Affiliation: University of Mainz
Bohn T, Rapp S, Luther N, Klein M, Bruehl T, Kojima N, et al
. Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages. Nat Immunol. 2018;19:1319-1329 pubmed publisher
..Collectively, our findings identify a molecular mechanism of metabolic communication between non-lymphoid tissue and the immune system that was exploited by high-glycolytic-rate tumors for evasion of the immune system. ..
Klein M, BrÃ¼hl T, Staudt V, Reuter S, Grebe N, Gerlitzki B, et al
. Tick Salivary Sialostatin L Represses the Initiation of Immune Responses by Targeting IRF4-Dependent Transcription in Murine Mast Cells. J Immunol. 2015;195:621-31 pubmed publisher
..In an experimental asthma model, mast cell-specific deficiency in IRF4 or administration of sialostatin L results in a strong reduction in asthma symptoms, demonstrating the immunosuppressive potency of tick-derived molecules. ..
Ulges A, Witsch E, Pramanik G, Klein M, Birkner K, Bühler U, et al
. Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development. Proc Natl Acad Sci U S A. 2016;113:10145-50 pubmed publisher
..Thus, these results identify CK2 as a nodal point in TH17 cell development and suggest this kinase as a potential therapeutic target to treat TH17 cell-driven autoimmune responses. ..
Schmitt E, Klein M, Bopp T. Th9 cells, new players in adaptive immunity. Trends Immunol. 2014;35:61-8 pubmed publisher
..We describe the challenges inherent to unambiguously defining roles for Th9 cells using the available experimental animal models, and suggest new experimental models to address these concerns. ..
Ulges A, Schmitt E, Becker C, Bopp T. Context- and Tissue-Specific Regulation of Immunity and Tolerance by Regulatory T Cells. Adv Immunol. 2016;132:1-46 pubmed publisher
..In this review, we discuss recent findings on these tissue-resident Treg cell subsets and how these cells may operate in a tissue- and context-dependent manner. ..
Ulges A, Schmitt E, Bopp T, Klein M. Messenger RNA Sequencing of Rare Cell Populations in the Lung and Lung-Draining Lymph Nodes. Methods Mol Biol. 2017;1559:199-219 pubmed publisher
..Here, we describe a protocol to isolate rare T cell populations from the lung and in particular the subsequent methods to isolate high-grade RNA in order to perform NGS-based transcriptome analyses. ..