E Bollschweiler

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi request reprint Vitamin intake and risk of subtypes of esophageal cancer in Germany
    Elfriede Bollschweiler
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    J Cancer Res Clin Oncol 128:575-80. 2002
  2. ncbi request reprint [Psychometric evaluation of the German version of the "Consultation and Relational Empathy" (CARE) measure at the example of cancer patients]
    Melanie Neumann
    Zentrum für Versorgungsforschung Köln ZVFK, Medizinische Fakultät der Universität zu Köln, Koln, Germany
    Psychother Psychosom Med Psychol 58:5-15. 2008
  3. ncbi request reprint ERCC1 RNA expression in peripheral blood predicts minor histopathological response to neoadjuvant radio-chemotherapy in patients with locally advanced cancer of the esophagus
    Jan Brabender
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Str 9, 50931, Cologne, Germany
    J Gastrointest Surg 12:1815-21. 2008
  4. doi request reprint Reflux esophagitis, high-grade neoplasia, and early Barrett's carcinoma-what is the place of the Merendino procedure?
    A H Holscher
    Department of General, Visceral and Cancer Surgery, University of Cologne, Kerpener Str 62, 50937, Cologne, Germany
    Langenbecks Arch Surg 394:417-24. 2009
  5. doi request reprint A multicenter study of survival after neoadjuvant radiotherapy/chemotherapy and esophagectomy for ypT0N0M0R0 esophageal cancer
    D Vallbohmer
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    Ann Surg 252:744-9. 2010
  6. ncbi request reprint [Quality of life and visceral surgery]
    E Bollschweiler
    Klinik und Poliklinik für Allgemein, Viszeral und Tumorchirurgie, Universitat zu Koln, Kerpener Str 62, 50937, Koln, Deutschland
    Chirurg 85:203-7. 2014
  7. ncbi request reprint Novel diagnostic and prognostic biomarkers in esophageal cancer
    Patrick S Plum
    University of Cologne, Department of General, Visceral and Cancer Surgery, Kerpener Str 62, Cologne, 50937, Germany 49 221 4786273 49 221 4785076
    Expert Opin Med Diagn 7:557-71. 2013
  8. doi request reprint Prognostic relevance of nutritional status in patients with advanced esophageal cancer
    Elfriede Bollschweiler
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    Expert Rev Anticancer Ther 13:275-8. 2013
  9. pmc Duodeno-gastric-esophageal reflux--what is pathologic? Comparison of patients with Barrett's esophagus and age-matched volunteers
    Eva Wolfgarten
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    J Gastrointest Surg 11:479-86. 2007
  10. pmc Prognostic relevance of demographics and surgical practice for patients with gastric cancer in two centers: in Poland versus Germany
    Radoslaw Jaworski
    Department of Surgical Oncology, Medical University of Gdansk, Gdansk, Poland
    Gastric Cancer 14:234-41. 2011

Collaborators

Detail Information

Publications95

  1. ncbi request reprint Vitamin intake and risk of subtypes of esophageal cancer in Germany
    Elfriede Bollschweiler
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    J Cancer Res Clin Oncol 128:575-80. 2002
    ..The goal of this pilot-study was to analyze the influence of daily vitamin consumption on the frequency of esophageal carcinoma in Germany...
  2. ncbi request reprint [Psychometric evaluation of the German version of the "Consultation and Relational Empathy" (CARE) measure at the example of cancer patients]
    Melanie Neumann
    Zentrum für Versorgungsforschung Köln ZVFK, Medizinische Fakultät der Universität zu Köln, Koln, Germany
    Psychother Psychosom Med Psychol 58:5-15. 2008
    ....
  3. ncbi request reprint ERCC1 RNA expression in peripheral blood predicts minor histopathological response to neoadjuvant radio-chemotherapy in patients with locally advanced cancer of the esophagus
    Jan Brabender
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Str 9, 50931, Cologne, Germany
    J Gastrointest Surg 12:1815-21. 2008
    ....
  4. doi request reprint Reflux esophagitis, high-grade neoplasia, and early Barrett's carcinoma-what is the place of the Merendino procedure?
    A H Holscher
    Department of General, Visceral and Cancer Surgery, University of Cologne, Kerpener Str 62, 50937, Cologne, Germany
    Langenbecks Arch Surg 394:417-24. 2009
    ..The deeper the submucosa is infiltrated, the higher is the rate of lymph node metastasis which is, on the average, 30% for submucosal carcinoma...
  5. doi request reprint A multicenter study of survival after neoadjuvant radiotherapy/chemotherapy and esophagectomy for ypT0N0M0R0 esophageal cancer
    D Vallbohmer
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    Ann Surg 252:744-9. 2010
    ..To evaluate 5-year survival of patients with locally advanced esophageal cancer (LAEC) who have undergone multimodality treatment with complete histopathologic response...
