Rainer Birck

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint 15-Deoxyspergualin and cyclophosphamide, but not mycophenolate mofetil, prolong survival and attenuate renal disease in a murine model of ANCA-associated crescentic nephritis
    Rainer Birck
    Fifth Department of Medicine, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
    Nephrol Dial Transplant 21:58-63. 2006
  2. ncbi request reprint Serial ANCA determinations for monitoring disease activity in patients with ANCA-associated vasculitis: systematic review
    Rainer Birck
    Fifth Department of Medicine, University Hospital Mannheim, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany
    Am J Kidney Dis 47:15-23. 2006
  3. doi request reprint ANCA-associated vasculitis following influenza vaccination: causal association or mere coincidence?
    Rainer Birck
    Fifth Department of Medicine, University Hospital Mannheim, Germany
    J Clin Rheumatol 15:289-91. 2009
  4. ncbi request reprint [Rapidly progressive glomerulonephritis:classification, pathogenesis and clinical management]
    R Birck
    V Medizinische Klinik Universitätsklinikum Mannheim, Fakultät für Klinische Medizin der Universität Heidelberg, Mannheim, Germany
    Internist (Berl) 44:1107-19. 2003
  5. ncbi request reprint Acetylcysteine for prevention of contrast nephropathy: meta-analysis
    Rainer Birck
    Fifth Department of Medicine, University Hospital Mannheim, Mannheim, Germany
    Lancet 362:598-603. 2003
  6. doi request reprint Donor desmopressin is associated with superior graft survival after kidney transplantation
    Urs Benck
    5th Department of Medicine, University Medical Centre Mannheim, Mannheim, Germany
    Transplantation 92:1252-8. 2011
  7. ncbi request reprint SCG/Kinjoh mice: a model of ANCA-associated crescentic glomerulonephritis with immune deposits
    Irmgard Neumann
    Fifth Department of Medicine, University Hospital Mannheim, Mannheim, Germany
    Kidney Int 64:140-8. 2003
  8. ncbi request reprint Prolonged treatment of refractory Wegener's granulomatosis with 15-deoxyspergualin: an open study in seven patients
    Wilhelm H Schmitt
    Fifth Medical Clinic, University Hospital Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
    Nephrol Dial Transplant 20:1083-92. 2005
  9. ncbi request reprint Influence of hypersulfated and low molecular weight heparins on ischemia/reperfusion: injury and allograft rejection in rat kidneys
    Uwe Gottmann
    V Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Transpl Int 20:542-9. 2007
  10. doi request reprint Effects of N-acetylcysteine on renal hemodynamics in contrast media-induced nephropathy
    Stefan Krzossok
    Fifth Medical Department, Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    Kidney Blood Press Res 34:125-34. 2011

Detail Information

Publications34

  1. ncbi request reprint 15-Deoxyspergualin and cyclophosphamide, but not mycophenolate mofetil, prolong survival and attenuate renal disease in a murine model of ANCA-associated crescentic nephritis
    Rainer Birck
    Fifth Department of Medicine, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
    Nephrol Dial Transplant 21:58-63. 2006
    ....
  2. ncbi request reprint Serial ANCA determinations for monitoring disease activity in patients with ANCA-associated vasculitis: systematic review
    Rainer Birck
    Fifth Department of Medicine, University Hospital Mannheim, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany
    Am J Kidney Dis 47:15-23. 2006
    ..To assess the diagnostic value of serial ANCA testing in the follow-up of patients with AASV, we conducted a systematic review of the available literature...
  3. doi request reprint ANCA-associated vasculitis following influenza vaccination: causal association or mere coincidence?
    Rainer Birck
    Fifth Department of Medicine, University Hospital Mannheim, Germany
    J Clin Rheumatol 15:289-91. 2009
    ..Although our report does not prove a causal association between vaccination and vasculitis, it seems possible that in rare cases vaccination might induce vasculitic disease...
  4. ncbi request reprint [Rapidly progressive glomerulonephritis:classification, pathogenesis and clinical management]
    R Birck
    V Medizinische Klinik Universitätsklinikum Mannheim, Fakultät für Klinische Medizin der Universität Heidelberg, Mannheim, Germany
    Internist (Berl) 44:1107-19. 2003
    ..Some forms also require the use of plasma exchange therapy. Rapid diagnosis and early therapy improves both renal and overall outcome in the affected patients...
