients with severe sepsis
    Michael Behnes
    First Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    J Crit Care 23:537-41. 2008
    ....
  50. doi request reprint Clinical and molecular genetics of the short QT syndrome
    Rainer Schimpf
    Ist Department of Medicine Cardiology, University Hospital Mannheim, Mannheim, Germany
    Curr Opin Cardiol 23:192-8. 2008
    ..Genetically determined arrhythmias are a potential cause for a primary electrical disease. A recently discovered primary electrical disease is discussed...
  51. doi request reprint Connective tissue growth factor (CTGF/CCN2): diagnostic and prognostic value in acute heart failure
    Michael Behnes
    First Department of Medicine, University Medical Centre Mannheim UMM, Faculty of Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Clin Res Cardiol 103:107-16. 2014
    ..However, the diagnostic and prognostic value of CTGF levels in acute heart failure (AHF) in addition to natriuretic peptide testing has not yet been evaluated...
  52. doi request reprint Coronary computed tomography and triple rule out CT in patients with acute chest pain and an intermediate cardiac risk profile. Part 1: impact on patient management
    Joachim Gruettner
    Emergency Department, University Medical Center, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Eur J Radiol 82:100-5. 2013
    ..To evaluate the impact of coronary CT angiography (coronary CTA) or "triple-rule-out" CT angiography (TRO-CTA) on patient management in the work-up of patients with acute chest pain and an intermediate cardiac risk profile...
  53. ncbi request reprint Enhanced coagulation activation by in vitro lipopolysaccharide challenge in patients with ventricular fibrillation complicating acute myocardial infarction
    Thorsten Kälsch
    1st Department of Medicine, University Hospital Mannheim, Germany
    J Cardiovasc Electrophysiol 16:858-63. 2005
    ..Indicators of coagulation and inflammation are elevated in patients with coronary heart disease. A role of coagulation activation in ventricular fibrillation during acute myocardial infarction has not been described...
  54. doi request reprint The impact of pulmonary disease on noninvasive measurement of cardiac output by the inert gas rebreathing method
    Joachim Saur
    1st Department of Medicine Cardiology, Angiology, Pneumology, Intensive Care, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Lung 188:433-40. 2010
    ..04, p = 0.82). IGR allows a feasible determination of CO even in patients with lung diseases. The accuracy of the IGR method is not influenced by either pulmonary obstructive and restrictive diseases or a reduced DLCO...
  55. ncbi request reprint Clinical characteristics and treatment of short QT syndrome
    Christian Wolpert
    1st Department of Medicine Cardiology, University Hospital Mannheim, Faculty of Clinical Medicine of the Ruprecht Karls University Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Expert Rev Cardiovasc Ther 3:611-7. 2005
    ....
  56. ncbi request reprint A novel regional right ventricular wall-motion abnormality observed in a case of acute pulmonary embolism (reverse McConnell sign)
    Dariusch Haghi
    First Medical Department, University Hospital Mannheim, 68167 Mannheim, Germany
    J Am Soc Echocardiogr 18:75-7. 2005
    ..We describe the case of a patient with acute pulmonary embolism who developed reversible akinesia of the apex and right ventricular midfree wall, a finding we would like to term "reverse McConnell sign."..
  57. ncbi request reprint [Short QT syndrome]
    Christian Wolpert
    Medizinische Klinik, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68259, Mannheim, Germany
    Herz 32:206-10. 2007
    ..g., sotalol or ibutilide in patients with a mutation in the IKr-coding gene KCNH2 (HERG). Quinidine proved to be efficient in prolonging the QT interval and normalizing the effective refractory periods in some patients...
  58. ncbi request reprint Magnetic resonance imaging findings in patients with Brugada syndrome
    Theano Papavassiliu
    1st Department of Medicine, University Hospital of Mannheim, Faculty of Clinical Medicine of the University of Heidelberg, Mannheim, Germany
    J Cardiovasc Electrophysiol 15:1133-8. 2004
    ..In the present study, we prospectively evaluated CMR findings in patients with Brugada syndrome compared to matched controls...