  6. ncbi request reprint [Quality of life and visceral surgery]
    E Bollschweiler
    Klinik und Poliklinik für Allgemein, Viszeral und Tumorchirurgie, Universitat zu Koln, Kerpener Str 62, 50937, Koln, Deutschland
    Chirurg 85:203-7. 2014
    ..The results for the various procedures of cholecystectomy or hernia repair are not always consistent...
  7. ncbi request reprint Novel diagnostic and prognostic biomarkers in esophageal cancer
    Patrick S Plum
    University of Cologne, Department of General, Visceral and Cancer Surgery, Kerpener Str 62, Cologne, 50937, Germany 49 221 4786273 49 221 4785076
    Expert Opin Med Diagn 7:557-71. 2013
    ..This article provides an overview of actual biomarkers with an impact on improvement of diagnosis and treatment of esophageal cancer patients...
  8. doi request reprint Prognostic relevance of nutritional status in patients with advanced esophageal cancer
    Elfriede Bollschweiler
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    Expert Rev Anticancer Ther 13:275-8. 2013
    ..Prospective randomized studies including the nutritional status and immune competence for patients with advanced cancer of the esophagus are necessary...
  9. pmc Duodeno-gastric-esophageal reflux--what is pathologic? Comparison of patients with Barrett's esophagus and age-matched volunteers
    Eva Wolfgarten
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    J Gastrointest Surg 11:479-86. 2007
    ..The aim of the study was to analyse pH- and bile-monitoring data in patients with Barrett's esophagus and in age- and gender-matched controls...
  10. pmc Prognostic relevance of demographics and surgical practice for patients with gastric cancer in two centers: in Poland versus Germany
    Radoslaw Jaworski
    Department of Surgical Oncology, Medical University of Gdansk, Gdansk, Poland
    Gastric Cancer 14:234-41. 2011
    ..This study aimed to compare demographics and surgical practice as well as the related prognostic impact on gastric cancer patients treated in Poland and Germany...
  11. ncbi request reprint Staging of esophageal carcinoma: length of tumor and number of involved regional lymph nodes. Are these independent prognostic factors?
    Elfriede Bollschweiler
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    J Surg Oncol 94:355-63. 2006
    ..The aim of this study was to analyze the prognostic relevance of tumor length as well as number of involved regional lymph nodes (LNM) in patients with esophageal carcinoma...
  12. ncbi request reprint [The prognostic relevance of age and comorbidity in patients with resected gastric cancer]
    E Bollschweiler
    Klinik und Poliklinik für Visceral und Gefässchirurgie, Universitat zu Koln, Deutschland
    Zentralbl Chir 134:71-6. 2009
    ..The aim of our study was to analyse the influence of age and comorbidity on the prognosis in patients with gastric cancer...
  13. doi request reprint Prevalence of dysphagia in patients with gastroesophageal reflux in Germany
    Elfriede Bollschweiler
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Dysphagia 23:172-6. 2008
    ..001). Swallowing problems are common in patients with GERD. Approximately two thirds of patients with long-term and severe reflux symptoms also have dysphagia symptoms. Dysphagia should always be investigated by a physician...
  14. doi request reprint Histologic tumor type and the rate of complete response after neoadjuvant therapy for esophageal cancer
    Elfriede Bollschweiler
    Department of General, Visceral and Cancer Surgery, University of Cologne, Kerpener Str 62, 50937 Koln, Germany
    Future Oncol 6:25-35. 2010
    ..However, when the tumor does respond, the rate of pCR with increasing dosage of chemoradiotherapy increases more rapidly in AC patients than in SCC patients...
  15. doi request reprint Improving informed consent of surgical patients using a multimedia-based program? Results of a prospective randomized multicenter study of patients before cholecystectomy
    Elfriede Bollschweiler
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Ann Surg 248:205-11. 2008
    ..The goal of the current study was to investigate whether standard methods of consenting can be improved using a multimedia-based information program (MM-IP)...
  16. doi request reprint Histological type of esophageal cancer might affect response to neo-adjuvant radiochemotherapy and subsequent prognosis
    E Bollschweiler
    Department of General, Visceral and Cancer Surgery, University of Cologne, Germany
    Ann Oncol 20:231-8. 2009
    ..This study investigates response and prognosis after neo-adjuvant chemoradiation (CTx/RTx) in patients with advanced esophageal carcinoma, according to histological type...
  17. doi request reprint Influence of neoadjuvant chemoradiation on the number and size of analyzed lymph nodes in esophageal cancer
    Elfriede Bollschweiler
    Department of General, Visceral, and Cancer Surgery, University of Cologne, Cologne, Germany
    Ann Surg Oncol 17:3187-94. 2010
    ..The goal of our study was to investigate the influence of neoadjuvant radiochemotherapy (RTx/CTx) on lymph nodes (LN)...
  18. doi request reprint High prevalence of colonic polyps in white males with esophageal adenocarcinoma
    Elfriede Bollschweiler
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    Dis Colon Rectum 52:299-304. 2009
    ..There is ongoing discussion regarding Barrett's esophagus and the prevalence of colonic neoplasms. The goal of this investigation was to evaluate colonoscopic findings in patients with esophageal carcinoma...
