Udo Bonnet

Summary

Affiliation: University of Essen
Country: Germany

Publications

  1. ncbi request reprint Gabapentin's acute effect on mood profile -- a controlled study on patients with alcohol withdrawal
    Udo Bonnet
    Rheinische Kliniken Essen, Klinik für Psychiatrie und Psychotherapie und Klinik für abhängiges Verhalten und Suchtmedizin, Universitat Duisburg Essen, Virchowstr 174, D 45147 Essen, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 31:434-8. 2007
  2. ncbi request reprint Treatment of acute alcohol withdrawal with gabapentin: results from a controlled two-center trial
    Udo Bonnet
    Department of Psychiatry and Psychotherapy, University of Essen, Essen, Germany
    J Clin Psychopharmacol 23:514-9. 2003
  3. ncbi request reprint Moclobemide: therapeutic use and clinical studies
    Udo Bonnet
    Department of Psychiatry and Psychotherapy, University of Essen, Germany
    CNS Drug Rev 9:97-140. 2003
  4. ncbi request reprint Moclobemide: evolution, pharmacodynamic, and pharmacokinetic properties
    Udo Bonnet
    Rheinische Kliniken Essen, Department of Psychiatry and Psycotherapy, University of Essen, Essen, Germany
    CNS Drug Rev 8:283-308. 2002
  5. ncbi request reprint Valproate acidifies hippocampal CA3-neurons--a novel mode of action
    Udo Bonnet
    Rheinische Kliniken, Universitatsklinik fur Psychiatrie und Psychotherapie, Virchowstrasse 174, D 45147 Essen, Germany
    Eur Neuropsychopharmacol 12:279-85. 2002
  6. ncbi request reprint Moclobemide reduces intracellular pH and neuronal activity of CA3 neurones in guinea-pig hippocampal slices-implication for its neuroprotective properties
    U Bonnet
    Rheinische Kliniken, Universitatsklinik fur Psychiatrie und Psychotherapie, Virchowstrasse 174, D 45147 Essen, Germany
    Neuropharmacology 39:2067-74. 2000
  7. ncbi request reprint Alteration of intracellular pH and activity of CA3-pyramidal cells in guinea pig hippocampal slices by inhibition of transmembrane acid extrusion
    U Bonnet
    Rheinische Kliniken, Universitatsklinik fur Psychiatrie und Psychotherapie, Universität GH Essen, Virchowstr 174, D 45147, Essen, Germany
    Brain Res 872:116-24. 2000
  8. ncbi request reprint Intracellular pH modulates spontaneous and epileptiform bioelectric activity of hippocampal CA3-neurones
    U Bonnet
    Rheinische Kliniken, Universitatsklinik fur Psychiatrie und Psychotherapie, POB 103043, D 45030, Essen, Germany
    Eur Neuropsychopharmacol 10:97-103. 2000
  9. ncbi request reprint [AWMF-guideline: disorders related to cannabis]
    U Bonnet
    Rheinische Kliniken Essen, Klinik fur Psychiatrie und Psychotherapie, Universitat Duisburg Essen
    Fortschr Neurol Psychiatr 72:318-29. 2004
  10. ncbi request reprint Carbonic anhydrase inhibitor sulthiame reduces intracellular pH and epileptiform activity of hippocampal CA3 neurons
    Tobias Leniger
    Department of Neurology, University of Essen, Essen, Germany
    Epilepsia 43:469-74. 2002

