Tobias M Boeckers

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. ncbi request reprint ProSAP/Shank proteins - a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease
    Tobias M Boeckers
    AG Molecular Neurobiology, Institute of Anatomy, UKM, Westfaelische Wilhelms University, Munster, Germany
    J Neurochem 81:903-10. 2002
  2. ncbi request reprint C-terminal synaptic targeting elements for postsynaptic density proteins ProSAP1/Shank2 and ProSAP2/Shank3
    Tobias M Boeckers
    Institute of Anatomy and Cell Biology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    J Neurochem 92:519-24. 2005
  3. pmc Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses
    Michael J Schmeisser
    Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
    J Biol Chem 284:29146-57. 2009
  4. doi request reprint The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation
    Stefanie Grabrucker
    WG Molecular Analysis of Synaptopathies, Neurology Dept, Neurocenter of Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    Exp Neurol 253:126-37. 2014
  5. doi request reprint Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued)
    Georges F Kuh
    Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    Cell Tissue Res 350:13-26. 2012
  6. doi request reprint The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian syndromes
    Marianne Stockmann
    Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    J Neural Transm 120:785-98. 2013
  7. pmc Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
    Andreas M Grabrucker
    Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
    EMBO J 30:569-81. 2011
  8. ncbi request reprint Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system
    Andreas M Grabrucker
    Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, D 89081 Ulm, Germany
    J Neurosci Methods 181:227-34. 2009
  9. doi request reprint ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3
    Stefan Liebau
    Institute of Anatomy and Cell Biology, Albert Einstein Allee 11, 89081 Ulm, Germany
    Biochem Biophys Res Commun 385:460-5. 2009
  10. ncbi request reprint Formation of cellular projections in neural progenitor cells depends on SK3 channel activity
    Stefan Liebau
    Department of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
    J Neurochem 101:1338-1350. 2007

