B Bondy

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Combined action of the ACE D- and the G-protein beta3 T-allele in major depression: a possible link to cardiovascular disease?
    B Bondy
    Psychiatric Department of University Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Mol Psychiatry 7:1120-6. 2002
  2. ncbi Psychopharmacogenetics--a challenge for pharmacotherapy in psychiatry
    B Bondy
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7 80336, Munich, Germany
    World J Biol Psychiatry 2:178-83. 2001
  3. ncbi Identification of dopamine D4 receptor mRNA in circulating human lymphocytes using nested polymerase chain reaction
    B Bondy
    University Munich, Neurochemistry Department, Germany
    J Neuroimmunol 71:139-44. 1996
  4. ncbi Phytohemagglutinin-stimulated calcium signal in lymphocytes of alcoholics before, during and after detoxification
    B Bondy
    Psychiatric Clinic, University of Munich, Munchen, Germany
    Psychiatry Res 81:157-62. 1998
  5. ncbi Lack of association of serotonin-2A receptor gene polymorphism (T102C) with suicidal ideation and suicide
    B Bondy
    Psychiatric Clinic, University of Munich, Munich, Germany
    Am J Med Genet 96:831-5. 2000
  6. ncbi Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patients
    P Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 284:113-5. 2000
  7. ncbi Antipsychotic drugs antagonize human serotonin type 3 receptor currents in a noncompetitive manner
    G Rammes
    Max-Planck-Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 9:846-58, 818. 2004
  8. ncbi GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal
    D Rujescu
    Department of Psychiatry, University of Munich, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 133:85-7. 2005
  9. ncbi Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patients
    P Zill
    Psychiatric Hospital, Ludwig Maximilians University, Munich Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 251:24-8. 2001
  10. ncbi Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism
    T C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Mol Psychiatry 11:1003-15. 2006

Collaborators

Detail Information

Publications48

  1. ncbi Combined action of the ACE D- and the G-protein beta3 T-allele in major depression: a possible link to cardiovascular disease?
    B Bondy
    Psychiatric Department of University Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Mol Psychiatry 7:1120-6. 2002
    ..Nevertheless our study reports for the first time that the same allelic combination of two genes that have been shown to increase the risk for myocardial infarction (Naber et al, 2000) increase the vulnerability for depressive disorder...
  2. ncbi Psychopharmacogenetics--a challenge for pharmacotherapy in psychiatry
    B Bondy
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7 80336, Munich, Germany
    World J Biol Psychiatry 2:178-83. 2001
    ..Although some controversy exists among the results, many studies are supportive of the hypothesis that psychopharmacogenetics will be helpful in predicting an individual patient's drug response while minimising the rate of side effects...
  3. ncbi Identification of dopamine D4 receptor mRNA in circulating human lymphocytes using nested polymerase chain reaction
    B Bondy
    University Munich, Neurochemistry Department, Germany
    J Neuroimmunol 71:139-44. 1996
    ..Direct sequencing of the RT-PCR product assured that it corresponds to the human DRD4 sequence. However, because of the unusual high G/C content of the DRD4, several precautions have to be applied for reliable results...
  4. ncbi Phytohemagglutinin-stimulated calcium signal in lymphocytes of alcoholics before, during and after detoxification
    B Bondy
    Psychiatric Clinic, University of Munich, Munchen, Germany
    Psychiatry Res 81:157-62. 1998
    ..05), and especially for the sustained influx at the end of the observation period (P = 0.001). The detailed mechanisms of this disturbed calcium homeostasis need further investigation...
  5. ncbi Lack of association of serotonin-2A receptor gene polymorphism (T102C) with suicidal ideation and suicide
    B Bondy
    Psychiatric Clinic, University of Munich, Munich, Germany
    Am J Med Genet 96:831-5. 2000
    ..Thus, our results suggest that this polymorphism may not commonly be involved in the susceptibility to suicidality. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:831-835, 2000...
  6. ncbi Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patients
    P Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 284:113-5. 2000
    ..This finding indicates that the serotonin transporter does not appear to be a major susceptibility factor in the pathophysiology of Alzheimer's disease and other psychogeriatric disorders...
  7. ncbi Antipsychotic drugs antagonize human serotonin type 3 receptor currents in a noncompetitive manner
    G Rammes
    Max-Planck-Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 9:846-58, 818. 2004
    ....
