B Bondy

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint A multicenter study about Neurobiology of Suicidal Behavior: design, development, and preliminary results
    Thomas Bronisch
    Max Planck Institute of Psychiatry, Munich, Germany
    Arch Suicide Res 9:19-26. 2005
  2. pmc Pharmacogenomics in depression and antidepressants
    Brigitta Bondy
    Psychiatric Clinic of University Munich, Department of Neurochemistry, Munich, Germany
    Dialogues Clin Neurosci 7:223-30. 2005
  3. ncbi request reprint Pharmacogenetics of antipsychotics: useful for the clinician?
    Brigitta Bondy
    Psychiatric Clinic of LMU Munich, Germany
    Curr Opin Psychiatry 20:126-30. 2007
  4. ncbi request reprint Genetics of suicide
    B Bondy
    Section Psychiatric Genetics and Neurochemistry, Psychiatric Clinic, Ludwig Maximilians University, Munich, Germany
    Mol Psychiatry 11:336-51. 2006
  5. ncbi request reprint Pharmacogenetics and psychopharmacology
    Brigitta Bondy
    Psychiatric Hospital of University Munich, Neurochemistry Department, Nussbaumstrasse 7, D 80336 Munich, Germany
    Curr Opin Pharmacol 4:72-8. 2004
  6. ncbi request reprint [Medicine and neurobiology: the of clinical of picture depression]
    Brigitta Bondy
    Psychiatrische Klinik und Poliklinik, Munchen
    Pharm Unserer Zeit 33:276-81. 2004
  7. ncbi request reprint Genetic variants in the angiotensin I-converting-enzyme (ACE) and angiotensin II receptor (AT1) gene and clinical outcome in depression
    Brigitta Bondy
    Psychiatric Hospital, University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1094-9. 2005
  8. ncbi request reprint Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patients
    P Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 284:113-5. 2000
  9. ncbi request reprint Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patients
    P Zill
    Psychiatric Hospital, Ludwig Maximilians University, Munich Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 251:24-8. 2001
  10. ncbi request reprint Antipsychotic drugs antagonize human serotonin type 3 receptor currents in a noncompetitive manner
    G Rammes
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 9:846-58, 818. 2004

Collaborators

Detail Information

Publications94

  1. ncbi request reprint A multicenter study about Neurobiology of Suicidal Behavior: design, development, and preliminary results
    Thomas Bronisch
    Max Planck Institute of Psychiatry, Munich, Germany
    Arch Suicide Res 9:19-26. 2005
    ..The design and development of this project as well as interconnections with the others subprojects are described. Preliminary results about the stress hormone system and suicidality are presented...
  2. pmc Pharmacogenomics in depression and antidepressants
    Brigitta Bondy
    Psychiatric Clinic of University Munich, Department of Neurochemistry, Munich, Germany
    Dialogues Clin Neurosci 7:223-30. 2005
    ..The inclusion of functional genomics, which investigates the complex gene and/or protein expression in response to a given drug, may lead to the development of novel and safer drugs...
  3. ncbi request reprint Pharmacogenetics of antipsychotics: useful for the clinician?
    Brigitta Bondy
    Psychiatric Clinic of LMU Munich, Germany
    Curr Opin Psychiatry 20:126-30. 2007
    ..This article reviews recent advances in this field with respect to their importance for the clinician...
  4. ncbi request reprint Genetics of suicide
    B Bondy
    Section Psychiatric Genetics and Neurochemistry, Psychiatric Clinic, Ludwig Maximilians University, Munich, Germany
    Mol Psychiatry 11:336-51. 2006
    ..This paper reviews the status of current knowledge in this area, points to the weakness of the investigations and presents new approaches beyond the serotonergic system...
  5. ncbi request reprint Pharmacogenetics and psychopharmacology
    Brigitta Bondy
    Psychiatric Hospital of University Munich, Neurochemistry Department, Nussbaumstrasse 7, D 80336 Munich, Germany
    Curr Opin Pharmacol 4:72-8. 2004
    ..The inclusion of functional genomics, which investigates the complex gene and/or protein expression in response to a given drug, could help lead to the development of novel and safer drugs...
