Stephan C Bischoff

Summary

Affiliation: University of Hohenheim
Country: Germany

Publications

  1. ncbi request reprint Food allergies
    Stephan C Bischoff
    Department of Medicine, Nutritional Medicine and Prevention, 140b, University of Hohenheim, Stuttgart, Fruwirthstr 12, 70593 Stuttgart, Germany
    Curr Gastroenterol Rep 8:374-82. 2006
  2. ncbi request reprint [Obesity-- current significance of nutritional therapy]
    Stephan C Bischoff
    Institut für Ernährungsmedizin, Universitat Hohenheim, Stuttgart
    Praxis (Bern 1994) 97:937-42. 2008
  3. doi request reprint Food allergy and eosinophilic gastroenteritis and colitis
    Stephan C Bischoff
    University of Hohenheim, 70593 Stuttgart, Germany
    Curr Opin Allergy Clin Immunol 10:238-45. 2010
  4. pmc Role of serotonin in fatty acid-induced non-alcoholic fatty liver disease in mice
    Yvonne Ritze
    Department of Nutritional Medicine, University of Hohenheim, Fruwirthstr, 12, 70599, Stuttgart, Germany
    BMC Gastroenterol 13:169. 2013
  5. pmc Multicenter evaluation of an interdisciplinary 52-week weight loss program for obesity with regard to body weight, comorbidities and quality of life--a prospective study
    S C Bischoff
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Int J Obes (Lond) 36:614-24. 2012
  6. pmc Effect of oral lactulose on clinical and immunohistochemical parameters in patients with inflammatory bowel disease: a pilot study
    Anne Hafer
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    BMC Gastroenterol 7:36. 2007
  7. ncbi request reprint Human mast cells, bacteria, and intestinal immunity
    Stephan C Bischoff
    Department of Nutritional Medicine and Immunology, University of Hohenheim, Stuttgart, Germany
    Immunol Rev 217:329-37. 2007
  8. ncbi request reprint Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data
    Stephan C Bischoff
    Department of Nutritional Medicine and Immunology, University of Hohenheim, Fruwirthstr 12, D 70593 Stuttgart, Germany
    Nat Rev Immunol 7:93-104. 2007
  9. ncbi request reprint Food allergies
    Stephan C Bischoff
    Stephan C Bischoff, MD Department of Medicine, Nutritional Medicine and Prevention, 140b, University of Hohenheim, Stuttgart, Fruwirthstr 12, 70593 Stuttgart, Germany
    Curr Treat Options Gastroenterol 10:34-43. 2007
  10. ncbi request reprint Nausea and nutrition
    Stephan C Bischoff
    Department of Nutritional Medicine and Prevention, University of Hohenheim, Fruwirthstr, 12, D 70593 Stuttgart, Germany
    Auton Neurosci 129:22-7. 2006

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Food allergies
    Stephan C Bischoff
    Department of Medicine, Nutritional Medicine and Prevention, 140b, University of Hohenheim, Stuttgart, Fruwirthstr 12, 70593 Stuttgart, Germany
    Curr Gastroenterol Rep 8:374-82. 2006
    ..Food intolerances (non-immunologic food incompatibilities often caused by specific enzyme deficiencies) must be diagnostically differentiated from food allergies...
  2. ncbi request reprint [Obesity-- current significance of nutritional therapy]
    Stephan C Bischoff
    Institut für Ernährungsmedizin, Universitat Hohenheim, Stuttgart
    Praxis (Bern 1994) 97:937-42. 2008
    ..The initial formula diet represents an initial aid, similar to anti-obesity drugs or the gastric banding, although comparative studies on the three procedures are lacking...
  3. doi request reprint Food allergy and eosinophilic gastroenteritis and colitis
    Stephan C Bischoff
    University of Hohenheim, 70593 Stuttgart, Germany
    Curr Opin Allergy Clin Immunol 10:238-45. 2010
    ..Their awareness increased enormously; therefore, we will review current knowledge about atopic gastrointestinal diseases for the allergologist...
