Hagen Blaszyk

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. ncbi request reprint Upper tract urothelial carcinoma: a clinicopathologic study including microsatellite instability analysis
    Hagen Blaszyk
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Mod Pathol 15:790-7. 2002
  2. ncbi request reprint Urothelial carcinoma of the upper urinary tract: inverted growth pattern is predictive of microsatellite instability
    Arndt Hartmann
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN, USA
    Hum Pathol 34:222-7. 2003
  3. ncbi request reprint High frequency of FGFR3 mutations in adenoid seborrheic keratoses
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 126:2404-7. 2006
  4. ncbi request reprint Elevated microsatellite instability at selected tetranucleotide repeats does not correlate with clinicopathologic features of bladder cancer
    Maximilian Burger
    Department of Urology, University of Regensburg, Germany
    Eur Urol 50:770-5; discussion 776. 2006
  5. ncbi request reprint Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer
    Wolfgang Dietmaier
    Department of Pathology and Molecular Diagnostics, University of Regensburg, Germany
    Int J Cancer 118:2247-54. 2006
  6. pmc Microsatellite analysis of pleural supernatants could increase sensitivity of pleural fluid cytology
    Matthias Woenckhaus
    Department of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    J Mol Diagn 7:517-24. 2005
  7. ncbi request reprint Role of the STK15 Phe31Ile polymorphism in renal cell carcinoma
    Christine G Hammerschmied
    Department of Urology, University of Regensburg, D 93042 Regensburg, Germany
    Oncol Rep 17:3-7. 2007
  8. pmc Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi
    Christian Hafner
    Department of Dermatology, University of Regensburg, Germany
    J Clin Invest 116:2201-2207. 2006
  9. ncbi request reprint No evidence for mutation of B-RAF in urothelial carcinomas of the bladder and upper urinary tract
    Robert Stoehr
    Institute of Pathology, University of Regensburg, 93042 Regensburg, Germany
    Oncol Rep 11:137-41. 2004
  10. ncbi request reprint Microsatellite instability at chromosome 8p in non-small cell lung cancer is associated with lymph node metastasis and squamous differentiation
    Matthias Woenckhaus
    Department of Pathology, University of Regensburg, Regensburg, Germany
    Int J Oncol 23:1357-63. 2003

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Upper tract urothelial carcinoma: a clinicopathologic study including microsatellite instability analysis
    Hagen Blaszyk
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Mod Pathol 15:790-7. 2002
    ....
  2. ncbi request reprint Urothelial carcinoma of the upper urinary tract: inverted growth pattern is predictive of microsatellite instability
    Arndt Hartmann
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN, USA
    Hum Pathol 34:222-7. 2003
    ..82. Inverted growth in urothelial carcinomas of the upper urinary tract may serve as a marker lesion for MSI and may help identify patients who should be offered testing for HNPCC...
  3. ncbi request reprint High frequency of FGFR3 mutations in adenoid seborrheic keratoses
    Christian Hafner
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 126:2404-7. 2006
    ..The mechanism for the high rate of somatic FGFR3 mutations in these benign skin tumors remains elusive, but UV light exposure may play a potential role, especially in the R248C mutations...
  4. ncbi request reprint Elevated microsatellite instability at selected tetranucleotide repeats does not correlate with clinicopathologic features of bladder cancer
    Maximilian Burger
    Department of Urology, University of Regensburg, Germany
    Eur Urol 50:770-5; discussion 776. 2006
    ..The aim of the present study was to evaluate whether elevated microsatellite instability (MSI) at selected tetranucleotide repeats (EMAST) is associated with clinicopathologic and molecular parameters in urinary bladder cancer (BC)...
  5. ncbi request reprint Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer
    Wolfgang Dietmaier
    Department of Pathology and Molecular Diagnostics, University of Regensburg, Germany
    Int J Cancer 118:2247-54. 2006
    ..Patients with negative immunohistochemical Maspin expression do not benefit from 5-FU treatment and may be candidates for an alternative (non-5-FU based) adjuvant therapy regime...
  6. pmc Microsatellite analysis of pleural supernatants could increase sensitivity of pleural fluid cytology
    Matthias Woenckhaus
    Department of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    J Mol Diagn 7:517-24. 2005
    ....
  7. ncbi request reprint Role of the STK15 Phe31Ile polymorphism in renal cell carcinoma
    Christine G Hammerschmied
    Department of Urology, University of Regensburg, D 93042 Regensburg, Germany
    Oncol Rep 17:3-7. 2007
    ..This first analysis of the STK15 T91A SNP in RCC patients revealed no correlation between a certain allelic variant and an increased risk for RCC...
  8. pmc Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi
    Christian Hafner
    Department of Dermatology, University of Regensburg, Germany
    J Clin Invest 116:2201-2207. 2006
    ..The R248C mutation appears to be a hot spot for FGFR3 mutations in epidermal nevi...
