C Bogdan

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc Fibroblasts as host cells in latent leishmaniosis
    C Bogdan
    Institute of Clinical Microbiology, Department of Anatomy, University of Erlangen, D 91054 Erlangen, Germany
    J Exp Med 191:2121-30. 2000
  2. ncbi request reprint Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, D 91054, Germany
    Curr Opin Immunol 12:64-76. 2000
  3. ncbi request reprint The function of type I interferons in antimicrobial immunity
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, D 91054, Germany
    Curr Opin Immunol 12:419-24. 2000
  4. ncbi request reprint How do protozoan parasites survive inside macrophages?
    C Bogdan
    Institut fur Klinische Mikrobiologie, Immunologie und Hygiene, Universitat Erlangen, Wasserturmstrasse 3, D 91054 Erlangen, Germany
    Parasitol Today 15:22-8. 1999
  5. ncbi request reprint [Leishmaniasis: principles of the immune response and function of nitric oxide]
    C Bogdan
    Institut fur Klinische Mikrobiologie, Immunologie und Hygiene der Friedrich Alexander Universität Erlangen Nürnberg
    Berl Munch Tierarztl Wochenschr 111:409-14. 1998
  6. ncbi request reprint Nitric oxide and the regulation of gene expression
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Wasserturmstrasse 3, D 91054, Erlangen, Germany
    Trends Cell Biol 11:66-75. 2001
  7. ncbi request reprint The immune response to Leishmania: mechanisms of parasite control and evasion
    C Bogdan
    Institute of Clinical Microbiology and Immunology, University of Erlangen, Germany
    Int J Parasitol 28:121-34. 1998
  8. ncbi request reprint Mechanism of suppression of macrophage nitric oxide release by IL-13: influence of the macrophage population
    C Bogdan
    Institute of Clinical Microbiology and Immunology, University of Erlangen, Germany
    J Immunol 159:4506-13. 1997
  9. ncbi request reprint Invasion, control and persistence of Leishmania parasites
    C Bogdan
    Institute of Clinical Microbiology and Immunology, University of Erlangen, Wasserturmstrasse 3, D 91054 Erlangen, Germany
    Curr Opin Immunol 8:517-25. 1996
  10. ncbi request reprint Nitric oxide and the immune response
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University of Erlangen Nuremberg, Wasserturmstrasse 3 5, D 91054 Erlangen, Germany
    Nat Immunol 2:907-16. 2001

