Norbert Blank

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Frequency of disease-associated and other nuclear autoantibodies in patients of the German Network for Systemic Scleroderma: correlation with characteristic clinical features
    Rudolf Mierau
    Laboratory at Rheumaklinik Aachen, Hauptstrasse 21, Aachen, D 52066, Germany
    Arthritis Res Ther 13:R172. 2011
  2. pmc Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS)
    Jasmin B Kuemmerle-Deschner
    Division of Pediatric Rheumatology, Department of Pediatrics, University Children s Hospital Tuebingen, Hoppe Seyler Strasse 1, 72076 Tubingen, Tuebingen, Germany
    Arthritis Res Ther 13:R34. 2011
  3. doi request reprint [Radiographic healing of sarcoid bone erosion]
    N Blank
    Innere Medizin 5, Sektion Rheumatologie, Universitat Heidelberg, 69120 Heidelberg
    Z Rheumatol 68:763-5. 2009
  4. doi request reprint [Diagnostics and therapy of AA amyloidosis]
    N Blank
    Medizinische Klinik V, Sektion Rheumatologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland
    Pathologe 30:219-25. 2009
  5. ncbi request reprint Atorvastatin inhibits T cell activation through 3-hydroxy-3-methylglutaryl coenzyme A reductase without decreasing cholesterol synthesis
    Norbert Blank
    Department of Medicine V, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany
    J Immunol 179:3613-21. 2007
  6. ncbi request reprint Familial early onset sarcoidosis with bone cysts and erosions
    Norbert Blank
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Skeletal Radiol 36:891-3. 2007
  7. ncbi request reprint Cholera toxin binds to lipid rafts but has a limited specificity for ganglioside GM1
    Norbert Blank
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany
    Immunol Cell Biol 85:378-82. 2007
  8. doi request reprint Apoptotic-cell-derived membrane vesicles induce an alternative maturation of human dendritic cells which is disturbed in SLE
    Eva Marie Fehr
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    J Autoimmun 40:86-95. 2013
  9. ncbi request reprint Inhibition of sphingolipid synthesis impairs cellular activation, cytokine production and proliferation in human lymphocytes
    Norbert Blank
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Biochem Pharmacol 71:126-35. 2005
  10. doi request reprint Decrease of sialic acid residues as an eat-me signal on the surface of apoptotic lymphocytes
    Hanna Marie Meesmann
    Department of Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    J Cell Sci 123:3347-56. 2010