  59. ncbi request reprint Congenital short QT syndrome and implantable cardioverter defibrillator treatment: inherent risk for inappropriate shock delivery
    Rainer Schimpf
    Ist Department of Medicine Cardiology, University Hospital Mannheim, Mannheim, Germany
    J Cardiovasc Electrophysiol 14:1273-7. 2003
    ..We report on the initial use of implantable cardioverter defibrillator (ICD) therapy in patients with inherited short QT interval and discuss sensing abnormalities and detection issues...
  60. ncbi request reprint Activation of coagulation during alimentary lipemia under real-life conditions
    Elif Elmas
    I Department of Medicine, University Hospital of Mannheim, Theodor Kutzer Ufer 1 3, D 68167, Mannheim, Germany
    Int J Cardiol 114:172-5. 2007
    ..9+/-94.6 to 273.6+/-122.5 mg/dl in coronary heart disease patients. Fat-rich meals may cause procoagulant episodes, which may promote vascular complications such as myocardial infarction, transient ischemia attacks in susceptible persons...
  61. doi request reprint Noninvasive determination of cardiac output by the inert-gas-rebreathing method--comparison with cardiovascular magnetic resonance imaging
    Joachim Saur
    1st Department of Medicine Cardiology, Angiology, Pneumology, Intensive Care, University of Heidelberg, Mannheim, Germany
    Cardiology 114:247-54. 2009
    ..Innocor, a novel inert-gas-rebreathing (IGR) system, has shown promising results in smaller studies. An extensive evaluation in a larger, less homogeneous patient collective is lacking...
  62. doi request reprint Quantitative analysis of coronary plaque composition by dual-source CT in patients with acute non-ST-elevation myocardial infarction compared to patients with stable coronary artery disease correlated with virtual histology intravascular ultrasound
    Sonja Sudarski
    Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Acad Radiol 20:995-1003. 2013
    ....
  63. ncbi request reprint Interleukin-1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis
    Jens J Kaden
    1st Department of Medicine Cardiology, Angiology, and Pneumology, University Hospital of Mannheim, Mannheim, Germany
    Atherosclerosis 170:205-11. 2003
    ..Cell proliferation was increased by IL-1 beta as determined by bromodesoxyuridine incorporation. Thus, IL-1 beta may regulate remodeling of the extracellular matrix in calcific AS...
  64. ncbi request reprint Evaluation of aortic valve stenosis using a hybrid approach of Doppler echocardiography and inert gas rebreathing
    Karsten Hamm
    First Department of Medicine Cardiology, Pneumology, Angiology, Intensive Care Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    In Vivo 26:1027-33. 2012
    ..The present study aimed to evaluate the use of inert gas rebreathing (IGR)-derived SV in this situation...
  65. doi request reprint [Is cardiotoxicity still an issue after breast-conserving surgery and could it be reduced by multifield IMRT?]
    Frank Lohr
    Klinik fur Strahlentherapie und Radioonkologie, Universitatsklinikum Mannheim, Germany
    Strahlenther Onkol 185:222-30. 2009
    ..A survival benefit after breast conservation, however, has only been proven recently which was in part due to excessive cardiac mortality of patients who had been treated with radiotherapy in the past...
  66. ncbi request reprint Cerebral infarction: incidence and risk factors after diagnostic and interventional cardiac catheterization--prospective evaluation at diffusion-weighted MR imaging
    Karen A Büsing
    Department of Clinical Radiology, University Hospital Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Radiology 235:177-83. 2005
    ..To prospectively evaluate incidence of clinically silent and clinically apparent embolic cerebral infarction following diagnostic and interventional coronary angiography and associated risk factors...
  67. doi request reprint Risk stratification in electrical cardiomyopathies
    Christian Veltmann
    1st Department of Medicine Cardiology, University Medicine Mannheim, Mannheim, Germany
    Herz 34:518-27. 2009
    ..The genotype contributes to risk stratification only in LQTS and CPVT.Patients with electrical cardiomyopathies have to be risk-stratified individually based on the data and the current guidelines available...
