Research Topics
Genomes and Genes | Tobias M BoeckersSummaryAffiliation: University of Ulm Country: Germany Publications
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Publications
ProSAP/Shank proteins - a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological diseaseTobias M Boeckers
AG Molecular Neurobiology, Institute of Anatomy, UKM, Westfaelische Wilhelms University, Munster, Germany
J Neurochem 81:903-10. 2002..This ProSAP2/Shank3 haploinsufficiency may cause a syndrome that is characterized by severe expressive language delay, mild mental retardation and minor facial dysmorphisms...- C-terminal synaptic targeting elements for postsynaptic density proteins ProSAP1/Shank2 and ProSAP2/Shank3Tobias M Boeckers
Institute of Anatomy and Cell Biology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
J Neurochem 92:519-24. 2005..Altogether, our data delineate a hitherto unknown targeting signal in both ProSAP1/Shank2 and ProSAP2/Shank3 and provide evidence for an implication of these proteins and their close homologue, Shank1, in distinct molecular pathways... - Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapsesMichael J Schmeisser
Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
J Biol Chem 284:29146-57. 2009..This calls for a novel role of Tcfe2a and c-Myc in plastic changes of neural tissue... - Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturationAndreas M Grabrucker
Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
EMBO J 30:569-81. 2011.... - Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector systemAndreas M Grabrucker
Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, D 89081 Ulm, Germany
J Neurosci Methods 181:227-34. 2009.... - ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3Stefan Liebau
Institute of Anatomy and Cell Biology, Albert Einstein Allee 11, 89081 Ulm, Germany
Biochem Biophys Res Commun 385:460-5. 2009..ProSAPiP2 is located in dendrites and spines, is enriched in the PSD and interacts with actin. Therefore ProSAPiP2 could be involved in the linkage between molecules of the PSD and the cytoskeleton... - Formation of cellular projections in neural progenitor cells depends on SK3 channel activityStefan Liebau
Department of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
J Neurochem 101:1338-1350. 2007..Both effects could be prevented by the pre-incubation of NPCs with ScTX. Our study gives first evidence that the formation and prolongation of filopodia in NPCs is, at least in part, effectively induced and regulated by SK3 channels... - Synaptogenesis of hippocampal neurons in primary cell cultureAndreas Grabrucker
Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
Cell Tissue Res 338:333-41. 2009.... - Dose-dependent modulation of apoptotic processes by fluoxetine in maturing neuronal cells: an in vitro studyUlrike Schaz
Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
World J Biol Psychiatry 12:89-98. 2011..Recent studies indicate that the selective serotonin reuptake inhibitor (SSRI) fluoxetine is not solely effective by the instant inhibition of the serotonin transporter (SERT) but also by its influence on mitotic and/or apoptotic processes... - Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cellsAlexander Kleger
Institute for Anatomy and Cell Biology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
Circulation 122:1823-36. 2010..Here we have investigated their impact on the differentiation of pluripotent cells toward the cardiac lineage... - ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3Doreen Wendholt
Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
J Biol Chem 281:13805-16. 2006..Thus, ProSAPiP1 and PSD-Zip70 are founders of a novel family of scaffolding proteins, the "Fezzins," which adds further complexity to the organization of the PSD protein network... - Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffoldAndreas M Grabrucker
Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, Ulm, 89081, Germany
Mol Neurodegener 6:65. 2011..abstract:.. - "Theatrum anatomicum" -- a revived teaching facility in gross anatomyAnja Boeckers
Institute of Anatomy and Cell Biology, Ulm University, Ulm, Baden Wuerttemberg, Germany
Ann Anat 190:495-501. 2008..We are confident that the anatomical theatre will further improve students' motivation and their efforts in gaining knowledge in the field of gross anatomy because of its clinical relevance... - How can we deal with mental distress in the dissection room?-An evaluation of the need for psychological supportAnja Boeckers
Ulm University, Faculty of Medicine, Institute of Anatomy and Cell Biology, Albert Einstein Allee 11, 89081 Ulm, Germany
Ann Anat 192:366-72. 2010..These measures reduce mental stress and help students to cope with it by the development of "detached concern" towards their "first patient" as this will decisively influence their future professional behavior... - Atomoxetine acts as an NMDA receptor blocker in clinically relevant concentrationsAndrea G Ludolph
Department of Child and Adolescent Psychiatry, University of Ulm, Germany
Br J Pharmacol 160:283-91. 2010..Atomoxetine, a selective noradrenaline reuptake inhibitor, is the first non-stimulant approved for the treatment of this disorder. Here we have evaluated the effects of atomoxetine on glutamate receptors in vitro... - The Potential of iPS Cells in Synucleinopathy ResearchLeonhard Linta
Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
Stem Cells Int 2012:629230. 2012.... - Maturation of synaptic contacts in differentiating neural stem cellsStefan Liebau
Institute of Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
Stem Cells 25:1720-9. 2007..Disclosure of potential conflicts of interest is found at the end of this article... - Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank familyBritta Qualmann
Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
J Neurosci 24:2481-95. 2004..This creates a functional connection between synaptic stimulation and cytoskeletal rearrangements... - An architectural framework that may lie at the core of the postsynaptic densityMarisa K Baron
Department of Chemistry and Biochemistry, Molecular Biology Institute, University of California, Los Angeles, 611 Charles E Young Drive East, Los Angeles, CA 90095 1570, USA
Science 311:531-5. 2006..Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex... - A role for zinc in postsynaptic density asSAMbly and plasticity?Eckart D Gundelfinger
Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany
Trends Biochem Sci 31:366-73. 2006..Based on these observations, we propose a new model of synaptic plasticity in which Zn2+ influx directly and instantly modulates the structure and function of the postsynaptic density... - Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formationChristian Proepper
Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany
EMBO J 26:1397-409. 2007..Data show that Abi-1 can act as a specific synapto-nuclear messenger and is essentially involved in dendrite and synapse formation... - Analysis of synaptic ultrastructure without fixative using high-pressure freezing and tomographyPhilippe Rostaing
INSERM U789, , 46 rue d'Ulm, 75005 Paris, France
Eur J Neurosci 24:3463-74. 2006..Particularly, filamentous projections were observed linking the PSD to the actin cytoskeleton. Thus, synaptic ultrastructure can be analysed under more realistic conditions following HPF... - The postsynaptic scaffold proteins ProSAP1/Shank2 and Homer1 are associated with glutamate receptor complexes at rat retinal synapsesJohann Helmut Brandstätter
Max Planck Institute for Brain Research, Department of Neuroanatomy, D 60528 Frankfurt am Main, Germany
J Comp Neurol 475:551-63. 2004..These data suggest that ProSAP1/Shank2 acts as an organizer at PSDs of different glutamatergic retinal synapses... - Brain synaptic junctional proteins at the acrosome of rat testicular germ cellsPeter Redecker
Department of Anatomy 1, Medical School of Hannover, Hannover, Germany
J Histochem Cytochem 51:809-19. 2003..Moreover, our data point to a possible role for neuroactive amino acids in reproductive physiology... - Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoonWilko D Altrock
Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
Neuron 37:787-800. 2003..These data show that Bassoon is not essential for synapse formation but plays an essential role in the regulated neurotransmitter release from a subset of glutamatergic synapses... - The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cellsGunnar Schuetz
MaxDelbrück Center for Molecular Medicine, Berlin, Germany
J Cell Biol 167:945-52. 2004..These results demonstrate that the Shank3 adaptor protein can mediate cellular signaling, and provide a molecular mechanism for the biological divergence between the Ret9 and Ret51 isoform...