  4. pmc Role of serotonin in fatty acid-induced non-alcoholic fatty liver disease in mice
    Yvonne Ritze
    Department of Nutritional Medicine, University of Hohenheim, Fruwirthstr, 12, 70599, Stuttgart, Germany
    BMC Gastroenterol 13:169. 2013
    ..Here, we examined the effect of fatty acid quantity (11% versus 15%) and quality (saturated, monounsaturated, or polyunsaturated fatty acids) on hepatic fat accumulation, intestinal barrier and the intestinal serotonergic system...
  5. pmc Multicenter evaluation of an interdisciplinary 52-week weight loss program for obesity with regard to body weight, comorbidities and quality of life--a prospective study
    S C Bischoff
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Int J Obes (Lond) 36:614-24. 2012
    ....
  6. pmc Effect of oral lactulose on clinical and immunohistochemical parameters in patients with inflammatory bowel disease: a pilot study
    Anne Hafer
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    BMC Gastroenterol 7:36. 2007
    ..The aim of the present study was to investigate the clinical and histological efficacy of lactulose in patients with inflammatory bowel disease (IBD), for which probiotic therapy yielded promising results...
  7. ncbi request reprint Human mast cells, bacteria, and intestinal immunity
    Stephan C Bischoff
    Department of Nutritional Medicine and Immunology, University of Hohenheim, Stuttgart, Germany
    Immunol Rev 217:329-37. 2007
    ..In particular, the role of bacteria and TLRs expression by mast cells for allergic reactions are discussed...
  8. ncbi request reprint Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data
    Stephan C Bischoff
    Department of Nutritional Medicine and Immunology, University of Hohenheim, Fruwirthstr 12, D 70593 Stuttgart, Germany
    Nat Rev Immunol 7:93-104. 2007
    ..This Review summarizes recent data on human mast cells, discusses differences with murine mast cells, and describes new tools to study this increasingly meaningful cell type in humans...
  9. ncbi request reprint Food allergies
    Stephan C Bischoff
    Stephan C Bischoff, MD Department of Medicine, Nutritional Medicine and Prevention, 140b, University of Hohenheim, Stuttgart, Fruwirthstr 12, 70593 Stuttgart, Germany
    Curr Treat Options Gastroenterol 10:34-43. 2007
    ..Food intolerances (nonimmunologic food incompatibilities often caused by specific enzyme deficiencies) must be diagnostically differentiated from food allergies...
  10. ncbi request reprint Nausea and nutrition
    Stephan C Bischoff
    Department of Nutritional Medicine and Prevention, University of Hohenheim, Fruwirthstr, 12, D 70593 Stuttgart, Germany
    Auton Neurosci 129:22-7. 2006
    ....
  11. doi request reprint Quercetin: potentials in the prevention and therapy of disease
    Stephan C Bischoff
    Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Curr Opin Clin Nutr Metab Care 11:733-40. 2008
    ..In the current review, we present the most recent findings on quercetin with regard to the pharmacology, the in-vitro and in-vivo effects in different cell systems and animal models, and the clinical effects in humans...
  12. doi request reprint Eosinophils and allergic diseases of the gastrointestinal tract
    Stephan C Bischoff
    Department of Nutritional Medicine 180, University of Hohenheim Stuttgart, Fruwirthstrasse 12, Stuttgart, Germany
    Best Pract Res Clin Gastroenterol 22:455-79. 2008
    ....
  13. ncbi request reprint Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice
    Stephan C Bischoff
    Department of Nutritional Medicine and Immunology, University of Hohenheim, D 70593 Stuttgart, Germany
    Am J Physiol Gastrointest Liver Physiol 296:G685-95. 2009
    ..Deletion of SERT thus increases the severity of TNBS colitis. These data suggest that 5-HT and its SERT-mediated termination play roles in intestinal immune/inflammatory responses in mice...
  14. pmc 'Gut health': a new objective in medicine?
    Stephan C Bischoff
    Institute of Nutritional Medicine, University of Hohenheim, Fruwirthstr 12, Stuttgart D 70599, Germany
    BMC Med 9:24. 2011
    ..In any case, methods of assessing, improving and maintaining gut health-related GI functions are of major interest in preventive medicine...
