Matthias Bluher

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. pmc Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity
    Dorit Schleinitz
    Interdisciplinary Center for Clinical Research, University of Leipzig, Leipzig, Germany
    PLoS ONE 6:e16155. 2011
  2. pmc Linagliptin improves insulin sensitivity and hepatic steatosis in diet-induced obesity
    Matthias Kern
    Department of Medicine, University of Leipzig, Leipzig, Germany
    PLoS ONE 7:e38744. 2012
  3. pmc MicroRNA expression in human omental and subcutaneous adipose tissue
    Nora Kloting
    Department of Medicine, University of Leipzig, Leipzig, Germany
    PLoS ONE 4:e4699. 2009
  4. ncbi request reprint [Adipose tissue--an endocrine organ]
    M Bluher
    Klinik und Poliklinik für Endokrinologie und Nephrologie, Department für Innere Medizin, Neurologie und Dermatologie, Universitatsklinikum Leipzig, AöR, Liebigstr 20, 04103, Leipzig, Deutschland
    Internist (Berl) 55:687-97; quiz 698. 2014
  5. pmc Clinical relevance of adipokines
    Matthias Bluher
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Diabetes Metab J 36:317-27. 2012
  6. pmc Vaspin inhibits kallikrein 7 by serpin mechanism
    John T Heiker
    Institute of Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, Universitat Leipzig, Brüderstraße 34, Leipzig, Germany
    Cell Mol Life Sci 70:2569-83. 2013
  7. doi request reprint Adipose tissue dysfunction contributes to obesity related metabolic diseases
    Matthias Bluher
    Department of Medicine, University of Leipzig, Liebigstr 20, 04103 Leipzig, Germany
    Best Pract Res Clin Endocrinol Metab 27:163-77. 2013
  8. ncbi request reprint Are there still healthy obese patients?
    Matthias Bluher
    Department of Medicine, University of Leipzig, Germany
    Curr Opin Endocrinol Diabetes Obes 19:341-6. 2012
  9. doi request reprint Vaspin in obesity and diabetes: pathophysiological and clinical significance
    Matthias Bluher
    Department of Medicine, University of Leipzig, Liebigstr 20, 04103 Leipzig, Germany
    Endocrine 41:176-82. 2012
  10. doi request reprint Adipose tissue dysfunction in obesity
    M Bluher
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Exp Clin Endocrinol Diabetes 117:241-50. 2009

Detail Information

Publications118 found, 100 shown here

  1. pmc Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity
    Dorit Schleinitz
    Interdisciplinary Center for Clinical Research, University of Leipzig, Leipzig, Germany
    PLoS ONE 6:e16155. 2011
    ..The BMPR2 locus has been suggested as target of recent selection in human populations. We hypothesized that BMPR2 might have a role in the pathophysiology of obesity...
  2. pmc Linagliptin improves insulin sensitivity and hepatic steatosis in diet-induced obesity
    Matthias Kern
    Department of Medicine, University of Leipzig, Leipzig, Germany
    PLoS ONE 7:e38744. 2012
    ..Long-term linagliptin treatment reduced liver fat content in animals with diet-induced hepatic steatosis and insulin resistance, and may account for improved insulin sensitivity...
  3. pmc MicroRNA expression in human omental and subcutaneous adipose tissue
    Nora Kloting
    Department of Medicine, University of Leipzig, Leipzig, Germany
    PLoS ONE 4:e4699. 2009
    ..In addition, human adipose tissue miRNA expression correlates with adipocyte phenotype, parameters of obesity and glucose metabolism...
  4. ncbi request reprint [Adipose tissue--an endocrine organ]
    M Bluher
    Klinik und Poliklinik für Endokrinologie und Nephrologie, Department für Innere Medizin, Neurologie und Dermatologie, Universitatsklinikum Leipzig, AöR, Liebigstr 20, 04103, Leipzig, Deutschland
    Internist (Berl) 55:687-97; quiz 698. 2014
    ..This review focuses on the clinical relevance of selected adipokines as markers or predictors of obesity-related diseases and as potential therapeutic tools or targets in metabolic and cardiovascular diseases. ..
  5. pmc Clinical relevance of adipokines
    Matthias Bluher
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Diabetes Metab J 36:317-27. 2012
    ..This review focuses on the clinical relevance of selected adipokines as markers or predictors of obesity related diseases and as potential therapeutic tools or targets in metabolic and cardiovascular diseases...
  6. pmc Vaspin inhibits kallikrein 7 by serpin mechanism
    John T Heiker
    Institute of Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, Universitat Leipzig, Brüderstraße 34, Leipzig, Germany
    Cell Mol Life Sci 70:2569-83. 2013
    ....
  7. doi request reprint Adipose tissue dysfunction contributes to obesity related metabolic diseases
    Matthias Bluher
    Department of Medicine, University of Leipzig, Liebigstr 20, 04103 Leipzig, Germany
    Best Pract Res Clin Endocrinol Metab 27:163-77. 2013
    ..A better understanding of mechanisms causing or maintaining AT dysfunction may provide new therapeutic strategies in the treatment of obesity-induced metabolic diseases...