  6. ncbi request reprint [Medicine and neurobiology: the of clinical of picture depression]
    Brigitta Bondy
    Psychiatrische Klinik und Poliklinik, Munchen
    Pharm Unserer Zeit 33:276-81. 2004
  7. ncbi request reprint Genetic variants in the angiotensin I-converting-enzyme (ACE) and angiotensin II receptor (AT1) gene and clinical outcome in depression
    Brigitta Bondy
    Psychiatric Hospital, University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1094-9. 2005
    ..Our data might further suggest that patients with a haplotype combining the CC and DD/ID genotypes respond better to treatment than those with either single allele. These results should however be replicated in future research...
  8. ncbi request reprint Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patients
    P Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 284:113-5. 2000
    ..This finding indicates that the serotonin transporter does not appear to be a major susceptibility factor in the pathophysiology of Alzheimer's disease and other psychogeriatric disorders...
  9. ncbi request reprint Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patients
    P Zill
    Psychiatric Hospital, Ludwig Maximilians University, Munich Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 251:24-8. 2001
    ..However, if we combine our results with three previous published positive reports there seems to be an association between the -491A/T polymorphism and AD, though its size is less than found in the original publication...
  10. ncbi request reprint Antipsychotic drugs antagonize human serotonin type 3 receptor currents in a noncompetitive manner
    G Rammes
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 9:846-58, 818. 2004
    ....
  11. doi request reprint Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression
    T Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Munich, Germany
    Mol Psychiatry 13:1093-101. 2008
    ..Patients with depression show reduced GM volumes, particularly when they are homozygous for the L(A)-allele, suggesting that these patients are more vulnerable for morphological changes during depressive episodes...
  12. ncbi request reprint GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal
    D Rujescu
    Department of Psychiatry, University of Munich, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 133:85-7. 2005
    ..These findings support the hypothesis that the GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal. This novel finding warrants replication...
  13. ncbi request reprint Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism
    T C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Mol Psychiatry 11:1003-15. 2006
    ..We could show that SNP rs4291 influences ACE activity and HPA-axis hyperactivity and might therefore represent a common pathophysiologic link for unipolar depression and cardiovascular disease...
  14. ncbi request reprint SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression
    P Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Munich D 80336, Germany
    Mol Psychiatry 9:1030-6. 2004
    ..These results may open up new research strategies for the analysis of the observed disturbances in the serotonergic system in patients suffering from several other psychiatric disorders...
  15. ncbi request reprint Association study of suicidal behavior and affective disorders with a genetic polymorphism in ABCG1, a positional candidate on chromosome 21q22.3
    D Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Neuropsychobiology 42:22-5. 2000
    ..Furthermore, we found no association with suicidal behavior. These findings do not support the hypothesis that ABCG1 is a susceptibility gene for affective disorders or suicidal behavior...
  16. ncbi request reprint Serotonin-2A-receptor and -transporter polymorphisms: lack of association in patients with major depression
    C Minov
    Department of Psychiatry, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 303:119-22. 2001
    ..However, subtypes might be identified at least on a basis of differential treatment response...
  17. doi request reprint Impact of gene-gender effects of adrenergic polymorphisms on hypothalamic-pituitary-adrenal axis activity in depressed patients
    S Haefner
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Neuropsychobiology 58:154-62. 2008
    ..We hypothesized that due to the multiple interactions between the sympathetic and the HPA systems via adrenoceptors, polymorphisms in these genes could have an impact on HPA axis activity in major depression...
  18. ncbi request reprint Combined action of the ACE D- and the G-protein beta3 T-allele in major depression: a possible link to cardiovascular disease?
    B Bondy
    Psychiatric Department of University Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Mol Psychiatry 7:1120-6. 2002
    ..Nevertheless our study reports for the first time that the same allelic combination of two genes that have been shown to increase the risk for myocardial infarction (Naber et al, 2000) increase the vulnerability for depressive disorder...