  15. doi request reprint Physiological and pathophysiological functions of intestinal mast cells
    Stephan C Bischoff
    Department of Nutritional Medicine and Immunology, University of Hohenheim, Stuttgart, Germany
    Semin Immunopathol 31:185-205. 2009
    ..The broad spectrum of functions makes mast cells a fascinating target for future pharmacological or nutritional interventions...
  16. ncbi request reprint A moderate weight reduction through dietary intervention decreases hepatic fat content in patients with non-alcoholic fatty liver disease (NAFLD): a pilot study
    Valentina Volynets
    Department of Nutritional Medicine 180 a, University of Hohenheim, Stuttgart, Germany
    Eur J Nutr 52:527-35. 2013
    ....
  17. doi request reprint Serotonin reuptake transporter (SERT) plays a critical role in the onset of fructose-induced hepatic steatosis in mice
    Synia Haub
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Am J Physiol Gastrointest Liver Physiol 298:G335-44. 2010
    ..Our data suggest that a loss of intestinal SERT is a critical factor in fructose-induced impairment of intestinal barrier function and subsequently the development of steatosis...
  18. doi request reprint Nutrition, intestinal permeability, and blood ethanol levels are altered in patients with nonalcoholic fatty liver disease (NAFLD)
    Valentina Volynets
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Dig Dis Sci 57:1932-41. 2012
    ..g., a diet rich in sugar) but also alterations at the level of the intestinal barrier have repeatedly been discussed to be involved in the development and progression of nonalcoholic fatty liver disease (NAFLD)...
  19. pmc Female mice are more susceptible to nonalcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response
    Astrid Spruss
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Mol Med 18:1346-55. 2012
    ..In conclusion, our data suggest that the sex-specific differences in the susceptibility to NAFLD are associated with differences in the regulation of the adiponectin-AMPK-PAI-1 signaling cascade...
  20. ncbi request reprint Laparoscopic sleeve gastrectomy compared to a multidisciplinary weight loss program for obesity--effects on body composition and protein status
    Asja E Friedrich
    Department of Nutritional Medicine, University of Hohenheim, Fruwirthstraße 12, 70593, Stuttgart, Germany
    Obes Surg 23:1957-65. 2013
    ..Therefore, we compared a favored surgical intervention with the most effective conservative treatment regarding anthropometry and nutritional status...
  21. doi request reprint Lactobacillus casei Shirota protects from fructose-induced liver steatosis: a mouse model
    Sabine Wagnerberger
    Department of Nutritional Medicine 180 a, University of Hohenheim, Fruwirthstrasse 12, 70599 Stuttgart, Germany
    J Nutr Biochem 24:531-8. 2013
    ..Taken together, the results of the present study suggest that the dietary intake of Lcs protects against the onset of fructose-induced NAFLD through mechanisms involving an attenuation of the TLR-4-signalling cascade in the liver...
  22. doi request reprint Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function
    Astrid Spruss
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Lab Invest 92:1020-32. 2012
    ....
  23. doi request reprint Toll-like receptors 1-9 are elevated in livers with fructose-induced hepatic steatosis
    Sabine Wagnerberger
    Department of Nutritional Medicine, University of Hohenheim 180 a, Fruwirthstrasse 12, 70599 Stuttgart, Germany
    Br J Nutr 107:1727-38. 2012
    ..g. MyD88 and iNOS) may be involved in the onset of fructose-induced NAFLD...
  24. pmc Protective effect of bile acids on the onset of fructose-induced hepatic steatosis in mice
    Valentina Volynets
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    J Lipid Res 51:3414-24. 2010
    ..Taken together, these data suggest that bile acids prevent fructose-induced hepatic steatosis in mice through mechanisms involving protection against the fructose-induced translocation of intestinal bacterial endotoxin...