  68. ncbi request reprint Delayed hyperenhancement in a case of Takotsubo cardiomyopathy
    Dariusch Haghi
    Medical Department, University Hospital Mannheim, Mannheim, Germany
    J Cardiovasc Magn Reson 7:845-7. 2005
    ..A gadolinium-enhanced CMR performed 6 weeks later exhibited complete reversal of all wall motion abnormalities and an identical area of subendocardial delayed hyperenhancement...
  69. ncbi request reprint Performance evaluation of a new rapid quantitative assay system for measurement of D-dimer in plasma and whole blood: PATHFAST D-dimer
    Carl Erik Dempfle
    Mannheim University Hospital, I Department of Medicine, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Thromb Res 120:591-6. 2007
    ..005 microg/ml FEU. In conclusion, the PATHFAST D-dimer assay is the first automated fully quantitative D-dimer assay, which can use plasma and whole blood as sample materials in parallel...
  70. ncbi request reprint Thrombogenicity of sirolimus-eluting stents and bare metal stents: evaluation in the early phase after stent implantation
    Thomas Walter
    University Medical Centre Mannheim, First Department of Medicine Cardiology, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    In Vivo 24:635-9. 2010
    ..Thrombogenicitiy of drug-eluting stents is a matter of controversial debate. The aim of this study was to evaluate the thrombogenicity of sirolimus-eluting stents (SES) compared to bare metal stents (BMS) in a standardised in vitro model...
  71. ncbi request reprint Statin therapy of calcific aortic stenosis: hype or hope?
    Volker Liebe
    First Department of Medicine Cardiology, University Hospital Mannheim, Germany
    Eur Heart J 27:773-8. 2006
    ....
  72. ncbi request reprint Non-invasive evaluation of left ventricular filling pressures in patients with abnormal relaxation
    Tudor C Poerner
    First Department of Medicine, University Hospital of Mannheim, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Clin Sci (Lond) 106:485-94. 2004
    ..In conclusion, DeltaP V (R)- A enabled the most accurate non-invasive estimation of LVEDP. A prolonged peak relaxation time was the only TDI-derived index that differed significantly between patient groups...
  73. ncbi request reprint Utilization of eptifibatide for treatment of severe dissections as a bail-out procedure
    Asvin Latsch
    I Department of Medicine, University Hospital of Mannheim, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Int J Cardiol 96:229-33. 2004
    ..We sought to determine the efficacy of eptifibatide in patients with severe dissections or threatened vessel closure after PTCA in small coronary arteries (< 2.5 mm)...
  74. ncbi request reprint Fatal inappropriate ICD shock
    Christian Veltmann
    Department of Medicine, University Hospital Mannheim, Mannheim, Germany
    J Cardiovasc Electrophysiol 18:326-8. 2007
    ....
  75. ncbi request reprint Activated protein C inhibits the release of macrophage inflammatory protein-1-alpha from THP-1 cells and from human monocytes
    Martina Brueckmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Cytokine 26:106-13. 2004
    ....
  76. doi request reprint Enhanced proinflammatory response of mononuclear cells to in vitro LPS-challenge in patients with ventricular fibrillation in the setting of acute myocardial infarction
    Elif Elmas
    University Hospital of Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Department of Medicine, Cardiology, Angiology, Pneumology, Intensive Care Medicine, D 68167 Mannheim, Germany
    Cytokine 43:138-42. 2008
    ....
  77. ncbi request reprint Use of soluble fibrin antigen instead of D-dimer as fibrin-related marker may enhance the prognostic power of the ISTH overt DIC score
    Carl Erik Dempfle
    University Hospital of Mannheim, I Department of Medicine, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Thromb Haemost 91:812-8. 2004
    ..The present data on the distribution of values may provide a basis for the selection of appropriate cutoff points for assigning 2, and 3 points in the score...
  78. doi request reprint Percutaneous treatment of a coronary aneurysm by stent graft and drug-eluting stent implantation: a potential method to reduce stent graft restenosis
    Tim Suselbeck
    1st Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Interv Cardiol 21:325-8. 2008
    ..The patient has remained asymptomatic during 12 months of follow-up. In conclusion, the present case suggests that CSG placement followed by DES implantation is a safe and effective approach to treat coronary aneurysms interventionally...