Collaborators

Detail Information

Publications34

  1. ncbi request reprint ProSAP/Shank proteins - a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease
    Tobias M Boeckers
    AG Molecular Neurobiology, Institute of Anatomy, UKM, Westfaelische Wilhelms University, Munster, Germany
    J Neurochem 81:903-10. 2002
    ..This ProSAP2/Shank3 haploinsufficiency may cause a syndrome that is characterized by severe expressive language delay, mild mental retardation and minor facial dysmorphisms...
  2. ncbi request reprint C-terminal synaptic targeting elements for postsynaptic density proteins ProSAP1/Shank2 and ProSAP2/Shank3
    Tobias M Boeckers
    Institute of Anatomy and Cell Biology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    J Neurochem 92:519-24. 2005
    ..Altogether, our data delineate a hitherto unknown targeting signal in both ProSAP1/Shank2 and ProSAP2/Shank3 and provide evidence for an implication of these proteins and their close homologue, Shank1, in distinct molecular pathways...
  3. pmc Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses
    Michael J Schmeisser
    Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
    J Biol Chem 284:29146-57. 2009
    ..This calls for a novel role of Tcfe2a and c-Myc in plastic changes of neural tissue...
  4. doi request reprint The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation
    Stefanie Grabrucker
    WG Molecular Analysis of Synaptopathies, Neurology Dept, Neurocenter of Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    Exp Neurol 253:126-37. 2014
    ..Thus, we conclude that the uncoupling of ProSAP2/Shank3 nuclear shuttling from synaptic activity may represent a molecular mechanism that contributes to the pathology of SCZ in patients with mutations in ProSAP2/Shank3. ..
  5. doi request reprint Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued)
    Georges F Kuh
    Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    Cell Tissue Res 350:13-26. 2012
    ..However, overexpression of TBCB leads to the decreased localization of p150 to the microtubule network that might result in a functional modulation of this protein complex...
  6. doi request reprint The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian syndromes
    Marianne Stockmann
    Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    J Neural Transm 120:785-98. 2013
    ..Our results suggest the presence of biological changes caused by some p150 mutants pointing to a potential pathogenetic significance as modifier of the phenotype of the human disease...
  7. pmc Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
    Andreas M Grabrucker
    Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
    EMBO J 30:569-81. 2011
    ....
  8. ncbi request reprint Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system
    Andreas M Grabrucker
    Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, D 89081 Ulm, Germany
    J Neurosci Methods 181:227-34. 2009
    ....
  9. doi request reprint ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3
    Stefan Liebau
    Institute of Anatomy and Cell Biology, Albert Einstein Allee 11, 89081 Ulm, Germany
    Biochem Biophys Res Commun 385:460-5. 2009
    ..ProSAPiP2 is located in dendrites and spines, is enriched in the PSD and interacts with actin. Therefore ProSAPiP2 could be involved in the linkage between molecules of the PSD and the cytoskeleton...
  10. ncbi request reprint Formation of cellular projections in neural progenitor cells depends on SK3 channel activity
    Stefan Liebau
    Department of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
    J Neurochem 101:1338-1350. 2007
    ..Both effects could be prevented by the pre-incubation of NPCs with ScTX. Our study gives first evidence that the formation and prolongation of filopodia in NPCs is, at least in part, effectively induced and regulated by SK3 channels...
  11. ncbi request reprint ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3
    Doreen Wendholt
    Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
    J Biol Chem 281:13805-16. 2006
    ..Thus, ProSAPiP1 and PSD-Zip70 are founders of a novel family of scaffolding proteins, the "Fezzins," which adds further complexity to the organization of the PSD protein network...
  12. doi request reprint Synaptogenesis of hippocampal neurons in primary cell culture
    Andreas Grabrucker
    Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    Cell Tissue Res 338:333-41. 2009
    ....
  13. doi request reprint Dose-dependent modulation of apoptotic processes by fluoxetine in maturing neuronal cells: an in vitro study
    Ulrike Schaz
    Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
    World J Biol Psychiatry 12:89-98. 2011
    ..Recent studies indicate that the selective serotonin reuptake inhibitor (SSRI) fluoxetine is not solely effective by the instant inhibition of the serotonin transporter (SERT) but also by its influence on mitotic and/or apoptotic processes...
  14. pmc Atomoxetine affects transcription/translation of the NMDA receptor and the norepinephrine transporter in the rat brain--an in vivo study
    Patrick T Udvardi
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Ulm, Ulm, Germany Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
    Drug Des Devel Ther 7:1433-46. 2013
    ..These alterations might contribute to atomoxetine's clinical effects in the treatment of ADHD, a neurodevelopmental disorder in which synaptic processes and especially a dysregulated glutamatergic metabolism seem to be involved...
  15. doi request reprint Expression of constitutively active FoxO3 in murine forebrain leads to a loss of neural progenitors
    Uta Schmidt-Strassburger
    Institute of Physiological Chemistry, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    FASEB J 26:4990-5001. 2012
    ..We therefore conclude that neural progenitors are particularly vulnerable to FOXO3-induced apoptosis, which is mediated by PIK3IP1, a negative PI3 kinase regulator...
  16. pmc Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1)
    Anke Wahler
    Department of Neurology, Ulm University, 89081 Ulm, Germany
    Biochem J 450:333-43. 2013
    ..The results from the present study indicate that Fe65 might have signalling properties together with APP and LRP1, whereas GULP1 only mediates LRP1 transactivation...
  17. pmc Microarray-Based Comparisons of Ion Channel Expression Patterns: Human Keratinocytes to Reprogrammed hiPSCs to Differentiated Neuronal and Cardiac Progeny