  25. doi request reprint Serotonin receptor type 3 antagonists improve obesity-associated fatty liver disease in mice
    Synia Haub
    Department of Nutritional Medicine 180, University of Hohenheim, Fruwirthstr 12, 70599 Stuttgart, Germany
    J Pharmacol Exp Ther 339:790-8. 2011
    ..The effect involves the intestinal nervous system, resulting in a reduction of endotoxin influx into the liver and subsequently of liver inflammation and fat accumulation...
  26. doi request reprint Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice
    Astrid Spruss
    Department of Nutritional Medicine 180 a, University of Hohenheim, Stuttgart, Germany
    Hepatology 50:1094-104. 2009
    ..Markers of insulin resistance (e.g., plasma TNFalpha, retinol binding protein 4, and hepatic phospho-AKT) were only altered in fructose-fed wildtype animals...
  27. doi request reprint Role of the inducible nitric oxide synthase in the onset of fructose-induced steatosis in mice
    Astrid Spruss
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Antioxid Redox Signal 14:2121-35. 2011
    ....
  28. pmc Micronutrient deficiency in obese subjects undergoing low calorie diet
    Antje Damms-Machado
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Nutr J 11:34. 2012
    ..Furthermore, we determined the micronutrient status in obese subjects undergoing a standardized DRI-covering low-calorie formula diet to analyze if the DRI meet the micronutrient requirements of obese individuals...
  29. pmc Dietary pattern and leisure time activity of overweight and normal weight children in Germany: sex-specific differences
    Ina B Maier
    Department of Nutritional Medicine 180a, University of Hohenheim, Fruwirthstrasse 12, Stuttgart 70599, Germany
    Nutr J 12:14. 2013
    ..The aim of the present study was to determine if sex-specific differences in dietary pattern and leisure time activity already exist and are associated with weight status in young childhood...
  30. doi request reprint Fructose-induced steatosis in mice: role of plasminogen activator inhibitor-1, microsomal triglyceride transfer protein and NKT cells
    Giridhar Kanuri
    Department of Nutritional Medicine 180 a, University of Hohenheim, Stuttgart, Germany
    Lab Invest 91:885-95. 2011
    ..Taken together, these data suggest that PAI-1 has a causal role in mediating the early phase of fructose-induced liver damage in mice through signaling cascades downstream of Kupffer cells and TNF-α...
  31. pmc The circadian clock is functional in eosinophils and mast cells
    Anja Baumann
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Immunology 140:465-74. 2013
    ..In summary, the biological clock controls MC and eosinophils leading to circadian expression and release of their mediators and, hence it might be involved in the pathophysiology of allergy. ..
  32. doi request reprint Role of tumor necrosis factor α (TNFα) in the onset of fructose-induced nonalcoholic fatty liver disease in mice
    Giridhar Kanuri
    Department of Nutritional Medicine 180 a, University of Hohenheim, 70599 Stuttgart, Germany
    J Nutr Biochem 22:527-34. 2011
    ..Taken together, these data suggest that TNFα plays a casual role in the onset of fructose-induced liver damage as well as insulin resistance in mice through signaling cascades downstream of TNFR1...
  33. doi request reprint Central role of IL-6 and MMP-1 for cross talk between human intestinal mast cells and human intestinal fibroblasts
    Yves Montier
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Immunobiology 217:912-9. 2012
    ..Our data indicate an intimate cross talk between mucosal MC and FB resulting in MC survival and induction of a fibrolytic rather than a profibrotic state in FB...
  34. doi request reprint Cinnamon extract protects against acute alcohol-induced liver steatosis in mice
    Giridhar Kanuri
    Department of Nutritional Medicine, University of Hohenheim, D 70599 Stuttgart, Germany
    J Nutr 139:482-7. 2009
    ..Taken together, our data show that an alcohol extract of cinnamon bark may protect the liver from acute alcohol-induced steatosis through mechanisms involving the inhibition of MyD88 expression...
