S Blankenberg

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint Different calculations of ankle-brachial index and their impact on cardiovascular risk prediction
    Christine Espinola-Klein
    Medical Department II, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Circulation 118:961-7. 2008
  2. ncbi request reprint Circulating cell adhesion molecules and death in patients with coronary artery disease
    S Blankenberg
    Department of Medicine II, Johannes Gutenberg University Mainz, Germany
    Circulation 104:1336-42. 2001
  3. ncbi request reprint Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease
    Stefan Blankenberg
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    N Engl J Med 349:1605-13. 2003
  4. ncbi request reprint Interleukin-18 and the risk of coronary heart disease in European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME)
    Stefan Blankenberg
    INSERM U525, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Circulation 108:2453-9. 2003
  5. ncbi request reprint [Homocysteine, methylenetetrahydrofolate reductase/C677T genotype and risk for coronary heart disease. The AtheroGene study]
    S Blankenberg
    II Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Germany
    Dtsch Med Wochenschr 127:729-35. 2002
  6. ncbi request reprint Cytomegalovirus infection with interleukin-6 response predicts cardiac mortality in patients with coronary artery disease
    S Blankenberg
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    Circulation 103:2915-21. 2001
  7. ncbi request reprint [Genetic variation of the cholesterol ester transfer protein gene and the prevalence of coronary artery disease. The AtheroGene case control study]
    S Blankenberg
    II Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Z Kardiol 93:IV16-23. 2004
  8. ncbi request reprint [The role of inflammation and infection in acute coronary syndrome]
    S Blankenberg
    II Medizinische Klinik, Johannes Gutenberg Universitat Mainz
    Herz 26:9-18. 2001
  9. ncbi request reprint Are morphological or functional changes in the carotid artery wall associated with Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, or herpes simplex virus infection?
    C Espinola-Klein
    2nd Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Stroke 31:2127-33. 2000
  10. ncbi request reprint Impact of viral and bacterial infectious burden on long-term prognosis in patients with coronary artery disease
    H J Rupprecht
    Department of Medicine II, Johannes Gutenberg University Mainz, Mainz
    Circulation 104:25-31. 2001

Detail Information

Publications87

  1. ncbi request reprint Different calculations of ankle-brachial index and their impact on cardiovascular risk prediction
    Christine Espinola-Klein
    Medical Department II, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Circulation 118:961-7. 2008
    ..9 indicates peripheral arterial disease (PAD) and is a strong predictor of cardiovascular events. The aim of the present study was to address the prognostic value of different methods of ABI calculation...
  2. ncbi request reprint Circulating cell adhesion molecules and death in patients with coronary artery disease
    S Blankenberg
    Department of Medicine II, Johannes Gutenberg University Mainz, Germany
    Circulation 104:1336-42. 2001
    ..In a model that simultaneously controlled for all inflammatory and soluble adhesion markers determined, only sVCAM-1 remained independently significant for future fatal cardiovascular events, with a 2.8-fold increase in risk (P=0.003)...
  3. ncbi request reprint Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease
    Stefan Blankenberg
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    N Engl J Med 349:1605-13. 2003
    ..In vitro data and studies in animal models suggest that these enzymes may protect against atherosclerosis, but little is known about their relevance to human disease...
  4. ncbi request reprint Interleukin-18 and the risk of coronary heart disease in European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME)
    Stefan Blankenberg
    INSERM U525, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Circulation 108:2453-9. 2003
    ..Interleukin (IL)-18 promotes atherosclerotic plaque growth and vulnerability. It is unknown, however, whether elevations of circulating IL-18 precede the onset of coronary events in apparently healthy individuals...
  5. ncbi request reprint [Homocysteine, methylenetetrahydrofolate reductase/C677T genotype and risk for coronary heart disease. The AtheroGene study]
    S Blankenberg
    II Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Germany
    Dtsch Med Wochenschr 127:729-35. 2002
  6. ncbi request reprint Cytomegalovirus infection with interleukin-6 response predicts cardiac mortality in patients with coronary artery disease
    S Blankenberg
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    Circulation 103:2915-21. 2001
    ..We investigated the effect of previous exposure to CMV infection on the risk of future cardiac disease-related death in relation to an underlying inflammatory response...