  19. ncbi request reprint [Prevalence of reflux symptoms in the general population of Cologne]
    E Bollschweiler
    Klinik und Poliklinik für Viszeral und Gefässchirurgie, Universitat zu Koln, Kerpener Strasse 62, 50931 Koln
    Z Gastroenterol 45:177-81. 2007
    ..At present, the prevalence of reflux symptoms in the general population has not been well enough established...
  20. doi request reprint Prognostic significance of a new grading system of lymph node morphology after neoadjuvant radiochemotherapy for esophageal cancer
    Elfriede Bollschweiler
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    Ann Thorac Surg 92:2020-7. 2011
    ..We investigated the influence of neoadjuvant radiochemotherapy on histomorphologic parameters of LNs...
  21. ncbi request reprint [18F]-fluorodeoxyglucose-positron emission tomography for the assessment of histopathologic response and prognosis after completion of neoadjuvant chemotherapy in gastric cancer
    D Vallbohmer
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    J Surg Oncol 102:135-40. 2010
    ..We evaluated the potential of FDG-PET for the assessment of response and prognosis in the multimodality treatment of gastric cancer...
  22. doi request reprint Survivin expression in gastric cancer: Association with histomorphological response to neoadjuvant therapy and prognosis
    D Vallbohmer
    Department of General, Visceral and Cancer Surgery, Center for Integrated Oncology, University Hospital Cologne, Cologne 50937, Germany
    J Surg Oncol 99:409-13. 2009
    ..We examined the association of survivin protein expression with histopathologic response to neoadjuvant chemotherapy and prognosis in patients with gastric cancer...
  23. doi request reprint Clinicopathologic and prognostic factors of young and elderly patients with esophageal adenocarcinoma: is there really a difference?
    D Vallbohmer
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Dis Esophagus 21:596-600. 2008
    ..The better prognosis of young patients is mainly caused by less comorbidity and more frequent use of neoadjuvant therapy...
  24. doi request reprint HIF-1alpha protein expression is associated with the environmental inflammatory reaction in Barrett's metaplasia
    F C Ling
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Dis Esophagus 22:694-9. 2009
    ..All were significantly increased in metaplasia compared to SE without further change in tumor development. HIF-1alpha protein expression appears to be associated with inflammatory processes in the development of BM...
  25. ncbi request reprint Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer
    H Alakus
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Histol Histopathol 23:917-23. 2008
    ....
  26. doi request reprint MicroRNA profiling in locally advanced esophageal cancer indicates a high potential of miR-192 in prediction of multimodality therapy response
    M Odenthal
    Institute of Pathology, University of Cologne, Cologne, Germany
    Int J Cancer 133:2454-63. 2013
    ....
  27. doi request reprint Prognostic impact of nodal micrometastasis in early esophageal cancer
    K L Prenzel
    Department of General, Visceral and Cancer Surgery, University of Cologne, Germany
    Eur J Surg Oncol 38:314-8. 2012
    ..There is a trend toward endoscopic resection for early cancer of the esophagus without lymphadenectomy. Frequency and prognostic impact of nodal micrometastasis in early cancer of the esophagus have not been investigated so far...
  28. ncbi request reprint Reduced incidence of nodal micrometastasis after major response to neoadjuvant chemoradiation in locally advanced esophageal cancer
    Klaus L Prenzel
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Ann Surg Oncol 14:954-9. 2007
    ..The influence on nodal micrometastasis has not yet been evaluated...
  29. doi request reprint GNAS1 T393C polymorphism is associated with histopathological response to neoadjuvant radiochemotherapy in esophageal cancer
    H Alakus
    Department of General, Visceral and Cancer Surgery, Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany
    Pharmacogenomics J 9:202-7. 2009
    ..The results support the role of the T393C polymorphism as a predictive molecular marker for tumor response to cisplatin/5-FU-based radiochemotherapy in esophageal cancer...
  30. ncbi request reprint High cyclooxygenase-2 expression following neoadjuvant radiochemotherapy is associated with minor histopathologic response and poor prognosis in esophageal cancer
    Huan Xi
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Clin Cancer Res 11:8341-7. 2005
    ..We analyzed the association of COX-2 mRNA and protein expression with histomorphologic response to neoadjuvant radiochemotherapy in esophageal cancer...
  31. ncbi request reprint Overexpression of survivin mRNA is associated with a favorable prognosis following neoadjuvant radiochemotherapy in esophageal cancer
    Ute Warnecke-Eberz
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Oncol Rep 13:1241-6. 2005
    ..However, overexpression of survivin mRNA in pretreatment biopsies (T/N ratio >1) was associated with superior survival probabilities...
  32. ncbi request reprint High-volume centers--effect of case load on outcome in cancer surgery
    A H Holscher
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Onkologie 27:412-6. 2004
    ..Surgery of pancreatic and esophageal cancer is a task for high-volume hospitals because they have less postoperative mortality and improved long-term prognosis compared to low-volume hospitals...
