Ulrich Bocker

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Expression and localization of IL-1beta mRNA is interrelated with cytoskeletal rearrangement in monocytes stimulated by adherence: a light microscopy in situ hybridization study
    U Bocker
    Center for Gastrointestinal Biology and Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Immunol Cell Biol 79:444-53. 2001
  2. ncbi request reprint Regulation of Staphylococcus aureus-mediated activation of interleukin-18 in peripheral blood mononuclear cells
    U Bocker
    Department of Medicine II, University Hospital Mannheim, Theodor Kutzer Ufer, D 68167 Mannheim, Germany
    Eur Cytokine Netw 12:631-8. 2001
  3. ncbi request reprint Responsiveness of intestinal epithelial cell lines to lipopolysaccharide is correlated with Toll-like receptor 4 but not Toll-like receptor 2 or CD14 expression
    Ulrich Bocker
    Department of Medicine II and Medical Research Center, University of Heidelberg, Medical Faculty of Mannheim, Theodor Kutzer Ufer, 68167 Mannheim, Germany
    Int J Colorectal Dis 18:25-32. 2003
  4. pmc Butyrate modulates intestinal epithelial cell-mediated neutrophil migration
    U Bocker
    Department of Medicine II, Gastroenterology Hepatology Infectious Diseases, Medical Research Center, University of Heidelberg, Medical Faculty of Mannheim, Mannheim, Germany
    Clin Exp Immunol 131:53-60. 2003
  5. ncbi request reprint Differential expression of toll-like receptors 2 and 4 in patients with liver cirrhosis
    Tobias Manigold
    Department of Medicine II Gastroenterology Hepatology Infectious Diseases, University Hospital of Mannheim, Mannheim, Germany
    Eur J Gastroenterol Hepatol 15:275-82. 2003
  6. ncbi request reprint Low-dose exposure of intestinal epithelial cells to formaldehyde results in MAP kinase activation and molecular alteration of the focal adhesion protein paxillin
    Peter Feick
    Department of Medicine II Gastroenterology Hepatology Infectious Diseases, Centre of Environmental Medicine, Medical Faculty of Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Toxicology 219:60-72. 2006
  7. doi request reprint Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response
    Stephan L Haas
    Department of Medicine II, Medical Faculty at Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Clin Immunol 29:620-8. 2009
  8. doi request reprint Interleukin-18 serum levels in inflammatory bowel diseases: correlation with disease activity and inflammatory markers
    Stephan L Haas
    Department of Medicine II, Medical Faculty at Mannheim, University of Heidelberg, Mannheim, Germany
    Swiss Med Wkly 139:140-5. 2009
  9. ncbi request reprint Hepatitis B core antigen is a potent inductor of interleukin-18 in peripheral blood mononuclear cells of healthy controls and patients with hepatitis B infection
    Tobias Manigold
    Department of Medicine II, Gastroenterology Hepatology Infectious Diseases, University Hospital Mannheim, Mannheim, Germany
    J Med Virol 71:31-40. 2003
  10. ncbi request reprint Predictors of disease-related concerns and other aspects of health-related quality of life in outpatients with inflammatory bowel disease
    Monika Mussell
    Department of Medicine II Gastroenterology Hepatology Infectious Diseases, University of Heidelberg, Medical Faculty of Mannheim, Mannheim, Germany
    Eur J Gastroenterol Hepatol 16:1273-80. 2004

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Expression and localization of IL-1beta mRNA is interrelated with cytoskeletal rearrangement in monocytes stimulated by adherence: a light microscopy in situ hybridization study
    U Bocker
    Center for Gastrointestinal Biology and Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Immunol Cell Biol 79:444-53. 2001
    ..The present study demonstrates that IL-1beta mRNA expression and localization in adherent monocytes is interrelated with the cytoskeletal rearrangement upon adherence, spreading and polarization...
  2. ncbi request reprint Regulation of Staphylococcus aureus-mediated activation of interleukin-18 in peripheral blood mononuclear cells
    U Bocker
    Department of Medicine II, University Hospital Mannheim, Theodor Kutzer Ufer, D 68167 Mannheim, Germany
    Eur Cytokine Netw 12:631-8. 2001
    ....
