Research Topics
Genomes and Genes | C BogdanSummaryAffiliation: University of Erlangen-Nuremberg Country: Germany Publications
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Publications
Fibroblasts as host cells in latent leishmaniosisC Bogdan
Institute of Clinical Microbiology, Department of Anatomy, University of Erlangen, D 91054 Erlangen, Germany
J Exp Med 191:2121-30. 2000..major. These data identify fibroblasts as an important host cell for Leishmania during the chronic phase of infection and suggest that they might serve as safe targets for the parasites in clinically latent disease...
Reactive oxygen and reactive nitrogen intermediates in innate and specific immunityC Bogdan
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, D 91054, Germany
Curr Opin Immunol 12:64-76. 2000..Components of several signal transduction pathways have been identified as intracellular targets for reactive nitrogen and oxygen intermediates...- The function of type I interferons in antimicrobial immunityC Bogdan
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, D 91054, Germany
Curr Opin Immunol 12:419-24. 2000.... - How do protozoan parasites survive inside macrophages?C Bogdan
Institut fur Klinische Mikrobiologie, Immunologie und Hygiene, Universitat Erlangen, Wasserturmstrasse 3, D 91054 Erlangen, Germany
Parasitol Today 15:22-8. 1999.... - [Leishmaniasis: principles of the immune response and function of nitric oxide]C Bogdan
Institut fur Klinische Mikrobiologie, Immunologie und Hygiene der Friedrich Alexander Universität Erlangen Nürnberg
Berl Munch Tierarztl Wochenschr 111:409-14. 1998..In this article, the main components of immune response against Leishmania and the role of nitrogen monoxide (nitric oxide, NO) in the Leishmania major mouse model will be reviewed... - Nitric oxide and the regulation of gene expressionC Bogdan
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Wasserturmstrasse 3, D 91054, Erlangen, Germany
Trends Cell Biol 11:66-75. 2001.... - The immune response to Leishmania: mechanisms of parasite control and evasionC Bogdan
Institute of Clinical Microbiology and Immunology, University of Erlangen, Germany
Int J Parasitol 28:121-34. 1998..It is probable that none of these mechanisms alone is sufficient to guarantee the survival of Leishmania, but together they might provide the safe environment which protects the parasite from elimination... - Mechanism of suppression of macrophage nitric oxide release by IL-13: influence of the macrophage populationC Bogdan
Institute of Clinical Microbiology and Immunology, University of Erlangen, Germany
J Immunol 159:4506-13. 1997.... - Invasion, control and persistence of Leishmania parasitesC Bogdan
Institute of Clinical Microbiology and Immunology, University of Erlangen, Wasserturmstrasse 3, D 91054 Erlangen, Germany
Curr Opin Immunol 8:517-25. 1996..The use of transgenic mice for (re)probing certain immunological aspects of leishmaniasis has yielded not only predictable and confirmatory but also unexpected and pioneering results which require critical appreciation... - Nitric oxide and the immune responseC Bogdan
Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University of Erlangen Nuremberg, Wasserturmstrasse 3 5, D 91054 Erlangen, Germany
Nat Immunol 2:907-16. 2001..Its striking inter- and intracellular signaling capacity makes it extremely difficult to predict the effect of NOS inhibitors and NO donors, which still hampers therapeutic applications... - Visceral leishmaniasis in a German child who had never entered a known endemic area: case report and review of the literatureC Bogdan
Institute for Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Germany
Clin Infect Dis 32:302-6. 2001..Congenital or blood transfusion-associated leishmaniasis was ruled out. Possible modes of transmission (including a potential new autochthonous focus of the disease in central Europe) are discussed... - The role of nitric oxide in innate immunityC Bogdan
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Germany
Immunol Rev 173:17-26. 2000..Some of these effects result from the function of NOS2/NO as an indispensable co-factor for the activation of Tyk2 kinase and, thus, for interleukin-12 and IFN-alpha/beta signaling in natural killer cells... - Requirement for type 2 NO synthase for IL-12 signaling in innate immunityA Diefenbach