  33. doi request reprint [Value of distal gastrectomy as a remedial operation for failed fundoplication]
    C A Gutschow
    Universitat zu Koln, Klinik und Poliklinik für Allgemein, Viszeral und Tumorchirurgie, Koln, Deutschland
    Zentralbl Chir 136:249-55. 2011
    ..Failure of conventional antireflux surgery is a challenging problem. This study aims at defining the role of distal gastrectomy with Roux-en-Y diversion in the treatment of failed fundoplication...
  34. ncbi request reprint Thoracoscopic enucleation of esophageal leiomyomas: a feasible and safe procedure
    D Vallbohmer
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Endoscopy 39:1097-9. 2007
    ..No relevant intra- or postoperative complications were detected. These data suggest that thoracoscopic enucleation is a feasible and safe procedure for esophageal leiomyomas...
  35. ncbi request reprint Evaluation of histological regression grading systems in the neoadjuvant therapy of rectal cancer: do they have prognostic impact?
    D Vallbohmer
    Department of General, Visceral and Cancer Surgery, University of Cologne, Kerpenerstrasse 62, Cologne, Germany
    Int J Colorectal Dis 27:1295-301. 2012
    ..However, currently no accepted comprehensive grading system for clinical use is available. Therefore, we studied the impact of four histological regression grading systems in the neoadjuvant therapy of rectal cancer...
  36. ncbi request reprint Preoperative risk analysis--a reliable predictor of postoperative outcome after transthoracic esophagectomy?
    W Schroder
    Department of Visceral and Vascular Surgery, University of Cologne, Kerpener Strasse 62, 50937 Cologne, Germany
    Langenbecks Arch Surg 391:455-60. 2006
    ..The question of this study was whether an individualized preoperative risk analysis is able to predict postoperative outcome...
  37. ncbi request reprint Histological grading in gastric cancer by Goseki classification: correlation with histopathological subtypes and prognosis
    S Monig
    Department of Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    Anticancer Res 21:617-20. 2001
    ..The aim of the study was to compare the Goseki classification with the currently used classification systems and to define the prognostic significance of the Goseki classification system...
  38. ncbi request reprint High rate of lymph-node metastasis in submucosal esophageal squamous-cell carcinomas and adenocarcinomas
    E Bollschweiler
    Dept of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Endoscopy 38:149-56. 2006
    ..The aim of this prospective study was to analyze the rate of lymph-node involvement relative to the depth of mucosal or submucosal tumor penetration, comparing squamous-cell carcinomas and adenocarcinomas...
  39. ncbi request reprint High volume centers for esophagectomy: what is the number needed to achieve low postoperative mortality?
    R Metzger
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Dis Esophagus 17:310-4. 2004
    ..9%, be achieved. Based on this survey, surgery of esophageal cancer is a task for high-volume hospitals because of decreased postoperative mortality and improved long-term prognosis compared with low volume hospitals...
  40. ncbi request reprint Is the urokinase-type plasminogen activator system a reliable prognostic factor in gastric cancer?
    T Luebke
    Department of Surgery, University of Cologne, Cologne, Germany
    Int J Biol Markers 21:162-9. 2006
    ..The aim of this prospective study was to evaluate the clinical and prognostic impact of immunohistochemically assessed uPA and PAI-1 in patients with gastric cancer...
  41. ncbi request reprint Quantitative analysis of survivin RNA expression in blood as a non-invasive predictor of response to neoadjuvant radiochemotherapy in esophageal cancer
    Peter Grimminger
    Department of General, Visceral, and Tumor Surgery, University of Cologne, 50931Cologne, Germany
    J Surg Oncol 100:447-51. 2009
    ..Analysis of survivin RNA expression in peripheral blood as a non-invasive molecular predictor of response to neoadjuvant radiochemotherapy in patients with locally advanced cancer of the esophagus...
  42. ncbi request reprint Vascular endothelial growth factor expression following ischemic conditioning of the gastric conduit
    M Bludau
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    Dis Esophagus 26:847-52. 2013
    ..In this model of ischemic conditioning with delayed reconstruction of 4-5 days, no induction of neo-angiogenesis could be demonstrated by measurement of VEGF expression. ..
  43. doi request reprint XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer
    Peter P Grimminger
    Department of General, Visceral, and Cancer Surgery, University of Cologne, Cologne, Germany
    J Surg Res 164:e61-6. 2010
    ..The gene polymorphism of the X-ray-repair-cross complementing (XRCC1-) gene (rs25487) was analyzed to predict response to neoadjuvant radiochemotherapy and prognosis in patients with locally advanced rectal cancer...
  44. doi request reprint Extracapsular lymph node involvement differs between squamous cell and adenocarcinoma of the esophagus
    Ralf Metzger
    Department of General, Visceral, and Cancer Surgery, University of Cologne, Germany
    Ann Surg Oncol 16:447-53. 2009
    ..005) higher in patients with pN1 AC (median = 5) compared with pN1 SCC (median = 3). We conclude that extracapsular LNI is an independent negative prognostic factor which occurs more frequently in esophageal AC than SCC...