  8. ncbi request reprint Are there still healthy obese patients?
    Matthias Bluher
    Department of Medicine, University of Leipzig, Germany
    Curr Opin Endocrinol Diabetes Obes 19:341-6. 2012
    ..However, a subgroup of 'healthy' obese patients seems to be protected against metabolic and cardiovascular obesity comorbidities. This review focuses on potential mechanisms underlying the healthy obese subphenotype...
  9. doi request reprint Vaspin in obesity and diabetes: pathophysiological and clinical significance
    Matthias Bluher
    Department of Medicine, University of Leipzig, Liebigstr 20, 04103 Leipzig, Germany
    Endocrine 41:176-82. 2012
    ..This review discusses the clinical relevance of vaspin in the pathophysiology of obesity and type 2 diabetes...
  10. doi request reprint Adipose tissue dysfunction in obesity
    M Bluher
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Exp Clin Endocrinol Diabetes 117:241-50. 2009
    ..A model is proposed how different pathogenic factors and mechanisms may cause dysfunction of adipose tissue...
  11. doi request reprint The distinction of metabolically 'healthy' from 'unhealthy' obese individuals
    Matthias Bluher
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Curr Opin Lipidol 21:38-43. 2010
    ..This review focuses on recent evidence suggesting that normal adipose tissue function contributes to the healthy obese phenotype...
  12. ncbi request reprint [Role of muscle and fat tissue in the pathogenesis of type 2 diabetes]
    M Bluher
    Medizinische Klinik und Poliklinik III, Universitat Leipzig, Leipzig, Germany
    Dtsch Med Wochenschr 131:S231-5. 2006
    ..In the characterization of the role of liver, adipose tissue and skeletal muscle in the pathogenesis of type 2 diabetes, tissue specific knockout mouse models have challenged our concepts of glucose homeostasis...
  13. ncbi request reprint The inflammatory process of adipose tissue
    Matthias Bluher
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Pediatr Endocrinol Rev 6:24-31. 2008
    ..A better understanding of the mechanisms and molecular components of obesity induced inflammatory response might lead to identifying novel therapeutic targets to prevent obesity-related complications...
  14. ncbi request reprint Association of interleukin-6, C-reactive protein, interleukin-10 and adiponectin plasma concentrations with measures of obesity, insulin sensitivity and glucose metabolism
    M Bluher
    Department of Internal Medicine 2, University of Koln, Koln, Germany
    Exp Clin Endocrinol Diabetes 113:534-7. 2005
    ..In conclusion, our data suggest that abnormal inflammatory markers in patients with type 2 diabetes are primarily related to decreased insulin sensitivity...
  15. doi request reprint Fat tissue and long life
    Matthias Bluher
    Department of Medicine, University of Leipzig, Germany
    Obes Facts 1:176-82. 2008
    ..There is growing evidence that the effect of reduced adipose tissue mass on life span could be due to the prevention of obesity-related metabolic disorders including type 2 diabetes and atherosclerosis...
  16. pmc Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention
    Matthias Bluher
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Diabetes Care 35:342-9. 2012
    ..Here, we sought to identify adipokine biomarkers that may reflect continued beneficial effects of dieting despite partial weight regain...
  17. ncbi request reprint Regulation of adiponectin receptor R1 and R2 gene expression in adipocytes of C57BL/6 mice
    Matthias Bluher
    Junior Research Group N03, IZKF Leipzig, University of Leipzig, Germany
    Biochem Biophys Res Commun 329:1127-32. 2005
    ..In addition, we have identified a coordinated circadian pattern of AdipoR1 and AdipoR2 gene expression in these tissues...
  18. doi request reprint [Metabolic and cardiovascular effects of physical activity, exercise and fitness in patients with type 2 diabetes]
    M Bluher
    Universitat Leipzig, Department für Innere Medizin, Klinik für Endokrinologie und Nephrologie, Leipzig, Germany
    Dtsch Med Wochenschr 135:930-4. 2010
    ..This review is focussing on recent studies that have examined the effects of increased physical activity and fitness on metabolic and cardiovascular parameters in patients with type 2 diabetes...
  19. ncbi request reprint Influence of dietary intake and physical activity on annual rhythm of human blood cholesterol concentrations
    M Bluher
    III Medical Department, Faculty of Medicine, University of Leipzig, Germany
    Chronobiol Int 18:541-57. 2001
    ..Therefore, the annual rhythm in cholesterol levels is most likely determined by endogenous factors or factors directly related to seasonal changes in the environment...
  20. doi request reprint Nicotinamide nucleotide transhydrogenase mRNA expression is related to human obesity
    John T Heiker
    Department of Medicine, Endocrinology and Diabetes, Universitat Leipzig, Leipzig, Germany
    Obesity (Silver Spring) 21:529-34. 2013
    ..A potential implication for NNT in human adipose tissue distribution has not been investigated so far...