  8. ncbi GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal
    D Rujescu
    Department of Psychiatry, University of Munich, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 133:85-7. 2005
    ..These findings support the hypothesis that the GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal. This novel finding warrants replication...
  9. ncbi Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patients
    P Zill
    Psychiatric Hospital, Ludwig Maximilians University, Munich Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 251:24-8. 2001
    ..However, if we combine our results with three previous published positive reports there seems to be an association between the -491A/T polymorphism and AD, though its size is less than found in the original publication...
  10. ncbi Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism
    T C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Mol Psychiatry 11:1003-15. 2006
    ..We could show that SNP rs4291 influences ACE activity and HPA-axis hyperactivity and might therefore represent a common pathophysiologic link for unipolar depression and cardiovascular disease...
  11. ncbi No association of alcohol dependence with HOMER 1 and 2 genetic variants
    U W Preuss
    Department of Psychiatry, Psychotherapy and Psychosomatics, University of Halle Wittenberg, Halle Saale, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:1102-9. 2010
    ..In conclusion, our results suggest that single SNPs, respectively, haplotypes of the HOMER 1 and 2 genes are unlikely to play a major role in the pathophysiology of AD...
  12. ncbi Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression
    T Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Munich, Germany
    Mol Psychiatry 13:1093-101. 2008
    ..Patients with depression show reduced GM volumes, particularly when they are homozygous for the L(A)-allele, suggesting that these patients are more vulnerable for morphological changes during depressive episodes...
  13. ncbi SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression
    P Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Munich D 80336, Germany
    Mol Psychiatry 9:1030-6. 2004
    ..These results may open up new research strategies for the analysis of the observed disturbances in the serotonergic system in patients suffering from several other psychiatric disorders...
  14. ncbi Association between suicide attempts and 5-HTTLPR-S-allele in alcohol-dependent and control subjects: further evidence from a German alcohol-dependent inpatient sample
    U W Preuss
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Biol Psychiatry 50:636-9. 2001
    ..A significant association between suicide attempts and the 5-HTT promoter polymorphisms (5-HTTLPR) S-allele has been reported in a sample of French alcohol-dependent subjects, and this paper evaluates this phenomenon in a German sample...
  15. ncbi Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Pharmacogenomics J 6:34-41. 2006
    ..Although this result is suggestive for a significant role of this polymorphism in the pathogenesis of delirium tremens in alcohol-dependent individuals, further investigation and confirmation are warranted...
  16. ncbi Serotonin-2A-receptor and -transporter polymorphisms: lack of association in patients with major depression
    C Minov
    Department of Psychiatry, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 303:119-22. 2001
    ..However, subtypes might be identified at least on a basis of differential treatment response...
  17. ncbi Impact of gene-gender effects of adrenergic polymorphisms on hypothalamic-pituitary-adrenal axis activity in depressed patients
    S Haefner
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Neuropsychobiology 58:154-62. 2008
    ..We hypothesized that due to the multiple interactions between the sympathetic and the HPA systems via adrenoceptors, polymorphisms in these genes could have an impact on HPA axis activity in major depression...
  18. ncbi Association study of suicidal behavior and affective disorders with a genetic polymorphism in ABCG1, a positional candidate on chromosome 21q22.3
    D Rujescu
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Neuropsychobiology 42:22-5. 2000
    ..Furthermore, we found no association with suicidal behavior. These findings do not support the hypothesis that ABCG1 is a susceptibility gene for affective disorders or suicidal behavior...
  19. ncbi No association of CRH1 receptor polymorphism haplotypes, harm avoidance and other personality dimensions in alcohol dependence: results from the Munich gene bank project for alcoholism
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Munich, Germany
    Addict Biol 9:73-9. 2004
    ..The possible implications of these findings are discussed...
  20. ncbi Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336, Munchen, Germany
    Psychiatry Res 96:51-61. 2000
    ..K(D) might be influenced by duration of alcohol dependence, but not sufficiently to yield differences between alcohol-dependent and control subjects...
  21. ncbi Association of 5-HT1B receptor gene and antisocial behavior in alcoholism
    M Soyka
    Psychiatric Hospital, University of Munich, Germany
    J Neural Transm 111:101-9. 2004
    ..Adult antisocial personality occurred more often in males than females. Possible implications of these findings are discussed...