  19. ncbi request reprint Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336, Munchen, Germany
    Psychiatry Res 96:51-61. 2000
    ..K(D) might be influenced by duration of alcohol dependence, but not sufficiently to yield differences between alcohol-dependent and control subjects...
  20. ncbi request reprint Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Pharmacogenomics J 6:34-41. 2006
    ..Although this result is suggestive for a significant role of this polymorphism in the pathogenesis of delirium tremens in alcohol-dependent individuals, further investigation and confirmation are warranted...
  21. ncbi request reprint Alcoholism-related phenotypes and genetic variants of the CB1 receptor
    U W Preuss
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universität Muenchen, Nussbaumstr 7, 80336 Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 253:275-80. 2003
    ..The aim of this study is to test the potential influence of a bi-allelic cannabinoid receptor gene (CNR1) polymorphism (G1359A) on severe alcohol withdrawal syndromes...
  22. ncbi request reprint Association of 5-HT1B receptor gene and antisocial behavior in alcoholism
    M Soyka
    Psychiatric Hospital, University of Munich, Germany
    J Neural Transm 111:101-9. 2004
    ..Adult antisocial personality occurred more often in males than females. Possible implications of these findings are discussed...
  23. ncbi request reprint No association of CRH1 receptor polymorphism haplotypes, harm avoidance and other personality dimensions in alcohol dependence: results from the Munich gene bank project for alcoholism
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Munich, Germany
    Addict Biol 9:73-9. 2004
    ..The possible implications of these findings are discussed...
  24. ncbi request reprint No association between a polymorphism in the promoter region of the MAOA gene with antisocial personality traits in alcoholics
    G Koller
    Psychiatrische Klinik und Poliklinik der LMU München, Nussbaumstrasse 7, 80336 Munchen, Germany
    Alcohol Alcohol 38:31-4. 2003
    ..We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits...
  25. ncbi request reprint Association of short-term response to haloperidol treatment with a polymorphism in the dopamine D(2) receptor gene
    M Schafer
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Am J Psychiatry 158:802-4. 2001
    ..Pharmacogenetic influences on therapeutic response to neuroleptic treatment are poorly understood. This study investigates the association of response to short-term haloperidol treatment with a Taq I polymorphism in the DRD2 gene...
  26. ncbi request reprint Association between suicide attempts and 5-HTTLPR-S-allele in alcohol-dependent and control subjects: further evidence from a German alcohol-dependent inpatient sample
    U W Preuss
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Biol Psychiatry 50:636-9. 2001
    ..A significant association between suicide attempts and the 5-HTT promoter polymorphisms (5-HTTLPR) S-allele has been reported in a sample of French alcohol-dependent subjects, and this paper evaluates this phenomenon in a German sample...
  27. ncbi request reprint Phytohemagglutinin-stimulated calcium signal in lymphocytes of alcoholics before, during and after detoxification
    B Bondy
    Psychiatric Clinic, University of Munich, Munchen, Germany
    Psychiatry Res 81:157-62. 1998
    ..05), and especially for the sustained influx at the end of the observation period (P = 0.001). The detailed mechanisms of this disturbed calcium homeostasis need further investigation...
  28. ncbi request reprint Dopamine D 4 receptor gene polymorphism and extraversion revisited: results from the Munich gene bank project for alcoholism
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 36:429-35. 2002
    ..These findings are in line with a number of more recent studies questioning the association between novelty-seeking and DRD4 dopamine receptor gene polymorphism. Possible implications of these findings are discussed...
  29. doi request reprint Predominant expression of tryptophan hydroxylase 1 mRNA in the pituitary: a postmortem study in human brain
    P Zill
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    Neuroscience 159:1274-82. 2009
    ..These observations may open up new research strategies not only for several psychiatric disorders, but also for the relationship between psychiatric and somatic diseases...
  30. ncbi request reprint Association of anger-related traits with SNPs in the TPH gene
    D Rujescu
    Molecular Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Mol Psychiatry 7:1023-9. 2002
    ..These findings support the hypothesis that the A218C and the A779C SNP in the TPH gene may be associated with anger-related traits in German samples...