  45. ncbi request reprint Health-related quality of life after Ivor Lewis esophagectomy
    Christian A Gutschow
    Department of General, Visceral, and Cancer Surgery, University of Cologne, Kerpener Strasse 62, Cologne, Germany
    Langenbecks Arch Surg 398:231-7. 2013
    ..Transthoracic Ivor Lewis esophagectomy is a surgical standard therapy for esophageal carcinoma. The aim of this study was to assess health-related quality of life (HRQL) in mid- and long-term survivors...
  46. ncbi request reprint Association of COX-2 expression with corresponding active and chronic inflammatory reactions in Barrett's metaplasia and progression to cancer
    F C Ling
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne corrected Germany
    Histopathology 50:203-9. 2007
    ....
  47. pmc Quantitative c-erbB-2 but not c-erbB-1 mRNA expression is a promising marker to predict minor histopathologic response to neoadjuvant radiochemotherapy in oesophageal cancer
    F Miyazono
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Br J Cancer 91:666-72. 2004
    ..This test could be used to prevent expensive, non effective and potentially harmful therapies in approximately one-fourth of our patients, and leads to a more individualised type of combined modality treatment...
  48. doi request reprint Death-associated protein kinase (DAPK) promoter methylation and response to neoadjuvant radiochemotherapy in esophageal cancer
    Jan Brabender
    Department of General, Visceral and Tumor Surgery, University of Cologne, Cologne, Germany
    Ann Surg Oncol 16:1378-83. 2009
    ....
  49. ncbi request reprint Response evaluation by endoscopy, rebiopsy, and endoscopic ultrasound does not accurately predict histopathologic regression after neoadjuvant chemoradiation for esophageal cancer
    Paul M Schneider
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Ann Surg 248:902-8. 2008
    ....
  50. ncbi request reprint Feasibility of sentinel node concept in gastric carcinoma: clinicopathological analysis of gastric cancer with solitary lymph node metastases
    S P Moenig
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    Anticancer Res 25:1349-52. 2005
    ..The feasibility and diagnostic reliability of sentinel lymph node biopsy of gastric carcinoma are still unclear and controversial...
  51. ncbi request reprint Quality-assured Efficient Engineering of Feedforward Neural Networks (QUEEN) -- pretherapeutic estimation of lymph node status in patients with gastric carcinoma
    K Hensler
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Str 9, 50931 Koln, Germany
    Methods Inf Med 44:647-54. 2005
    ..Lymph node metastasis (LNM) is an important prognostic indicator in patients with gastric carcinoma. However, the methods that have been established for preoperative diagnosis of LNM show insufficient accuracy...
  52. ncbi request reprint Demographic variations in the rising incidence of esophageal adenocarcinoma in white males
    E Bollschweiler
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Cancer 92:549-55. 2001
    ..The purpose of the current investigation was to collect the available data and to analyze them in a unified manner...
  53. ncbi request reprint Esophageal cancer in Germany is associated with Epstein-Barr-virus but not with papillomaviruses
    S Awerkiew
    Institute of Virology, University of Cologne, Germany
    Med Microbiol Immunol 192:137-40. 2003
    ..In contrast, 35% of squamous cell carcinomas and 36% of adenocarcinomas were shown to contain EBV DNA by nested polymerase chain reaction...
  54. ncbi request reprint Options in the management of esophageal perforation: analysis over a 12-year period
    D Vallbohmer
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    Dis Esophagus 23:185-90. 2010
    ..053). In three patients, the diagnostic interval was not determinable retrospectively. An individualized therapy depending on etiology, diagnostic delay, and septic status leads to a low mortality of esophageal perforation...
  55. doi request reprint Leukocyte depletion in allogeneic blood transfusion does not change the negative influence on survival following transthoracic resection for esophageal cancer
    Frederike C Ling
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    J Gastrointest Surg 13:581-6. 2009
    ..This study evaluates the association between receipt of leucocyte-depleted and non-depleted allogeneic blood and survival following esophagectomy for cancer...
  56. ncbi request reprint The overexpression of c-met as a prognostic indicator for gastric carcinoma compared to p53 and p21 nuclear accumulation
    Uta Drebber
    Institute of Pathology, University of Cologne, Cologne, Germany
    Oncol Rep 19:1477-83. 2008
    ..P21 proved to be a significant prognostic factor in the multivariate analysis. Our data suggest that the overexpression of c-met and p21 may represent independent prognostic factors in gastric carcinoma...
  57. ncbi request reprint Histological grading in gastric cancer by Ming classification: correlation with histopathological subtypes, metastasis, and prognosis
    Thomas Luebke
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, Cologne 50931, Germany
    World J Surg 29:1422-7; discussion 1428. 2005
    ..The 3-year survival rates were lower in the infiltrative tumor type than in the expansive tumor type according to Ming. However, the Ming classification is not an independent prognostic factor...
  58. doi request reprint Choosing the best treatment for esophageal cancer : criteria for selecting the best multimodal therapy
    A H Holscher
    Department of General, Visceral and Cancer Surgery, University of Cologne, Koln, Germany
    Recent Results Cancer Res 196:169-77. 2012
    ..The principle item of multimodal therapy is still transthoracic en bloc esophagectomy which should be performed in high volume centers in order to guarantee stable and good results...
