F Birklein

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. doi request reprint Neuropeptides, neurogenic inflammation and complex regional pain syndrome (CRPS)
    Frank Birklein
    Department of Neurology, Pain Research Unit, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Neurosci Lett 437:199-202. 2008
  2. ncbi request reprint Vagus nerve stimulation suppresses pain but has limited effects on neurogenic inflammation in humans
    Annette Kirchner
    Neurologische Klinik, University of Erlangen Nuremberg, Germany
    Eur J Pain 10:449-55. 2006
  3. ncbi request reprint Isolated insular infarction eliminates contralateral cold, cold pain, and pinprick perception
    Frank Birklein
    Department of Neurology, University of Mainz, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Neurology 65:1381. 2005
  4. pmc Substantial and reversible brain gray matter reduction but no acute brain lesions in ultramarathon runners: experience from the TransEurope-FootRace Project
    Wolfgang Freund
    Department of Diagnostic and Interventional Radiology, University Hospitals Ulm, Albert Einstein Allee 23, 89081 Ulm, Germany
    BMC Med 10:170. 2012
  5. ncbi request reprint Mechanisms of neuropathic pain and their importance in Fabry disease
    F Birklein
    Neurologische Klinik, Johannes Gutenberg University, Mainz, Germany
    Acta Paediatr Suppl 91:34-7. 2002
  6. ncbi request reprint Botulinum Toxin A reduces neurogenic flare but has almost no effect on pain and hyperalgesia in human skin
    H H Kramer
    Neurologische Klinik, Universitat Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    J Neurol 250:188-93. 2003
  7. ncbi request reprint Botulinum toxin type B blocks sudomotor function effectively: a 6 month follow up
    Frank Birklein
    Neurologische Klinik, Johannes Gutenberg Universitat, Mainz, Germany
    J Invest Dermatol 121:1312-6. 2003
  8. ncbi request reprint Sudomotor testing predicts the presence of neutralizing botulinum A toxin antibodies
    Frank Birklein
    Neurologische Klinik, Johannes Gutenberg Universitat Mainz, Germany
    Ann Neurol 52:68-73. 2002
  9. ncbi request reprint [Mechanism-based treatment principles of neuropathic pain]
    F Birklein
    Neurologische Universitätsklinik Mainz, Germany
    Fortschr Neurol Psychiatr 70:88-94. 2002
  10. ncbi request reprint The important role of neuropeptides in complex regional pain syndrome
    F Birklein
    Neurologische Klinik, Friedrich Alexander Universität Erlangen, Germany
    Neurology 57:2179-84. 2001

Collaborators

Detail Information

Publications89

  1. doi request reprint Neuropeptides, neurogenic inflammation and complex regional pain syndrome (CRPS)
    Frank Birklein
    Department of Neurology, Pain Research Unit, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Neurosci Lett 437:199-202. 2008
    ..This favors the possibility that CRPS patients share genetic similarities. The future search for genetic commonalities will help us to further unravel the "mystery" CRPS...
  2. ncbi request reprint Vagus nerve stimulation suppresses pain but has limited effects on neurogenic inflammation in humans
    Annette Kirchner
    Neurologische Klinik, University of Erlangen Nuremberg, Germany
    Eur J Pain 10:449-55. 2006
    ....
  3. ncbi request reprint Isolated insular infarction eliminates contralateral cold, cold pain, and pinprick perception
    Frank Birklein
    Department of Neurology, University of Mainz, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Neurology 65:1381. 2005
  4. pmc Substantial and reversible brain gray matter reduction but no acute brain lesions in ultramarathon runners: experience from the TransEurope-FootRace Project
    Wolfgang Freund
    Department of Diagnostic and Interventional Radiology, University Hospitals Ulm, Albert Einstein Allee 23, 89081 Ulm, Germany
    BMC Med 10:170. 2012
    ..The effects of this endurance run on brain volume changes but also possible formation of brain edema or new lesions were explored by repeated magnetic resonance imaging (MRI) studies...
  5. ncbi request reprint Mechanisms of neuropathic pain and their importance in Fabry disease
    F Birklein
    Neurologische Klinik, Johannes Gutenberg University, Mainz, Germany
    Acta Paediatr Suppl 91:34-7. 2002
    ..The most important mechanisms are accumulation and maldistribution of sodium channels on injured axons, pathological sympatho-afferent coupling, disinhibition of nociception and central or peripheral nociceptive sensitization...