  7. ncbi request reprint [Genetic variation of the cholesterol ester transfer protein gene and the prevalence of coronary artery disease. The AtheroGene case control study]
    S Blankenberg
    II Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Z Kardiol 93:IV16-23. 2004
    ..We evaluated in a large case-control study the impact of various CETP genotypes and haplotypes on HDL concentration and the prevalence of CAD...
  8. ncbi request reprint [The role of inflammation and infection in acute coronary syndrome]
    S Blankenberg
    II Medizinische Klinik, Johannes Gutenberg Universitat Mainz
    Herz 26:9-18. 2001
    ..In animal models Chlamydia pneumoniae and cytomegalovirus increase accelerated neointimal response, however, molecular mechanisms are not entirely clear...
  9. ncbi request reprint Are morphological or functional changes in the carotid artery wall associated with Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, or herpes simplex virus infection?
    C Espinola-Klein
    2nd Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Stroke 31:2127-33. 2000
    ....
  10. ncbi request reprint Impact of viral and bacterial infectious burden on long-term prognosis in patients with coronary artery disease
    H J Rupprecht
    Department of Medicine II, Johannes Gutenberg University Mainz, Mainz
    Circulation 104:25-31. 2001
    ..This result was mainly driven by the pathogen burden of seropositivities to Herpesviridae (P<0.0001). The prognostic impact of total or viral pathogen burden was independent of the C-reactive protein level...
  11. ncbi request reprint Impact of pathogen burden in patients with coronary artery disease in relation to systemic inflammation and variation in genes encoding cytokines
    Jean Louis Georges
    INSERM U525, Paris, France
    Am J Cardiol 92:515-21. 2003
    ..05). This interaction appeared to be mediated by variations in serum IL-6 levels. No such interaction was detected with any of the 2 TNF-alpha polymorphisms...
  12. ncbi request reprint Haemostatic factors and the risk of cardiovascular death in patients with coronary artery disease: the AtheroGene study
    P E Morange
    INSERM UMR S 525 and Université Pierre et Marie Curie Paris 6, Paris, France
    Arterioscler Thromb Vasc Biol 26:2793-9. 2006
    ....
  13. ncbi request reprint [Acute coronary syndrome (without ST-elevation)]
    H J Rupprecht
    II Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Z Kardiol 93:IV1-8. 2004
    ..Aspirin should be given in the chronic phase lifelong, Clopidogrel for at least nine months. An invasive strategy is recommended in high-risk patients within 48 hours...
  14. ncbi request reprint Herpesvirus DNA (Epstein-Barr virus, herpes simplex virus, cytomegalovirus) in circulating monocytes of patients with coronary artery disease
    Axel Schlitt
    Department of Medicine II and Virology, and Institute for Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, Germany
    Acta Cardiol 60:605-10. 2005
    ..As a possible trigger, several studies in recent years have suggested that different viruses and bacteria are associated with atherosclerotic diseases...
  15. doi request reprint Haplotypic analysis of tag SNPs of the interleukin-18 gene in relation to cardiovascular disease events: the MORGAM Project
    Marie Lise Grisoni
    INSERM, UMR_S 525, Paris, France
    Eur J Hum Genet 16:1512-20. 2008
    ..In conclusion, using the concerted effort of several European prospective CVD cohorts, we are able to show that one IL-18 tag SNP interacts with smoking to modulate the risk of developing CVD...
  16. ncbi request reprint SELPLG gene polymorphisms in relation to plasma SELPLG levels and coronary artery disease
    D A Tregouet
    INSERM U525, Faculte de Medecine, Hopital Pitie Salpetriere, 91 Bld de l Hôpital, 75634 Paris Cedex 13, France
    Ann Hum Genet 67:504-11. 2003
    ..Haplotype analysis revealed that two polymorphisms of SELPLG, the M62I and the VNTR, independently influenced plasma SELPLG levels. Conversely, haplotypes of SELPLG were not associated with CAD risk...
  17. ncbi request reprint Analytical and clinical evaluation of troponin I determination on dimension RXL-HM
    G Hafner
    Institute of Clinical Chemistry and Laboratory Medicine, University Hospital, Mainz, Germany
    Clin Chem Lab Med 38:355-61. 2000
    ..In patients with unstable angina, increased cTnI was found more often than on Stratus analyzer. In conclusion, the new assay is a very sensitive cTnI assay, fast and easy to perform in parallel to enzyme and substrate assays...