Institut fur Klinische Mikrobiologie, Immunologie und Hygiene, Universitat Erlangen, Wasserturmstrasse 3, D 91054 Erlangen, Germany
Science 284:951-5. 1999..Activation of Tyk2 in NK cells by IFN-alpha/beta also required NOS2. Thus, NOS2-derived NO is a prerequisite for cytokine signaling and function in innate immunity... - The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4H Schindler
Institute of Clinical Microbiology, Immunology, and Hygiene, University of Erlangen, Erlangen, Germany
J Immunol 166:3075-82. 2001..These results further define the production of IFN-gamma by macrophages and point to a diversity in the signals required for IFN-gamma production by various cell types... - Rapidly fatal leishmaniasis in resistant C57BL/6 mice lacking TNFP Wilhelm
Institut fur Klinische Mikrobiologie, Immunologie, Universitat Erlangen Nurnberg, Erlangen, Germany
J Immunol 166:4012-9. 2001..TNF(-/-) mice, but its expression was more disperse and less focal in the absence of TNF. These are the first data to demonstrate that TNF is essential for the in vivo control of L. major... - Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania majorS Stenger
Institute of Clinical Microbiology and Immunology, University of Erlangen, Germany
J Exp Med 180:783-93. 1994..The relative lack of iNOS in susceptible mice might be a consequence of macrophage deactivation by TGF-beta and reduced responsiveness to IFN-gamma... - Suppression of type 2 NO-synthase activity in macrophages by Candida albicansK Schröppel
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Germany
Int J Med Microbiol 290:659-68. 2001..NO suppression and Mphi killing are potent activities of C. albicans that may augment virulence of C. albicans... - A case of aortic valve disease associated with Tropheryma whippelii infection in the absence of other signs of Whipple's diseaseW Geissdörfer
Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University of Erlangen Nurnberg, Germany
Infection 29:44-7. 2001..The histological examination of the aortic valve was compatible with Whipple's disease. A duodenal biopsy revealed an infection with Giardia lamblia, but T. whippelii and histological signs of Whipple's disease were not detectable... - A case of equine granulocytic ehrlichiosis provides molecular evidence for the presence of pathogenic anaplasma phagocytophilum (HGE agent) in GermanyF D Von Loewenich
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Wasserturmstrasse 3 5, 91054, Erlangen, Germany
Eur J Clin Microbiol Infect Dis 22:303-5. 2003..Thus, the current lack of clinical cases of HGE in Germany is unlikely to result from the absence of pathogenic granulocytic ehrlichiae strains in German ticks... - Traces of bacterial lipopolysaccharide suppress IFN-gamma-induced nitric oxide synthase gene expression in primary mouse macrophagesC Bogdan
Beatrice and Samuel A Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, NY 10021
J Immunol 151:301-9. 1993..Regulation of iNOS in vivo may depend on the relative tempo with which the inflammatory and immune responses evolve... - Partial impairment of cytokine responses in Tyk2-deficient miceM Karaghiosoff
Institute of Animal Breeding and Genetics, Veterinary University of Vienna, Austria
Immunity 13:549-60. 2000..Tyk2-/- mice are unable to clear vaccinia virus and show a reduced T cell response after LCMV challenge. These data imply a selective contribution of Tyk2 to the signals triggered by various biological stimuli and cytokine receptors... - An antimicrobial activity of cytolytic T cells mediated by granulysinS Stenger
Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA
Science 282:121-5. 1998..The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intracellular pathogens... - IFN-gamma production by antigen-presenting cells: mechanisms emergeD M Frucht
Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Trends Immunol 22:556-60. 2001..Understanding these processes in lymphoid, and now nonlymphoid, cells remains an important challenge... - Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophagesC Bogdan
Beatrice and Samuel A Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, NY 10021
J Leukoc Biol 55:227-33. 1994....