  59. ncbi request reprint High specificity of quantitative excision repair cross-complementing 1 messenger RNA expression for prediction of minor histopathological response to neoadjuvant radiochemotherapy in esophageal cancer
    Ute Warnecke-Eberz
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Clin Cancer Res 10:3794-9. 2004
    ....
  60. ncbi request reprint Benefits and limitations of Kaplan-Meier calculations of survival chance in cancer surgery
    Elfriede Bollschweiler
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Langenbecks Arch Surg 388:239-44. 2003
    ..However, mistakes and distortions frequently arise in the display and interpretation of survival plots. This review aims to highlight such pitfalls and provide recommendations for future practice...
  61. ncbi request reprint [Experience with an interdisciplinary surgical handbook for medical students]
    E Wolfgarten
    Uniklinik Köln, Klinik und Poliklinik für Allgemein, Viszeral und Tumorchirurgie, Koln, Deutschland
    Zentralbl Chir 137:180-6. 2012
    ..It was tested in a pilot phase and should increase the number of final year students and their interest in surgery in the long-term...
  62. ncbi request reprint [Conventional surgery in peptic ulcer perforation: indications and procedure]
    A H Holscher
    Klinik und Poliklinik für Visceral und Gefässchirurgie, Universitat zu Koln, Joseph Stelzmann Strasse 9, 50931 Koln
    Kongressbd Dtsch Ges Chir Kongr 118:285-8. 2001
    ..Conservative treatment includes the risk of safety of diagnosis and difficulties in the continuous clinical monitoring as well as significant disadvantages in case of delayed laparotomy...
  63. ncbi request reprint [GERD and complications: when is surgery necessary?]
    A H Holscher
    Klinik und Poliklinik für Visceral und Gefässchirurgie der Universität zu Köln
    Z Gastroenterol 45:1150-5. 2007
    ..Indications for surgery by limited or radical esophagectomy are incomplete removal of neoplasia after mucosectomy, long Barrett's esophagus with multifocal lesions or suspicion of submucosal carcinoma...
  64. ncbi request reprint Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer
    Hakan Alakus
    Department of General, Visceral and Cancer Surgery, Center for Integrated Oncology, University of Cologne, Kerpenerstrasse 62, 50937, Cologne, Germany
    World J Surg 34:2853-9. 2010
    ....
  65. pmc Neoadjuvant chemoradiotherapy for esophageal cancer: impact on extracapsular lymph node involvement
    Ralf Metzger
    Department of General, Visceral and Cancer Surgery, Center for Integrated Oncology, University Hospital of Cologne, Kerpener Strasse 62, Cologne, Germany
    World J Gastroenterol 16:1986-92. 2010
    ..To assess the effects of neoadjuvant chemoradiotherapy (CRT) on the presence of extracapsular lymph node involvement (LNI) and its prognostic value in patients with resected esophageal cancer...
  66. doi request reprint Prognostic relevance of skip metastases in esophageal cancer
    Klaus L Prenzel
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    Ann Thorac Surg 90:1662-7. 2010
    ..Little is known about this form of lymphatic spread in esophageal cancer. The aim of this study was to assess nodal skip metastasis and its clinical importance for patients with cancer of the esophagus...
  67. ncbi request reprint Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases
    Ute Warnecke-Eberz
    Department of Visceral and Vascular Surgery, Laboratory for Molecular Oncology, University of Cologne, Kerpener Strasse 62, Cologne, Germany
    Oncol Rep 20:619-24. 2008
    ..8%). Down-regulation occurs already in the early stage of NSCLC and is either directly involved in the lymphatic progression in NSCLC or represents a surrogate marker...
  68. ncbi request reprint Prognostic impact of protein overexpression of the proto-oncogene PIM-1 in gastric cancer
    Ute Warnecke-Eberz
    Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Kerpener Str 62, 50937 Cologne, Germany
    Anticancer Res 29:4451-5. 2009
    ..Here the prognostic impact of proto-oncogene PIM-1 was analyzed in gastric carcinoma...
  69. doi request reprint TaqMan low-density arrays and analysis by artificial neuronal networks predict response to neoadjuvant chemoradiation in esophageal cancer
    Ute Warnecke-Eberz
    Center for Integrated Oncology CIO, University Hospital of Cologne, Kerpener Strasse 62, 50937 Koln, Germany
    Pharmacogenomics 11:55-64. 2010
    ..A total of 17 genes were selected to predict histopathologic tumor response to chemoradiation (cisplatin, 5-fluorouracil, 36 Gy)...
  70. ncbi request reprint Up-regulation of survivin mRNA might be a marker for non-invasive detection of non-small cell lung cancer rather than for prognosis
    Ute Warnecke-Eberz
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Anticancer Res 28:1525-9. 2008
    ..To evaluate the prognostic importance of the apoptosis inhibitor survivin for non-small cell lung cancer (NSCLC), a study was performed in 64 patients with R0 resections for NSCLC and histopathological stages I-IIIA...
