Armin Blesch

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Optimization of adult sensory neuron electroporation to study mechanisms of neurite growth
    Julianne McCall
    Spinal Cord Injury Center, Heidelberg University Hospital Heidelberg, Germany
    Front Mol Neurosci 5:11. 2012
  2. doi request reprint Gene therapy, neurotrophic factors and spinal cord regeneration
    Armin Blesch
    Department of Neurosciences, University of California, La Jolla, CA, USA
    Handb Clin Neurol 109:563-74. 2012
  3. pmc Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: superiority to camp-mediated effects
    Armin Blesch
    Spinal Cord Injury Center, University Hospital Heidelberg, 69118 Heidelberg, Germany
    Exp Neurol 235:162-73. 2012
  4. pmc Dependence of regenerated sensory axons on continuous neurotrophin-3 delivery
    Shaoping Hou
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 32:13206-20. 2012
  5. pmc Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury
    Ken Kadoya
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 64:165-72. 2009
  6. pmc Local and remote growth factor effects after primate spinal cord injury
    John H Brock
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 30:9728-37. 2010
  7. pmc IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury
    Edmund R Hollis
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Exp Neurol 215:53-9. 2009
  8. pmc Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery
    Alan H Nagahara
    Department of Neurosciences 0626, University of California San Diego, La Jolla, California 92093, USA
    Exp Neurol 215:153-9. 2009
  9. pmc Partial restoration of cardiovascular function by embryonic neural stem cell grafts after complete spinal cord transection
    Shaoping Hou
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, Veterans Administration Medical Center, San Diego, California 92161, Spinal Cord Injury Center, Heidelberg University Hospital, D 69118 Heidelberg, Germany, Spinal Cord Research Center, Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129
    J Neurosci 33:17138-49. 2013
  10. ncbi request reprint A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
    Mark H Tuszynski
    Department of Neurosciences, University of California at San Diego, La Jolla 92093, USA
    Nat Med 11:551-5. 2005