Collaborators

Detail Information

Publications22

  1. pmc Frequency of disease-associated and other nuclear autoantibodies in patients of the German Network for Systemic Scleroderma: correlation with characteristic clinical features
    Rudolf Mierau
    Laboratory at Rheumaklinik Aachen, Hauptstrasse 21, Aachen, D 52066, Germany
    Arthritis Res Ther 13:R172. 2011
    ..In the present study, we analysed in detail nuclear autoantibodies and their associations in systemic sclerosis (SSc) patients included in the German Network for Systemic Scleroderma Registry...
  2. pmc Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS)
    Jasmin B Kuemmerle-Deschner
    Division of Pediatric Rheumatology, Department of Pediatrics, University Children s Hospital Tuebingen, Hoppe Seyler Strasse 1, 72076 Tubingen, Tuebingen, Germany
    Arthritis Res Ther 13:R34. 2011
    ..Canakinumab, a fully human anti-IL-1β antibody, produces sustained selective inhibition of IL-1β. This study was conducted to assess the efficacy, safety, and pharmacokinetics of canakinumab in the treatment of pediatric CAPS patients...
  3. doi request reprint [Radiographic healing of sarcoid bone erosion]
    N Blank
    Innere Medizin 5, Sektion Rheumatologie, Universitat Heidelberg, 69120 Heidelberg
    Z Rheumatol 68:763-5. 2009
    ..Treatment with methotrexate and steroids can relieve symptoms and stabilize the disease. In refractory cases leflunomide, azathioprine, hydroxychloroquine or antibodies against TNF-alpha can be additionally administered...
  4. doi request reprint [Diagnostics and therapy of AA amyloidosis]
    N Blank
    Medizinische Klinik V, Sektion Rheumatologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland
    Pathologe 30:219-25. 2009
    ..Eprodisate is currently being investigated for AA amyloidosis and renal involvement...
  5. ncbi request reprint Atorvastatin inhibits T cell activation through 3-hydroxy-3-methylglutaryl coenzyme A reductase without decreasing cholesterol synthesis
    Norbert Blank
    Department of Medicine V, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany
    J Immunol 179:3613-21. 2007
    ..Statins induce both lower levels of low-density lipoprotein cholesterol and inhibition of T cell activation, which might contribute to an inhibition of atherosclerosis...
  6. ncbi request reprint Familial early onset sarcoidosis with bone cysts and erosions
    Norbert Blank
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Skeletal Radiol 36:891-3. 2007
    ..This is the first report demonstrating bone cysts and erosions which could be a diagnostic feature in this rare disease and may help to differentiate other rheumatoid disorders...
  7. ncbi request reprint Cholera toxin binds to lipid rafts but has a limited specificity for ganglioside GM1
    Norbert Blank
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany
    Immunol Cell Biol 85:378-82. 2007
    ....
  8. doi request reprint Apoptotic-cell-derived membrane vesicles induce an alternative maturation of human dendritic cells which is disturbed in SLE
    Eva Marie Fehr
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    J Autoimmun 40:86-95. 2013
    ..Interestingly, when compared to normal healthy donors SLE patients-derived dendritic cells showed a significantly different phenotype lacking the downregulation of MHC class II, which correlated to disease activity...
  9. ncbi request reprint Inhibition of sphingolipid synthesis impairs cellular activation, cytokine production and proliferation in human lymphocytes
    Norbert Blank
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Biochem Pharmacol 71:126-35. 2005
    ..However, inhibition of glucosphingolipid synthesis itself did not inhibit cellular activation. Our data show that glucosphingolipids - in contrast to cholesterol - are not essential for the stabilisation of MM...
  10. doi request reprint Decrease of sialic acid residues as an eat-me signal on the surface of apoptotic lymphocytes
    Hanna Marie Meesmann
    Department of Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    J Cell Sci 123:3347-56. 2010
    ..Thus, depending on cell type and activation status, changes in surface glycosylation can either directly mediate cellular engulfment or enhance phagocytosis by cooperation with further engulfment signals...
  11. doi request reprint Clinical manifestations but not cytokine profiles differentiate adult-onset Still's disease and sepsis
    Monika Rau
    University of Heidelberg Rheumatology, Im Neuenheimer Feld 410, Internal Medicine 5, Heidelberg 69120, Germany
    J Rheumatol 37:2369-76. 2010
    ..To analyze clinical manifestations, serum ferritin, and serum cytokine levels in patients with adult-onset Still's disease (AOSD) or bacterial sepsis and to evaluate their potential use for differential diagnosis...
  12. doi request reprint Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127 -/low regulatory T cells in patients with active systemic lupus erythematosus
    Ram Kumar Chowdary Venigalla
    University of Heidelberg, Heidelberg, Germany
    Arthritis Rheum 58:2120-30. 2008
    ..To overcome this problem, we analyzed the phenotype and function of CD4+,CD25high,CD127(-/low) natural Treg (nTreg) cells isolated from the peripheral blood of patients with SLE...
  13. ncbi request reprint Apo material as a trigger for inflammation in systemic lupus erythematosus
    Hanna Marie Meesmann
    Department of Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Autoimmunity 42:251-3. 2009
    ..This review highlights the role of apo material as source for AAg and as a trigger for chronic inflammation in the pathogenesis of SLE...
  14. pmc Exercise training in pulmonary arterial hypertension associated with connective tissue diseases
    Ekkehard Grunig
    Centre for Pulmonary Hypertension at Thoraxclinic Heidelberg, Thoraxclinic at the University Hospital Heidelberg, Amalienstrasse 5, Heidelberg, 69126, Germany
    Arthritis Res Ther 14:R148. 2012
    ..The objective of this prospective study was to assess short- and long-term efficacy of exercise training (ET) as add-on to medical therapy in patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-APAH)...
  15. ncbi request reprint Multiple bone lesions of systemic multifocal fibrosclerosis
    Norbert Blank
    Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, 69120 Heidelberg, Germany
    AJR Am J Roentgenol 185:668-70. 2005
  16. doi request reprint Anti-HLA-DR-triggered monocytes mediate in vitro T cell anergy
    Martin A Kriegel
    Department of Medicine III, Institute for Clinical Immunology and Rheumatology, University of Erlangen Nuremberg, Erlangen, Germany
    Int Immunol 20:601-13. 2008
    ..In summary, anti-HLA-DR treatment can generate tolerogenic monocytes transmitting T cell anergy that may be exploited for future immunomodulatory strategies to treat immune-mediated disease states...
  17. pmc Interleukin-4 supports interleukin-12-induced proliferation and interferon-gamma secretion in human activated lymphoblasts and T helper type 1 cells
    Martin A Kriegel
    Department of Medicine III, Institute for Clinical Immunology and Rheumatology, University of Erlangen Nuremberg, Erlangen, Germany
    Immunology 119:43-53. 2006
    ..These findings should be of importance for the design of cytokine-targeted therapies of human Th-cell-driven diseases...
  18. ncbi request reprint A fast, simple and sensitive method for the detection and quantification of detergent-resistant membranes
    Norbert Blank
    Institute for Clinical Immunology and Rheumatology, University of Erlangen Nuremberg, Glueckstrasse 4a, Germany
    J Immunol Methods 271:25-35. 2002
    ..The presence of protein in these fractions was confirmed by silver-stained polyacrylamide gels. We confirmed the presence of adaptor molecules (LAT) and Src kinases (Lck) in the DRM containing fractions 4 to 6...
  19. ncbi request reprint Hyporesponsiveness to gammac-chain cytokines in activated lymphocytes from patients with systemic lupus erythematosus leads to accelerated apoptosis
    Hanns Martin Lorenz
    Department of Medicine III, Institute for Clinical Immunology Rheumatology, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 32:1253-63. 2002
    ....
  20. pmc Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II
    Martin A Kriegel
    Department of Medicine III, Institute for Clinical Immunology and Rheumatology, University of Erlangen Nuremberg, Germany
    J Exp Med 199:1285-91. 2004
    ..The defect was persistent and not due to responder cell resistance. These data provide novel insights into the pathogenesis of APS-II and possibly human autoimmunity in general...
  21. ncbi request reprint Accumulation of histones in cell lysates precedes expression of apoptosis-related phagocytosis signals in human lymphoblasts
    Christoph Gabler
    Department of Medicine III, Institute for Clinical Immunology, Krankenhausstrasse 12, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Ann N Y Acad Sci 1010:221-4. 2003
    ..We hypothesize that a dysregulation of apoptosis during these early phases may contribute to the induction of autoimmunity against nuclear autoantigens as seen in SLE...
  22. ncbi request reprint MEK inhibitor U0126 interferes with immunofluorescence analysis of apoptotic cell death
    Norbert Blank
    Institute for Clinical Immunology, Department of Medicine III, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Cytometry 48:179-84. 2002
    ..We investigated the limitations of detection of apoptotic cell death and cytofluorometry in cells cultured in the presence of the MEK inhibitor U0126...