  71. doi request reprint Mean and maximum standardized uptake values in [18F]FDG-PET for assessment of histopathological response in oesophageal squamous cell carcinoma or adenocarcinoma after radiochemotherapy
    Matthias Schmidt
    Department of Nuclear Medicine, University of Cologne, Cologne, Germany
    Eur J Nucl Med Mol Imaging 36:735-44. 2009
    ..To evaluate the potential of [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET) for the assessment of histopathological response and survival after neoadjuvant radiochemotherapy in patients with oesophageal cancer...
  72. pmc Evaluation of POSSUM scoring system in patients with gastric cancer undergoing D2-gastrectomy
    Elfriede Bollschweiler
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Str, 9, 50931 Koln, Germany
    BMC Surg 5:8. 2005
    ..The aim of the present study was to assess the accuracy of POSSUM in predicting mortality and morbidity in patients with gastric cancer undergoing D2-gastrectomy...
  73. ncbi request reprint Increased human telomerase reverse transcriptase (hTERT) mRNA expression but not telomerase activity is related to survival in curatively resected non-small cell lung cancer
    Ralf Metzger
    Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Joseph Stelzmann Strasse 9, D 50931 Cologne, Germany
    Anticancer Res 29:1157-62. 2009
    ..The purpose of this study was to evaluate the significance of human telomerase reverse transcriptase (hTERT) mRNA expression and telomerase activity as prognostic markers in non-small cell lung cancer (NSCLC)...
  74. doi request reprint ERCC1 and XRCC1 gene polymorphisms predict response to neoadjuvant radiochemotherapy in esophageal cancer
    Ute Warnecke-Eberz
    Department of General, Visceral, and Cancer Surgery, Center for Integrated Oncology, University Hospital of Cologne, Kerpener Str 62, 50937, Cologne, Germany
    J Gastrointest Surg 13:1411-21. 2009
    ..We examined a panel of selected gene polymorphisms to predict response to neoadjuvant radiochemotherapy (cisplatin, 5-fluorouracil, 36 Gy) in esophageal cancer patients...
  75. ncbi request reprint A multimedia tool for the informed consent of patients prior to gastric banding
    Carsten Eggers
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Obesity (Silver Spring) 15:2866-73. 2007
    ..The current study developed and evaluated a multimedia program aimed at obtaining informed consent from obese patients before gastric banding...
  76. doi request reprint Early gastric cancer: lymph node metastasis starts with deep mucosal infiltration
    Arnulf H Holscher
    Department of General, Visceral and Cancer Surgery, University of Cologne, Kerpener St 62, D 50937 Cologne, Germany
    Ann Surg 250:791-7. 2009
    ..The purpose of this study was to evaluate the frequency of lymph node metastasis according to the depth of tumor infiltration of the mucosa and submucosa...
  77. ncbi request reprint Determinants and patient-reported long-term outcomes of physician empathy in oncology: a structural equation modelling approach
    Melanie Neumann
    Centre for Health Services Research Cologne, Medical Department of the University of Cologne, Germany
    Patient Educ Couns 69:63-75. 2007
    ..The aim of the present cross-sectional study was to explore patient- and physician-specific determinants of physician empathy (PE) and to analyse the influence of PE on patient-reported long-term outcomes in German cancer patients...
  78. pmc Histomorphologic tumor regression and lymph node metastases determine prognosis following neoadjuvant radiochemotherapy for esophageal cancer: implications for response classification
    Paul M Schneider
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Ann Surg 242:684-92. 2005
    ..We sought to quantitatively and objectively evaluate histomorphologic tumor regression and establish a relevant prognostic regression classification system for esophageal cancer patients receiving neoadjuvant radiochemotherapy...
  79. ncbi request reprint [Ulcer surgery - what remains?]
    A H Holscher
    Klinik und Poliklinik für Visceral und Gefässchirurgie der Universität, Koln, Kerpener Strasse 62, 50937 Koln
    Internist (Berl) 47:602, 604-6, 608, passim. 2006
    ..Altogether ulcer surgery has become very safe although it is practiced quite rarely...
  80. doi request reprint Ivor-Lewis esophagectomy with and without laparoscopic conditioning of the gastric conduit
    Wolfgang Schroder
    Department of General, Visceral and Cancer Surgery, University of Cologne, Kerpener Str 62, 50937, Cologne, Germany
    World J Surg 34:738-43. 2010
    ..Modifications of this standard procedure aim to reduce postoperative morbidity and mortality...
  81. pmc Differential c-erbB-1 and c-erbB-2 mRNA expression in cancer of the pancreas compared with cancer of the papilla of Vater
    Klaus L Prenzel
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Str 9, 50931 Cologne, Germany
    World J Gastroenterol 12:437-42. 2006
    ....