  18. ncbi request reprint CD14+CD16+ monocytes in coronary artery disease and their relationship to serum TNF-alpha levels
    Axel Schlitt
    Department of Medicine II and Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, Mainz, Germany
    Thromb Haemost 92:419-24. 2004
    ..In accordance, recent animal studies suggest a possibly important role of these monocytes in the development of atherosclerosis...
  19. ncbi request reprint [Influence of impaired fasting glucose on the incidence and prognosis of atherosclerosis in various vascular regions]
    C Espinola-Klein
    II Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Z Kardiol 93:IV48-55. 2004
    ..The aim of this study was to evaluate the impact of diabetes mellitus (DM) and IFG on the incidence of atherosclerotic manifestations and on the long-term prognosis of patients with atherosclerosis in various vascular regions...
  20. ncbi request reprint Glutathione peroxidase-1 and homocysteine for cardiovascular risk prediction: results from the AtheroGene study
    Renate Schnabel
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    J Am Coll Cardiol 45:1631-7. 2005
    ..This prospective study was designed to evaluate the effect of joint determination of two important contrary biomarkers--homocysteine and glutathione peroxidase (GPx)-1--on cardiovascular risk stratification...
  21. doi request reprint Activated thrombin activatable fibrinolysis inhibitor levels are associated with the risk of cardiovascular death in patients with coronary artery disease: the AtheroGene study
    D A Tregouet
    INSERM, UMR_S 525, F 75013, Paris, France
    J Thromb Haemost 7:49-57. 2009
    ..Thrombin activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis. Results on the association between TAFI levels and the risk of coronary artery disease (CAD) are inconsistent...
  22. ncbi request reprint Relation of markers of inflammation (C-reactive protein, fibrinogen, von Willebrand factor, and leukocyte count) and statin therapy to long-term mortality in patients with angiographically proven coronary artery disease
    Christoph Bickel
    Department of Medicine II, Johannes Gutenberg University Mainz, Germany
    Am J Cardiol 89:901-8. 2002
    ..Statin therapy is associated with elevated hs-CRP, with a risk reduction for fatal coronary events, independent of LDL levels; this, in part, may be explained by the anti-inflammatory effects on atherosclerosis...
  23. doi request reprint [The length of hospital stay in patients with acute coronary syndrome is reduced by establishing a chest pain unit]
    T Keller
    II Medizinische Klinik und Poliklinik für Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsmedizin der Johannes Gutenberg Universität, Mainz, Mainz, Deutschland
    Herz 37:301-7. 2012
    ..The aim of the present analysis is to evaluate to what extent establishing a dedicated chest pain unit (CPU) influences the length of hospital stay in ACS patients...
  24. ncbi request reprint Association between P-selectin gene polymorphisms and soluble P-selectin levels and their relation to coronary artery disease
    S C Barbaux
    Institut National de la Santé et de la Recherche Médicale INSERM U525, Paris, France
    Arterioscler Thromb Vasc Biol 21:1668-73. 2001
    ....
  25. ncbi request reprint Comparison of diagnostic performance of cardiac troponin I on the IMMULITE system with other automated troponin I assays in minor myocardial damage
    G Hafner
    Institute of Clinical Chemistry and Laboratory Medicine, University Hospital, Mainz, Germany
    Scand J Clin Lab Invest 61:227-35. 2001
    ..In conclusion, the new assay is sensitive for the determination of cTnI and easy to perform within 45 min...
  26. ncbi request reprint Comparative impact of multiple biomarkers and N-Terminal pro-brain natriuretic peptide in the context of conventional risk factors for the prediction of recurrent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study
    Stefan Blankenberg
    Department of Medicine II, Johannes Gutenberg University Mainz, Mainz, Germany
    Circulation 114:201-8. 2006
    ....
  27. ncbi request reprint Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease
    Christoph Bickel
    Department of Medicine II, Johannes Gutenberg University Mainz, Mainz, Germany
    Am J Cardiol 89:12-7. 2002
    ..23 [95% CI 1.11 to 1.36], p <0.001) in patients with CAD. Thus, uric acid is an independent predictor of mortality in patients with CAD...