Detail Information

Publications29

  1. ncbi request reprint Gabapentin's acute effect on mood profile -- a controlled study on patients with alcohol withdrawal
    Udo Bonnet
    Rheinische Kliniken Essen, Klinik für Psychiatrie und Psychotherapie und Klinik für abhängiges Verhalten und Suchtmedizin, Universitat Duisburg Essen, Virchowstr 174, D 45147 Essen, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 31:434-8. 2007
    ..Delayed beneficial effects of gabapentin on mood were frequently reported in various patient populations. This is the first controlled study which addressed acute effects of gabapentin on mood...
  2. ncbi request reprint Treatment of acute alcohol withdrawal with gabapentin: results from a controlled two-center trial
    Udo Bonnet
    Department of Psychiatry and Psychotherapy, University of Essen, Essen, Germany
    J Clin Psychopharmacol 23:514-9. 2003
    ..The combination of GP and CLO was safe...
  3. ncbi request reprint Moclobemide: therapeutic use and clinical studies
    Udo Bonnet
    Department of Psychiatry and Psychotherapy, University of Essen, Germany
    CNS Drug Rev 9:97-140. 2003
    ..There is no evidence that moclobemide would increase body weight or produce seizures. Some preclinical data suggest that moclobemide may have anticonvulsant property...
  4. ncbi request reprint Moclobemide: evolution, pharmacodynamic, and pharmacokinetic properties
    Udo Bonnet
    Rheinische Kliniken Essen, Department of Psychiatry and Psycotherapy, University of Essen, Essen, Germany
    CNS Drug Rev 8:283-308. 2002
    ..In addition, other CNS effects are reviewed with special respect to experimental serotonergic syndrome, anxiolytic and antinociceptive activity, sleep, cognition and driving performance, neuroprotection and seizures...
  5. ncbi request reprint Valproate acidifies hippocampal CA3-neurons--a novel mode of action
    Udo Bonnet
    Rheinische Kliniken, Universitatsklinik fur Psychiatrie und Psychotherapie, Virchowstrasse 174, D 45147 Essen, Germany
    Eur Neuropsychopharmacol 12:279-85. 2002
    ....
  6. ncbi request reprint Moclobemide reduces intracellular pH and neuronal activity of CA3 neurones in guinea-pig hippocampal slices-implication for its neuroprotective properties
    U Bonnet
    Rheinische Kliniken, Universitatsklinik fur Psychiatrie und Psychotherapie, Virchowstrasse 174, D 45147 Essen, Germany
    Neuropharmacology 39:2067-74. 2000
    ..We suggest that the latter effect is responsible for the moderate decrease in the steady-state pH(i) which in turn reduced neuronal activity. This mechanism may substantially contribute to the neuroprotective properties of moclobemide...
  7. ncbi request reprint Alteration of intracellular pH and activity of CA3-pyramidal cells in guinea pig hippocampal slices by inhibition of transmembrane acid extrusion
    U Bonnet
    Rheinische Kliniken, Universitatsklinik fur Psychiatrie und Psychotherapie, Universität GH Essen, Virchowstr 174, D 45147, Essen, Germany
    Brain Res 872:116-24. 2000
    ....
  8. ncbi request reprint Intracellular pH modulates spontaneous and epileptiform bioelectric activity of hippocampal CA3-neurones
    U Bonnet
    Rheinische Kliniken, Universitatsklinik fur Psychiatrie und Psychotherapie, POB 103043, D 45030, Essen, Germany
    Eur Neuropsychopharmacol 10:97-103. 2000
    ..Together, these results indicate that intracellular acidification inhibits bioelectric activity of hippocampal CA3-neurones. This supports the hypothesis that pH(i) contributes to the control of cortical excitability...
  9. ncbi request reprint [AWMF-guideline: disorders related to cannabis]
    U Bonnet
    Rheinische Kliniken Essen, Klinik fur Psychiatrie und Psychotherapie, Universitat Duisburg Essen
    Fortschr Neurol Psychiatr 72:318-29. 2004
    ..In this context, the guideline for treatment of cannabis-related disorders is introduced...
  10. ncbi request reprint Carbonic anhydrase inhibitor sulthiame reduces intracellular pH and epileptiform activity of hippocampal CA3 neurons
    Tobias Leniger
    Department of Neurology, University of Essen, Essen, Germany
    Epilepsia 43:469-74. 2002
    ..The aim of the study was to elucidate the mode of action of sulthiame with respect to possible changes of intracellular pH (pHi) that might develop along with sulthiame's anticonvulsant properties...
  11. pmc Levetiracetam inhibits Na+-dependent Cl-/HCO3- exchange of adult hippocampal CA3 neurons from guinea-pigs