  21. pmc Gene expression of PPARgamma and PGC-1alpha in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical training
    Karen Ruschke
    Department of Medicine, Endocrinology Diabetes, University of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany
    Eur J Endocrinol 162:515-23. 2010
    ....
  22. ncbi request reprint Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance
    Andreas Oberbach
    Junior Research Group N03, IZKF Leipzig, Faculty of Medicine, University of Leipzig, Germany
    Eur J Endocrinol 154:577-85. 2006
    ..The beneficial effects of physical activity on a reduced risk of coronary heart disease could at least in part be mediated by improved markers of inflammation...
  23. doi request reprint Serum levels of the adipokine fibroblast growth factor-21 are increased in preeclampsia
    Holger Stepan
    University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany
    Cytokine 62:322-6. 2013
    ..Fibroblast growth factor (FGF)-21 was recently introduced as a novel adipokine improving glucose metabolism in vitro and in vivo...
  24. doi request reprint Interleukin-1beta induces the novel adipokine chemerin in adipocytes in vitro
    Susan Kralisch
    University of Leipzig, Department of Internal Medicine III, 04103 Leipzig, Germany
    Regul Pept 154:102-6. 2009
    ..Taken together, we show that chemerin is upregulated in fat cells by IL-1beta and might modulate the effects of IL-1beta on adipocyte metabolism and insulin sensitivity...
  25. doi request reprint Circulating levels of the adipokine chemerin in gestational diabetes mellitus
    Dörte Pfau
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Horm Res Paediatr 74:56-61. 2010
    ..In the current study, we investigated circulating chemerin levels in patients with gestational diabetes mellitus (GDM) as compared to healthy pregnant controls matched for gestational age and fasting insulin...
  26. ncbi request reprint Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes
    Susan Kralisch
    University of Leipzig, Department of Internal Medicine III, 04103 Leipzig, Germany
    J Endocrinol 185:R1-8. 2005
    ....
  27. doi request reprint Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro
    Susan Kralisch
    University of Leipzig, Department of Internal Medicine III, Leipzig, Germany
    FEBS Lett 583:1196-200. 2009
    ..Taken together, TIARP/STAMP2 is highly upregulated in 3T3-L1 cells and hMSC-Ad by IL-1beta and might, therefore, modulate proinflammatory and insulin resistance-inducing effects of IL-1beta...
  28. ncbi request reprint Plasma visfatin concentrations and fat depot-specific mRNA expression in humans
    Janin Berndt
    University of Leipzig, D 04103 Leipzig, Germany
    Diabetes 54:2911-6. 2005
    ..In addition, we did not find differences in visfatin mRNA expression between visceral and subcutaneous adipose tissue in humans...
  29. doi request reprint Serum levels of the adipokine adipocyte fatty acid-binding protein are increased in preeclampsia
    Mathias Fasshauer
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Am J Hypertens 21:582-6. 2008
    ..In this study, we investigated serum concentrations of the adipokine AFABP in patients with PE as compared to healthy controls of similar gestational age...
  30. doi request reprint Preliminary report: Serum levels of retinol-binding protein 4 in preeclampsia
    Holger Stepan
    Department of Obstetrics, University of Leipzig, Leipzig 04103, Germany
    Metabolism 58:275-7. 2009
    ..Furthermore, RBP4 did not correlate to clinical and biochemical measures of pregnancy outcome, renal function, glucose, and lipid metabolism, as well as inflammation. Our results do not support a role of RBP4 in the pathogenesis of PE...
  31. pmc Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity
    Matthias Bluher
    University of Leipzig, Medical Department III, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetes 55:3053-60. 2006
    ..Thus, the endocannabinoid system may represent a primary target for the treatment of abdominal obesity and associated metabolic changes...
  32. doi request reprint Serum levels of the myokine irisin in relation to metabolic and renal function
    Thomas Ebert
    Department of Endocrinology and Nephrology, University of Leipzig, Liebigstraße 20, 04103 Leipzig, Germany
    Eur J Endocrinol 170:501-6. 2014
    ..However, regulation of irisin in humans in relation to renal and metabolic disease has not been comprehensively studied...
  33. ncbi request reprint Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression
    Peter Kovacs
    Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany
    Diabetes 56:3095-100. 2007
    ..Serum retinol binding protein 4 (RBP4) is a new liver- and adipocyte-derived signal that may contribute to insulin resistance. Therefore, the RBP4 gene represents a plausible candidate gene involved in susceptibility to type 2 diabetes...
  34. ncbi request reprint Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes
    Nora Kloting
    University of Leipzig, Department of Internal Medicine III, 04103 Leipzig, Germany
    Biochem Biophys Res Commun 339:430-6. 2006
    ..In conclusion, our data indicate that induction of human vaspin mRNA expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism...