  6. ncbi request reprint Botulinum Toxin A reduces neurogenic flare but has almost no effect on pain and hyperalgesia in human skin
    H H Kramer
    Neurologische Klinik, Universitat Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    J Neurol 250:188-93. 2003
    ..In contrast, the analgesic effect of BoNT/A was very limited. Therefore we assume that other than neuropeptide mechanisms must be important for BoNT/A induced pain relief in clinical pain syndromes...
  7. ncbi request reprint Botulinum toxin type B blocks sudomotor function effectively: a 6 month follow up
    Frank Birklein
    Neurologische Klinik, Johannes Gutenberg Universitat, Mainz, Germany
    J Invest Dermatol 121:1312-6. 2003
    ..Analysis by iodine-starch staining and QSART indicated that botulinum toxin type B suppresses sudomotor function effectively, in a concentration-dependent manner...
  8. ncbi request reprint Sudomotor testing predicts the presence of neutralizing botulinum A toxin antibodies
    Frank Birklein
    Neurologische Klinik, Johannes Gutenberg Universitat Mainz, Germany
    Ann Neurol 52:68-73. 2002
    ..Therefore, sudometry is a useful tool for identifying patients with neutralizing ABAs and might be helpful for identifying reasons for BoNT/A treatment failure...
  9. ncbi request reprint [Mechanism-based treatment principles of neuropathic pain]
    F Birklein
    Neurologische Universitätsklinik Mainz, Germany
    Fortschr Neurol Psychiatr 70:88-94. 2002
    ..However, future research has to focus on exploring tools to recognise individual pain mechanisms in single patients. Thereby treatment will become more effective...
  10. ncbi request reprint The important role of neuropeptides in complex regional pain syndrome
    F Birklein
    Neurologische Klinik, Friedrich Alexander Universität Erlangen, Germany
    Neurology 57:2179-84. 2001
    ..To test the contribution of neurogenic inflammation and neuropeptide release to the pathophysiology of complex regional pain syndrome (CRPS)...
  11. ncbi request reprint Complex regional pain syndrome
    Frank Birklein
    Neurologische Klinik, Universitat Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    J Neurol 252:131-8. 2005
    ..The recognition of these mechanisms in individual CRPS patients is the prerequisite for a mechanism-oriented treatment...
  12. doi request reprint A family-based investigation of cold pain tolerance
    F Birklein
    Department of Neurology, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Pain 138:111-8. 2008
    ..In conclusion our results suggest that cold pain tolerance may be at least partially inherited. Genetic or environmental factors might explain family clustering of cold pain sensitivity...
  13. doi request reprint Stress and thermoregulation: different sympathetic responses and different effects on experimental pain
    M Fechir
    Department of Neurology, Johannes Gutenberg University Mainz, Mainz, Germany
    Eur J Pain 13:935-41. 2009
    ..Whether SNS activation is causally responsible for analgesia needs to be further investigated...
  14. doi request reprint Naloxone inhibits not only stress-induced analgesia but also sympathetic activation and baroreceptor-reflex sensitivity
    M Fechir
    Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstrasse 1, D 55101, Mainz, Germany
    Eur J Pain 16:82-92. 2012
    ..This mechanism might underlie increased perception of noxious stimuli in patients with chronic pain or mood disorders...
  15. doi request reprint Mechanical but not painful electrical stimuli trigger TNF alpha release in human skin
    T Eberle
    Department of Neurology, University Medical Centre Mainz, Mainz, Germany
    Exp Neurol 221:246-50. 2010
    ..Our results show that minimal mechanical trauma is sufficient to induce significant TNF-alpha release in the skin. These results may be relevant to the treatment of posttraumatic pain disorders...
  16. doi request reprint Cortical control of thermoregulatory sympathetic activation
    M Fechir
    Department of Neurology, University Medical Center Mainz, Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Eur J Neurosci 31:2101-11. 2010
    ..These findings may represent reasonable explanations for sympathetic hyperactivity, which occurs, for example, after hemispheric stroke...
  17. ncbi request reprint Facilitated neurogenic inflammation in complex regional pain syndrome
    M Weber
    Neurologische Klinik, , , D-91054 Erlangen, Germany
    Pain 91:251-7. 2001
    ..We conclude that neurogenic inflammation is facilitated in CRPS. Our results suggest an increased releasability of neuropeptides in CRPS...