  35. ncbi request reprint Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake
    Sabine Thuy
    Department of Nutritional Medicine 180a, University of Hohenheim, 70599 Stuttgart, Germany
    J Nutr 138:1452-5. 2008
    ..01), and sucrose (Spearman r = 0.70; P < 0.01). In conclusion, our results suggest that dietary fructose intake, increased intestinal translocation of bacterial endotoxin, and PAI-1 may contribute to the development of NAFLD in humans...
  36. ncbi request reprint Combined arginine and glutamine decrease release of de novo synthesized leukotrienes and expression of proinflammatory cytokines in activated human intestinal mast cells
    Sandra Lechowski
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Eur J Nutr 52:505-12. 2013
    ..Glutamine and arginine modulate inflammatory responses of epithelial cells and monocytes. Here, we studied the response of human mast cells to pharmacological doses of arginine and glutamine...
  37. doi request reprint Human intestinal mast cells are a potent source of multiple chemokines
    Katrin Feuser
    Department of Nutritional Medicine, University of Hohenheim, Fruwirthstraße 12, 70599 Stuttgart, Germany
    Cytokine 58:178-85. 2012
    ..Furthermore, combined treatment with IL-4 and SCF increases the antigen-mediated expression and release of multiple chemokines, but IL-4 priming inhibits the expression of CCL20, CXCL2, and CXCL3...
  38. doi request reprint A low fructose diet in the treatment of pediatric obesity: a pilot study
    Ina B Maier
    Department of Nutritional Medicine 180 a, University of Hohenheim, Stuttgart, Germany
    Pediatr Int 53:303-8. 2011
    ....
  39. doi request reprint Akt cross-links IL-4 priming, stem cell factor signaling, and IgE-dependent activation in mature human mast cells
    Katrin Feuser
    Department of Nutritional Medicine, University of Hohenheim, Fruwirthstraße 12, 70593 Stuttgart, Germany
    Mol Immunol 48:546-52. 2011
    ..In summary, our data demonstrate that ERK, p38, and especially Akt play an important role in cross-linking IL-4 priming, SCF signaling, and IgE-dependent activation of mature human mast cells...
  40. ncbi request reprint Effect of tryptophan supplementation on diet-induced non-alcoholic fatty liver disease in mice
    Yvonne Ritze
    Department of Nutritional Medicine, University of Hohenheim, Fruwirthstrasse 12, Stuttgart70599, Germany
    Br J Nutr 112:1-7. 2014
    ..The underlying mechanisms are not clear, but probably involve stabilisation of the intestinal barrier in the upper small intestine and amelioration of the dysregulated intestinal serotonergic system...
  41. doi request reprint Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin
    Ina Bergheim
    Department of Nutritional Medicine 180, University of Hohenheim, Fruwirthstrasse 12, 70599 Stuttgart, Germany
    J Hepatol 48:983-92. 2008
    ..The aim of the present study was to test the effects of ad libitum access to different sugars consumed in drinking water on hepatic fat accumulation...
  42. ncbi request reprint Selective activation of human intestinal mast cells by Escherichia coli hemolysin
    Sigrid Krämer
    Department of Nutritional Medicine and Immunology, University of Hohenheim, Stuttgart, Germany
    J Immunol 181:1438-45. 2008
    ..coli. Our data indicate that human intestinal mast cells interact with selected Gram-negative bacteria, establish E. coli Hly as a factor regulating MC effector functions, and argue further for a role of human MCs in innate immunity...
  43. doi request reprint Pre- and postoperative nutritional deficiencies in obese patients undergoing laparoscopic sleeve gastrectomy
    Antje Damms-Machado
    Department of Nutritional Medicine, University of Hohenheim, Fruwirthstr 12, 70593, Stuttgart, Germany
    Obes Surg 22:881-9. 2012
    ..However, data on outcome of LSG regarding nutrient deficiencies, protein status, and body composition are scarce...
  44. ncbi request reprint Effect of high sugar intake on glucose transporter and weight regulating hormones in mice and humans
    Yvonne Ritze
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    PLoS ONE 9:e101702. 2014
    ..Thus, we compared liquid versus solid high-sugar diets with regard to dietary intake, intestinal uptake and metabolic parameters in mice and partly in humans...