  35. ncbi request reprint Genetic variation in the visfatin gene (PBEF1) and its relation to glucose metabolism and fat-depot-specific messenger ribonucleic acid expression in humans
    Yvonne Bottcher
    Medical Department III, University of Leipzig, Philipp Rosenthal Strasse 27, D 04103 Leipzig, Germany
    J Clin Endocrinol Metab 91:2725-31. 2006
    ..Visfatin is a peptide suggested to play a role in glucose homeostasis. In the present study, we investigated the role of genetic variation in the visfatin gene in the pathophysiology of obesity/type 2 diabetes mellitus (T2DM)...
  36. doi request reprint Role of genetic variation in the cannabinoid type 1 receptor gene (CNR1) in the pathophysiology of human obesity
    Dorit Schleinitz
    Interdisciplinary Centre for Clinical Research, Medical Faculty, University of Leipzig, Leipzig, Germany
    Pharmacogenomics 11:693-702. 2010
    ..Here we investigated the effects of genetic variation in the cannabinoid type 1 receptor gene (CNR1) on its mRNA expression in adipose tissue from visceral and subcutaneous depots and on the development of obesity...
  37. doi request reprint Effects of weight loss and exercise on apelin serum concentrations and adipose tissue expression in human obesity
    Joanna Krist
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Obes Facts 6:57-69. 2013
    ....
  38. doi request reprint Adipokines influencing metabolic and cardiovascular disease are differentially regulated in maintenance hemodialysis
    Michaela Ziegelmeier
    Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany
    Metabolism 57:1414-21. 2008
    ..Furthermore, regulation of adipokines in vivo strongly depends on renal function. Regulation of HMW adiponectin is similar as compared with total adiponectin in the patients studied...
  39. ncbi request reprint Endogenous soluble receptor for advanced glycation endproducts is increased in preeclampsia
    Mathias Fasshauer
    Department of Internal Medicine III, University of Leipzig, Ph Rosenthal Strasse 27, Leipzig, Germany
    J Hypertens 26:1824-8. 2008
    ..In the current study, we investigated esRAGE serum levels in patients with preeclampsia as compared to healthy gestational age-matched controls...
  40. ncbi request reprint Preliminary report: circulating levels of the adipokine vaspin in gestational diabetes mellitus and preeclampsia
    Holger Stepan
    Department of Obstetrics, University of Leipzig, Leipzig, Germany
    Metabolism 59:1054-6. 2010
    ..Circulating vaspin levels are not significantly different between GDM, PE, and control subjects and do not correlate with insulin sensitivity in pregnant subjects...
  41. doi request reprint Insulin-sensitive obesity
    Nora Kloting
    Department of Medicine, Interdisciplinary Centre for Clinical Research, University of Leipzig, Germany
    Am J Physiol Endocrinol Metab 299:E506-15. 2010
    ..This suggests that mechanisms beyond a positive caloric balance such as inflammation and adipokine release determine the pathological metabolic consequences in patients with obesity...
  42. ncbi request reprint Serum levels of the adipokine visfatin are increased in pre-eclampsia
    Mathias Fasshauer
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Clin Endocrinol (Oxf) 69:69-73. 2008
    ..In the current study, we investigated visfatin serum levels in pre-eclamptic patients as compared to healthy gestational age-matched controls...
  43. ncbi request reprint Isoproterenol, TNFalpha, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes
    Susan Kralisch
    University of Leipzig, Department of Internal Medicine III, Leipzig, Germany
    Mol Cell Endocrinol 240:43-9. 2005
    ..Taken together, downregulation of ATGL by isoproterenol, TNFalpha, and insulin might contribute to dysregulated expression and function of this lipase in obesity, hyperlipidemia, and insulin resistance...
  44. pmc Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity
    Yvonne Bottcher
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Diabetes 58:2119-28. 2009
    ..Members of the family of bone morphogenetic proteins (BMPs) are important regulators of adipogenesis. We examined the role of the BMP receptor 1A gene (BMPR1A) in the pathophysiology of human obesity...
  45. ncbi request reprint Serum vaspin concentrations in human obesity and type 2 diabetes
    Byung Soo Youn
    University of Leipzig, Department of Medicine, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetes 57:372-7. 2008
    ..We have recently shown that vaspin mRNA expression in adipose tissue is related to parameters of obesity and glucose metabolism. However, the regulation of vaspin serum concentrations in human obesity and type 2 diabetes is unknown...
  46. doi request reprint Serum fibroblast growth factor 21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia
    Sebastian Stein
    Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany
    Metabolism 59:33-7. 2010
    ..Fibroblast growth factor 21 is independently associated with markers of insulin resistance and an adverse lipid profile but is not dysregulated in GDM if patients are matched with controls for fasting insulin...
  47. doi request reprint Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity
    Rima Chakaroun
    Department of Medicine, University of Leipzig, 04103 Leipzig, Germany
    Metabolism 61:706-14. 2012
    ..Reduced chemerin expression and serum concentration may contribute to improved insulin sensitivity and subclinical inflammation beyond significant weight loss...