  3. ncbi request reprint Responsiveness of intestinal epithelial cell lines to lipopolysaccharide is correlated with Toll-like receptor 4 but not Toll-like receptor 2 or CD14 expression
    Ulrich Bocker
    Department of Medicine II and Medical Research Center, University of Heidelberg, Medical Faculty of Mannheim, Theodor Kutzer Ufer, 68167 Mannheim, Germany
    Int J Colorectal Dis 18:25-32. 2003
    ..We analyzed receptor expression and signaling pathways involved in activation of human primary IEC and carcinoma-derived cell lines by lipopolysaccharide (LPS)...
  4. pmc Butyrate modulates intestinal epithelial cell-mediated neutrophil migration
    U Bocker
    Department of Medicine II, Gastroenterology Hepatology Infectious Diseases, Medical Research Center, University of Heidelberg, Medical Faculty of Mannheim, Mannheim, Germany
    Clin Exp Immunol 131:53-60. 2003
    ..Pharmacological inhibition of enhanced IL-1 beta-mediated IL-8 secretion in a subpopulation of IEC may improve the clinical efficacy of butyrate...
  5. ncbi request reprint Differential expression of toll-like receptors 2 and 4 in patients with liver cirrhosis
    Tobias Manigold
    Department of Medicine II Gastroenterology Hepatology Infectious Diseases, University Hospital of Mannheim, Mannheim, Germany
    Eur J Gastroenterol Hepatol 15:275-82. 2003
    ....
  6. ncbi request reprint Low-dose exposure of intestinal epithelial cells to formaldehyde results in MAP kinase activation and molecular alteration of the focal adhesion protein paxillin
    Peter Feick
    Department of Medicine II Gastroenterology Hepatology Infectious Diseases, Centre of Environmental Medicine, Medical Faculty of Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Toxicology 219:60-72. 2006
    ..The data suggest a modifier role of environmental or endogenous formaldehyde for epithelial cell functions...
  7. doi request reprint Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response
    Stephan L Haas
    Department of Medicine II, Medical Faculty at Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Clin Immunol 29:620-8. 2009
    ..Recently, two functional IL18 promoter variants, -607C>A (rs1946518) and -137G>C (rs187238), were associated with viral clearance in patients with hepatitis C. The present study focused on their relevance for treatment response...
  8. doi request reprint Interleukin-18 serum levels in inflammatory bowel diseases: correlation with disease activity and inflammatory markers
    Stephan L Haas
    Department of Medicine II, Medical Faculty at Mannheim, University of Heidelberg, Mannheim, Germany
    Swiss Med Wkly 139:140-5. 2009
    ..An imbalance of cytokines is believed to contribute to the immunopathogenesis of inflammatory bowel diseases (IBD). Serum cytokine levels may correlate with disease activity and acute phase reactivity...
  9. ncbi request reprint Hepatitis B core antigen is a potent inductor of interleukin-18 in peripheral blood mononuclear cells of healthy controls and patients with hepatitis B infection
    Tobias Manigold
    Department of Medicine II, Gastroenterology Hepatology Infectious Diseases, University Hospital Mannheim, Mannheim, Germany
    J Med Virol 71:31-40. 2003
    ..Taken together, these results indicate that HBcAg induces IL-18 secretion by induction of Caspase-1. Differential regulation in HBeAg-negative and positive patients suggests an important role of IL-18 in CHB infection...
  10. ncbi request reprint Predictors of disease-related concerns and other aspects of health-related quality of life in outpatients with inflammatory bowel disease
    Monika Mussell
    Department of Medicine II Gastroenterology Hepatology Infectious Diseases, University of Heidelberg, Medical Faculty of Mannheim, Mannheim, Germany
    Eur J Gastroenterol Hepatol 16:1273-80. 2004
    ..The aim of this study was to assess the concerns of IBD patients in an outpatient sample, and to determine the impact of psychological and disease factors on concerns and on other variables of health-related quality of life...