  18. doi request reprint Central opioidergic neurotransmission in complex regional pain syndrome
    A Klega
    Department of Nuclear Medicine, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Neurology 75:129-36. 2010
    ..As there is evidence for central pathophysiology which might be related to an altered opioidergic neurotransmission, we investigated the cerebral opioid receptor status under resting conditions in this patient population...
  19. ncbi request reprint Substance-P-induced protein extravasation is bilaterally increased in complex regional pain syndrome
    Stefan Leis
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Exp Neurol 183:197-204. 2003
    ..The underlying mechanism might be impaired SP inactivation. Thus, our results further support the hypothesis that neurogenic inflammation plays an important role in the initiation of CRPS...
  20. ncbi request reprint Experimental tissue acidosis leads to increased pain in complex regional pain syndrome (CRPS)
    F Birklein
    Neurologische Klinik, Universitat Erlangen Nurnberg, Schwabachanlage 6, D 91054, Erlangen, Germany
    Pain 87:227-34. 2000
    ..Our results suggest that hyperalgesia to protons is present in patients with CRPS. Further, we could demonstrate that pain is not only restricted to the skin but is also generated in deep somatic tissue of the affected limb...
  21. ncbi request reprint [Vagus nerve stimulation - a new option for the treatment of chronic pain syndromes?]
    A Kirchner
    Neurologische Klinik, Friedrich Alexander Universität Erlangen
    Schmerz 15:272-7. 2001
    ..First reports of attenuation of chronic pain by VNS indicate that the method might be an option for pain treatment in the future...
  22. doi request reprint Sympathetic activity at rest and motor brain areas: FDG-PET study
    P Schlindwein
    Department of Neurology, Johannes Gutenberg University Mainz, Germany
    Auton Neurosci 143:27-32. 2008
    ..This might have clinical implications for the understanding of stress-related disorders, which are frequently accompanied by increased sympathetic activity as well as muscle tone...
  23. ncbi request reprint Inhibition of neutral endopeptidase (NEP) facilitates neurogenic inflammation
    H H Kramer
    Department of Neurology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    Exp Neurol 195:179-84. 2005
    ..Our findings suggest that NEP but not ACE is most important for CGRP degradation in human skin. This may be of particular importance for the understanding of pain disorders like migraine or complex regional pain syndrome...
  24. ncbi request reprint The unpleasantness of tonic pain is encoded by the insular cortex
    M Schreckenberger
    Department of Nuclear Medicine, Johannes Gutenberg University Mainz, Mainz, Germany
    Neurology 64:1175-83. 2005
    ..This study was conducted to identify the brain regions associated with the affective-motivational component of tonic skin and muscle pain...
  25. ncbi request reprint Despite clinical similarities there are significant differences between acute limb trauma and complex regional pain syndrome I (CRPS I)
    F Birklein
    Neurologische Klinik, Friedrich Alexander Universität Erlangen, Universitatsstrasse 17, D 91054 Erlangen, Germany
    Pain 93:165-71. 2001
    ..Despite the clinical similarity, additional changes in the peripheral or central nervous system are required for CRPS. In the light of our observations, it seems unlikely that CRPS is a simple exaggeration of post-traumatic inflammation...
  26. ncbi request reprint No alpha-adrenoreceptor-induced C-fiber activation in healthy human skin
    Sebastian Zahn
    Department of Neurology, Friedrich Alexander Universität Erlangen, Erlangen, Germany
    J Appl Physiol 96:1380-4. 2004
    ..Our results indicate that, in healthy human skin, exogenously supplied alpha-adrenoreceptor agonists alone do not activate nociceptors sufficiently to induce axon reflex flare...
  27. ncbi request reprint Mechanical hyperalgesia in complex regional pain syndrome: a role for TNF-alpha?
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Neurology 65:311-3. 2005
    ..9 +/- 56.3 pg/mL) and controls (1,239.5 +/- 42.9 pg/mL). This study suggests involvement of TNF-alpha in mechanical hyperalgesia of CRPS...
  28. ncbi request reprint Activation of the cortical pain network by soft tactile stimulation after injection of sumatriptan
    Heidrun H Krämer
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    Pain 133:72-8. 2007
    ....
  29. ncbi request reprint Chemically and electrically induced sweating and flare reaction
    Barbara Namer
    Department of Neurology, Friedrich Alexander University, Erlangen, Germany
    Auton Neurosci 114:72-82. 2004
    ..31 vs. 0.21 microl/cm2/min, p<0.01), which might be attributed to an increased effectiveness of synchronized discharge in sympathetic fibers upon electrical stimulation...