  48. doi request reprint Serum levels of the adipokine zinc-α2-glycoprotein are increased in chronic hemodialysis
    Anne Philipp
    Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany
    Metabolism 60:669-72. 2011
    ..Moreover, CD independently predicted ZAG concentrations in multiple regression analysis. Renal filtration appears to be an important route of ZAG elimination, and markers of renal function should be included in studies on ZAG physiology...
  49. doi request reprint Serum levels of angiopoietin-related growth factor are increased in preeclampsia
    Holger Stepan
    Department of Obstetrics, University of Leipzig, Leipzig, Germany
    Am J Hypertens 22:314-8. 2009
    ..In the current study, we hypothesized that serum levels of AGF would be lower in preeclamptic patients as compared to healthy controls...
  50. ncbi request reprint Serum levels of the adipokine vaspin in relation to metabolic and renal parameters
    Jeannette Seeger
    Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany
    J Clin Endocrinol Metab 93:247-51. 2008
    ..Recently, vaspin was identified as an insulin-sensitizing adipokine. However, regulation of this adipocyte-secreted factor in human disease has not been determined...
  51. ncbi request reprint Secretory products from human adipocytes stimulate proinflammatory cytokine secretion from human endothelial cells
    Grit Sommer
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    J Cell Biochem 106:729-37. 2009
    ..Our findings suggest that endothelial cell secretion is significantly influenced towards a proinflammatory pattern by adipocyte-secreted factors...
  52. pmc Adipokine pattern in subjects with impaired fasting glucose and impaired glucose tolerance in comparison to normal glucose tolerance and diabetes
    Anke Tonjes
    Department of Medicine, University of Leipzig, Leipzig, Germany
    PLoS ONE 5:e13911. 2010
    ..Therefore, the aim of this study was to assess distinct adipokine profiles in patients with normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or T2D...
  53. pmc COMP-angiopoietin-1 recovers molecular biomarkers of neuropathy and improves vascularisation in sciatic nerve of ob/ob mice
    Joanna Kosacka
    Department of Medicine, University of Leipzig, Leipzig, Germany
    PLoS ONE 7:e32881. 2012
    ....
  54. pmc Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training
    Matthias Bluher
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Diabetes Care 30:3110-5. 2007
    ..We also studied whether their expression in visceral and subcutaneous fat depots is associated with metabolic parameters and whether their expression is regulated by intensive physical exercise...
  55. doi request reprint Serum vaspin concentrations are decreased after exercise-induced oxidative stress
    Andreas Oberbach
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Obes Facts 3:328-31. 2010
    ..In conclusion, vaspin serum concentrations are decreased by exercise-induced oxidative stress, but not by exercise-associated improvement in insulin sensitivity...
  56. ncbi request reprint Monocyte chemoattractant protein 1 expression is stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes
    Mathias Fasshauer
    University of Leipzig, Department of Internal Medicine III, 04103 Leipzig, Germany
    Biochem Biophys Res Commun 317:598-604. 2004
    ..This adipocytokine could thus be a potential pharmacological target for the treatment of impaired insulin sensitivity...
  57. ncbi request reprint Proinflammatory adipocytokines induce TIMP-1 expression in 3T3-L1 adipocytes
    Susan Kralisch
    University of Leipzig, Department of Internal Medicine III, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    FEBS Lett 579:6417-22. 2005
    ..Taken together, we demonstrate that TIMP-1 expression is selectively upregulated in fat cells by proinflammatory adipocytokines and might play a role in maintaining adipose tissue mass in obesity...
  58. ncbi request reprint Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass
    Nora Kloting
    Department of Internal Medicine III, University of Leipzig, D 04103 Leipzig, Germany
    Cell Metab 6:79-87. 2007
    ..RBP4 mRNA correlated inversely with GLUT4 mRNA in Vis fat and positively with adipocyte size in both depots. RBP4 levels are therefore linked to Vis adiposity, and Vis fat may be a major source of RBP4 in insulin-resistant states...
  59. ncbi request reprint Serum levels of the atherosclerosis biomarker sTWEAK are decreased in type 2 diabetes and end-stage renal disease
    Susan Kralisch
    Department of Medicine, University of Leipzig, 04103 Leipzig, Germany
    Atherosclerosis 199:440-4. 2008
    ..Furthermore, both conditions have an additive and independent negative effect on sTWEAK levels. Our results support the view that circulating sTWEAK might be a novel biomarker of atherosclerosis...
  60. doi request reprint Serum levels of adipocyte fatty acid binding protein are increased in gestational diabetes mellitus
    Susan Kralisch
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Eur J Endocrinol 160:33-8. 2009
    ..In the current study, we investigated serum concentrations of AFABP in patients with gestational diabetes mellitus (GDM) as compared with healthy pregnant controls matched for gestational age and fasting insulin...
  61. pmc Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth
    Nora Kloting
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Diabetes 57:2074-82. 2008
    ..IGF-1 and the IGF-1 receptor (IGF-1R) have been implicated in the regulation of adipocyte differentiation and lipid accumulation in vitro...