Collaborators

Detail Information

Publications42

  1. pmc Optimization of adult sensory neuron electroporation to study mechanisms of neurite growth
    Julianne McCall
    Spinal Cord Injury Center, Heidelberg University Hospital Heidelberg, Germany
    Front Mol Neurosci 5:11. 2012
    ..Application of this optimized protocol will contribute to furthering the study of neuron-intrinsic mechanisms responsible for growth and survival under physiological and pathophysiological conditions...
  2. doi request reprint Gene therapy, neurotrophic factors and spinal cord regeneration
    Armin Blesch
    Department of Neurosciences, University of California, La Jolla, CA, USA
    Handb Clin Neurol 109:563-74. 2012
    ..In this chapter we will review the potential and current limitations of neurotrophic factors and gene therapy, in combination with cellular transplants, for axon regeneration and sprouting in the injured spinal cord...
  3. pmc Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: superiority to camp-mediated effects
    Armin Blesch
    Spinal Cord Injury Center, University Hospital Heidelberg, 69118 Heidelberg, Germany
    Exp Neurol 235:162-73. 2012
    ....
  4. pmc Dependence of regenerated sensory axons on continuous neurotrophin-3 delivery
    Shaoping Hou
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 32:13206-20. 2012
    ..Thus, multiple mechanisms underlie the inability of transient NT-3 expression to fully sustain regenerated sensory axons...
  5. pmc Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury
    Ken Kadoya
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 64:165-72. 2009
    ..Collectively, these findings provide evidence that regeneration is achievable at unprecedented postinjury time points...
  6. pmc Local and remote growth factor effects after primate spinal cord injury
    John H Brock
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 30:9728-37. 2010
    ..Remote cortical effects of spinally administered growth factors could "prime" the neuron to respond to experimental therapies that promote axonal plasticity or regeneration...
  7. pmc IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury
    Edmund R Hollis
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Exp Neurol 215:53-9. 2009
    ..We conclude that developmental patterns of growth factor responsiveness are not simply recapitulated after adult injury, potentially due to post-natal shifts in patterns of IGF-I receptor expression...
  8. pmc Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery
    Alan H Nagahara
    Department of Neurosciences 0626, University of California San Diego, La Jolla, California 92093, USA
    Exp Neurol 215:153-9. 2009
    ..These findings also support the safety and feasibility of lentiviral NGF gene transfer for potential testing in human clinical trials to protect degenerating cholinergic neurons in Alzheimer's disease...
  9. pmc Partial restoration of cardiovascular function by embryonic neural stem cell grafts after complete spinal cord transection
    Shaoping Hou
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, Veterans Administration Medical Center, San Diego, California 92161, Spinal Cord Injury Center, Heidelberg University Hospital, D 69118 Heidelberg, Germany, Spinal Cord Research Center, Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129
    J Neurosci 33:17138-49. 2013
    ..Thus, grafted embryonic brainstem-derived neurons can act as functional relays to restore supraspinal regulation of denervated SPNs, thereby contributing to cardiovascular functional improvement. ..
  10. ncbi request reprint A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
    Mark H Tuszynski
    Department of Neurosciences, University of California at San Diego, La Jolla 92093, USA
    Nat Med 11:551-5. 2005
    ..05) increases in cortical 18-fluorodeoxyglucose after treatment. Brain autopsy from one subject suggested robust growth responses to NGF. Additional clinical trials of NGF for Alzheimer disease are warranted...
  11. pmc Motor axonal regeneration after partial and complete spinal cord transection
    Paul Lu
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 32:8208-18. 2012
    ..These findings highlight the complexity of spinal cord repair and the need for additional control and shaping of axonal regeneration...
  12. pmc Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation
    Edmund R Hollis
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0626, USA
    Proc Natl Acad Sci U S A 106:7215-20. 2009
    ....
  13. pmc Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury
    Laura Taylor Alto
    Department of Neurosciences, University of California, San Diego, La Jolla, California, USA
    Nat Neurosci 12:1106-13. 2009
    ..Thus, we report for the first time, to the best of our knowledge, the reinnervation of brainstem targets after SCI and an essential role for chemotropic axon guidance in target selection...
  14. pmc Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
    Alan H Nagahara
    Department of Neurosciences 0626, 9500 Gilman Drive, University of California San Diego, La Jolla, California 92093, USA
    Nat Med 15:331-7. 2009
    ..BDNF therapeutic delivery merits exploration as a potential therapy for Alzheimer's disease...
  15. ncbi request reprint Transient growth factor delivery sustains regenerated axons after spinal cord injury
    Armin Blesch
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 27:10535-45. 2007
    ..Thus, the adult CNS appears capable of sustaining axons that have extended after transient growth factor delivery, an effect potentially attributable to the persistence of Schwann cells in lesion/graft sites...
  16. ncbi request reprint NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection
    Mark H Tuszynski
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Exp Neurol 181:47-56. 2003
    ..Thus, growth factor gene delivery can elicit growth of corticospinal axons in chronic stages of injury and improves functional outcomes compared to non-growth-factor-treated animals...
  17. ncbi request reprint Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord
    Laura Taylor
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 26:9713-21. 2006
    ..These findings indicate that a localized and continuous gradient of NT-3 can achieve axonal bridging beyond the glial scar, but growth for longer distances is not sustainable simply with a trophic stimulus...
  18. pmc Long-distance growth and connectivity of neural stem cells after severe spinal cord injury
    Paul Lu
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 150:1264-73. 2012
    ..These therapeutic properties extend across stem cell sources and species...
  19. pmc Gene therapy approaches to enhancing plasticity and regeneration after spinal cord injury
    Steffen Franz
    Spinal Cord Injury Center, Heidelberg University Hospital, Germany
    Exp Neurol 235:62-9. 2012
    ....
  20. pmc A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth
    Ronald W Alfa
    Department of Neurosciences 0626, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Neurosci Res 87:2624-31. 2009
    ..These results demonstrate that small ligand-induced dimerization of the intracellular domain of trkA can efficiently simulate the biological activity of NGF and provide a means to regulate intracellular neurotrophin receptor signaling...
  21. doi request reprint Regeneration of long-tract axons through sites of spinal cord injury using templated agarose scaffolds
    Thomas Gros
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Biomaterials 31:6719-29. 2010
    ..Further development must reduce reactive cellular interfaces to support effective axonal penetration of host parenchyma...