  28. ncbi request reprint Common genetic variation of the cholesteryl ester transfer protein gene strongly predicts future cardiovascular death in patients with coronary artery disease
    Stefan Blankenberg
    Department of Medicine II, Johannes Gutenberg University Mainz, Mainz, Germany
    J Am Coll Cardiol 41:1983-9. 2003
    ..We sought to evaluate the association between cholesteryl ester transfer protein (CETP) genotypes and the risk of future cardiovascular mortality in patients with coronary artery disease (CAD)...
  29. doi request reprint [Patient satisfaction in acute coronary syndrome. Improvement through the establishment of a chest pain unit]
    S Tzikas
    II Medizinische Klinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg Universität, 55131 Mainz, Deutschland
    Herz 35:403-9. 2010
    ..The aim of this study is to evaluate the experiences of patients receiving CPU care and routine emergency department (ED) treatment for acute chest pain...
  30. ncbi request reprint Analysis of N-terminal-pro-brain natriuretic peptide and C-reactive protein for risk stratification in stable and unstable coronary artery disease: results from the AtheroGene study
    Renate Schnabel
    Department of Medicine II, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Eur Heart J 26:241-9. 2005
    ..Little is known about patients with stable angina pectoris (SAP). We aimed to investigate the prognostic impact of Nt-proBNP in a population with CAD especially focussing on patients with SAP...
  31. ncbi request reprint Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease
    Ewa Ninio
    INSERM U525 IFR14 Coeur Muscle Vaisseaux and Université PM Curie Faculté de Médecine Pitié Salpêtriére, Paris, France
    Hum Mol Genet 13:1341-51. 2004
    ..A more likely interpretation is that the A379V polymorphism might modify the enzyme function towards a more anti-atherogenic form. Polymorphisms of the PTAFR gene were not related to any phenotype...
  32. pmc Genetics and beyond--the transcriptome of human monocytes and disease susceptibility
    Tanja Zeller
    Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    PLoS ONE 5:e10693. 2010
    ....
  33. ncbi request reprint High plasma phospholipid transfer protein levels as a risk factor for coronary artery disease
    Axel Schlitt
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    Arterioscler Thromb Vasc Biol 23:1857-62. 2003
    ..PLTP-deficient mice have demonstrated increased antioxidation potential as well as a decrease in apolipoprotein B secretion and atherosclerotic lesions. In humans, high PLTP is associated with type II diabetes and obesity...
  34. doi request reprint Sensitive troponin I assay in early diagnosis of acute myocardial infarction
    Till Keller
    Department of Medicine II, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    N Engl J Med 361:868-77. 2009
    ..Cardiac troponin testing is central to the diagnosis of acute myocardial infarction. We evaluated a sensitive troponin I assay for the early diagnosis and risk stratification of myocardial infarction...
  35. doi request reprint [The Gutenberg Health Study]
    P S Wild
    Centrum für Thrombose und Hämostase, Universitätsmedizin Mainz, Johannes Gutenberg Universitat Mainz, Langenbeckstr 1, 55131, Mainz, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 55:824-9. 2012
    ..5 years. After 5 years a detailed follow-up examination comparable to the visit at study inclusion will be performed in the study center. Further follow-up visits of the cohort are envisaged...
  36. ncbi request reprint Contribution of 30 biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts: the MONICA, risk, genetics, archiving, and monograph (MORGAM) biomarker project
    Stefan Blankenberg
    Department of Medicine II, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Circulation 121:2388-97. 2010
    ..We report results from 2 cohorts in such a continuing study...
  37. ncbi request reprint The superiority of TIMI frame count in detecting coronary flow changes after coronary stenting compared to TIMI Flow Classification
    Christoph Bickel
    II Medical Clinic, Johannes Gutenburg University, Mainz, Germany
    J Invasive Cardiol 14:590-6. 2002
    ....
  38. ncbi request reprint Lack of association between complement factor H polymorphisms and coronary artery disease or myocardial infarction
    Viviane Nicaud
    INSERM UMR S525, Faculté de Médecine Pitié Salpêtrière, 91 Boulevard de l Hopital, Paris, 75013, France
    J Mol Med (Berl) 85:771-5. 2007
    ..Genotype and allele frequencies were similar in cases and controls. These results do not support an involvement of common nonsynonymous polymorphisms of the CFH gene in predisposition to CAD and its complications...