Collaborators

Detail Information

Publications24

  1. pmc Fibroblasts as host cells in latent leishmaniosis
    C Bogdan
    Institute of Clinical Microbiology, Department of Anatomy, University of Erlangen, D 91054 Erlangen, Germany
    J Exp Med 191:2121-30. 2000
    ..major. These data identify fibroblasts as an important host cell for Leishmania during the chronic phase of infection and suggest that they might serve as safe targets for the parasites in clinically latent disease...
  2. ncbi request reprint Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, D 91054, Germany
    Curr Opin Immunol 12:64-76. 2000
    ..Components of several signal transduction pathways have been identified as intracellular targets for reactive nitrogen and oxygen intermediates...
  3. ncbi request reprint The function of type I interferons in antimicrobial immunity
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, D 91054, Germany
    Curr Opin Immunol 12:419-24. 2000
    ....
  4. ncbi request reprint How do protozoan parasites survive inside macrophages?
    C Bogdan
    Institut fur Klinische Mikrobiologie, Immunologie und Hygiene, Universitat Erlangen, Wasserturmstrasse 3, D 91054 Erlangen, Germany
    Parasitol Today 15:22-8. 1999
    ....
  5. ncbi request reprint [Leishmaniasis: principles of the immune response and function of nitric oxide]
    C Bogdan
    Institut fur Klinische Mikrobiologie, Immunologie und Hygiene der Friedrich Alexander Universität Erlangen Nürnberg
    Berl Munch Tierarztl Wochenschr 111:409-14. 1998
    ..In this article, the main components of immune response against Leishmania and the role of nitrogen monoxide (nitric oxide, NO) in the Leishmania major mouse model will be reviewed...
  6. ncbi request reprint Nitric oxide and the regulation of gene expression
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Wasserturmstrasse 3, D 91054, Erlangen, Germany
    Trends Cell Biol 11:66-75. 2001
    ....
  7. ncbi request reprint The immune response to Leishmania: mechanisms of parasite control and evasion
    C Bogdan
    Institute of Clinical Microbiology and Immunology, University of Erlangen, Germany
    Int J Parasitol 28:121-34. 1998
    ..It is probable that none of these mechanisms alone is sufficient to guarantee the survival of Leishmania, but together they might provide the safe environment which protects the parasite from elimination...
  8. ncbi request reprint Mechanism of suppression of macrophage nitric oxide release by IL-13: influence of the macrophage population
    C Bogdan
    Institute of Clinical Microbiology and Immunology, University of Erlangen, Germany
    J Immunol 159:4506-13. 1997
    ....
  9. ncbi request reprint Invasion, control and persistence of Leishmania parasites
    C Bogdan
    Institute of Clinical Microbiology and Immunology, University of Erlangen, Wasserturmstrasse 3, D 91054 Erlangen, Germany
    Curr Opin Immunol 8:517-25. 1996
    ..The use of transgenic mice for (re)probing certain immunological aspects of leishmaniasis has yielded not only predictable and confirmatory but also unexpected and pioneering results which require critical appreciation...
  10. ncbi request reprint Nitric oxide and the immune response
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University of Erlangen Nuremberg, Wasserturmstrasse 3 5, D 91054 Erlangen, Germany
    Nat Immunol 2:907-16. 2001
    ..Its striking inter- and intracellular signaling capacity makes it extremely difficult to predict the effect of NOS inhibitors and NO donors, which still hampers therapeutic applications...
  11. ncbi request reprint Visceral leishmaniasis in a German child who had never entered a known endemic area: case report and review of the literature
    C Bogdan
    Institute for Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Germany
    Clin Infect Dis 32:302-6. 2001
    ..Congenital or blood transfusion-associated leishmaniasis was ruled out. Possible modes of transmission (including a potential new autochthonous focus of the disease in central Europe) are discussed...
  12. ncbi request reprint The role of nitric oxide in innate immunity
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Germany
    Immunol Rev 173:17-26. 2000
    ..Some of these effects result from the function of NOS2/NO as an indispensable co-factor for the activation of Tyk2 kinase and, thus, for interleukin-12 and IFN-alpha/beta signaling in natural killer cells...
  13. ncbi request reprint Requirement for type 2 NO synthase for IL-12 signaling in innate immunity
    A Diefenbach
    Institut fur Klinische Mikrobiologie, Immunologie und Hygiene, Universitat Erlangen, Wasserturmstrasse 3, D 91054 Erlangen, Germany
    Science 284:951-5. 1999
    ..Activation of Tyk2 in NK cells by IFN-alpha/beta also required NOS2. Thus, NOS2-derived NO is a prerequisite for cytokine signaling and function in innate immunity...
  14. ncbi request reprint The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4
    H Schindler
    Institute of Clinical Microbiology, Immunology, and Hygiene, University of Erlangen, Erlangen, Germany
    J Immunol 166:3075-82. 2001
    ..These results further define the production of IFN-gamma by macrophages and point to a diversity in the signals required for IFN-gamma production by various cell types...
  15. ncbi request reprint Rapidly fatal leishmaniasis in resistant C57BL/6 mice lacking TNF
    P Wilhelm
    Institut fur Klinische Mikrobiologie, Immunologie, Universitat Erlangen Nurnberg, Erlangen, Germany
    J Immunol 166:4012-9. 2001
    ..TNF(-/-) mice, but its expression was more disperse and less focal in the absence of TNF. These are the first data to demonstrate that TNF is essential for the in vivo control of L. major...
  16. pmc Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major
    S Stenger
    Institute of Clinical Microbiology and Immunology, University of Erlangen, Germany
    J Exp Med 180:783-93. 1994
    ..The relative lack of iNOS in susceptible mice might be a consequence of macrophage deactivation by TGF-beta and reduced responsiveness to IFN-gamma...
  17. ncbi request reprint Suppression of type 2 NO-synthase activity in macrophages by Candida albicans
    K Schröppel
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Germany
    Int J Med Microbiol 290:659-68. 2001
    ..NO suppression and Mphi killing are potent activities of C. albicans that may augment virulence of C. albicans...
  18. ncbi request reprint A case of aortic valve disease associated with Tropheryma whippelii infection in the absence of other signs of Whipple's disease
    W Geissdörfer
    Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University of Erlangen Nurnberg, Germany
    Infection 29:44-7. 2001
    ..The histological examination of the aortic valve was compatible with Whipple's disease. A duodenal biopsy revealed an infection with Giardia lamblia, but T. whippelii and histological signs of Whipple's disease were not detectable...
  19. ncbi request reprint A case of equine granulocytic ehrlichiosis provides molecular evidence for the presence of pathogenic anaplasma phagocytophilum (HGE agent) in Germany
    F D Von Loewenich
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Wasserturmstrasse 3 5, 91054, Erlangen, Germany
    Eur J Clin Microbiol Infect Dis 22:303-5. 2003
    ..Thus, the current lack of clinical cases of HGE in Germany is unlikely to result from the absence of pathogenic granulocytic ehrlichiae strains in German ticks...
  20. ncbi request reprint Traces of bacterial lipopolysaccharide suppress IFN-gamma-induced nitric oxide synthase gene expression in primary mouse macrophages
    C Bogdan
    Beatrice and Samuel A Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, NY 10021
    J Immunol 151:301-9. 1993
    ..Regulation of iNOS in vivo may depend on the relative tempo with which the inflammatory and immune responses evolve...
  21. ncbi request reprint Partial impairment of cytokine responses in Tyk2-deficient mice
    M Karaghiosoff
    Institute of Animal Breeding and Genetics, Veterinary University of Vienna, Austria
    Immunity 13:549-60. 2000
    ..Tyk2-/- mice are unable to clear vaccinia virus and show a reduced T cell response after LCMV challenge. These data imply a selective contribution of Tyk2 to the signals triggered by various biological stimuli and cytokine receptors...
  22. ncbi request reprint An antimicrobial activity of cytolytic T cells mediated by granulysin
    S Stenger
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Science 282:121-5. 1998
    ..The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intracellular pathogens...
  23. ncbi request reprint IFN-gamma production by antigen-presenting cells: mechanisms emerge
    D M Frucht
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Immunol 22:556-60. 2001
    ..Understanding these processes in lymphoid, and now nonlymphoid, cells remains an important challenge...
  24. ncbi request reprint Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages
    C Bogdan
    Beatrice and Samuel A Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, NY 10021
    J Leukoc Biol 55:227-33. 1994
    ....