  5. ncbi request reprint Acetylcysteine for prevention of contrast nephropathy: meta-analysis
    Rainer Birck
    Fifth Department of Medicine, University Hospital Mannheim, Mannheim, Germany
    Lancet 362:598-603. 2003
    ..We aimed to assess the efficacy of acetylcysteine to prevent contrast nephropathy after administration of radiocontrast media in patients with chronic renal insufficiency...
  6. doi request reprint Donor desmopressin is associated with superior graft survival after kidney transplantation
    Urs Benck
    5th Department of Medicine, University Medical Centre Mannheim, Mannheim, Germany
    Transplantation 92:1252-8. 2011
    ..gov Identifier: NCT00115115). This study determines whether donor exposure to desmopressin (1-deamino-8-d-arginine-vasopressin [DDAVP]) before organ retrieval affects renal transplant outcome...
  7. ncbi request reprint SCG/Kinjoh mice: a model of ANCA-associated crescentic glomerulonephritis with immune deposits
    Irmgard Neumann
    Fifth Department of Medicine, University Hospital Mannheim, Mannheim, Germany
    Kidney Int 64:140-8. 2003
    ..Since no systematic serologic, immunohistologic, or structural evaluation had been performed thus far, we reinvestigated the development of ANCA and CGN in these mice...
  8. ncbi request reprint Prolonged treatment of refractory Wegener's granulomatosis with 15-deoxyspergualin: an open study in seven patients
    Wilhelm H Schmitt
    Fifth Medical Clinic, University Hospital Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
    Nephrol Dial Transplant 20:1083-92. 2005
    ..A 6 month course of the immunosuppressant 15-deoxyspergualin (DSG) has previously been employed successfully in these refractory cases. However, there are no reports on long-term treatment with DSG...
  9. ncbi request reprint Influence of hypersulfated and low molecular weight heparins on ischemia/reperfusion: injury and allograft rejection in rat kidneys
    Uwe Gottmann
    V Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Transpl Int 20:542-9. 2007
    ..Chemically modified heparins without anticoagulatory effects may offer a new treatment option in preventing I/R injury and CAN in human kidney transplantation...
  10. doi request reprint Effects of N-acetylcysteine on renal hemodynamics in contrast media-induced nephropathy
    Stefan Krzossok
    Fifth Medical Department, Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    Kidney Blood Press Res 34:125-34. 2011
    ..Conclusions: Renal perfusion is not affected by NAC application in a model of experimental contrast nephropathy in rats. Other effects of NAC might thus account for the presumed renoprotective properties...
  11. ncbi request reprint Dopamine treatment in brain-dead rats mediates anti-inflammatory effects: the role of hemodynamic stabilization and D-receptor stimulation
    Simone Hoeger
    Department of Medicine V, University Medical Center Mannheim, University of Heidelberg, Germany, and Départment de Médecine, Interne et Néphrologie, Centre Hospitalier Kirchberg, Luxembourg
    Transpl Int 20:790-9. 2007
    ..Hence, DA might reduce BD-induced monocyte infiltration possibly by hemodynamic stabilization, D-receptor activation, or a combination of both...
  12. doi request reprint Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized controlled trial
    Peter Schnuelle
    University Medical Centre Mannheim, 5th Department of Medicine, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    JAMA 302:1067-75. 2009
    ..Kidney graft function after transplantation can be improved through pharmacological donor pretreatment to limit organ injury from cold preservation...
  13. doi request reprint Effects of donor pre-treatment with dopamine on survival after heart transplantation: a cohort study of heart transplant recipients nested in a randomized controlled multicenter trial
    Urs Benck
    University Medical Centre Mannheim, Mannheim, Germany
    J Am Coll Cardiol 58:1768-77. 2011
    ..We determined the outcome of cardiac allografts from multiorgan donors enrolled in a randomized trial of donor pre-treatment with dopamine...
  14. ncbi request reprint Retinoid X receptor beta polymorphisms do not explain functional differences in vitamins D and A response in Antineutrophil cytoplasmic antibody associated vasculitis patients
    Anna Isabelle Kälsch
    Fifth Department of Medicine, University Hospital Mannheim, Faculty of Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Autoimmunity 42:467-74. 2009
    ..Since the inhibition of TNFalpha was more effective in patients, vitamin D supplementation might be an additional therapeutical approach...