  22. ncbi request reprint Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination
    Armin Blesch
    Department of Neurosciences 0626, University of California San Diego, La Jolla, California 92093 0626, USA
    J Comp Neurol 467:403-17. 2003
    ..Thus, GDNF exerts tropic effects on adult spinal axons and Schwann cells that contribute to axon growth after injury...
  23. ncbi request reprint Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons
    Armin Blesch
    Department of Neurosciences 0626, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Ther 11:916-25. 2005
    ..These data demonstrate for the first time that NGF delivery by lentiviral gene transfer using tetracycline-regulated promoters can completely regulate neuronal rescue and protein production in the brain...
  24. ncbi request reprint New strategies in neural repair
    Mark H Tuszynski
    Department of Neurosciences 0626, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Prog Brain Res 138:401-9. 2002
  25. ncbi request reprint Axonal responses to cellularly delivered NT-4/5 after spinal cord injury
    Armin Blesch
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Cell Neurosci 27:190-201. 2004
    ..Thus, NT-4/5 and BDNF appear to be interchangeable to elicit substantial axonal growth in the injured spinal cord...
  26. ncbi request reprint Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord
    Beatrice Sandner
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    Stem Cell Res 11:758-71. 2013
    ..Thus, neutralization of BMP or BMP signaling might be required to allow for BMSC-induced oligodendroglial differentiation of grafted NPCs in the injured spinal cord. ..
  27. ncbi request reprint Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair
    Armin Blesch
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Brain Res Bull 57:833-8. 2002
    ..In this review we discuss the use of neural stem cell transplants and neurotrophic factor delivery by gene therapy to improve axonal regeneration in animal models of spinal cord injury...
  28. ncbi request reprint Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury
    Armin Blesch
    Department of Neurosciences 0626, University of California, 9500 Gilman Drive, San Diego, La Jolla, CA 92093 0626, USA
    Prog Brain Res 137:415-23. 2002
  29. doi request reprint Spinal cord injury: plasticity, regeneration and the challenge of translational drug development
    Armin Blesch
    Department of Neurosciences 0626, University of California, San Diego, La Jolla, CA 92093, USA
    Trends Neurosci 32:41-7. 2009
    ..Therapeutic candidates are most likely to have a detectable effect in human trials if they elicit benefits in severe contusion and larger animal models and pass the test of independent replication...
  30. ncbi request reprint Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease
    Mark H Tuszynski
    Department of Neurosciences 0626, University of California, San Diego, La Jolla, CA 92093, USA
    Prog Brain Res 146:441-9. 2004
    ....
  31. ncbi request reprint Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury
    Armin Blesch
    Department of Neurosciences Center for Neural Repair, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Yonsei Med J 45:28-31. 2004
    ..Thus, strategies have evolved for the delivery of potentially neuroprotective molecules, such as neurotrophic factors, and the replacement of cells and tissue lost due to CNS injury and degeneration...
  32. ncbi request reprint Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact?
    Paul Lu
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci Res 77:174-91. 2004
    ....
  33. pmc Neurotrophic factors in combinatorial approaches for spinal cord regeneration
    Julianne McCall
    Spinal Cord Injury Center, Heidelberg University Hospital, Schlierbacher Landstrasse 200 A, 69118 Heidelberg, Germany
    Cell Tissue Res 349:27-37. 2012
    ..Here, we will review the rationale for combinatorial treatments in axonal regeneration and summarize some recent progress in promoting axonal regeneration in the injured CNS using such approaches...
  34. ncbi request reprint A neurovascular niche for neurogenesis after stroke
    John J Ohab
    Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 1735, USA
    J Neurosci 26:13007-16. 2006
    ..These experiments define a novel brain environment for neuronal regeneration after stroke and identify molecular mechanisms that are shared between angiogenesis and neurogenesis during functional recovery from brain injury...
  35. ncbi request reprint Thoracic rat spinal cord contusion injury induces remote spinal gliogenesis but not neurogenesis or gliogenesis in the brain
    Steffen Franz
    Spinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany
    PLoS ONE 9:e102896. 2014
    ..Gliogenesis was increased in the cervical spinal cord remote from the injury site, however, is unlikely to contribute to functional improvement. ..
  36. doi request reprint Characterization of supraspinal vasomotor pathways and autonomic dysreflexia after spinal cord injury in F344 rats
    Shaoping Hou
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Auton Neurosci 176:54-63. 2013
    ..Hence, F344 rats with complete T4 transections provide a reliable model for investigating means to improve cardiovascular functional recovery after SCI...
  37. ncbi request reprint Spontaneous and augmented growth of axons in the primate spinal cord: effects of local injury and nerve growth factor-secreting cell grafts
    Mark H Tuszynski
    Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0626, USA
    J Comp Neurol 449:88-101. 2002
    ..Furthermore, as in rodent studies, cellular delivery of a trophic factor significantly augments axonal plasticity in the primate spinal cord...
  38. ncbi request reprint Nerve growth factor gene therapy for Alzheimer's disease
    Mark H Tuszynski
    La Jolla, University of California San Diego, USA
    J Mol Neurosci 19:207. 2002
  39. ncbi request reprint Murine and HIV-based retroviral vectors for in vitro and in vivo gene transfer
    Ronald W Alfa
    Department of Neurosciences, University of California, San Diego, La Jolla, USA
    Methods Mol Med 129:241-54. 2006
    ..Here, we describe protocols to produce and standardize high quality MLV-based retroviral and HIV-based lentiviral vectors for ex vivo and in vivo gene delivery...
  40. doi request reprint Neural stem cells for spinal cord repair
    Beatrice Sandner
    Spinal Cord Injury Center, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69121 Heidelberg, Germany
    Cell Tissue Res 349:349-62. 2012
    ..This review aims to provide an overview about the current status of preclinical and clinical neural stem cell transplantation and discusses future perspectives in the field...
  41. ncbi request reprint Neurotrophic factors in neurodegeneration
    Armin Blesch
    Department of Neurosciences 0626, Center for Neural Repair, University of California, San Diego, La Jolla, California 92093 0626, USA
    Brain Pathol 16:295-303. 2006
    ..In this review, we will discuss some of the potential therapeutic applications of NTFs in neurodegenerative diseases and the potential contribution of disturbed neurotrophic factor signaling to neurodegenerative diseases...
  42. ncbi request reprint Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer
    Armin Blesch
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Methods 33:164-72. 2004
    ..This review will briefly summarize the background of these vector systems and provide some common protocols available for the preparation of MLV based retroviral vectors and HIV-1 based lentiviral vectors...