  22. ncbi Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: possible association but no influence of personality disorders
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Germany
    Neuropsychobiology 43:186-91. 2001
    ..Alcohol dependents were investigated because these personality disorders and impulsive behavior are very frequent in alcohol dependence anf of clinical relevance...
  23. ncbi Dopamine D 4 receptor gene polymorphism and extraversion revisited: results from the Munich gene bank project for alcoholism
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 36:429-35. 2002
    ..These findings are in line with a number of more recent studies questioning the association between novelty-seeking and DRD4 dopamine receptor gene polymorphism. Possible implications of these findings are discussed...
  24. ncbi No association between a polymorphism in the promoter region of the MAOA gene with antisocial personality traits in alcoholics
    G Koller
    Psychiatrische Klinik und Poliklinik der LMU München, Nussbaumstrasse 7, 80336 Munchen, Germany
    Alcohol Alcohol 38:31-4. 2003
    ..We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits...
  25. ncbi Genetics of suicide
    B Bondy
    Section Psychiatric Genetics and Neurochemistry, Psychiatric Clinic, Ludwig Maximilians University, Munich, Germany
    Mol Psychiatry 11:336-51. 2006
    ..This paper reviews the status of current knowledge in this area, points to the weakness of the investigations and presents new approaches beyond the serotonergic system...
  26. ncbi Association of short-term response to haloperidol treatment with a polymorphism in the dopamine D(2) receptor gene
    M Schafer
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Am J Psychiatry 158:802-4. 2001
    ..Pharmacogenetic influences on therapeutic response to neuroleptic treatment are poorly understood. This study investigates the association of response to short-term haloperidol treatment with a Taq I polymorphism in the DRD2 gene...
  27. ncbi 5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder
    T Zetzsche
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Genes Brain Behav 7:306-13. 2008
    ..Future research is recommended to clarify possible interactions between this functional polymorphism and symptoms, course and treatment responses in this disorder...
  28. ncbi D2 dopamine receptor gene haplotypes and their influence on alcohol and tobacco consumption magnitude in alcohol-dependent individuals
    U W Preuss
    Pediatric Hospital of Ludwig Maximilians University, Munich, Germany
    Alcohol Alcohol 42:258-66. 2007
    ....
  29. ncbi Predominant expression of tryptophan hydroxylase 1 mRNA in the pituitary: a postmortem study in human brain
    P Zill
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    Neuroscience 159:1274-82. 2009
    ..These observations may open up new research strategies not only for several psychiatric disorders, but also for the relationship between psychiatric and somatic diseases...
  30. ncbi No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336 Munchen, Germany
    Alcohol Alcohol 37:174-8. 2002
    ..The negative results in this study question the role of these polymorphisms in the pathogenesis of alcohol withdrawal-induced seizures and delirium tremens...
  31. ncbi Postmortem proteomic analysis in human amygdala of drug addicts: possible impact of tubulin on drug-abusing behavior
    P Zill
    Department of Psychiatry, Division of Psychiatric Genetics and Neurochemistry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 261:121-31. 2011
    ..Although further studies have to confirm our results, this might be a possible pathway that may increase our understanding of drug addiction...
  32. ncbi Platelet monoamine oxidase activity in alcoholics with and without a family history of alcoholism
    M Soyka
    Psychiatrische Klinik der Universität München, Munchen, Germany
    Eur Addict Res 6:57-63. 2000
    ..Our findings question the hypothesis of reduced platelet MAO activity to be a possible vulnerability marker for alcoholism...
  33. ncbi Association of anger-related traits with SNPs in the TPH gene
    D Rujescu
    Molecular Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Mol Psychiatry 7:1023-9. 2002
    ..These findings support the hypothesis that the A218C and the A779C SNP in the TPH gene may be associated with anger-related traits in German samples...
  34. ncbi Polymorphisms in the alpha-2 macroglobulin gene in psychogeriatric patients
    P Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 294:69-72. 2000
    ....
  35. ncbi Cytosolic free [Ca2+] in mononuclear blood cells from demented patients and healthy controls
    B Bondy
    Department of Neurochemistry, University of Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 243:224-8. 1994
    ..However, there might be some difference in [Ca2+]i values between early- and late-onset AD, which could have pathophysiological importance...