  30. ncbi request reprint Quantitative sensory testing: a comprehensive protocol for clinical trials
    R Rolke
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Saarstr 21, D 55099 Mainz, Germany
    Eur J Pain 10:77-88. 2006
    ..Case examples of selected patients illustrate the value of z-transformed QST data for an easy survey of individual symptom profiles...
  31. doi request reprint Basal opioid receptor binding is associated with differences in sensory perception in healthy human subjects: a [18F]diprenorphine PET study
    Christina Mueller
    Department of Nuclear Medicine, Johannes Gutenberg University, Langenbeckstrasse 1, Gebäude 210, Mainz, Germany
    Neuroimage 49:731-7. 2010
    ..These results suggest that the opioid receptor system is involved in the perception not only of pain but also of non-painful somatosensory stimuli...
  32. ncbi request reprint Mislocalization of tactile stimulation in patients with complex regional pain syndrome
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    J Neurol 253:772-9. 2006
    ..In contrast, in a healthy control group, no mislocalizations were found. Thus, our results further support the concept of pain-induced reorganization in the somatosensory system of CRPS patients...
  33. doi request reprint Illusion of pain: pre-existing knowledge determines brain activation of 'imagined allodynia'
    Heidrun H Krämer
    Department of Neurology, University of Mainz, Mainz, Germany
    J Pain 9:543-51. 2008
    ..According to our results, the medial pain system is involved in the encoding of imagined allodynia...
  34. ncbi request reprint Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values
    R Rolke
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Pain 123:231-43. 2006
    ..Application of this standardized QST protocol in patients and human surrogate models will allow to infer underlying mechanisms from somatosensory phenotypes...
  35. ncbi request reprint Sensory and sympathetic correlates of heat pain sensitization and habituation in men and women
    M Breimhorst
    Department of Neurology, University Medical Center of Johannes Gutenberg University Mainz, Germany
    Eur J Pain 16:1281-92. 2012
    ....
  36. doi request reprint Explicit episodic memory for sensory-discriminative components of capsaicin-induced pain: immediate and delayed ratings
    H H F Jantsch
    Department of Neurology, Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany
    Pain 143:97-105. 2009
    ..These results indicate a reliable memory for magnitude and duration of experimentally induced pain. The data further suggest that the consolidation of this memory is an important interim stage, and may take up to one day...
  37. doi request reprint Warm and cold complex regional pain syndromes: differences beyond skin temperature?
    T Eberle
    Department of Neurology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Neurology 72:505-12. 2009
    ..To investigate clinical differences in warm and cold complex regional pain syndrome (CRPS) phenotypes...
  38. ncbi request reprint Increased skin lactate in complex regional pain syndrome: evidence for tissue hypoxia?
    F Birklein
    Neurologische Klinik, Friedrich Alexander Universität Erlangen, Germany
    Neurology 55:1213-5. 2000
    ..95 mmol/L; control subjects 1.74 mmol/L; p < 0.005). These results suggest enhanced anaerobic glycolysis, probably as a result of chronic tissue hypoxia...
  39. ncbi request reprint Patterns of cortical reorganization in complex regional pain syndrome
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Neurology 61:1707-15. 2003
    ..To use magnetoencephalography to assess possible cortical reorganization in the primary somatosensory cortex (S1) of patients with complex regional pain syndrome (CRPS)...
  40. ncbi request reprint The motor system shows adaptive changes in complex regional pain syndrome
    Christian Maihofner
    Department of Neurology, Institute for Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    Brain 130:2671-87. 2007
    ..In summary, the results of this study suggest that substantial adaptive changes within the central nervous system may contribute to motor symptoms in CRPS...
  41. doi request reprint Increased pain and neurogenic inflammation in mice deficient of neutral endopeptidase
    Heidrun H Krämer
    Department of Neurology, Johannes Gutenberg University Mainz, Langenbeckstr 1, Mainz 55101, Germany
    Neurobiol Dis 35:177-83. 2009
    ..These findings resemble human 'cold' CRPS and suggest that ET 1 plays an important role in the pathogenesis of CRPS with nerve injury...
  42. ncbi request reprint Catecholamine release in human skin--a microdialysis study
    Stefan Leis
    Department of Neurology, University of Erlangen Nurnberg, Germany
    Exp Neurol 188:86-93. 2004
    ..Additional to non-enzymatic oxidation, DA increase probably reflects metabolic degradation of tyramine by non-neuronal pathways and therefore does not reflect local sympathetic innervation...