  9. ncbi request reprint No evidence for mutation of B-RAF in urothelial carcinomas of the bladder and upper urinary tract
    Robert Stoehr
    Institute of Pathology, University of Regensburg, 93042 Regensburg, Germany
    Oncol Rep 11:137-41. 2004
    ..The most frequent alterations in the B-RAF gene do not seem to be involved in urothelial carcinogenesis, and there is no correlation between MMR-deficiency and B-RAF mutations in urothelial tumors...
  10. ncbi request reprint Microsatellite instability at chromosome 8p in non-small cell lung cancer is associated with lymph node metastasis and squamous differentiation
    Matthias Woenckhaus
    Department of Pathology, University of Regensburg, Regensburg, Germany
    Int J Oncol 23:1357-63. 2003
    ..The tetranucleotide marker panel used in this study was able to indicate lymph node metastasis and high risk disease in patients with resectable squamous cell lung cancer...
  11. ncbi request reprint Cancer of unknown primary: clinicopathologic correlations
    Hagen Blaszyk
    Mayo Clinic and Foundation, Rochester, MN, USA
    APMIS 111:1089-94. 2003
    ..Our findings show that (1) autopsy studies provide a valuable tool for quality control in the setting of CUP, and (2) treated patients have a small but significant survival benefit...
  12. ncbi request reprint Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer
    Edgar Dahl
    Institute of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany
    Clin Cancer Res 12:3950-60. 2006
    ..The aim of the present study was to identify human genes that might prove useful in the diagnosis and therapy of primary breast cancer...
  13. ncbi request reprint Histologic-genetic mapping by allele-specific PCR reveals intraurothelial spread of p53 mutant tumor clones
    Robert Stoehr
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Lab Invest 82:1553-61. 2002
    ..The excellent correlation of immunohistochemically positive urothelial patches with the presence of a specific mutation highlights the biologic significance of p53-positive cells in the urothelium of tumor patients...
  14. ncbi request reprint Frequent microsatellite instability in sporadic tumors of the upper urinary tract
    Arndt Hartmann
    Institute of Pathology, University of Regensburg, 93042 Regensburg, Germany
    Cancer Res 62:6796-802. 2002
    ....
  15. pmc Nuclear and cytoplasmic Maspin expression in primary non-small cell lung cancer
    Matthias Woenckhaus
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    J Clin Pathol 60:483-6. 2007
    ..To investigate whether nuclear and cytoplasmic Maspin expression is associated with distinct clinicopathological parameters and TP53 expression in a representative series of primary non-small cell lung cancer (NSCLC)...
  16. ncbi request reprint MIB-1 and MCM-2 immunohistochemical analysis does not aid in identification of serrated colorectal polyps with abnormal proliferation
    David Gray
    Department of Pathology, University of Vermont College of Medicine, Burlington 05405, USA
    Am J Clin Pathol 125:407-12. 2006
    ....
  17. ncbi request reprint Molecular evidence for progression of nephrogenic metaplasia of the urinary bladder to clear cell adenocarcinoma
    Arndt Hartmann
    Institute of Pathology, University of Regensburg, D 93042, Germany
    Hum Pathol 37:117-20. 2006
    ..Results of molecular studies, particularly comparative genomic hybridization analysis, suggest clonal evolution of nephrogenic metaplasia to clear cell adenocarcinoma in this case...
  18. ncbi request reprint Microsatellite instability predicts poor short-term survival in patients with advanced breast cancer after high-dose chemotherapy and autologous stem-cell transplantation
    Peter J Wild
    Departments of Pathology and Hematology and Oncology, University of Regensburg, Regensburg, Germany
    Clin Cancer Res 10:556-64. 2004
    ..The purpose is to define molecular prognostic factors in patients with advanced breast cancer treated with high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT)...
  19. ncbi request reprint High-throughput tissue microarray analysis of COX2 expression in urinary bladder cancer
    Peter J Wild
    Institute of Pathology, University of Regensburg, Regensburg D 93053, Germany
    Int J Oncol 27:385-91. 2005
    ..Expression of COX2 is common in advanced BC with poor prognostic characteristics, supporting efforts to initiate clinical trials on the efficacy of COX2 inhibitors in the adjuvant treatment of high-risk urinary BC...
  20. ncbi request reprint Multitarget FISH and LOH analyses at chromosome 3p in non-small cell lung cancer and adjacent bronchial epithelium
    Matthias Woenckhaus
    Department of Pathology, University of Regensburg, Germany
    Am J Clin Pathol 123:752-61. 2005
    ..Multicolor FISH analysis is able to detect a tumor-associated molecular field effect in bronchi adjacent to NSCLC...
  21. ncbi request reprint Distinct secreted Frizzled receptor protein 1 staining pattern in patients with hyperplastic polyposis coli syndrome
    Barbara I Oberschmid
    Institute of Pathology, University of Regensburg, Germany
    Arch Pathol Lab Med 128:967-73. 2004
    ..Hypermethylation of the secreted Frizzled receptor protein 1 gene on chromosome 8p12 is one of the earliest molecular alterations in colorectal carcinogenesis, potentially disrupting the Wnt signaling cascade of cellular growth control...
