L Cornelius Bollheimer

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. ncbi request reprint Intracellular depletion of insulin by oleate is due to an inhibited synthesis and not to an increased secretion
    L C Bollheimer
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Biochem Biophys Res Commun 287:397-401. 2001
  2. ncbi request reprint Folate and its preventive potential in colorectal carcinogenesis. How strong is the biological and epidemiological evidence?
    L Cornelius Bollheimer
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Crit Rev Oncol Hematol 55:13-36. 2005
  3. ncbi request reprint Glucagon production of the rat insulinoma cell line INS-1-A quantitative comparison with primary rat pancreatic islets
    L Cornelius Bollheimer
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Biochem Biophys Res Commun 330:327-32. 2005
  4. ncbi request reprint Intracellular depletion of insulin: a comparative study with palmitate, oleate and elaidate in INS-1 cells
    L Cornelius Bollheimer
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Eur J Endocrinol 148:481-6. 2003
  5. ncbi request reprint Antisense oligonucleotides against the lipid phosphatase SHIP2 improve muscle insulin sensitivity in a dietary rat model of the metabolic syndrome
    Roland Buettner
    Depaertment of Internal Medicine I, Univ of Regensburg, 93042 Regensburg, Germany
    Am J Physiol Endocrinol Metab 292:E1871-8. 2007
  6. ncbi request reprint High-fat diets: modeling the metabolic disorders of human obesity in rodents
    Roland Buettner
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Obesity (Silver Spring) 15:798-808. 2007
  7. ncbi request reprint Stimulatory short-term effects of free fatty acids on glucagon secretion at low to normal glucose concentrations
    L Cornelius Bollheimer
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Metabolism 53:1443-8. 2004
  8. ncbi request reprint Synergistic effects of troglitazone and oleate on the translatability of preproinsulin mRNA from INS-1 cells
    L Cornelius Bollheimer
    Department of Internal Medicine I, University of Regensburg, 93042, Regensburg, Germany
    Biochem Pharmacol 64:1629-36. 2002
  9. ncbi request reprint Insulin-sparing effects of troglitazone in rat pancreatic islets
    L C Bollheimer
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    J Mol Endocrinol 31:61-9. 2003
  10. ncbi request reprint Definition and characterization of relative hypo- and hyperleptinemia in a large Caucasian population
    R Buettner
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    J Endocrinol 175:745-56. 2002