  43. doi request reprint Application of local anesthesia inhibits effects of low-energy extracorporeal shock wave treatment (ESWT) on nociceptors
    T Klonschinski
    Department of Trauma Surgery, University Medical Centre, Mainz, Germany
    Pain Med 12:1532-7. 2011
    ..Clinical studies of extracorporeal shock wave therapy (ESWT) provided conflicting results depending on the use of local anesthesia (LA)...
  44. doi request reprint Functional imaging of sympathetic activation during mental stress
    M Fechir
    Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    Neuroimage 50:847-54. 2010
    ..The results might furthermore serve as a basis for future investigations of the connection between these cortical regions in the generation of stress-related diseases...
  45. ncbi request reprint [Complex regional pain syndrome. A rare complication after acetabular fracture]
    A Lingawi
    Klinik und Poliklinik fur Unfallchirurgie, Johannes Gutenberg Universitat, Mainz
    Unfallchirurg 111:197-200. 2008
    ..Differential diagnostic evaluation should include CRPS in patients with persistent or progressive pain in the distal extremity after acetabular fracture. Early diagnosis and therapy contribute significantly to a successful outcome...
  46. ncbi request reprint [Sudeck's atrophy: pathophysiology and treatment of a complex pain syndrome]
    M Weber
    Neurologische Klinik, Friedrich Alexander Universität Erlangen, Germany
    Dtsch Med Wochenschr 127:384-9. 2002
    ..Sudeck's atrophy: pathophysiology and treatment of a complex pain syndrome...
  47. ncbi request reprint Follow-up of advanced diabetic neuropathy: useful variables and possible pitfalls
    H H Kramer
    Department of Neurology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    J Neurol 252:315-20. 2005
    ..The course of advanced diabetic neuropathy (DN) is largely unknown...
  48. ncbi request reprint [The assessment of sudomotor function for diagnosis of autonomic diseases. Principles and methods]
    F Birklein
    Neurologische Klinik, Friedrich Alexander Universität Erlangen
    Fortschr Neurol Psychiatr 67:287-95. 1999
    ..In this way autonomic dysfunction e.g. after nerve lesions, in polyneuropathies, central lesions and certain pain disorders can be assessed. The sudomotor function tests complete the conventional electrophysiological methods...
  49. ncbi request reprint [Horner's syndrome -- update on neuroanatomy, topographic diagnosis and etiology]
    J J Marx
    Klinik und Poliklinik fur Neurologie, Johannes Gutenberg Universitat Mainz
    Fortschr Neurol Psychiatr 73:23-9. 2005
    ..Finally, a schematic overview is given on the most common pathology, considering additional clinical signs and symptoms...
  50. ncbi request reprint Electrically stimulated axon reflexes are diminished in diabetic small fiber neuropathies
    Heidrun H Krämer
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    Diabetes 53:769-74. 2004
    ..83, P < 0.004). Intracutaneous electrical stimulation of C-fibers and scanning the flare with LDI is a sensitive tool to reliably detect small fiber impairment in diabetic SFN subjects and even increased neuropeptide release in NO-Ns...
  51. doi request reprint Numbness in clinical and experimental pain--a cross-sectional study exploring the mechanisms of reduced tactile function
    Christian Geber
    Neurologische Universitatsklinik, Johannes Gutenberg Universitat, Mainz, Germany
    Pain 139:73-81. 2008
    ..Hypaesthesia (numbness) often encountered in clinical pain can be reproduced by experimental nociceptive stimulation. The time course of effects suggests a mechanism involving central plasticity...
  52. ncbi request reprint Keeping memory clear and stable--the contribution of human basal ganglia and prefrontal cortex to working memory
    Bernhard Baier
    Department of Neurology, University of Mainz, 55131 Mainz, Germany
    J Neurosci 30:9788-92. 2010
    ..These findings support basal ganglia-prefrontal cortex models of WM whereby the basal ganglia play a gatekeeper role and allow only relevant information to enter prefrontal cortex where this information then is actively maintained in WM...
  53. ncbi request reprint Spreading of sudomotor axon reflexes in human skin
    Tanja Schlereth
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    Neurology 64:1417-21. 2005
    ..In some neuropathies, however, there is increased axon reflex sweating, a response pattern that has never been observed for vasodilator flares...