  22. ncbi request reprint Gene expression profiling of colorectal cancer and metastases divides tumours according to their clinicopathological stage
    Astrid Koehler
    Department of Pathology, University of Regensburg, Germany
    J Pathol 204:65-74. 2004
    ..These genes may represent important targets in colorectal carcinogenesis and might provide useful clinicopathological tools in the management of colorectal cancer...
  23. ncbi request reprint Low frequency of molecular changes and tumor recurrence in inverted papillomas of the urinary tract
    Matthias Eiber
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Am J Surg Pathol 31:938-46. 2007
    ..Ancillary markers may help to resolve such cases and clarify the reported malignant potential of some IPs...
  24. ncbi request reprint Low level STK15 amplification in histologically benign urothelium of patients with bladder cancer adversely predicts patient outcome following cystectomy
    Stefan Denzinger
    Department of Urology, University of Regensburg, Franz Josef Strauss Allee, D 93053 Regensburg, Germany
    Int J Oncol 31:793-802. 2007
    ..A large randomized prospective study comparing early versus delayed cystectomy in patients with pT1 bladder cancer is currently conducted to validate our findings...
  25. ncbi request reprint Elevated nuclear maspin expression is associated with microsatellite instability and high tumour grade in colorectal cancer
    Marcus Bettstetter
    Department of Pathology, University of Regensburg, D 93053 Regensburg, Germany
    J Pathol 205:606-14. 2005
    ..013), de-differentiated tumours (p = 0.006), and at the invasion front. These findings provide new insights into the role of maspin in colorectal cancer progression and may be useful for diagnosis and treatment strategies...
  26. ncbi request reprint Minute gastric sclerosing stromal tumors (GIST tumorlets) are common in adults and frequently show c-KIT mutations
    Abbas Agaimy
    Institute of Pathology, Klinikum Nürnberg, Prof Ernst Nathan Strasse 1, 90419 Nuremberg, Germany
    Am J Surg Pathol 31:113-20. 2007
    ..GIST tumorlets likely represent preclinical (preneoplastic) lesions that need additional stimuli to evolve into clinical GISTs, raising the possibility of a hyperplasia-neoplasia sequence in the development of sporadic GISTs...
  27. ncbi request reprint [Urothelial neoplasms in individuals younger than 20 years show very few genetic alterations and have a favourable clinical outcome]
    Johannes Giedl
    Institut fur Pathologie, Universitat Regensburg, Regensburg
    Verh Dtsch Ges Pathol 90:253-63. 2006
    ..Urothelial neoplasms in patients 19 years or younger are rare, with conflicting data regarding clinical outcome and no molecular data available...
  28. ncbi request reprint Esophageal squamous papillomatosis
    Patricia C Kao
    Department of Internal Medicine, University of Vermont College of Medicine, Burlington, 05405, USA
    Eur J Gastroenterol Hepatol 17:1233-7. 2005
    ..This case illustrates the difficulties in clinical management and establishing a definite etiology in esophageal squamous papillomatosis...
  29. ncbi request reprint The effect of tissue fixation and processing on breast cancer size
    Bobbi Pritt
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Hum Pathol 36:756-60. 2005
    ..One can arguably measure the size of an invasive breast cancer from either the fresh or fixed state without affecting accuracy, but caution should be exercised in relying solely on the microscopic measurements...
  30. ncbi request reprint Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome
    Matthew D Coates
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Gastroenterology 126:1657-64. 2004
    ..Our aim was to test whether enteric 5-HT signaling is defective in these disorders...
  31. ncbi request reprint Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer
    Robert Stoehr
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Lab Invest 84:465-78. 2004
    ..The sFRP1 gene on chromosome 8p12-11.1 could be a candidate gene for the predicted, progression-related tumor suppressor gene in bladder cancer and could contribute to urothelial carcinogenesis...
  32. ncbi request reprint Hereditary nonpolyposis colorectal cancer syndrome in a patient with urothelial carcinoma of the upper urothelial tract
    Arndt Hartmann
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Arch Pathol Lab Med 127:E60-3. 2003
    ..Subsequent identification of individuals with HNPCC enables the patient and at-risk relatives to benefit from targeted surveillance and management programs...
  33. ncbi request reprint Interobserver agreement on what constitutes visceral pleural invasion by non-small cell lung carcinoma: an internet-based assessment of international current practices
    Kelly J Butnor
    Department of Pathology, University of Vermont Fletcher Allen Health Care, Burlington, VT 05401, USA
    Am J Clin Pathol 128:638-47. 2007
    ..However, the formation of internationally recognized guidelines for assessing VPI by NSCLC is likely to improve diagnostic consensus...