  15. ncbi request reprint Treatment of proteinuria with low-molecular-weight heparin after renal transplantation
    Stefan Krzossok
    Fifth Medical Clinic, Nephrology Endocrinology Rheumatology, University Hospital of Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Transpl Int 17:468-72. 2004
    ..This approach might represent a promising new strategy for treatment of proteinuria after kidney transplantation...
  16. ncbi request reprint Persistent T-cell activation and clinical correlations in patients with ANCA-associated systemic vasculitis
    Smaragdi Marinaki
    Fifth Department of Medicine, University Hospital Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
    Nephrol Dial Transplant 21:1825-32. 2006
    ..This study was conducted to define persistent T-cell activation (PTA) in AASV patients and to assess whether this correlates with disease activity, disease severity, age or therapy...
  17. ncbi request reprint 15-Deoxyspergualin in patients with refractory ANCA-associated systemic vasculitis: a six-month open-label trial to evaluate safety and efficacy
    Rainer Birck
    Department of Nephrology, University Hospital Mannheim, Mannheim, Germany
    J Am Soc Nephrol 14:440-7. 2003
    ..It is concluded that treatment with DSG is successful in patients with refractory Wegener granulomatosis under careful monitoring of WBC count...
  18. ncbi request reprint The renoprotective potential of endothelin receptor antagonists
    T Knoll
    Department of Urology, University Hospital Mannheim, University of Heidelberg, Germany Faculty of Clinical Medicine of the University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
    Expert Opin Investig Drugs 9:1041-52. 2000
    ..So far, most data were derived from animal models, but they provide strong evidence that endothelin receptor antagonists may represent a powerful therapeutic strategy in ameliorating the course of acute and chronic renal failure...
  19. ncbi request reprint Therapeutic administration of an endothelin-A receptor antagonist after acute ischemic renal failure dose-dependently improves recovery of renal function
    T Knoll
    Department of Urology, University Hospital Mannheim, Faculty of Clinical Medicine of the University of Heidelberg, Germany
    J Cardiovasc Pharmacol 37:483-8. 2001
    ..It can be concluded from these results that recovery from ischemic ARF is significantly and dose-dependently enhanced by treatment with a selective ET(A)-receptor antagonist...
  20. doi request reprint Modulation of brain dead induced inflammation by vagus nerve stimulation
    S Hoeger
    Department of Medicine V Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, and Clinic for Anaesthesiology and Intensive Care Medicine, University Hospital of Mannheim, Mannheim, Germany
    Am J Transplant 10:477-89. 2010
    ..Vagus nerve stimulation variably affected gene expression in donor organs and improved renal function in recipients...
  21. ncbi request reprint Clinical benefit of a short term dietary oatmeal intervention in patients with type 2 diabetes and severe insulin resistance: a pilot study
    A Lammert
    V Medizinische Klinik, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
    Exp Clin Endocrinol Diabetes 116:132-4. 2008
    ..To evaluate the potential effectiveness of 'carbohydrate days' as a dietary intervention to overcome insulin resistance in type 2 diabetes...
  22. pmc Abnormalities of CD4 T cell subpopulations in ANCA-associated vasculitis
    S Marinaki
    Fifth Department of Medicine, University Hospital Mannheim, University of Heidelberg, Germany
    Clin Exp Immunol 140:181-91. 2005
    ..These findings were confined to the memory population of CD4(+) cells. We conclude that AAV patients are lymphopenic and have low numbers of CD4(+) T cells, which seem to be in a persistent state of activation...
  23. ncbi request reprint Impact of donor dopamine on immediate graft function after kidney transplantation
    P Schnuelle
    Vth Medical Clinic Department of Nephrology and Endocrinology, University Hospital Mannheim, Mannheim, Germany
    Am J Transplant 4:419-26. 2004
    ..The beneficial effect of dopamine is achievable without side-effects for the recipients, and correlates with superior long-term graft survival...