    Tobias Leniger
    Department of Neurology, University of Essen, Hufelandstr 55, Essen 45122, Germany
    Br J Pharmacol 142:1073-80. 2004
    ..These data show that LEV at clinically relevant concentrations inhibits Na+-dependent Cl-/HCO3- exchange, lowers neuronal pHi, and thereby may contribute to its anticonvulsive activity...
  12. pmc Modulatory effects of neuropsychopharmaca on intracellular pH of hippocampal neurones in vitro
    Udo Bonnet
    Department of Psychiatry and Psychotherapy, LVR Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Br J Pharmacol 159:474-83. 2010
    ..As moclobemide, an antidepressant, and also some antiepileptic drugs can reduce neuronal pHi in hippocampus slices in vitro, we screened a panel of currently used neuropsychopharmaca for comparable effects...
  13. ncbi request reprint The endogenous alkaloid harmane: acidifying and activity-reducing effects on hippocampal neurons in vitro
    Udo Bonnet
    Department of Addictive Behaviour and Addiction Medicine, University of Duisburg Essen, Virchowstr 174, D 45147 Essen, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 32:362-7. 2008
    ..As harmane affects neuronal activity and viability and because both parameters are strongly influenced by intracellular pH (pH(i)), we tested whether effects of harmane are correlated with altered pH(i) regulation...
  14. doi request reprint An open trial of gabapentin in acute alcohol withdrawal using an oral loading protocol
    Udo Bonnet
    LVR Hospital of Essen, University of Duisburg Essen, Virchowstr 174, D 45147 Essen, Germany
    Alcohol Alcohol 45:143-5. 2010
    ..Because earlier works showed that moderate gabapentin doses were too low to clearly ameliorate severe AWS, we tested a higher gabapentin entry dose...
  15. doi request reprint Comparison of two oral symptom-triggered pharmacological inpatient treatments of acute alcohol withdrawal: clomethiazole vs. clonazepam
    Udo Bonnet
    Department of Addictive Behaviour and Addiction Medicine, LVR Hospital of Essen, University of Duisburg Essen, Virchowstr 174, D 45147 Essen, Germany
    Alcohol Alcohol 46:68-73. 2011
    ..To compare two inpatient symptom-triggered pharmacological treatments of acute alcohol withdrawal (AWS) (clomethiazole vs. clonazepam)...
  16. doi request reprint Efficacy and safety of levetiracetam for the prevention of alcohol relapse in recently detoxified alcohol-dependent patients: a randomized trial
    Christoph Richter
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Charite Campus Mitte, Berlin, Germany
    J Clin Psychopharmacol 32:558-62. 2012
    ..Antiepileptics have been shown to reduce alcohol intake or to prevent relapse in patients with alcoholism...
  17. ncbi request reprint Vermal atrophy of alcoholics correlate with serum thiamine levels but not with dentate iron concentrations as estimated by MRI
    Matthias Maschke
    Department of Neurology, University Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    J Neurol 252:704-11. 2005
    ..344, p = 0.028). These results support the view that thiamine deficiency rather than direct neurotoxic effects of alcohol is the main causative factor for the development of alcoholic cerebellar degeneration...
  18. ncbi request reprint Age-related changes of the dentate nuclei in normal adults as revealed by 3D fast low angle shot (FLASH) echo sequence magnetic resonance imaging
    Matthias Maschke
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    J Neurol 251:740-6. 2004
    ..These age-dependent changes have to be taken into account in interpretation of disease related MR changes of cerebellar nuclei in patients with degenerative or acquired cerebellar ataxia...
  19. ncbi request reprint Lack of efficacy of naltrexone in the prevention of alcohol relapse: results from a German multicenter study
    Markus Gastpar
    Department of Psychiatry of the University of Essen, Germany
    J Clin Psychopharmacol 22:592-8. 2002
    ..Nevertheless, the question arises whether self-reports of drinking are more reliable than gamma-GT as a measure of recent alcohol consumption...
  20. ncbi request reprint Different effects of GABAergic anticonvulsants on 4-aminopyridine-induced spontaneous GABAergic hyperpolarizations of hippocampal pyramidal cells--implication for their potency in migraine therapy
    T Leniger