  39. ncbi request reprint Glutathione peroxidase-1 activity, atherosclerotic burden, and cardiovascular prognosis
    Christine Espinola-Klein
    Medical Department II, Johannes Gutenberg University Mainz, Germany
    Am J Cardiol 99:808-12. 2007
    ..9%, p <0.0001). In conclusion, decreased red blood cell GPX-1 activity is associated with increased cardiovascular risk according to the extent of atherosclerosis...
  40. ncbi request reprint Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice
    Michael Torzewski
    Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, 55101 Mainz, Germany
    Arterioscler Thromb Vasc Biol 27:850-7. 2007
    ..The present study analyzed the effect of glutathione peroxidase-1 deficiency on atherogenesis in the apolipoprotein E-deficient mouse...
  41. ncbi request reprint Differential haplotypic expression of the interleukin-18 gene
    Sandrine Barbaux
    INSERM, UMR S 525, Paris, France
    Eur J Hum Genet 15:856-63. 2007
    ....
  42. ncbi request reprint Impact of metabolic syndrome on atherosclerotic burden and cardiovascular prognosis
    Christine Espinola-Klein
    Department of Medicine II, Johannes Gutenberg University, Mainz, and Department of Internal Medicine, Bundeswehrzentralkrankenhaus, Koblenz, Germany
    Am J Cardiol 99:1623-8. 2007
    ..Moreover, patients with high atherosclerotic burden and MS should be considered a high-risk population and treated accordingly...
  43. ncbi request reprint Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro
    Jörn F Dopheide
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    Coron Artery Dis 18:523-31. 2007
    ..So far, their role in atherosclerosis has not been fully elucidated. We investigated the phenotypic properties of DCs in patients with coronary artery disease (CAD) in comparison to healthy individuals...
  44. doi request reprint Impact of inflammatory markers on cardiovascular mortality in patients with metabolic syndrome
    Christine Espinola-Klein
    Medical Department II, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz, Germany
    Eur J Cardiovasc Prev Rehabil 15:278-84. 2008
    ..The aim of this study was to address the role of C-reactive protein, fibrinogen, interleukin-6 (IL-6) and IL-18 (IL-18) on cardiovascular prognosis in accordance to MS...
  45. doi request reprint Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: results of the randomized, double-blind, placebo-controlled INEF study
    Ascan Warnholtz
    Department of Medicine II, Johannes Gutenberg University Mainz, Mainz, Germany
    Atherosclerosis 204:216-21. 2009
    ..D.) N: +3.25+/-3.88%, C: +1.03+/-2.71% in low tertile HDL-C <or=45 mg/dl. P=0.047). The present findings indicate that ER-niacin treatment improves endothelial dysfunction in patients with CAD and low HDL-C, but not with normal HDL-C...
  46. doi request reprint Type-D personality and depersonalization are associated with suicidal ideation in the German general population aged 35-74: results from the Gutenberg Heart Study
    Matthias Michal
    Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Germany
    J Affect Disord 125:227-33. 2010
    ..The present study aims to investigate the contribution of under researched factors contributing to SID such as depersonalization, Type-D personality and cardiovascular risk factors...
  47. ncbi request reprint Plasma PAF-acetylhydrolase in patients with coronary artery disease: results of a cross-sectional analysis
    Stefan Blankenberg
    INSERM U525 IFR14, Coeur Muscle Vaisseaux and Université Pierre and Marie Curie, Faculté de Médecine Pitié Salpêtrière, Paris, France
    J Lipid Res 44:1381-6. 2003
    ..No correlation was found between PAF-AH levels and those of common markers of inflammation. This study and the previous ones raise the important issue of whether PAF-AH is simply a marker of risk or directly promotes atherosclerosis...
  48. ncbi request reprint Inflammatory markers and cardiovascular risk in the metabolic syndrome
    Christine Espinola-Klein
    2nd Department of Internal Medicine, University Medical Center of the Johannes, Gutenberg University Mainz, Germany
    Front Biosci (Landmark Ed) 16:1663-74. 2011
    ..Inflammation has a central role in the pathogenesis of MetS and in mediating its impact on the development of cardiovascular disease. Knowledge of these mechanisms has relevance in the context of preventive and therapeutic strategies...
  49. ncbi request reprint Annexin V does not represent a diagnostic alternative to myoglobin for early detection of myocardial infarction
    Dirk Peetz
    Institute of Clinical Chemistry, Johannes Gutenberg University Hospital, Mainz, Germany
    Clin Lab 48:517-23. 2002
    ..Increased annexin V levels are induced by several diseases, leading to a low specificity for the diagnosis of a myocardial injury...