  54. ncbi request reprint Evolving understandings about complex regional pain syndrome and its treatment
    Marcel Fechir
    Klinik und Poliklinik fur Neurologie, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, Mainz, Germany
    Curr Pain Headache Rep 12:186-91. 2008
    ..The common therapeutic aim is to maintain or restore normal function of the affected extremity. Beyond highlighting pathophysiologic concepts, this article describes recent therapeutic approaches...
  55. ncbi request reprint Botulinum toxin A (Botox) and sweating-dose efficacy and comparison to other BoNT preparations
    Tanja Schlereth
    Department of Neurology, University of Mainz, Germany
    Auton Neurosci 117:120-6. 2005
    ..Neurology 49, 189-194]. Botulinum toxins block motor nerves as well as autonomic fibres [Rand, M.J., Whaler, B.C., 1965. Impairment of sympathetic transmission by botulinum toxin. Nature 206, 588-591]...
  56. ncbi request reprint Thermal thresholds predict painfulness of diabetic neuropathies
    Heidrun H Krämer
    Department of Neurology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    Diabetes Care 27:2386-91. 2004
    ..Pathophysiology explaining pain in diabetic neuropathy (DN) is still unknown...
  57. doi request reprint Anatomical correlate of impaired covert visual attentional processes in patients with cerebellar lesions
    Bernhard Baier
    Department of Neurology, University of Mainz, 55131 Mainz, Germany
    J Neurosci 30:3770-6. 2010
    ..We suggest that these midcerebellar regions are indirectly involved in covert visual attention via oculomotor control mechanisms. Thus, specific cerebellar structures do influence attentional orienting, whereas others do not...
  58. pmc Hyperhidrosis--causes and treatment of enhanced sweating
    Tanja Schlereth
    Klinik fur Neurologie, Johannes Gutenberg Universitat Mainz, Germany
    Dtsch Arztebl Int 106:32-7. 2009
    ..Secondary hyperhidrosis develops due to dysfunction of the central or peripheral nervous system...
  59. ncbi request reprint Facilitated neurogenic inflammation in unaffected limbs of patients with complex regional pain syndrome
    Stefan Leis
    Department of Neurology, University of Erlangen Nurnberg, Erlangen, Germany
    Neurosci Lett 359:163-6. 2004
    ..The lack of protein extravasation indicates that an initiating trauma is necessary to induce neuropeptide up-regulation in primary afferents...
  60. doi request reprint Evidence for modulation of opioidergic activity in central vestibular processing: A [(18)F] diprenorphine PET study
    Bernhard Baier
    Department of Neurology, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Hum Brain Mapp 31:550-5. 2010
    ..These data give evidence that the opioidergic system plays a role in the right hemispheric dominance of the vestibular cortical system in right-handers...
  61. ncbi request reprint Comparison of continuous wave Doppler ultrasound of the radial artery and laser Doppler flowmetry of the fingertips with sympathetic stimulation
    Bernhard M Eicke
    Dept of Neurology, University Clinic of Mainz, Langenbeckstr 1, 55101 Mainz, Germany
    J Neurol 251:958-62. 2004
    ..Latencies and relative quantitative changes were closely correlated.Thus, cw Doppler is a valid alternative approach to laser Doppler flowmetry in healthy volunteers...
  62. ncbi request reprint Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin
    Heidrun H Krämer
    Department of Neurology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    Peptides 27:917-20. 2006
    ..These findings suggest that NEP and ACE do not have additive effects regarding neuropeptide degradation. In contrast, inhibition of ACE seems to augment CGRP catabolism...
  63. ncbi request reprint In vivo release of non-neuronal acetylcholine from human skin by dermal microdialysis: effects of sunlight, UV-A and tactile stimulus
    Tanja Schlereth
    Clinic of Neurology, Johannes Gutenberg University Mainz, Langenbeckstr 1, D 55101 Mainz, Germany
    Life Sci 80:2239-42. 2007
    ..In conclusion, the in vivo release of ACh from the human skin appears to be regulated by external stimuli like sunlight and tactile stimuli...
  64. ncbi request reprint Somatotopic arrangement of sudomotor axon reflex sweating in humans
    Tanja Schlereth
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    Auton Neurosci 123:76-81. 2005
    ..The aim of our study was to compare both tests at three different sites on the leg: foot, lower leg and thigh...
  65. pmc Peripheral amplification of sweating--a role for calcitonin gene-related peptide
    Tanja Schlereth
    Department of Neurology, Johannes Gutenberg University Langenbeckstr 1, D 55101 Mainz, Germany
    J Physiol 576:823-32. 2006
    ..01), but not the amount of sweat, was reduced by SP. ACh-induced skin blood flow was significantly increased by CGRP (P < 0.01), but unaltered by VIP and SP. The results indicate that CGRP amplifies axon reflex sweating in human skin...