  62. doi request reprint Fibroblast growth factor-21 serum concentrations are associated with metabolic and hepatic markers in humans
    Susan Kralisch
    Medical Department, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany
    J Endocrinol 216:135-43. 2013
    ..FGF21 serum concentrations are associated with facets of the metabolic syndrome, hepatocellular function, as well as GH status...
  63. pmc Serum levels of the adipokine FGF21 depend on renal function
    Sebastian Stein
    University of Leipzig, Department of Internal Medicine III, Leipzig, Germany
    Diabetes Care 32:126-8. 2009
    ....
  64. ncbi request reprint Serum amyloid A3 expression is stimulated by dexamethasone and interleukin-6 in 3T3-L1 adipocytes
    Mathias Fasshauer
    Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany
    J Endocrinol 183:561-7. 2004
    ....
  65. ncbi request reprint Growth hormone induces apelin mRNA expression and secretion in mouse 3T3-L1 adipocytes
    Susan Kralisch
    University of Leipzig, Department of Internal Medicine III, 04103 Leipzig, Germany
    Regul Pept 139:84-9. 2007
    ..Taken together, our results show a significant induction of apelin mRNA synthesis and protein secretion by GH...
  66. doi request reprint Serum levels of adipocyte fatty acid-binding protein (AFABP) are increased in chronic haemodialysis (CD)
    Grit Sommer
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Clin Endocrinol (Oxf) 69:901-5. 2008
    ..We hypothesized that if renal filtration is a significant route of elimination of AFABP, it would accumulate in CD patients...
  67. doi request reprint Repin1 maybe involved in the regulation of cell size and glucose transport in adipocytes
    Karen Ruschke
    Department of Medicine, University of Leipzig, 04103 Leipzig, Germany
    Biochem Biophys Res Commun 400:246-51. 2010
    ..We have identified a potential role for Repin1 in the regulation of adipocyte size and expression of glucose transporters GLUT1 and GLUT4 in adipocytes...
  68. doi request reprint Tissue inhibitor of metalloproteinase-1 mRNA production and protein secretion are induced by interleukin-1 beta in 3T3-L1 adipocytes
    Sebastian Weise
    Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany
    J Endocrinol 198:169-74. 2008
    ....
  69. ncbi request reprint Isoproterenol stimulates monocyte chemoattractant protein-1 expression and secretion in 3T3-L1 adipocytes
    Susan Kralisch
    University of Leipzig, Department of Internal Medicine III, 04103 Leipzig, Germany
    Regul Pept 135:12-6. 2006
    ....
  70. ncbi request reprint Visfatin is a positive regulator of MCP-1 in human adipocytes in vitro and in mice in vivo
    Grit Sommer
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Obesity (Silver Spring) 18:1486-92. 2010
    ..Taken together, our results demonstrate that visfatin upregulates MCP-1 supporting a possible role of MCP-1 in mediating the proinflammatory effects of visfatin...
  71. ncbi request reprint Effect of genetic variation in the human fatty acid synthase gene (FASN) on obesity and fat depot-specific mRNA expression
    Dorit Schleinitz
    Interdisciplinary Centre for Clinical Research, Leipzig, Germany
    Obesity (Silver Spring) 18:1218-25. 2010
    ..04). No effect of genetic variation in FASN on obesity was found in children. In conclusion, our data indicate a role of FASN genetic variation in susceptibility to obesity in adults...
  72. doi request reprint Circulating high-molecular-weight adiponectin is upregulated in preeclampsia and is related to insulin sensitivity and renal function
    Mathias Fasshauer
    Department of Internal Medicine III, University of Leipzig, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    Eur J Endocrinol 158:197-201. 2008
    ..Furthermore, high-molecular-weight (HMW) adiponectin has been suggested as the biologically active form of this adipokine...
  73. ncbi request reprint Tissue inhibitor of metalloproteinase-1 predicts adiposity in humans
    Susan Kralisch
    Department of Internal Medicine III, University of Leipzig, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    Eur J Endocrinol 156:257-61. 2007
    ..However, it is unclear whether TIMP-1 independently predicts adiposity in humans and whether serum levels are increased in s.c. and visceral obesity...
  74. doi request reprint Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the -174G/C variant in IL-6 gene
    Andreas Oberbach
    Department of Medicine, Faculty of Medicine, University of Leipzig, Philipp Rosenthal Str 27, D 04103 Leipzig, Germany
    Eur J Endocrinol 159:129-36. 2008
    ..However, there are heterogeneous data on whether circulating IL-6 is altered by exercise training. We therefore hypothesize that genetic factors modify the individual changes in IL-6 levels after long-term training...
  75. doi request reprint R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians
    Yvonne Bottcher
    Medical Department III, University of Leipzig, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    J Hum Genet 53:365-7. 2008
    ..Our study replicated associations of the R1467H with increased risk of T2D or T2D/IGT, thus, implicating a potential role of ARHGEF11 in the aetiology of T2D and IGT...
  76. ncbi request reprint Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes
    Mathias Fasshauer
    Department of Internal Medicine III, University of Leipzig, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    FEBS Lett 558:27-32. 2004
    ....