    Leonhard Linta
    Institute for Anatomy Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    Stem Cells Int 2013:784629. 2013
    ..To conclude, hiPSCs exhibit a very considerable and diverse ion channel expression pattern. Their detailed analysis could give an insight into their contribution to many cellular processes and even disease mechanisms...
  18. doi request reprint Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2
    Michael J Schmeisser
    Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
    Nature 486:256-60. 2012
    ..Accordingly, we propose that appropriate therapies for autism spectrum disorders are to be carefully matched to the underlying synaptopathic phenotype...
  19. doi request reprint Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells
    Alexander Kleger
    Institute for Anatomy and Cell Biology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Circulation 122:1823-36. 2010
    ..Here we have investigated their impact on the differentiation of pluripotent cells toward the cardiac lineage...
  20. pmc Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold
    Andreas M Grabrucker
    Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, Ulm, 89081, Germany
    Mol Neurodegener 6:65. 2011
    ..abstract:..
  21. doi request reprint How can we deal with mental distress in the dissection room?-An evaluation of the need for psychological support
    Anja Boeckers
    Ulm University, Faculty of Medicine, Institute of Anatomy and Cell Biology, Albert Einstein Allee 11, 89081 Ulm, Germany
    Ann Anat 192:366-72. 2010
    ..These measures reduce mental stress and help students to cope with it by the development of "detached concern" towards their "first patient" as this will decisively influence their future professional behavior...
  22. doi request reprint "Theatrum anatomicum" -- a revived teaching facility in gross anatomy
    Anja Boeckers
    Institute of Anatomy and Cell Biology, Ulm University, Ulm, Baden Wuerttemberg, Germany
    Ann Anat 190:495-501. 2008
    ..We are confident that the anatomical theatre will further improve students' motivation and their efforts in gaining knowledge in the field of gross anatomy because of its clinical relevance...
  23. pmc Atomoxetine acts as an NMDA receptor blocker in clinically relevant concentrations
    Andrea G Ludolph
    Department of Child and Adolescent Psychiatry, University of Ulm, Germany
    Br J Pharmacol 160:283-91. 2010
    ..Atomoxetine, a selective noradrenaline reuptake inhibitor, is the first non-stimulant approved for the treatment of this disorder. Here we have evaluated the effects of atomoxetine on glutamate receptors in vitro...
  24. pmc The Potential of iPS Cells in Synucleinopathy Research
    Leonhard Linta
    Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
    Stem Cells Int 2012:629230. 2012
    ....
  25. ncbi request reprint Maturation of synaptic contacts in differentiating neural stem cells
    Stefan Liebau
    Institute of Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    Stem Cells 25:1720-9. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  26. ncbi request reprint A role for zinc in postsynaptic density asSAMbly and plasticity?
    Eckart D Gundelfinger
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany
    Trends Biochem Sci 31:366-73. 2006
    ..Based on these observations, we propose a new model of synaptic plasticity in which Zn2+ influx directly and instantly modulates the structure and function of the postsynaptic density...
  27. pmc Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation
    Christian Proepper
    Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany
    EMBO J 26:1397-409. 2007
    ..Data show that Abi-1 can act as a specific synapto-nuclear messenger and is essentially involved in dendrite and synapse formation...
  28. ncbi request reprint An architectural framework that may lie at the core of the postsynaptic density
    Marisa K Baron
    Department of Chemistry and Biochemistry, Molecular Biology Institute, University of California, Los Angeles, 611 Charles E Young Drive East, Los Angeles, CA 90095 1570, USA
    Science 311:531-5. 2006
    ..Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex...
  29. ncbi request reprint Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family
    Britta Qualmann
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Neurosci 24:2481-95. 2004
    ..This creates a functional connection between synaptic stimulation and cytoskeletal rearrangements...
  30. ncbi request reprint Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon
    Wilko D Altrock
    Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    Neuron 37:787-800. 2003
    ..These data show that Bassoon is not essential for synapse formation but plays an essential role in the regulated neurotransmitter release from a subset of glutamatergic synapses...
  31. pmc The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells
    Gunnar Schuetz
    MaxDelbrück Center for Molecular Medicine, Berlin, Germany
    J Cell Biol 167:945-52. 2004
    ..These results demonstrate that the Shank3 adaptor protein can mediate cellular signaling, and provide a molecular mechanism for the biological divergence between the Ret9 and Ret51 isoform...
  32. ncbi request reprint Analysis of synaptic ultrastructure without fixative using high-pressure freezing and tomography
    Philippe Rostaing
    INSERM U789, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Eur J Neurosci 24:3463-74. 2006
    ..Particularly, filamentous projections were observed linking the PSD to the actin cytoskeleton. Thus, synaptic ultrastructure can be analysed under more realistic conditions following HPF...
  33. ncbi request reprint The postsynaptic scaffold proteins ProSAP1/Shank2 and Homer1 are associated with glutamate receptor complexes at rat retinal synapses
    Johann Helmut Brandstätter
    Max Planck Institute for Brain Research, Department of Neuroanatomy, D 60528 Frankfurt am Main, Germany
    J Comp Neurol 475:551-63. 2004
    ..These data suggest that ProSAP1/Shank2 acts as an organizer at PSDs of different glutamatergic retinal synapses...
  34. ncbi request reprint Brain synaptic junctional proteins at the acrosome of rat testicular germ cells
    Peter Redecker
    Department of Anatomy 1, Medical School of Hannover, Hannover, Germany
    J Histochem Cytochem 51:809-19. 2003
    ..Moreover, our data point to a possible role for neuroactive amino acids in reproductive physiology...