  50. ncbi request reprint Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina
    Stefan Blankenberg
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    Circulation 106:24-30. 2002
    ..However, epidemiological data evaluating the role of IL-18 levels in atherosclerosis are lacking...
  51. ncbi request reprint Inflammation, atherosclerotic burden and cardiovascular prognosis
    Christine Espinola-Klein
    Medical Department II, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Atherosclerosis 195:e126-34. 2007
    ..The aim of this study was to evaluate the impact of various inflammatory markers on atherosclerotic burden and cardiovascular prognosis...
  52. ncbi request reprint Prognostic value of lipoproteins and their relation to inflammatory markers among patients with coronary artery disease
    Axel Schlitt
    Department of Medicine II, Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, 55101 Mainz, Germany
    Int J Cardiol 102:477-85. 2005
    ..There is growing evidence indicating that those lipoprotein factors are related to the inflammatory process in atherogenesis...
  53. ncbi request reprint [Modern therapy in acute coronary syndrome]
    Hans Jurgen Rupprecht
    II Medizinische Klinik und Poliklinik der Johannes Gutenberg Universität Mainz
    Med Klin (Munich) 97:236-43. 2002
    ..Antianginal treatment should include nitrates and betablockers. A treatment with statins and ACE-inhibitors should be initiated in the early course of acute coronary syndrome for plaque stabilization...
  54. ncbi request reprint Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk
    Stefan Blankenberg
    Department of Medicine II, Johannes Gutenberg University Mainz, Mainz, Germany
    Circ Res 99:102-8. 2006
    ..The role of CASP1 genetic variations in the susceptibility to myocardial infarction requires further investigation...
  55. ncbi request reprint [Manifestations of atherosclerosis in various vascular regions. Similarities and differences regarding epidemiology, etiology and prognosis]
    Christine Espinola-Klein
    II Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz
    Med Klin (Munich) 97:221-8. 2002
    ..Another important therapeutic regime is the use of statins, which seem to be not only effective in lipid lowering but also in plaque stabilization...
  56. ncbi request reprint Impact of infectious burden on extent and long-term prognosis of atherosclerosis
    Christine Espinola-Klein
    Department of Medicine II, Johannes Gutenberg University Mainz, Germany
    Circulation 105:15-21. 2002
    ..Moreover, this effect could be multiplied by the number of pathogens to which an individual had been exposed...
  57. ncbi request reprint Impact of infectious burden on progression of carotid atherosclerosis
    Christine Espinola-Klein
    Department of Medicine II, Johannes Gutenberg University Mainz, Germany
    Stroke 33:2581-6. 2002
    ..In a prospective study, we evaluated the effect of 8 pathogens and the aggregate pathogen burden on the progression of carotid atherosclerosis...
  58. doi request reprint Tako-Tsubo syndrome: dying of a broken heart?
    Ch Sinning
    Department of Internal Medicine II, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Clin Res Cardiol 99:771-80. 2010
    ..The Tako-Tsubo syndrome is a diagnosis encountered in patients with acute coronary syndrome and, therefore, is important to consider...
  59. ncbi request reprint Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease
    Laurence Tiret
    INSERM U525, Universite Pierre et Marie Curie, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Circulation 112:643-50. 2005
    ..The present study investigated the genetic variability of 4 genes of the IL-18 system-IL18, IL18R1, IL18RAP, and IL18BP-in relation to circulating IL-18 levels and cardiovascular mortality...
  60. pmc Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease The SElenium Therapy in Coronary Artery disease Patients (SETCAP) Study
    Renate Schnabel
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    Am Heart J 156:1201.e1-11. 2008
    ..We assessed the effect of selenium supplementation on GPx-1 in cell culture and on endothelial function in a prospective clinical trial...
  61. ncbi request reprint Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: results from the AtheroGene Study
    Renate Schnabel
    Department of Medicine II, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Circ Res 97:e53-9. 2005
    ..001) as the strongest risk predictors. High levels of baseline ADMA independently predict future cardiovascular risk. ADMA has prognostic value beyond traditional risk factors and novel biomarkers and might guide therapeutic strategies...