  79. doi request reprint Point of care coagulation tests in critically ill patients
    Carl Erik Dempfle
    I Department of Medicine, University Hospital of Mannheim, Mannheim, Germany
    Semin Thromb Hemost 34:445-50. 2008
    ....
  80. doi request reprint Elevation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in patients presenting with acute myocardial infarction
    Stefan Kralev
    I Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Clin Chem Lab Med 47:446-51. 2009
    ..CML reacts with the receptor of advanced glycation end products inducing impairment of endothelium dependent relaxation and is a marker of oxidative stress...
  81. ncbi request reprint Radial force and wall apposition of balloon-expandable vascular stents in eccentric stenoses: an in vitro evaluation in a curved vessel model
    Gabor Kalmar
    Department of Medicine I, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Vasc Interv Radiol 13:499-508. 2002
    ..The aim of this study was to develop a simple method to assess these parameters under controlled experimental conditions and to compare vascular stents of different designs with regard to these parameters...
  82. ncbi request reprint Correlation of degree of aortic valve stenosis by Doppler echocardiogram to quantity of calcium in the valve by electron beam tomography
    Jens J Kaden
    Department of Internal Medicine I Cardiology, Angiology, and Pneumology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Am J Cardiol 90:554-7. 2002
  83. doi request reprint Electric impedance spectroscopy of human atherosclerotic lesions
    Ines Streitner
    First Department of Medicine, University Hospital of Mannheim, Faculty of Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Atherosclerosis 206:464-8. 2009
    ..The aim of this in vitro study was to investigate the feasibility of a new highly flexible microelectrode on human tissue and its potential of differentiating atherosclerotic lesions by electric impedance spectroscopy (EIS)...
  84. ncbi request reprint Stabilization of monocyte chemoattractant protein-1-mRNA by activated protein C
    Martina Brueckmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Thromb Haemost 89:149-60. 2003
    ....
  85. ncbi request reprint Course of indicators of thrombin activity in the early phase of acute myocardial infarction: effect of fibrinolytic therapy and acute percutaneous coronary angioplasty
    Carl Erik Dempfle
    University Hospital of Mannheim, I Department of Medicine, Mannheim, Germany
    Thromb Haemost 90:147-54. 2003
    ....
  86. ncbi request reprint Takotsubo cardiomyopathy is not due to plaque rupture: an intravascular ultrasound study
    Dariusch Haghi
    First Department of Medicine, University Medical Centre and Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Clin Cardiol 33:307-10. 2010
    ..Plaque rupture with subsequent transient thrombotic coronary occlusion by a fast-dissolving clot is one of the proposed pathogenic mechanisms in Takotsubo cardiomyopathy (TC)...
  87. ncbi request reprint A way to improve the reproducibility of measurements of myocardial velocity gradients
    Tudor C Poerner
    Department of Medicine, University Hospital of Mannheim, Germany
    Int J Cardiovasc Imaging 20:183-8. 2004
    ..The reproducibility of MVG measurements by color M-Mode tissue Doppler imaging (TDI) is still unsatisfactory, restraining its use in clinical practice. Aim of the study was to improve the reproducibility of measurements of MVG...
  88. ncbi request reprint Increased plasma levels of NT-proANP and NT-proBNP as markers of cardiac dysfunction in septic patients
    Ursula Hoffmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Clin Lab 51:373-9. 2005
    ..71; p<0.001). NT-proANP and NT-proBNP may serve as useful laboratory markers to indicate myocardial dysfunction and may help to differentiate between survivors and non-survivors of severe sepsis...
  89. ncbi request reprint A coronary embolus originating from the interatrial septum
    Ole A Breithardt
    I Medizinische Klinik, Department of Cardiology, Klinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Eur Heart J 27:2745. 2006
  90. ncbi request reprint Assessment of markers of thrombin generation in patients with acute myocardial infarction complicated by ventricular fibrillation
    Elif Elmas
    Department of Cardiology, First Department of Medicine, University of Heidelberg, Mannheim, Germany
    Clin Cardiol 29:165-9. 2006
    ....