  31. doi request reprint Postmortem proteomic analysis in human amygdala of drug addicts: possible impact of tubulin on drug-abusing behavior
    P Zill
    Department of Psychiatry, Division of Psychiatric Genetics and Neurochemistry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 261:121-31. 2011
    ..Although further studies have to confirm our results, this might be a possible pathway that may increase our understanding of drug addiction...
  32. ncbi request reprint D2 dopamine receptor gene haplotypes and their influence on alcohol and tobacco consumption magnitude in alcohol-dependent individuals
    U W Preuss
    Pediatric Hospital of Ludwig Maximilians University, Munich, Germany
    Alcohol Alcohol 42:258-66. 2007
    ....
  33. ncbi request reprint Platelet monoamine oxidase activity in alcoholics with and without a family history of alcoholism
    M Soyka
    Psychiatrische Klinik der Universität München, Munchen, Germany
    Eur Addict Res 6:57-63. 2000
    ..Our findings question the hypothesis of reduced platelet MAO activity to be a possible vulnerability marker for alcoholism...
  34. doi request reprint 5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder
    T Zetzsche
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Genes Brain Behav 7:306-13. 2008
    ..Future research is recommended to clarify possible interactions between this functional polymorphism and symptoms, course and treatment responses in this disorder...
  35. ncbi request reprint Lack of association of serotonin-2A receptor gene polymorphism (T102C) with suicidal ideation and suicide
    B Bondy
    Psychiatric Clinic, University of Munich, Munich, Germany
    Am J Med Genet 96:831-5. 2000
    ..Thus, our results suggest that this polymorphism may not commonly be involved in the susceptibility to suicidality. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:831-835, 2000...
  36. ncbi request reprint Psychopharmacogenetics--a challenge for pharmacotherapy in psychiatry
    B Bondy
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7 80336, Munich, Germany
    World J Biol Psychiatry 2:178-83. 2001
    ..Although some controversy exists among the results, many studies are supportive of the hypothesis that psychopharmacogenetics will be helpful in predicting an individual patient's drug response while minimising the rate of side effects...
  37. ncbi request reprint Identification of dopamine D4 receptor mRNA in circulating human lymphocytes using nested polymerase chain reaction
    B Bondy
    University Munich, Neurochemistry Department, Germany
    J Neuroimmunol 71:139-44. 1996
    ..Direct sequencing of the RT-PCR product assured that it corresponds to the human DRD4 sequence. However, because of the unusual high G/C content of the DRD4, several precautions have to be applied for reliable results...
  38. ncbi request reprint Polymorphisms in the alpha-2 macroglobulin gene in psychogeriatric patients
    P Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 294:69-72. 2000
    ....
  39. ncbi request reprint Cytosolic free [Ca2+] in mononuclear blood cells from demented patients and healthy controls
    B Bondy
    Department of Neurochemistry, University of Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 243:224-8. 1994
    ..However, there might be some difference in [Ca2+]i values between early- and late-onset AD, which could have pathophysiological importance...
  40. ncbi request reprint Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: possible association but no influence of personality disorders
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Germany
    Neuropsychobiology 43:186-91. 2001
    ..Alcohol dependents were investigated because these personality disorders and impulsive behavior are very frequent in alcohol dependence anf of clinical relevance...
  41. ncbi request reprint Tryptophan hydroxylase gene 1 polymorphisms are not associated with suicide attempts in alcohol-dependent individuals
    G Koller
    Substitutionsambulanz, Pestalozzistrasse 2, 80469 München, Germany
    Addict Biol 10:269-73. 2005
    ..Our data do not support the hypothesis of A-6526G, G-5806T or A-779C polymorphisms to be associated with suicide attempts in alcohol-dependent individuals...
  42. ncbi request reprint GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Germany
    J Psychiatr Res 42:184-91. 2008
    ..These findings support and extend the three previous studies implicating a GABA-A receptor subunit as contributing to the genetic risk for alcohol dependence. Possible implications of these findings are discussed...