  62. ncbi request reprint Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease
    Stefan Blankenberg
    Department of Medicine II, Johannes Gutenberg University Mainz, Germany
    Circulation 107:1579-85. 2003
    ..However, epidemiological data evaluating the prognostic impact of circulating concentrations and functional genetic variations of MMP-9 are lacking...
  63. doi request reprint Copeptin improves early diagnosis of acute myocardial infarction
    Till Keller
    Department of Medicine II, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    J Am Coll Cardiol 55:2096-106. 2010
    ..Early identification of myocardial infarction in chest pain patients is crucial to identify patients at risk and to maintain a fast treatment initiation...
  64. ncbi request reprint Resistin, acute coronary syndrome and prognosis results from the AtheroGene study
    Edith Lubos
    Department of Medicine II, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Atherosclerosis 193:121-8. 2007
    ..We investigated the impact of resistin as a diagnostic marker in patients with acute coronary syndrome and its prognostic value for future cardiovascular events...
  65. doi request reprint Distribution and categorization of left ventricular measurements in the general population: results from the population-based Gutenberg Heart Study
    Philipp S Wild
    Department of Medicine II, Institute for Clinical Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    Circ Cardiovasc Imaging 3:604-13. 2010
    ..This work presents empirically derived reference values from a large-scale, epidemiologic study conducted with state-of-the-art imaging technology and methods...
  66. ncbi request reprint B-type natriuretic peptide and the risk of cardiovascular events and death in patients with stable angina: results from the AtheroGene study
    Renate Schnabel
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    J Am Coll Cardiol 47:552-8. 2006
    ..The aim of this study was to assess the predictive value of the cardiac hormone B-type natriuretic peptide (BNP) for long-term outcome in a large cohort of stable angina patients...
  67. ncbi request reprint [Immunactivation in chronic heart failure. Inflammatory mediators]
    S Genth-Zotz
    II Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Z Kardiol 93:IV24-30. 2004
    ..Nevertheless, TNF antagonism remains a therapeutic option and should be focussed on patients with systemic immune activation, particularly at times of exacerbation...
  68. doi request reprint Cystatin C and cardiovascular mortality in patients with coronary artery disease and normal or mildly reduced kidney function: results from the AtheroGene study
    Till Keller
    Department of Medicine II, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Eur Heart J 30:314-20. 2009
    ..Cystatin C is a promising marker to reliably mirror renal function. The role of cystatin C in patients with coronary artery disease (CAD) and normal or mildly reduced kidney function is the subject of current investigation...
  69. ncbi request reprint Adhesion molecules and atherosclerosis
    Stefan Blankenberg
    INSERM U525, Faculte de Medecine, 91 Bd de l Hopital, 75634 Paris Cedex 13, France
    Atherosclerosis 170:191-203. 2003
    ....
  70. doi request reprint Improved outcome in acute coronary syndrome by establishing a chest pain unit
    Till Keller
    Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Clin Res Cardiol 99:149-55. 2010
    ..The aim of this analysis was to elucidate whether treatment of ACS patients in the CPU versus emergency department (ED) has prognostic implications...
  71. ncbi request reprint Prognostic value of tissue inhibitor of metalloproteinase-1 for cardiovascular death among patients with cardiovascular disease: results from the AtheroGene study
    Edith Lubos
    Department of Medicine II, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Eur Heart J 27:150-6. 2006
    ..Little is known about the prognostic impact of the TIMP-1/matrix metalloproteinase complex in patients with future cardiovascular death...
  72. ncbi request reprint Influence of HMG-CoA reductase inhibitors on markers of coagulation, systemic inflammation and soluble cell adhesion
    Christoph Bickel
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    Int J Cardiol 82:25-31. 2002
    ..We therefore examined the impact of statins on laboratory markers of coagulation, inflammation and soluble cell adhesion to further explore these effects in 950 hospitalised patients with angiographically proven CAD...
  73. pmc Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study
    Edith Lubos
    Department of Medicine II, Johannes Gutenberg University Mainz, Langenbeckstr 1, Mainz, Germany
    Atherosclerosis 209:271-7. 2010
    ..We aimed to investigate the impact of serum selenium concentration in patients presenting with stable angina pectoris (SAP) or acute coronary syndrome (ACS) on long term prognosis...
  74. ncbi request reprint Up-and-coming markers: myeloperoxidase, a novel biomarker test for heart failure and acute coronary syndrome application?