  45. pmc Lactobacillus rhamnosus GG protects against non-alcoholic fatty liver disease in mice
    Yvonne Ritze
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    PLoS ONE 9:e80169. 2014
    ..Within this study, we examined the possible effect of the probiotic bacterial strain Lactobacillus rhamnosus GG (LGG) as protective agent against experimental NAFLD in a mouse model...
  46. doi request reprint Bifidobacterium adolescentis protects from the development of nonalcoholic steatohepatitis in a mouse model
    Astrid Reichold
    Department of Nutritional Medicine, University of Hohenheim, Fruwirthstr 12, 70599 Stuttgart, Germany
    J Nutr Biochem 25:118-25. 2014
    ..adolescentis attenuates diet-induced steatohepatitis, and this effect is associated with prevention from lipid peroxidation, NFκB activation and finally inflammation in the liver. ..
  47. doi request reprint SNAP-23 and syntaxin-3 are required for chemokine release by mature human mast cells
    Simon P C Frank
    Department of Nutritional Medicine, University of Hohenheim, Fruwirthstraße 12, D 70593 Stuttgart, Germany
    Mol Immunol 49:353-8. 2011
    ..In summary, STX-3 and SNAP-23 are crucial for the release of all chemokines in mature human mast cells whereas other SNAREs affect only release of selected chemokines...
  48. pmc Impaired inhibitory control in anorexia nervosa elicited by physical activity stimuli
    Stephanie Kullmann
    fMEG Center, University of Tubingen, 72076 Tubingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, 72076 Tubingen, Germany, German Center for Diabetes Research, 85764 Neuherberg, Germany, Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, 72076 Tubingen, Germany, Department of Psychiatry, University of Bonn, 53105 Bonn, Germany, Institute of Nutritional Medicine, University Hohenheim, 70599 Stuttgart, Germany, and Institute of Sport Science, University Tübingen, 72076 Tubingen, GermanyfMEG Center, University of Tubingen, 72076 Tubingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, 72076 Tubingen, Germany, German Center for Diabetes Research, 85764 Neuherberg, Germany, Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, 72076 Tubingen, Germany, Department of Psychiatry, University of Bonn, 53105 Bonn, Germany, Institute of Nutritional Medicine, University Hohenheim, 70599 Stuttgart, Germany, Department of Hematology/Oncology
    Soc Cogn Affect Neurosci 9:917-23. 2014
    ..The resulting hyperactivity of the PFC and cerebellum may lead to altered executive function and motor control, sustaining increased physical activity in AN patients. ..
  49. ncbi request reprint Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells
    Leif E Sander
    Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Eur J Immunol 38:855-63. 2008
    ..In summary, our data show that mature human MC express a specific pattern of SNARE and that VAMP-7 and VAMP-8, but not VAMP-2, are required for rapid degranulation...
  50. ncbi request reprint Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release
    Thomas Gebhardt
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, Germany
    Eur J Immunol 32:2308-16. 2002
    ..In conclusion, our data show that human intestinal mast cells express functional IL-3R, indicating that IL-3 not only regulates growth and function of immature, but also that of mature human mast cells...
  51. ncbi request reprint Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins
    Axel Lorentz
    Department of Internal Medicine Gastroenterology, Medical School of Hannover, D 30623 Hannover, Germany
    Blood 99:966-72. 2002
    ..In conclusion, these data indicate that SCF induces the adhesion of cultured mast cells to ECM proteins, whereas IL-4 may promote detachment from the ECM...
  52. ncbi request reprint Mast cell dynamics and involvement in the development of peritoneal adhesions in the rat
    Xiang Xu
    Department of Pharmacology, School of Pharmacy, The Hebrew Universiry Hadassah Medical School, Jerusalem, Israel
    Life Sci 70:951-67. 2002
    ..In vitro mast cell induced fibroplasia. Therefore, mast cells have a profibrogenic role in this model of peritoneal adhesions...