  43. ncbi request reprint Relationship of substance P, 5-hydroxyindole acetic acid and tryptophan in serum of fibromyalgia patients
    M J Schwarz
    Psychiatric Hospital, University of Munich, Germany
    Neurosci Lett 259:196-8. 1999
    ..Moreover, 5-HIAA was strongly related to good quality of sleep (P = .000), while SP was related to sleep disturbance (P = .005). These data are valid to support the hypothesis of a systemic involvement of 5-HT and SP in fibromyalgia...
  44. ncbi request reprint Methodology of 3H-spiperone binding to lymphocytes
    B Bondy
    Psychiatric Hospital, University of Munich, F R G
    J Psychiatr Res 24:83-92. 1990
    ..A detailed methodological description of the binding assay and subsequent calculations has therefore been given in this paper...
  45. ncbi request reprint Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor
    B Eisensamer
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 8:994-1007. 2003
    ..In conclusion, structurally different types of antidepressants modulate the function of this ligand-gated ion channel. This may represent a yet unrecognized pharmacological principle of antidepressants...
  46. ncbi request reprint Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression
    Alexander Neumeister
    National Institutes of Health, NIMH, Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670
    Arch Gen Psychiatry 59:613-20. 2002
    ..We studied the behavioral responses to tryptophan depletion (TD) in healthy women with and without a first-degree family history of depression and examined the relationship to 5HTTLPR alleles...
  47. ncbi request reprint SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Neuropsychopharmacology 32:1687-94. 2007
    ..Further analysis are needed to confirm these results...
  48. ncbi request reprint Association analysis of a polymorphism in the G-protein stimulatory alpha subunit in patients with major depression
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet 114:530-2. 2002
    ....
  49. ncbi request reprint Pooling pharmacogenetic studies on the serotonin transporter: a mega-analysis
    Alessandro Serretti
    Department of Psychiatry, Vita Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
    Psychiatry Res 145:61-5. 2006
    ..This result supports the involvement of the SERTPR gene in response to antidepressant treatments...
  50. ncbi request reprint Hypothalamic-pituitary-adrenocortical axis dysregulation in patients with major depression is influenced by the insertion/deletion polymorphism in the angiotensin I-converting enzyme gene
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 328:299-303. 2002
    ..The HPA axis stimulating properties of higher ACE and consecutively higher AT-II and/or lower substance P concentrations may be crucial factors for the HPA system hyperactivity during major depressive episodes...
  51. ncbi request reprint Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Psychoneuroendocrinology 31:1019-25. 2006
    ....
  52. ncbi request reprint [Suicide attempt, psychopathology and genetics]
    Sandor Fekete
    Pécsi Tudományegyetem Altalános Orvosi Kar, Pszichiatriai es Pszichoterapias Klinika
    Psychiatr Hung 20:18-24. 2005
    ..Thus genes coding for proteins of the serotonergic pathways are leading candidates for investigating possible associations...
  53. ncbi request reprint [Clinical and neurological aspects of schizophrenia. The disease structure of schizophrenia]
    Brigitta Bondy
    LMU München Psychiatrische Klinik und Poliklinik Klinikum Innenstadt Nussbaumstr 7 80336 München
    Pharm Unserer Zeit 31:530-6. 2002
  54. ncbi request reprint A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study
    Nicole Praschak-Rieder
    Department of General Psychiatry, Medical University of Vienna, Austria
    J Psychiatr Res 39:561-7. 2005
    ....
  55. ncbi request reprint C-reactive protein is associated with polymorphisms of the angiotensin-converting enzyme gene in major depressed patients
    Sibylle Häfner
    J Psychiatr Res 42:163-5. 2008
  56. ncbi request reprint Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy and Radiology, Ludwig Maximilians University, Munich, Germany
    Arch Gen Psychiatry 64:410-6. 2007
    ..Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity, which is believed to be altered in patients with major depression...