  91. ncbi request reprint Chicken's valve in a human heart
    Dariusch Haghi
    I Medizinische Klinik, Universitatsklinikum Mannheim, 68167 Mannheim, Germany
    Eur Heart J 27:2157. 2006
  92. ncbi request reprint Tumor necrosis factor alpha promotes an osteoblast-like phenotype in human aortic valve myofibroblasts: a potential regulatory mechanism of valvular calcification
    Jens J Kaden
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany
    Int J Mol Med 16:869-72. 2005
    ..In addition, the data demonstrate direct mechanistic evidence that aortic valve calcification may be actively regulated by an inflammatory process involving TNF-alpha...
  93. ncbi request reprint Time course of systemic markers of inflammation in patients presenting with acute coronary syndromes
    Martina Brueckmann
    First Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Clin Chem Lab Med 42:1132-9. 2004
    ..During long-term follow-up the pro-inflammatory activity remains elevated in ACS patients, supporting the concept of a systemic rather than a local vascular inflammation contributing to the development of atherosclerosis...
  94. ncbi request reprint Severe calcification in left main stem coronary artery stenosis visible on routine chest radiograph
    Jens J Kaden
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Acta Med Austriaca 31:79-80. 2004
    ..In this article, we describe a patient with a high grade left main stem coronary artery stenosis who presented with a severe focal calcification on the plain chest radiograph in projection of the offspring of the left coronary artery...
  95. ncbi request reprint Side branch occlusion after coronary stent implantation in patients presenting with ST-elevation myocardial infarction: clinical impact and angiographic predictors
    Stefan Kralev
    First Department of Medicine, University Hospital of Mannheim, Mannheim, Germany
    Am Heart J 151:153-7. 2006
    ....
  96. ncbi request reprint Matrix-metalloproteinases and their inhibitors are elevated in severe sepsis: prognostic value of TIMP-1 in severe sepsis
    Ursula Hoffmann
    First Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Scand J Infect Dis 38:867-72. 2006
    ..14-17.6, p = 0.014). Our results indicate that MMP-9, TIMP-2 and TIMP-1 are elevated in severe sepsis. Furthermore, TIMP-1 may serve as a useful laboratory marker to predict the clinical outcome of patients presenting with severe sepsis...
  97. ncbi request reprint High plasma levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) and interleukin-8 (IL-8) characterize patients prone to ventricular fibrillation complicating myocardial infarction
    Elif Elmas
    1st Department of Medicine, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
    Clin Chem Lab Med 45:1360-5. 2007
    ..The aim of the present study was to assess potential differences of levels of MMP-9, TIMP-1 and IL-8 in postmyocardial infarction patients with or without VF complicating acute MI...
  98. ncbi request reprint In vivo intravascular electric impedance spectroscopy using a new catheter with integrated microelectrodes
    Tim Suselbeck
    Department of Medicine, University Hospital of Mannheim, 68167, Mannheim, Germany
    Basic Res Cardiol 100:28-34. 2005
    ..0% +/- 4.1% after 56 days (14 days vs. 56 days; p < 0.01). Intravascular EIS can be performed by a balloon catheter with integrated microelectrodes and allows the detection of neointimal proliferation after stent implantation...
  99. ncbi request reprint Physiological range of mechanical synchronicity of the human heart: comparison between different echocardiographic assessment modalities
    Tudor C Poerner
    Department of Medicine, University Hospital of Mannheim, Mannheim, Germany
    Ultrasound Med Biol 31:1163-72. 2005
    ..There was no significant association between a certain LV wall and the occurrence of the earliest, respectively latest peak values of any parameter...
  100. ncbi request reprint ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European Societ
    Douglas P Zipes
    Eur Heart J 27:2099-140. 2006
  101. ncbi request reprint Proposed diagnostic criteria for the Brugada syndrome: consensus report
    Arthur A M Wilde
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, and the Interuniversity Cardiology Institute, The Netherlands
    Circulation 106:2514-9. 2002