Detail Information

Publications22

  1. ncbi request reprint Intracellular depletion of insulin by oleate is due to an inhibited synthesis and not to an increased secretion
    L C Bollheimer
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Biochem Biophys Res Commun 287:397-401. 2001
    ..This is due to an inhibited biosynthetic supply which can not compensate for intracellular IRI-degradation and (to a neglible extent) for insulin secretion...
  2. ncbi request reprint Folate and its preventive potential in colorectal carcinogenesis. How strong is the biological and epidemiological evidence?
    L Cornelius Bollheimer
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Crit Rev Oncol Hematol 55:13-36. 2005
    ..The recommendation of folate intake to prevent colorectal cancer is therefore not evidence-based...
  3. ncbi request reprint Glucagon production of the rat insulinoma cell line INS-1-A quantitative comparison with primary rat pancreatic islets
    L Cornelius Bollheimer
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Biochem Biophys Res Commun 330:327-32. 2005
    ..Taken together, it is obvious that INS-1 cells do not represent an exclusively insulin producing beta-cell line...
  4. ncbi request reprint Intracellular depletion of insulin: a comparative study with palmitate, oleate and elaidate in INS-1 cells
    L Cornelius Bollheimer
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Eur J Endocrinol 148:481-6. 2003
    ..Palmitate, cis-monoenic oleate and the trans-monoenic elaidate were employed as model FFAs to elucidate potentially different effects due to chain length and configuration...
  5. ncbi request reprint Antisense oligonucleotides against the lipid phosphatase SHIP2 improve muscle insulin sensitivity in a dietary rat model of the metabolic syndrome
    Roland Buettner
    Depaertment of Internal Medicine I, Univ of Regensburg, 93042 Regensburg, Germany
    Am J Physiol Endocrinol Metab 292:E1871-8. 2007
    ..We conclude that treatment with SHIP2-AS can rapidly improve muscle insulin sensitivity in dietary insulin resistance. The long-term feasibility of such a strategy should be examined further...
  6. ncbi request reprint High-fat diets: modeling the metabolic disorders of human obesity in rodents
    Roland Buettner
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Obesity (Silver Spring) 15:798-808. 2007
    ..Therefore, in this review, metabolic data obtained with different HF diet approaches are compiled. Both whole-body and organ-specific diet effects are analyzed...
  7. ncbi request reprint Stimulatory short-term effects of free fatty acids on glucagon secretion at low to normal glucose concentrations
    L Cornelius Bollheimer
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Metabolism 53:1443-8. 2004
    ..6 mmol/L glucose. The present analysis therefore points to a new role for FFA as a nutritient secretagogue and a modulator of alpha-cellular glucagon metabolism...
  8. ncbi request reprint Synergistic effects of troglitazone and oleate on the translatability of preproinsulin mRNA from INS-1 cells
    L Cornelius Bollheimer
    Department of Internal Medicine I, University of Regensburg, 93042, Regensburg, Germany
    Biochem Pharmacol 64:1629-36. 2002
    ..6+/-0.3 x CTRL; P=0.01). It is concluded that troglitazone and oleate synergistically affect the translational rate at the level of the PPI-mRNA molecule...
  9. ncbi request reprint Insulin-sparing effects of troglitazone in rat pancreatic islets
    L C Bollheimer
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    J Mol Endocrinol 31:61-9. 2003
    ....
  10. ncbi request reprint Definition and characterization of relative hypo- and hyperleptinemia in a large Caucasian population
    R Buettner
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    J Endocrinol 175:745-56. 2002
    ..In conclusion, we report the first percentile curves for serum leptin by BMI in a large Caucasian population. Relatively low leptin values may be associated with a lower metabolic risk than relatively high serum leptin values...
  11. ncbi request reprint Preserved direct hepatic insulin action in rats with diet-induced hepatic steatosis
    Roland Buettner
    Dept of Internal Medicine I, Univ of Regensburg, 93042 Regensburg, Germany
    Am J Physiol Endocrinol Metab 286:E828-33. 2004
    ..The data argue for an important role of systemic factors in the regulation of hepatic glucose output and hepatic insulin sensitivity in vivo...
  12. ncbi request reprint Increased insulin resistance and beta cell activity in patients with Crohn's disease
    Nicole Bregenzer
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Inflamm Bowel Dis 12:53-6. 2006
    ..In this study, we investigated whether the endocrine pancreatic function is also disturbed in patients with inflammatory bowel disease...
  13. ncbi request reprint [Surgical resection of the thyroid and parathyroid glands]
    U Woenckhaus
    Klinik und Poliklinik für Innere Medizin I, Klinikum der Universitat Regensburg, 93042 Regensburg, Germany
    Internist (Berl) 48:569-77. 2007
    ..If treatment with oral calcium is insufficient, the addition of a vitamin D analogue is necessary. This requires close monitoring to avoid renal or other hypercalcaemic complications...
  14. ncbi request reprint Defining high-fat-diet rat models: metabolic and molecular effects of different fat types
    R Buettner
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    J Mol Endocrinol 36:485-501. 2006
    ..Diets based on LC-SFA and MUFA induced hepatic steatosis with SREBP1c activation. This points to an intact transcriptional hepatic insulin effect despite resistance to insulin's metabolic actions...
  15. ncbi request reprint Association between serum ferritin and the insulin resistance syndrome in a representative population
    C E Wrede
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Eur J Endocrinol 154:333-40. 2006
    ..However, as yet the association between IRS and SF in a representative population has not been investigated...
  16. ncbi request reprint Systematic analysis of the insulinotropic and glucagonotropic potency of saturated and monounsaturated fatty acid mixtures in rat pancreatic islets
    C E Wrede
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Horm Metab Res 39:482-8. 2007
    ..Based on the theory of lipotoxicity for the development of type 2 diabetes such variances in the FFA composition might interfere with lipotoxic effects on the endocrine pancreas...
  17. ncbi request reprint Efficient analysis of hepatic glucose output and insulin action using a liver slice culture system
    R Buettner
    Department of Internal Medicine I, University of Regensburg, Germany
    Horm Metab Res 37:127-32. 2005
    ..However, whether this method is suitable to measure hepatic glucose output is unknown...
  18. ncbi request reprint [Drugs in interventional radiology. 1: Prevention of allergy, antibiotic prophylaxis, inhibiting gastrointestinal motility, antiemetics, conscious sedation, vasodilation]
    O W Hamer
    Institut für Röntgendiagnostik, Universitat Regensburg, 93042 Regensburg
    Radiologe 42:398-409; quiz 410-1. 2002
  19. ncbi request reprint The Pro115Gln polymorphism within the PPAR gamma2 gene has no epidemiological impact on morbid obesity
    O W Hamer
    Department of Internal Medicine I, University of Regensburg, Germany
    Exp Clin Endocrinol Diabetes 110:230-4. 2002
    ..It needs further investigation whether this polymorphism might play a role in related metabolic disorders...
  20. ncbi request reprint Frequency and outcome of patients with nonthyroidal illness syndrome in a medical intensive care unit
    Katharina Plikat
    Department of Internal Medicine I, University Hospital of Regensburg, University of Regensburg, 93042 Regensburg, Germany
    Metabolism 56:239-44. 2007
    ..Nonthyroidal illness syndrome is frequent at a medical ICU. A reduction of FT(4) together with FT(3) is associated with an increase in mortality and might reflect a maladaptive process, thereby worsening the disease...
  21. ncbi request reprint Correlation between iron status and genetic hemochromatosis (codon C282Y) in a large German population
    Christian E Wrede
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Isr Med Assoc J 6:30-3. 2004
    ..Representative population studies are needed to evaluate the phenotype of people heterozygous and homozygous for the C282Y mutation...
  22. ncbi request reprint Hepatocyte growth factor stimulates proliferation of pancreatic beta-cells particularly in the presence of subphysiological glucose concentrations
    S Gahr
    Department of Internal Medicine I, University of Regensburg, F J Strauss Allee 11, 93042, Germany
    J Mol Endocrinol 28:99-110. 2002
    ..HGF, in contrast to other growth factors, seems to be of importance particularly in the presence of low glucose concentrations and therefore takes a special role in this complex concert...