  57. ncbi request reprint Role of family history and 5-HTTLPR polymorphism in female seasonal affective disorder patients with and without premenstrual dysphoric disorder
    Nicole Praschak-Rieder
    Department of General Psychiatry, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 12:129-34. 2002
    ..The elevated rate of affective disorders in relatives of patients with SAD and PMDD suggests higher genetic vulnerability in this subgroup when compared to patients with SAD alone...
  58. ncbi request reprint Analysis of polymorphisms in the olfactory G-protein Golf in major depression
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Psychiatr Genet 12:17-22. 2002
    ..The results of this study agree with the reported parent-of-origin effects on chromosome 18, but do not support the hypothesis that the Golf gene is a major susceptibility factor for major depression...
  59. ncbi request reprint Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Neuropsychopharmacology 26:489-93. 2002
    ..Our results suggest that the investigated polymorphisms are not major susceptibility factors in the etiology of major depression...
  60. doi request reprint Low level of harm avoidance is associated with serotonin transporter functional haplotype in alcohol-dependent individuals
    Gabi Koller
    Department of addiction research Clinic of Psychiatry LMU Munich Nussbaumstrasse 7 80336 Munich Germany
    Psychiatr Genet 18:59-63. 2008
    ..Higher serotonin levels among carriers of the S allele might exhibit increased liability of serotonin-mediated, psychopathology-like anxiety and depression and may impair social skills reflected by harm avoidance...
  61. doi request reprint Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:1003-7. 2008
    ....
  62. doi request reprint Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Alcohol Clin Exp Res 32:430-4. 2008
    ..The aim of the present study was to analyze these variants in a large sample of the Munich Gene Bank of Alcoholism...
  63. doi request reprint SNAP-25 gene polymorphisms and weight gain in schizophrenic patients
    Richard Musil
    Psychiatric Clinic of University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 42:963-70. 2008
    ..In conclusion our study can at least partly replicate the previous findings concerning the impact of SNAP-25 gene polymorphisms on weight gain during antipsychotic treatment...
  64. ncbi request reprint Enhanced serotonin transporter function during depression in seasonal affective disorder
    Matthaus Willeit
    Department of Biological Psychiatry, Medical University of Vienna, Vienna, Austria
    Neuropsychopharmacology 33:1503-13. 2008
    ..5-HTTLPR was not associated with any of the 5-HTT parameters. In sum, we conclude that the 5-HTT is in a hyperfunctional state during depression in SAD and normalizes after light therapy and in natural summer remission...
  65. ncbi request reprint C825T polymorphism in the G protein beta3-subunit gene is associated with seasonal affective disorder
    Matthaus Willeit
    Department of General Psychiatry, University Hospital of Psychiatry, Vienna, Austria
    Biol Psychiatry 54:682-6. 2003
    ....
  66. pmc Common genetic factors for depression and cardiovascular disease
    Brigitta Bondy
    Psychiatric Hospital, University of Munich, Germany
    Dialogues Clin Neurosci 9:19-28. 2007
    ....
  67. ncbi request reprint Influence of a functional polymorphism within the angiotensin I-converting enzyme gene on partial sleep deprivation in patients with major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neurosci Lett 339:223-6. 2003
    ..This should result in earlier and more intense additional therapeutic interventions in this group of patients...
  68. ncbi request reprint The dysbindin gene in major depression: an association study
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 129:55-8. 2004
    ..Further analysis are needed to confirm these results...
  69. ncbi request reprint Analysis of polymorphisms in the alpha-subunit of the olfactory G-protein Golf in lithium-treated bipolar patients
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatr Genet 13:65-9. 2003
    ..The alpha-subunit of the G(olf) gene maps to a region on chromosome 18p that has been implicated in several linkage studies as a potential site of a bipolar disorder susceptibility loci...
  70. ncbi request reprint Regional mRNA expression of a second tryptophan hydroxylase isoform in postmortem tissue samples of two human brains
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Eur Neuropsychopharmacol 14:282-4. 2004
    ..Our finding may open up new research strategies for the analysis of the repeatedly observed disturbances in the serotonergic system in patients suffering from several psychiatric disorders...