  11. ncbi request reprint IL-1 beta transcript stability in monocytes is linked to cytoskeletal reorganization and the availability of mRNA degradation factors
    Oksana Sirenko
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, USA
    Immunol Cell Biol 80:328-39. 2002
    ..These data suggest that the control of mRNA degradation is linked with changes in the CSK. Mitogen-activated protein kinase activation or alterations in the availability of mRNA degradation factors may mediate these effects...
  12. ncbi request reprint Detection of Chlamydophila pneumoniae in the bone marrow of two patients with unexplained chronic anaemia
    C Thomas Nebe
    Central Laboratory, University Hospital Mannheim, Mannheim, Germany
    Eur J Haematol 74:77-83. 2005
    ..This is a first report of chlamydial presence in the BM of anaemic patients. The cases are presented because persistent chlamydial infection may contribute more frequently to chronic refractory anaemia than previously suspected...
  13. ncbi request reprint Severe TNF receptor-associated periodic syndrome due to 2 TNFRSF1A mutations including a new F60V substitution
    Stephan L Haas
    Department of Medicine II, University Hospital Mannheim, Mannheim, Germany
    Gastroenterology 130:172-8. 2006
    ..A history of recurrent sterile peritonitis should prompt genotyping for periodic fever syndromes...
  14. doi request reprint Comparison of magnetic resonance imaging and video capsule enteroscopy in diagnosing small-bowel pathology: localization-dependent diagnostic yield
    Ulrich Bocker
    University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Scand J Gastroenterol 45:490-500. 2010
    ....
  15. ncbi request reprint -137 (G/C) IL-18 promoter polymorphism in patients with inflammatory bowel disease
    Stephan L Haas
    Department of Medicine II, Medical Faculty at Mannheim, University of Heidelberg, Mannheim, Germany
    Scand J Gastroenterol 40:1438-43. 2005
    ..The aim of this study was to determine whether the -137 (G/C) IL-18 promoter polymorphism was associated with IBD susceptibility...
  16. doi request reprint Discriminatory potential of C-reactive protein, cytokines, and fecal markers in infectious gastroenteritis in adults
    Julia Weh
    Department of Medicine II, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Diagn Microbiol Infect Dis 77:79-84. 2013
    ..To differentiate between bacterial and viral gastroenteritis, CRP, serum IFNγ, and the fecal proteins lactoferrin and calprotectin may be useful. A corresponding algorithm should be evaluated prospectively. ..
  17. ncbi request reprint Inflammatory bowel disease and smoking: a review of epidemiology, pathophysiology, and therapeutic implications
    Tanja Birrenbach
    Department of Medicine II, Gastroenterology Hepatology Infectious Diseases, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany
    Inflamm Bowel Dis 10:848-59. 2004
    ..In this article, we review the relationship between cigarette smoking and IBD, considering epidemiological, pathogenetic, and clinical aspects...
  18. ncbi request reprint Infliximab in ulcerative colitis
    Ulrich Bocker
    Department of Medicine II, University Hospital Mannheim, Faculty of Medicine, University of Heidelberg, Mannheim, Germany
    Scand J Gastroenterol 41:997-1000. 2006
  19. ncbi request reprint Endoscopy and magnetic resonance imaging in patients with Crohn's disease: a retrospective single-centre comparative study
    Dietmar J Dinter
    Institute of Clinical Radiology, University Hospital Mannheim, University of Heidelberg, Germany
    Scand J Gastroenterol 43:207-16. 2008
    ..The aim of this study was retrospectively to assess the correlation of endoscopy, histology and MRI findings for the terminal ileum and the colon in a cohort of patients with Crohn's disease...
  20. doi request reprint Double-contrast micro-CT colonoscopy in live mice
    Hanne Boll
    Department of Neuroradiology Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Int J Colorectal Dis 26:721-7. 2011
    ....
  21. doi request reprint Prospective noninvasive analysis of hepatic fibrosis in patients with Crohn's disease: correlation of transient elastography and laboratory-based markers
    Johannes Brühl
    Department of Medicine II, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Germany
    Eur J Gastroenterol Hepatol 23:923-30. 2011
    ..This study aimed to prospectively assess the potential of noninvasive markers for the evaluation of liver fibrosis in patients with Crohn's disease...