    Christoph Sinning
    Department of Medicine II, Johannes Gutenberg University Mainz, Germany
    Congest Heart Fail 14:46-8. 2008
    ..In terms of ACS, inclusion of MPO into a multiple marker strategy might add to enhance diagnosis and therapy decision making. Therefore, MPO is a biomarker worthwhile of further evaluation in the setting of cardiovascular disease...
  75. pmc Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease
    Sarah Gora
    INSERM, UMRS937, UPMC Université Paris 06 and Faculté de Médecine Pierre et Marie Curie, 91, Boulevard de l Hopital, 75634, Paris, France
    J Mol Med (Berl) 87:723-33. 2009
    ..Due to the potential role of hGX sPLA2 in inflammatory processes, these polymorphisms should be investigated in other inflammatory diseases...
  76. ncbi request reprint Impact of C-reactive protein and fibrinogen on cardiovascular prognosis in patients with stable angina pectoris: the AtheroGene study
    Jan Malte Sinning
    Department of Medicine, Bundeswehrzentralkrankenhaus Koblenz, Germany
    Eur Heart J 27:2962-8. 2006
    ..We evaluated the potential clinical use of C-reactive protein and fibrinogen in patients already suffering from coronary artery disease (CAD)...
  77. ncbi request reprint The inflammatory hypothesis: any progress in risk stratification and therapeutic targets?
    Stefan Blankenberg
    Circulation 114:1557-60. 2006
  78. ncbi request reprint Is heme oxygenase-1 a causal player for plaque stability?
    Christine Espinola-Klein
    Stroke 36:1901-3. 2005
  79. pmc Genomewide association analysis of coronary artery disease
    Nilesh J Samani
    University of Leicester, Leicester, United Kingdom
    N Engl J Med 357:443-53. 2007
    ..Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed a joint analysis of two genomewide association studies of coronary artery disease...
  80. ncbi request reprint Association of classical and related inflammatory markers with high-sensitivity C-reactive protein in healthy individuals: results from the Stanislas cohort
    Hind Berrahmoune
    INSERM, U525, Equipe 4, Nancy, France
    Clin Chem Lab Med 45:1339-46. 2007
    ..Therefore, as a first step, we examined interrelationships between serum hs-CRP concentrations and inflammatory, adhesion and growth factors in healthy adults...
  81. ncbi request reprint Activation of polymorphonuclear neutrophils in patients with impaired left ventricular function
    Volker Rudolph
    Department of Cardiology, Heart Center, University Hospital Hamburg Eppendorf, Hamburg 20246, Germany
    Free Radic Biol Med 43:1189-96. 2007
    ..Given its potent proinflammatory properties, MPO may represent an important mechanistic link to LV dysfunction and deserves to be evaluated as both marker and therapeutic target in this disease...
  82. ncbi request reprint Oxidative stress in cardiovascular disease: successful translation from bench to bedside?
    Renate Schnabel
    Circulation 116:1338-40. 2007
  83. doi request reprint The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study
    Malcolm J West
    University of Queensland, Brisbane, Australia
    Eur Heart J 29:923-31. 2008
    ....
  84. pmc Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease
    Heribert Schunkert
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Circulation 117:1675-84. 2008
    ..3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis...
  85. ncbi request reprint Atherosclerosis, oxidative stress and glutathione peroxidase-1: a new kid on the block
    Karl J Lackner
    Ital Heart J 5:169-72. 2004
  86. ncbi request reprint Phospholipid transfer protein in hemodialysis patients
    Axel Schlitt
    Department of Medicine III, Martin Luther University, Halle Wittenberg, Germany
    Am J Nephrol 27:138-43. 2007
    ..The role of PLTP in atherogenesis is still controversial. We aimed to investigate PLTP activity in hemodialysis (HD) patients, a population which has an increased risk for the development of atherosclerosis...
  87. ncbi request reprint Serum sphingomyelin levels are related to the clearance of postprandial remnant-like particles
    Axel Schlitt
    Department of Anatomy and Cell Biology and Scientific Computing Center, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
    J Lipid Res 46:196-200. 2005
    ..Serum SM was positively correlated with serum TG (P <0.001), RLP SM (P <0.001), RLP TG (P <0.001), and RLP cholesterol (P <0.001) levels. It is our conclusion that serum SM is a marker for the clearance of RLPs...