  71. ncbi request reprint The angiotensin I converting enzyme insertion/deletion polymorphism influences therapeutic outcome in major depressed women, but not in men
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neurosci Lett 363:38-42. 2004
    ..Our investigation gives the first hint that the speed of onset of antidepressant therapies may be dependent on both variants of the ACE genes and the gender of the patients...
  72. ncbi request reprint Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension
    Nikola Jeck
    Department of Pediatrics, University of Marburg, Germany
    Hypertension 43:1175-81. 2004
    ..In conclusion, the mutation ClC-Kb(T481S) of the renal epithelial Cl- channel ClC-Kb strongly activates ClC-Kb chloride channel function in vitro and may predispose to the development of essential hypertension in vivo...
  73. ncbi request reprint Beta-1-adrenergic receptor gene in major depression: influence on antidepressant treatment response
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 120:85-9. 2003
    ..05). However, after correction for multiple testing (Bonferroni) these results did not remain significant. Nevertheless, these findings suggest that the presence of the C allele might be an indicator for antidepressant treatment response...
  74. ncbi request reprint Serotonin 1B (5HT-1B) receptor polymorphism (G861C) in suicide victims: association studies in German and Slavic population
    Jasminka Stefulj
    Laboratory of Neurochemistry and Molecular Neurobiology, Rudjer Boskovic Institute, Bijenicka 54, Zagreb, Croatia
    Am J Med Genet B Neuropsychiatr Genet 127:48-50. 2004
    ..Results provide evidence that the investigated 5HT-1B receptor gene variants are not implicated in the susceptibility to suicide...
  75. ncbi request reprint The gamma amino butyric acid (GABA) receptor alpha-3 subunit gene polymorphism in unipolar depressive disorder: a genetic association study
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 126:82-7. 2004
    ....
  76. ncbi request reprint No Influence of a functional polymorphism within the serotonin transporter gene on partial sleep deprivation in major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 4:111-4. 2003
    ..Thus, the previously reported influence of the serotonin transporter gene on PSD outcome in bipolar depression could not be confirmed in unipolar depressed patients...
  77. ncbi request reprint Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Arch Gen Psychiatry 61:177-83. 2004
    ..Several studies have found reciprocal interactions between the serotonergic system and both brain-derived neurotrophic factor and glutamate, which are known to modulate or affect hippocampal morphologic characteristics...
  78. ncbi request reprint Serotonin transporter promoter gene polymorphic region (5-HTTLPR) and personality in female patients with seasonal affective disorder and in healthy controls
    Nikolaus Thierry
    Department of General Psychiatry, Waehringer Guertel 18 20, University of Vienna, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 14:53-8. 2004
    ..The s allele was associated with lower Self-Directedness scores in SAD patients, whereas there were no significant differences in TCI dimensions between patients and controls in carriers of the long allele...
  79. ncbi request reprint Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts
    Gunter Schumann
    Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 54:1422-6. 2003
    ....
  80. ncbi request reprint Deficits in gain of smooth pursuit eye movements in schizophrenia and affective disorder patients and their unaffected relatives
    Norbert Kathmann
    Psychiatrische Klinik, Ludwig Maximilians Universitat Munchen
    Am J Psychiatry 160:696-702. 2003
    ..Previous studies are not conclusive in regard to the specificity of this marker. Therefore, oculomotor pursuit was evaluated in unaffected family members of index probands diagnosed as having either schizophrenia or affective disorders...
  81. ncbi request reprint Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients
    Bernd Frank
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Clin Rheumatol 23:338-44. 2004
    ..Sequence variants of the serotonin receptor subunit genes HTR3A and HTR3B indicate no obvious significance in the aetiology of fibromyalgia, yet they represent the basis for future studies on their pharmacogenetic relevance...
  82. ncbi request reprint Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    J Psychiatr Res 41:168-73. 2007
    ....
  83. ncbi request reprint Substance P serum levels are increased in major depression: preliminary results
    Brigitta Bondy
    Psychiatric Hospital, University of Munich, Germany
    Biol Psychiatry 53:538-42. 2003
    ..The aim of this study was to analyze the serum SP levels in healthy control subjects and in depressed patients before and after antidepressant treatments...