  36. ncbi Tryptophan hydroxylase gene 1 polymorphisms are not associated with suicide attempts in alcohol-dependent individuals
    G Koller
    Substitutionsambulanz, Pestalozzistrasse 2, 80469 München, Germany
    Addict Biol 10:269-73. 2005
    ..Our data do not support the hypothesis of A-6526G, G-5806T or A-779C polymorphisms to be associated with suicide attempts in alcohol-dependent individuals...
  37. ncbi GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Germany
    J Psychiatr Res 42:184-91. 2008
    ..These findings support and extend the three previous studies implicating a GABA-A receptor subunit as contributing to the genetic risk for alcohol dependence. Possible implications of these findings are discussed...
  38. ncbi Relationship of substance P, 5-hydroxyindole acetic acid and tryptophan in serum of fibromyalgia patients
    M J Schwarz
    Psychiatric Hospital, University of Munich, Germany
    Neurosci Lett 259:196-8. 1999
    ..Moreover, 5-HIAA was strongly related to good quality of sleep (P = .000), while SP was related to sleep disturbance (P = .005). These data are valid to support the hypothesis of a systemic involvement of 5-HT and SP in fibromyalgia...
  39. ncbi Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor
    B Eisensamer
    Max-Planck-Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 8:994-1007. 2003
    ..In conclusion, structurally different types of antidepressants modulate the function of this ligand-gated ion channel. This may represent a yet unrecognized pharmacological principle of antidepressants...
  40. ncbi Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia
    J Erdmann
    Institute of Human Genetics, University of Bonn, Germany
    Hum Genet 97:614-9. 1996
    ..However, the reported association of the non-coding polymorphism 102T/C with the disease has also been detected in our sample (P=0.041, odds ratio=1.28, 95% confidence interval 1.012-1.623)...
  41. ncbi Alcoholism-related phenotypes and genetic variants of the CB1 receptor
    U W Preuss
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universität Muenchen, Nussbaumstr 7, 80336 Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 253:275-80. 2003
    ..The aim of this study is to test the potential influence of a bi-allelic cannabinoid receptor gene (CNR1) polymorphism (G1359A) on severe alcohol withdrawal syndromes...
  42. ncbi No association between suicidal behavior and 5-HT2A-T102C polymorphism in alcohol dependents
    U W Preuss
    Am J Med Genet 96:877-8. 2000
  43. ncbi Serotonin receptor gene HTR3A variants in schizophrenic and bipolar affective patients
    B Niesler
    Institute of Human Genetics, University of Heidelberg, Germany
    Pharmacogenetics 11:21-7. 2001
    ..Further studies are needed to support the hypothesis that HTR3A may contribute to the schizophrenia in these patients...
  44. ncbi The serotonin transporter promoter repeat length polymorphism, seasonal affective disorder and seasonality
    C Johansson
    Department of Molecular Medicine, Karolinska Institute and Karolinska Hospital, Stockholm, Sweden
    Psychol Med 33:785-92. 2003
    ..The aim of this study was to test for association in new case-control and population-based materials, and to perform a combined analysis of all published studies of 5-HTTLPR and SAD...
  45. ncbi A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder
    M Willeit
    Department of General Psychiatry, University Hospital of Psychiatry, Vienna, Austria
    Mol Psychiatry 8:942-6. 2003
    ..007). Our data are compatible with the hypothesis of a disease process that is not causally related to 5-HTTLPR, but involves 5-HT neurotransmission and 5-HTTLPR somewhere on its way to phenotypic disease expression...
  46. ncbi Is MAO-B activity in platelets associated with the occurrence of suicidality and behavioural personality traits in depressed patients?
    U Lewitzka
    Department of Psychiatry and Psychotherapy, Technical University of Dresden, Dresden, Germany
    Acta Psychiatr Scand 117:41-9. 2008
    ..The present study investigated the relationship between MAO-B activity in platelets and aspects of suicidality in depressed patients and controls...
  47. ncbi A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior
    P Zill
    Mol Psychiatry 11:525-7. 2006
  48. ncbi Significant frequency deviation of the class I polymorphism HLA-A10 in schizophrenic patients
    B Laumbacher
    J Med Genet 40:217-9. 2003