  82. ncbi request reprint [18F]-Fluorodeoxyglucose-positron emission tomography for the assessment of histopathologic response and prognosis after completion of neoadjuvant chemoradiation in esophageal cancer
    Daniel Vallbohmer
    General, Visceral, and Cancer Surgery, University of Cologne, Germany
    Ann Surg 250:888-94. 2009
    ....
  83. pmc Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer
    Hakan Alakus
    Department of General, Visceral and Cancer Surgery, Center for Integrated Oncology, University Hospital of Cologne, Kerpener Str 62, D 50937 Cologne, Germany
    World J Gastroenterol 15:6061-7. 2009
    ..To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer...
  84. doi request reprint Significant down-regulation of the plasminogen activator inhibitor 1 mRNA in pancreatic cancer
    Ute Warnecke-Eberz
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Pancreas 36:173-7. 2008
    ..Expression profiles were compared with paired uninvolved normal tissues to define a possible differential role of these genes in tumorigenesis of both tumor types...
  85. ncbi request reprint Extracapsular lymph node spread: a new prognostic factor in gastric cancer
    Hakan Alakus
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    Cancer 116:309-15. 2010
    ..The aim of the current study was to examine the prognostic value of extracapsular lymph node involvement in gastric cancer and to find correlations with clinicopathological parameters...
  86. ncbi request reprint Impact of antireflux surgery on Barrett's esophagus
    Christian A Gutschow
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Langenbecks Arch Surg 387:138-45. 2002
    ..The rising incidence of Barrett's carcinoma is a matter of major concern in Western societies. We realized a review of the literature to evaluate the impact of antireflux surgery on prevention of Barrett's carcinoma...
  87. doi request reprint CUL2 and STK11 as novel response-predictive genes for neoadjuvant radiochemotherapy in esophageal cancer
    Ralf Metzger
    Department of General, Visceral and Cancer Surgery, Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, Kerpener Strasse 62, Koln, Germany
    Pharmacogenomics 11:1105-13. 2010
    ..Since only patients with major histopathological response benefit from multimodality treatment, we profiled the genome of patients with esophageal cancer for markers indicating response or nonresponse...
  88. ncbi request reprint [Outcome quality in visceral surgery interventions for benign illnesses]
    A H Holscher
    Klinik und Poliklinik für Visceral und Gefässchirurgie, Universitat zu Koln, Joseph Stelzmann Strasse 9, 50931 Koln
    Chirurg 73:567-75. 2002
    ..For the assessment of the surgical results in different diseases, specific criteria have to be taken into account...
  89. ncbi request reprint Differences between biopsy- or specimen-related Laurén and World Health Organization classification in gastric cancer
    Uta Flucke
    Department of Visceral and VascularSurgery, University of Cologne, Joseph Stelzmann Str 9, 50931 Cologne, Germany
    World J Surg 26:137-40. 2002
    ..Since this may have consequences for the surgical strategy, the extent of surgical resection, rebiopsies, and reconfirmation of an intestinal type should be performed at least in those cases with any doubts of this classification...
  90. ncbi request reprint Bile reflux into the stomach and the esophagus for volunteers older than 40 years
    Elfriede Bollschweiler
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Digestion 71:65-71. 2005
    ..The volunteers serving as controls in those studies were significantly younger than the patients. The aim of this study was to analyze bile reflux patterns of healthy volunteers aged comparably to patients with Barrett's esophagus...
  91. doi request reprint NERD, GERD, and Barrett's esophagus: role of acid and non-acid reflux revisited with combined pH-impedance monitoring
    Christian A Gutschow
    Department of Visceral and Vascular Surgery, University of Cologne, Kerpener Strasse 62, 50962, Cologne, Germany
    Dig Dis Sci 53:3076-81. 2008
    ..With introduction of combined esophageal pH-impedance monitoring, a precise diagnostic test for acid and non-acid reflux is now available...
  92. ncbi request reprint Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater
    Klaus L Prenzel
    Department of Visceral and Vascular Surgery, University of Cologne, 50931 Cologne, Germany
    Oncol Rep 15:1397-401. 2006
    ..In conclusion, SPARC mRNA overexpression is significantly more frequent in CP than CPV and adds further evidence that CP and CPV are biologically different tumor entities...
  93. ncbi request reprint Effect of "white diet" during bile monitoring with Bilitec 2000 on esophageal pH-metry in patients with gastroesophageal reflux disease
    Christian A Gutschow
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    J Gastrointest Surg 9:508-13. 2005
    ..Data derived from simultaneous esophageal pH and bile monitoring should be interpreted with care...
  94. doi request reprint Variable 18F-fluorodeoxyglucose uptake in gastric cancer is associated with different levels of GLUT-1 expression
    Hakan Alakus
    Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Cologne, Germany
    Nucl Med Commun 31:532-8. 2010
    ..To clarify this observation, FDG uptake in gastric carcinoma was analyzed by focusing on histopathology and on the expression of the glucose transporter (GLUT-1) in the primary tumor...
  95. pmc Prognosis of early esophageal cancer: differences between squamous cell carcinoma and adenocarcinoma
    Elfriede Bollschweiler
    Ann Surg 245:334. 2007