  84. ncbi request reprint Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens
    Andre Tadic
    Dept of Psychiatry, University of Mainz, 55131 Mainz, Germany
    Eur Arch Psychiatry Clin Neurosci 255:129-35. 2005
    ..Moreover, we hypothesized that another genetic variation within GRIN2B (rs1806191) may have an effect in the etiology of alcoholism or withdrawal-related traits...
  85. ncbi request reprint Interleukin-6-174 G/C promoter gene polymorphism C allele reduces Alzheimer's disease risk
    Frank Faltraco
    J Am Geriatr Soc 51:578-9. 2003
  86. ncbi request reprint Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Nat Genet 36:1319-25. 2004
    ..These findings support a central role of genes regulating the HPA axis in the causality of depression and the mechanism of action of antidepressant drugs...
  87. ncbi request reprint Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 56:581-6. 2004
    ..In a previous postmortem study of our own group, we could demonstrate that TPH2 is also expressed in the human brain but not in peripheral tissues...
  88. ncbi request reprint Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients
    Bernd Frank
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Am J Med Genet B Neuropsychiatr Genet 131:1-5. 2004
    ..49, 95% CI: 0.3-0.82; genotype-wise: 15,5% vs. 29,0%, P = 0.005, OR = 0.45, 95% CI: 0.26-0.77). We suggest that this deletion may influence translational efficiency, thereby possibly affecting the development of bipolar affective disease...
  89. ncbi request reprint 5HT-2C receptor polymorphism in suicide victims. Association studies in German and Slavic populations
    Jasminka Stefulj
    Laboratory of Neurochemistry and Molecular Neurobiology, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia
    Eur Arch Psychiatry Clin Neurosci 254:224-7. 2004
    ..Results did not provide supporting evidence for the potential involvement of the investigated variants of 5HT-2C receptor in the susceptibility to suicide...
  90. ncbi request reprint Paroxetine with pindolol augmentation: a double-blind, randomized, placebo-controlled study in depressed in-patients
    Christian Geretsegger
    University Clinics of Psychiatry and Psychotherapy I, Paracelsus Medical University, Ignaz Harrer Str 79, 5020 Salzburg, Austria
    Eur Neuropsychopharmacol 18:141-6. 2008
    ..Nevertheless patients with bipolar depression irrespective of previous treatments and duration of illness, and unipolar patients not previously treated demonstrated a significant benefit from pindolol augmentation...
  91. ncbi request reprint Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins
    Elvira Larque
    Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children Hospital, Ludwig Maximilians University of Munich, Munich, Germany
    Am J Clin Nutr 84:853-61. 2006
    ..Better understanding of the mechanisms involved in docosahexaenoic acid (DHA) transfer to the neonate may contribute to improve dietary support for infants born prematurely to mothers with placental lipid transport disorders...
  92. ncbi request reprint Serotonin platelet-transporter measures in childhood attention-deficit/hyperactivity disorder (ADHD): clinical versus experimental measures of impulsivity
    Robert D Oades
    University Clinic for Child and Adolescent Psychiatry, Essen, Germany
    World J Biol Psychiatry 3:96-100. 2002
    ..Increased affinity of the transporter may also be related to conduct disturbance...
  93. ncbi request reprint Platelet 5-HT2A receptor binding and tryptophan availability in depression are not associated with recent history of suicide attempts but with personality traits characteristic for suicidal behavior
    Erik Lauterbach
    University of Schleswig Holstein, Campus Luebeck, Department of Psychiatry and Psychotherapy, Ratzeburger Allee 160, 23538 Luebeck, Germany
    J Affect Disord 91:57-62. 2006
    ..A number of personality traits were assessed in order to provide a basis for a psychobiological model of suicidal behavior...
  94. ncbi request reprint Comparative proteomic analysis with postmortem prefrontal cortex tissues of suicide victims versus controls
    Katja Schlicht
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 41:493-501. 2007
    ..Proteomics is a powerful method to investigate modifications in protein expression...