  66. ncbi request reprint Psychophysics, flare, and neurosecretory function in human pain models: capsaicin versus electrically evoked pain
    Christian Geber
    Klinik und Poliklinik für Neurologie der Universität Mainz, Germany
    J Pain 8:503-14. 2007
    ..The different time courses of pain stimulation (CAP: rapidly decaying pain versus ES: pain plateau) led to different peripheral neurosecretory effects but induced similar central plasticity and hyperalgesia...
  67. pmc In vivo release of non-neuronal acetylcholine from the human skin as measured by dermal microdialysis: effect of botulinum toxin
    Tanja Schlereth
    Department of Neurology, Johannes Gutenberg University Mainz, Reisinger Weg, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Br J Pharmacol 147:183-7. 2006
    ..Organic cation transporters are not predominantly involved in the release of non-neuronal acetylcholine from the human skin...
  68. ncbi request reprint Functional imaging of allodynia in complex regional pain syndrome
    Christian Maihofner
    Department of Neurology, Institute for Experimental Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    Neurology 66:711-7. 2006
    ..To investigate cerebral activations underlying touch-evoked pain (dynamic-mechanical allodynia) in patients with neuropathic pain...
  69. ncbi request reprint The sympathetic nervous system and pain
    Tanja Schlereth
    Department of Neurology, Johannes Gutenberg University, Langenbeckstr 1, Mainz 55101, Germany
    Neuromolecular Med 10:141-7. 2008
    ..Unraveling the detailed molecular mechanisms of how this interaction of SNS and pain is established in health and disease will help us to treat pain more successfully in the future...
  70. ncbi request reprint Use of gabapentin to reduce chronic neuropathic pain in Fabry disease
    M Ries
    Centre for Lysosomal Storage Disorders, Children s Hospital, Mainz, Germany
    J Inherit Metab Dis 26:413-4. 2003
    ..Treatment was generally well tolerated. This study indicates that gabapentin should be considered as a treatment option for the neuropathic pain of Fabry disease...
  71. doi request reprint Anatomical correlate of positive spontaneous visual phenomena: a voxelwise lesion study
    B Baier
    Department of Neurology, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Neurology 74:218-22. 2010
    ..To determine which brain regions might be involved in such visual phenomena, we used new brain imaging and lesion analysis tools that allow a direct comparison with control patients...
  72. ncbi request reprint Successful treatment of axillary hyperhidrosis with very low doses of botulinum toxin B: a pilot study
    Martin J Hecht
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Arch Dermatol Res 295:318-9. 2004
  73. doi request reprint Revised definition of neuropathic pain and its grading system: an open case series illustrating its use in clinical practice
    Christian Geber
    Department of Neurology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    Am J Med 122:S3-12. 2009
    ..Its clinical use should be further validated in prospective studies...
  74. ncbi request reprint Clonidine induces nitric oxide- and prostaglandin-mediated vasodilation in healthy human skin
    Daniel Hermann
    Department of Neurology, University of Mainz, Germany
    J Appl Physiol 99:2266-70. 2005
    ..001). Our results demonstrate that sustained alpha(2)-receptor stimulation induces vasodilation in a dose-dependent way, which is mediated by nitric oxide and prostaglandin mechanisms in human skin...
  75. ncbi request reprint Brain processing during mechanical hyperalgesia in complex regional pain syndrome: a functional MRI study
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Pain 114:93-103. 2005
    ..The results of our study indicate a complex cortical network activated during pin-prick hyperalgesia in CRPS. The underlying neuronal matrix comprises areas not only involved in nociceptive, but also in cognitive and motor processing...
  76. ncbi request reprint Cortical reorganization during recovery from complex regional pain syndrome
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Neurology 63:693-701. 2004
    ..To characterize reorganization of the primary somatosensory cortex (S1) during healing process in complex regional pain syndrome (CRPS)...
  77. ncbi request reprint Tissue hypoxia in complex regional pain syndrome
    M Koban
    Neurologische Klinik, Friedrich Alexander Universitat Erlangen Nurnberg, Universitatsstrasse 17, D 91054 Erlangen, Germany
    Pain 104:149-57. 2003
    ..Impairment of nutritive blood flow in the affected limb may be one factor contributing to atrophy and ulceration in chronic CRPS. The investigation of patients after surgery revealed that edema could not be the only reason for hypoxia...