    Department of Neurology, University of Essen, Germany
    Cephalalgia 20:533-7. 2000
    ..As migraine therapy benefits from an augmentation of GABA activity, we recommend clinical studies of tiagabine as a fast-acting agent in migraine attacks...
  21. ncbi request reprint Transient restless legs-like syndrome as a complication of opiate withrawal
    N Scherbaum
    Department of Psychiatry and Psychotherapy, University Hospital, Essen, Germany
    Pharmacopsychiatry 36:70-2. 2003
    ..Transient RLS during opiate detoxification merits further interst in order to improve the treatment of sleep disturbances during detoxification and as a model of interaction of the dopaminergic and endorphine system in motor activity...
  22. ncbi request reprint Selective inhibition of the Na+/H+ exchanger type 3 activates CO2/H+-sensitive medullary neurones
    M Wiemann
    Institut fur Physiologie, Universität GH Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Pflugers Arch 438:255-62. 1999
    ..It is concluded that the selective inhibition of NHE3 acidifies and activates CO2/H+-sensitive neurones within the ventrolateral medulla oblongata...
  23. ncbi request reprint A case report of propofol dependence in a physician
    Udo Bonnet
    Rhine Hospital of Essen, Department of Addictive Behaviour and Addiction Medicine, Essen, Germany
    J Psychoactive Drugs 40:215-7. 2008
    ..The present case shows for the first time that craving for propofol can be quite intense and able to induce addictive behaviour...
  24. doi request reprint [Anticonvulsants in the treatment of alcoholism]
    U Bonnet
    Arbeitsgruppe für klinische Suchtforschung an der Klinik für Psychiatrie und Psychotherapie, LVR Klinikum Essen, Universitat Duisburg Essen, Essen
    Fortschr Neurol Psychiatr 77:192-202. 2009
    ..Currently, there exists any published controlled study for levetiracetam, which would be well suited in the treatment of alcoholism due to its favorable safety profile and low pharmacological interaction potential...
  25. doi request reprint Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients
    Michael Specka
    Addiction Research Group at the Department of Psychiatry and Psychotherapy, LVR Hospital Essen, Hospital of the University Duisburg Essen, Essen, Germany
    Hum Psychopharmacol 26:404-11. 2011
    ..Cross-sectional studies show that considerable proportions of opiate dependents in methadone maintenance treatment (MMT) consume benzodiazepines (BZD). The longitudinal patterns of BZD use over time were described here...
  26. doi request reprint [Use of an outpatient treatment center for cannabis abuse]
    F Hölscher
    Arbeitsgruppe Sucht an der Klinik für Psychiatrie und Psychotherapie, Klinik für Abhängiges Verhalten und Suchtmedizin, Rheinische Kliniken Essen, Universitat Duisburg Essen, Virchowstrasse 174, Essen, Germany
    Nervenarzt 79:571-6. 2008
    ..There has been an increase of cannabis-related disorders in Germany during the last 10 years. According treatments are being established, however little is known about the treatment populations...
  27. doi request reprint Intensity of opiate withdrawal in relation to the 825C>T polymorphism of the G-protein beta 3 subunit gene
    B Lieb
    Addiction Research Group at Department of Psychiatry and Psychotherapy, LVR Hospital Essen, University of Duisburg Essen, Virchowstr 174, 45147 Essen, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 33:663-7. 2009
    ..This study was carried out in order to test the hypothesis that carriers of the T allele have an increased sympathetic activity in opiate withdrawal...
  28. doi request reprint Cannabinoid receptor 1 blocker rimonabant (SR 141716) for treatment of alcohol dependence: results from a placebo-controlled, double-blind trial
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University of Munich, Munich, Germany
    J Clin Psychopharmacol 28:317-24. 2008
    ..Taking the substantial numbers of animal studies suggesting a possible role of CB1 antagonists for the treatment of alcohol dependence into account, it seems worthwhile to further test cannabinoid blockers in the treatment of alcoholism...
  29. ncbi request reprint Low hospital admission rates following MDMA (Ecstasy) intake in Essen (Germany)
    Norbert Scherbaum
    Department of Addictive Behaviour and Addiction Medicine, Rhine State Hospital, University Hospital Essen, Germany
    Am J Addict 16:428-9. 2007