  77. doi request reprint Amyloid precursor protein expression is induced by tumor necrosis factor alpha in 3T3-L1 adipocytes
    Grit Sommer
    Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany
    J Cell Biochem 108:1418-22. 2009
    ..Taken together, we show for the first time a potent upregulation of APP by TNFalpha suggesting a potential role of this adipocyte-secreted protein in TNFalpha-induced insulin resistance and inflammatory disease...
  78. ncbi request reprint Plasminogen activator inhibitor-1 expression and secretion are stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes
    Susan Kralisch
    University of Leipzig, Department of Internal Medicine III, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    Mol Cell Endocrinol 253:56-62. 2006
    ..Taken together, our results show a differential regulation of PAI-1 mRNA by insulin resistance-inducing hormones including GH and IL-6...
  79. ncbi request reprint Interleukin-6 is a positive regulator of tumor necrosis factor alpha-induced adipose-related protein in 3T3-L1 adipocytes
    Mathias Fasshauer
    University of Leipzig, Department of Internal Medicine III, 04103 Leipzig, Germany
    FEBS Lett 560:153-7. 2004
    ..Taken together, these results show that TIARP is acutely regulated in adipose tissue not only by TNFalpha but also by IL-6 which has been shown to be another important cytokine implicated in the pathogenesis of insulin resistance...
  80. doi request reprint Vaspin serum concentrations in patients with carotid stenosis
    Gabriela Aust
    Center of Surgery, Department of Visceral, Transplantation, Thoracic, and Vascular Surgery, Medical Faculty, University of Leipzig, Leipzig, Germany
    Atherosclerosis 204:262-6. 2009
    ....
  81. ncbi request reprint Serum levels of adipokine retinol-binding protein-4 in relation to renal function
    Michaela Ziegelmeier
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Diabetes Care 30:2588-92. 2007
    ..The majority of the diabetic subjects used oral hypoglycemic agents or insulin...
  82. ncbi request reprint Therapeutic perspectives of adipocytokines
    Susan Kralisch
    Department of Internal Medicine III, University of Leipzig, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    Expert Opin Pharmacother 6:863-72. 2005
    ..The current knowledge on function, regulation and therapeutic potential of various adipocytokines, as well as their clinical implications, are discussed in this review...
  83. pmc Serum levels of the adipokine chemerin in relation to renal function
    Dörte Pfau
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Diabetes Care 33:171-3. 2010
    ..To investigate serum levels of the adipokine chemerin in patients on chronic hemodialysis (CD) as compared with control patients with a glomerular filtration rate (GFR) >50 ml/min...
  84. ncbi request reprint [Visceral adipose tissue and metabolic syndrome]
    M Bluher
    Medizinische Klinik und Poliklinik III, und Nachwuchsgruppe N03, IZKF Leipzig, Universitat Leipzig
    Dtsch Med Wochenschr 128:2319-23. 2003
  85. doi request reprint TSH compensates thyroid-specific IGF-I receptor knockout and causes papillary thyroid hyperplasia
    Kathrin Müller
    Department of Internal Medicine, University of Leipzig, Germany
    Mol Endocrinol 25:1867-79. 2011
    ..This could indicate that the IGF-I receptor signaling is less essential for thyroid hormone synthesis but maintains homeostasis and normal thyroid morphogenesis...
  86. doi request reprint Altered sciatic nerve fiber morphology and endoneural microvessels in mouse models relevant for obesity, peripheral diabetic polyneuropathy, and the metabolic syndrome
    Marcin Nowicki
    Institute of Anatomy, University of Leipzig, Leipzig, Germany
    J Neurosci Res 90:122-31. 2012
    ..Upregulation of oxLDL-dependent receptors in endoneural microvessels might be connected to different degrees of oxidative stress in severe diabetic db/db mice and in the mild diabetic ob/ob group...
  87. doi request reprint Circulating Nampt and RBP4 levels in patients with carotid stenosis undergoing carotid endarterectomy (CEA)
    Gabriela Aust
    Department of Surgery, Research Laboratories and Clinic of Visceral, Transplantation, Thoracic, and Vascular Surgery, University of Leipzig, Leipzig, Germany
    Clin Chim Acta 412:1195-200. 2011
    ..Altered adipokine secretion, including increased production of nicotinamide phosphoribosyltransferase (Nampt) and retinol binding protein 4 (RBP4) may link adipose tissue dysfunction to cardiovascular complications...
  88. ncbi request reprint Molecular characteristics of serum visfatin and differential detection by immunoassays
    Antje Körner
    Research Laboratory, University Hospital for Children and Adolescents, University of Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany
    J Clin Endocrinol Metab 92:4783-91. 2007
    ..We aimed to characterize molecular features of visfatin, to assess visfatin detection by different immunoassays, and evaluate the association with human obesity and glucose metabolism...