  78. doi request reprint High sensitivity of free lambda and free kappa light chains for detection of intrathecal immunoglobulin synthesis in cerebrospinal fluid
    B Arneth
    Institute of Clinical Chemistry, University of Mainz, Germany
    Acta Neurol Scand 119:39-44. 2009
    ..With the free kappa and lambda light chains, new markers to diagnose intrathecal synthesis are available...
  79. ncbi request reprint Dysynchiria is not a common feature of neuropathic pain
    Heidrun H Krämer
    Department of Neurology, University of Mainz, Langenbeckstr 1, 55101 Mainz, Germany
    Eur J Pain 12:128-31. 2008
    ..The results imply a difference in cortical pain processing between complex regional pain syndrome and other chronic neuropathic pain...
  80. doi request reprint [Current aspects of the therapy of complex regional pain syndrome]
    F Birklein
    Klinik und Poliklinik fur Neurologie, Universitätsmedizin der Johannes Gutenberg Universität Mainz, Langenbeckstr 1, 55101, Mainz, Deutschland
    Nervenarzt 84:1436-44. 2013
    ..Complex regional pain syndrome (CRPS) constitutes an enigmatic post-traumatic pain disorder...
  81. ncbi request reprint Influence of vagus nerve stimulation on histamine-induced itching
    A Kirchner
    Neurologische Klinik, Friedrich Alexander Universität Erlangen, Germany
    Neurology 59:108-12. 2002
    ..To investigate whether vagus nerve stimulation (VNS) reduces pruritus in humans...
  82. ncbi request reprint Autoimmunity in complex-regional pain syndrome
    F Blaes
    Department of Neurology, Justus Liebig University, Giessen, Germany
    Ann N Y Acad Sci 1107:168-73. 2007
    ..Autoimmune etiology of CRPS is a new pathophysiological concept and may have severe impact on the treatment of this often chronic disease...
  83. ncbi request reprint Differential expression patterns of cytokines in complex regional pain syndrome
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Pain 132:195-205. 2007
    ..Sensory testing showed a predominant loss of small fiber-related modalities in the patient group. The shift towards a pro-inflammatory cytokine profile in patients with CRPS suggests a potential pathogenic role in the generation of pain...
  84. ncbi request reprint Increased seroprevalence of parvovirus B 19 IgG in complex regional pain syndrome is not associated with antiendothelial autoimmunity
    Oliver Gross
    Department of Neurology, Justus Liebig University, Am Steg 14, 35385 Giessen, Germany
    Eur J Pain 11:237-40. 2007
    ..s.) and AECA were not associated with parvovirus B19 seropositivity. Our findings suggest the involvement of parvovirus B19, but not autoantibody-mediated endothelial cell damage, in the pathogenesis of CRPS...
  85. doi request reprint Thinking about movement hurts: the effect of motor imagery on pain and swelling in people with chronic arm pain
    G Lorimer Moseley
    Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
    Arthritis Rheum 59:623-31. 2008
    ..Chronic painful disease is associated with pain on movement, which is presumed to be caused by noxious stimulation. We investigated whether motor imagery, in the absence of movement, increases symptoms in patients with chronic arm pain...
  86. ncbi request reprint Successful intravenous regional block with low-dose tumor necrosis factor-alpha antibody infliximab for treatment of complex regional pain syndrome 1
    Michael Bernateck
    Department of Anesthesiology, Pain Clinic, Hannover Medical School, Hannover, Germany
    Anesth Analg 105:1148-51, table of contents. 2007
    ..A significant improvement of clinical variables was observed 24 h after infliximab treatment. Almost complete remission was reached within 8 wk, but sensory signs improved only after 6 mo. No adverse events were observed...
  87. ncbi request reprint Does pain change the brain?
    Frank Birklein
    Neurology 65:666-7. 2005
  88. ncbi request reprint Micro-lightguide spectrophotometry as an intraoral monitoring method in free vascular soft tissue flaps
    Stefan Schultze-Mosgau
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    J Oral Maxillofac Surg 61:292-7; discussion 297. 2003
    ..The objective was to measure the normal range and topographic differences in HbO(2)% and rel. Hb conc. in tissue transfers before establishing this as a clinical method for monitoring perfusion and vitality...
  89. ncbi request reprint Use your imagination: training the brain and not the body to improve chronic pain and restore function
    Frank Birklein
    Neurology 67:2115-6. 2006