  24. pmc In vivo effects of cyclic administration of 15-deoxyspergualin on leucocyte function in patients with Wegener's granulomatosis
    A I Kälsch
    Department of Clinical Chemistry, University Hospital Mannheim, University of Heidelberg, Germany
    Clin Exp Immunol 146:455-62. 2006
    ..Our data demonstrate that DSG influences T cell and monocyte activation in a reversible fashion. Although DSG causes neutropenia in these patients, it does not influence neutrophil function...
  25. pmc Central vein stenosis in a dialysis patient: a case report
    Uwe Gottmann
    5th Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68135, Mannheim, Germany
    J Med Case Rep 6:189. 2012
    ..abstract:..
  26. doi request reprint Use of highly sensitive C-reactive protein for followup of Wegener's granulomatosis
    Anna Isabelle Kälsch
    Fifth Medical Department, University Medical Centre Mannheim, Medical Faculty of Mannheim of the University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68187 Mannheim, Germany
    J Rheumatol 37:2319-25. 2010
    ..We evaluated whether during remission elevated highly sensitive CRP (hsCRP) precedes relapse as a marker of subclinical inflammation and thus might improve clinical assessment...
  27. ncbi request reprint Comparison of early renal function parameters for the prediction of 5-year graft survival after kidney transplantation
    Peter Schnuelle
    University Hospital Mannheim, Vth Medical Clinic, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Nephrol Dial Transplant 22:235-45. 2007
    ..Early graft function (EGF) has an enduring effect on the subsequent course after kidney transplantation. This study compares quantitative parameters of EGF for the prediction of graft survival...
  28. ncbi request reprint Targets for endothelin in the diseased kidney: clues for therapeutic intervention
    P Rohmeiss
    Fifth Department of Medicine, University Hospital Mannheim, University of Heidelberg, Germany
    Exp Nephrol 7:1-10. 1999
    ..Future developments concerning the use of endothelin receptor antagonists and the role of endothelin in the kidney transplantation setting are discussed...
  29. pmc Imatinib mesylate, a new kid on the block for the treatment of anti-neutrophil cytoplasmic autoantibodies-associated vasculitis?
    A I Kälsch
    Fifth Medical Department, University Hospital Mannheim, Medical Faculty of Mannheim of the University of Heidelberg, Germany
    Clin Exp Immunol 151:391-8. 2008
    ..These observed effects of imatinib were similar in T cells from AASV patients and from healthy individuals. Imatinib might be an alternative therapeutical option for AASV patients refractory to conventional therapy...
  30. doi request reprint Aneurysmal subarachnoid hemorrhage (aSAH) results in low prevalence of neuro-endocrine dysfunction and NOT deficiency
    Alexander Lammert
    Fifth Department of Medicine, University Medical Center Mannheim, Mannheim, Germany
    Pituitary 15:505-12. 2012
    ..This hypothesis is strengthened by the fact that only patients with inferior clinical outcome after aSAH as assessed by GOS demonstrated neuro-endocrine dysfunction...
  31. ncbi request reprint Increased activity of the renal kallikrein-kinin system in autosomal dominant polycystic kidney disease in rats, but not in humans
    Claude Braun
    Fifth Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, D 68135 Mannheim, Germany
    Int Immunopharmacol 2:1949-56. 2002
    ..These data indicate that there are fundamental differences in the factors influencing the course of the disease in human and rat ADPKD...
  32. pmc Inhibition of neutrophil-mediated production of reactive oxygen species (ROS) by endothelial cells is not impaired in anti-neutrophil cytoplasmic autoantibodies (ANCA)-associated vasculitis patients
    F Al Laham
    Vth Medical Department, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany
    Clin Exp Immunol 161:268-75. 2010
    ..Our data do not support the hypothesis that endothelial cells inhibit ROS production of neutrophils from AAV patients inadequately. Impaired neutrophil degranulation may exist in active patients, but this finding needs to be confirmed...
  33. ncbi request reprint Nephropathy induced by contrast medium
    Claude Braun
    N Engl J Med 348:2257-9; author reply 2257-9. 2003
  34. ncbi request reprint Glomerular immune deposits are associated with increased proteinuria in patients with ANCA-associated crescentic nephritis
    Irmgard Neumann
    Department of Nephrology, Wilhelminenspital, Vienna, Austria
    Nephrol Dial Transplant 18:524-31. 2003
    ..In some patients, however, significant amounts of immune deposits may be detected. Therefore, we evaluated the clinical significance of these immune deposits in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune CGN...