  89. doi request reprint PACAP up-regulates the expression of apolipoprotein D in 3T3-L1 adipocytes. DRG/3T3-L1 co-cultures study
    Joanna Kosacka
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Neurosci Res 69:8-16. 2011
    ..Thus, a bidirectional loop seems to exist regulating the innervation of fatty tissues: PACAP released from sensory fibres might stimulate fat cells to synthesize neurotrophic adipokines, which, in turn, support peripheral innervation...
  90. ncbi request reprint TCF7L2 gene expression in human visceral and subcutaneous adipose tissue is differentially regulated but not associated with type 2 diabetes mellitus
    Peter Kovacs
    Junior Research Group N06, Interdisciplinary Centre for Clinical Research Leipzig, Faculty of Medicine, University of Leipzig, 04103 Leipzig, Germany
    Metabolism 57:1227-31. 2008
    ..Based on our data, TCF7L2 mRNA expression is fat-depot specific but does not seem to provide the mechanistic link explaining genetic association with T2DM...
  91. pmc Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis
    Jonas Rosendahl
    Department of Gastroenterology and Hepatology, University of Leipzig, Leipzig, Germany
    Pancreatology 10:243-9. 2010
    ..Mesotrypsin (PRSS3) can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for CP...
  92. pmc Sequence analysis of the human tyrosylprotein sulfotransferase-2 gene in subjects with chronic pancreatitis
    Jonas Rosendahl
    Department of Gastroenterology and Hepatology, University of Leipzig, Leipzig, Germany
    Pancreatology 10:165-72. 2010
    ..Because increased trypsinogen autoactivation has been implicated as a pathogenic mechanism in chronic pancreatitis, we hypothesized that genetic variants of TPST2 might alter the risk for the disease...
  93. ncbi request reprint Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels
    Antje Böttner
    Research Laboratory, University Hospital for Children and Adolescents, University of Leipzig, Oststrasse 21 25, 04317 Leipzig, Germany
    J Clin Endocrinol Metab 89:4053-61. 2004
    ..0001). Hence, there is a strong association of adiponectin serum concentrations with obesity, pubertal development, and metabolic parameters in children indicating epidemiological and pathophysiological relevance already in childhood...
  94. ncbi request reprint Glucose concentration and AMP-dependent kinase activation regulate expression of insulin receptor family members in rat islets and INS-1E beta cells
    K Raile
    University Hospital for Children and Adolescents, Oststr 21 25, 04317 Leipzig, Germany
    Diabetologia 48:1798-809. 2005
    ..Glucose and the peptide growth factors insulin, IGF-I and IGF-II strongly regulate beta cell mass. Furthermore, beta cell expression of IGF-I receptor (Igf1r) and insulin receptor (Insr) is mandatory for several steps of insulin secretion...
  95. ncbi request reprint Differential regulation of visfatin and adiponectin in pregnancies with normal and abnormal placental function
    M Fasshauer
    Department of Internal Medicine III, University of Leipzig, Germany
    Clin Endocrinol (Oxf) 66:434-9. 2007
    ..As dysregulation of visfatin and adiponectin is found in insulin resistance, both adipokines might contribute to pregnancy disorders...
  96. ncbi request reprint Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes
    J Berndt
    Department of Internal Medicine III, University of Leipzig, Ph Rosenthal Str 27, 04103, Leipzig, Germany
    Diabetologia 50:1472-80. 2007
    ..In the present study we tested the hypothesis that increased FASN expression links metabolic alterations of excess energy intake, including hyperinsulinaemia, dyslipidaemia and altered adipokine profile to increased body fat mass...
  97. doi request reprint Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans
    N Kloting
    Department of Medicine, University of Leipzig, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetologia 51:641-7. 2008
    ..We also investigated whether the FTO obesity risk alleles might explain variability in FTO and RPGRIP1L mRNA expression...
  98. ncbi request reprint Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes
    Mathias Fasshauer
    Department of Internal Medicine III, University of Leipzig, Ph Rosenthal Str 27, 04103, Leipzig, Germany
    Biochem Biophys Res Commun 301:1045-50. 2003
    ..Taken together, our results suggest that adiponectin gene expression is reversibly downregulated by IL-6 and support the concept of adiponectin being an important selectively controlled modulator of insulin sensitivity...
  99. doi request reprint Activated Ask1-MKK4-p38MAPK/JNK stress signaling pathway in human omental fat tissue may link macrophage infiltration to whole-body Insulin sensitivity
    Matthias Bluher
    Department of Medicine, University of Leipzig, 04107 Leipzig, Germany
    J Clin Endocrinol Metab 94:2507-15. 2009
    ..We recently reported that p38MAPK and Jun N-terminal kinase (JNK), but not ERK and inhibitory-kappaB kinase beta, are more highly expressed and activated in human omental (OM) adipose tissue in obesity...
  100. ncbi request reprint Transgenic animal models for the study of adipose tissue biology
    Matthias Bluher
    Department of Internal Medicine II, University of Koln, Germany
    Best Pract Res Clin Endocrinol Metab 19:605-23. 2005
    ..This review presents an overview of transgenic animal models for the study of adipose tissue biology...