  53. doi request reprint Preface. Eosinophils and the digestive tract
    Stephan C Bischoff
    Best Pract Res Clin Gastroenterol 22:389. 2008
  54. ncbi request reprint Mast cell hyperplasia: role of cytokines
    Stephan C Bischoff
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Germany
    Int Arch Allergy Immunol 127:118-22. 2002
    ..However, several other cytokines such as IL-3 and IL-4 have been shown to influence mast cell proliferation and function also. This review focuses on the role of cytokines in the regulation of mast cell hyperplasia...
  55. ncbi request reprint The stem cell factor-c-kit system and mast cells in human pancreatic cancer
    Irene Esposito
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Lab Invest 82:1481-92. 2002
    ..In conclusion, the SCF-c-kit system, possibly with the contribution of mast cells, may have a growth-regulating role in the normal pancreas, which is altered during malignant transformation...
  56. ncbi request reprint Role of activator protein 1, nuclear factor-kappaB, and nuclear factor of activated T cells in IgE receptor-mediated cytokine expression in mature human mast cells
    Axel Lorentz
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany
    J Allergy Clin Immunol 111:1062-8. 2003
    ..On activation by cross-linking the high-affinity IgE receptor (FcepsilonRI), expression of TNF-alpha, IL-3, IL-5, and IL-13 is induced in human intestinal mast cells...
  57. ncbi request reprint IL-4-induced priming of human intestinal mast cells for enhanced survival and Th2 cytokine generation is reversible and associated with increased activity of ERK1/2 and c-Fos
    Axel Lorentz
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Germany
    J Immunol 174:6751-6. 2005
    ..In summary, our data show that the IL-4 effects on human intestinal mast cell functions are reversible and accompanied by an increased activity of ERK1/2 and c-Fos...
  58. pmc IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells
    Shafaqat Ali
    Immunology FB08, Justus Liebig University Giessen, Winchesterstrasse 2, D 35394 Giessen, Germany
    Proc Natl Acad Sci U S A 104:18660-5. 2007
    ..These data demonstrate that IL-1RAcP is indispensable for IL-33 signaling. Furthermore, they suggest that IL-1RAcP is used by more than one alpha-chain of the IL-1 receptor family and thus may resemble a common beta-chain of that family...
  59. ncbi request reprint beta2-Adrenoceptor-mediated suppression of human intestinal mast cell functions is caused by disruption of filamentous actin dynamics
    Thomas Gebhardt
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, Germany
    Eur J Immunol 35:1124-32. 2005
    ..Furthermore, the data support the concept of neuroimmune interactions regulating intestinal MC distribution, density, and functionality in vivo...
  60. ncbi request reprint The European Competence Network on Mastocytosis (ECNM)
    Peter Valent
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Austria
    Wien Klin Wochenschr 116:647-51. 2004
    ..In addition, the ECNM is dedicated to provide the best available information about the disease to patients and physicians...
  61. ncbi request reprint Isolation, culture, and characterization of intestinal mast cells
    Gernot Sellge
    Department of Cell Biology and Infection, Institute Pasteur, Paris, France
    Methods Mol Biol 315:123-38. 2006
    ..This chapter describes a rather new technique of mast cell isolation from human intestinal mucosal tissue yielding approx 1-5 million pure and viable human mast cells suitable to perform functional and cell culture experiments...
  62. ncbi request reprint The German hospital malnutrition study
    Matthias Pirlich
    Medizinische Klinik Gastroenterologie, Hepatologie und Endokrinologie, Charite Universitatsmedizin Berlin, D 10098 Berlin, Germany
    Clin Nutr 25:563-72. 2006
    ..Malnutrition is frequently observed in chronic and severe diseases and associated with impaired outcome. In Germany general data on prevalence and impact of hospital malnutrition are missing...
  63. ncbi request reprint Human intestinal fibroblasts prevent apoptosis in human intestinal mast cells by a mechanism independent of stem cell factor, IL-3, IL-4, and nerve growth factor
    Gernot Sellge
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany
    J Immunol 172:260-7. 2004
    ..Such interactions between MCs and FBs may explain why MCs accumulate at sites of inflammatory bowel disease and intestinal fibrosis...