Research Topics
Genomes and Genes | Katharina BiermannSummaryAffiliation: University of Bonn Country: Germany Publications
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Detail Information
Publications
Cancer stem cells as targets for cancer therapy: selected cancers as examplesSabine Hombach-Klonisch
Department Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Canada
Arch Immunol Ther Exp (Warsz) 56:165-80. 2008..Finally, alternative targeted anticancer therapies arising from recently identified molecules with cancer-(semi-)selective capabilities (e.g. apoptin, Brevinin-2R) are considered...
Genome-wide expression profiling reveals new insights into pathogenesis and progression of testicular germ cell tumorsKatharina Biermann
Department of Pathology, University of Bonn, Bonn, Germany
Cancer Genomics Proteomics 4:359-67. 2007..In summary, our data identified tumor type-specific gene signatures of GCT and provided new insights into genetic pathways driving the transition to seminomas and embryonal carcinomas from their respective precursor lesions...- Uterine tumor resembling an ovarian sex cord tumor associated with metastasisKatharina Biermann
Department of Pathology, University of Bonn, Bonn, Germany
Int J Gynecol Pathol 27:58-60. 2008..This case indicates that although the majority of UTROSCT are benign tumors, some of them might undergo malignant transformation and have a metastatic potency... - Diagnostic value of markers M2A, OCT3/4, AP-2gamma, PLAP and c-KIT in the detection of extragonadal seminomasK Biermann
Institute of Pathology, Department of Developmental Pathology, University of Bonn, Germany
Histopathology 49:290-7. 2006..To compare the suitability of new seminoma markers including transcription factors AP-2gamma, OCT3/4 and M2A for detection of metastatic and extragonadal seminomas with the two well-known markers c-KIT and PLAP... - Gene expression profiling identifies new biological markers of neoplastic germ cellsKatharina Biermann
Institute of Pathology, University Hospital Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
Anticancer Res 27:3091-100. 2007..There is only limited knowledge about gene expression in human testicular germ cell tumors of adolescents and adults (TGCTs), and, in particular in its preinvasive stage intratubular germ cell neoplasia unclassified (IGCNU)... - c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminomaK Biermann
Institute of Pathology, University of Bonn, Germany
J Pathol 213:311-8. 2007..Furthermore, our findings show that c-KIT down-regulation occurs during the progression of IGCNU to seminoma... 
The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expressionDaniel Nettersheim
Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, Germany
Genes Chromosomes Cancer 50:1033-42. 2011..Hence, NANOG is not a primary target gene responsible for the inhibition of differentiation in seminomas...- Critical function of AP-2 gamma/TCFAP2C in mouse embryonic germ cell maintenanceSusanne Weber
Institute of Pathology, Department of Developmental Pathology, University of Bonn, Bonn, Germany
Biol Reprod 82:214-23. 2010..Our results implicate Tcfap2c as an important effector of Prdm1 activity that is required for PGC maintenance, most likely mediating Prdm1-induced suppression of mesodermal differentiation... - NANOG promoter methylation and expression correlation during normal and malignant human germ cell developmentDaniel Nettersheim
Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, Germany
Epigenetics 6:114-22. 2011..Finally, methylation of CpGs in the NANOG promoter in germ cell tumors and derived cell lines correlated to differentiation state... - Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumorsDawid Eckert
Department of Developmental Pathology, Institute of Pathology, University of Bonn, Germany
BMC Dev Biol 8:106. 2008..This imposes epigenetic modifications leading to transcriptional repression in mouse PGCs enabling them to escape the somatic differentiation program during migration, while expressing markers of pluripotency... - First report of an unexpected blind-ending duplication of the ureter as a rare pitfall in kidney transplantationStefan Hauser
Department of Urology, University of Bonn, Bonn, Germany
Transpl Int 21:696-7. 2008..Accuracy should be ensured when exploring the exact anatomy of the donor organ... - CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancerJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
Urology 71:161-7. 2008..CpG island hypermethylation causes gene silencing and could be decisive in prostate carcinogenesis and progression. We investigated its role at multiple gene sites during prostate carcinogenesis... - [Aggressive course of a malignant alveolar soft tissue sarcoma]T Strunk
Klinik und Poliklinik fur Urologie, Medizinische Einrichtungen der Universität Bonn, 53127 Bonn
Urologe A 46:1422-4. 2007..We report a patient's history who rapidly died of his sickness despite the low initial tumor stage... - Prostate cancer tissue is masked by bicalutamide: a case reportJ Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
Eur J Med Res 12:212-5. 2007..Despite of detailed histological work-up and immunohistochemistry cancer suspicious lesions were not found. We think that bicalutamide may be capable of masking prostate cancer cells... - Aggressive angiomyxoma of the prostate mimicking benign prostatic hyperplasiaPatrick J Bastian
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
Eur J Med Res 11:167-9. 2006..Only few cases in males have been reported in the literature. We describe what we think is the first case of an aggressive angiomyxoma arising in the prostate presenting with classical symptoms of benign prostatic hyperplasia... - [Pediatric renal cell carcinoma. A rare differential diagnosis of Wilms' tumor]N Fischer
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Deutschland
Urologe A 47:620-3. 2008..Our objective is to discuss the difficulties in clinical diagnosis, prognosis, and therapy of this very rare disease in children and to provide a review of the current literature... - Stem cell marker expression in small cell lung carcinoma and developing lung tissueLin Kristin Koch
Institut of Pathology, University of Bonn, Bonn, Germany
Hum Pathol 39:1597-605. 2008..Taken together, we show that small cell lung cancers and clustered epithelial cells in developing proximal bronchi share the expression of stem cell markers, suggesting a possible histogenetic link... - [Primitive neuroectodermal tumor of the kidney]J Ellinger
Klinik und Poliklinik fur Urologie, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Strasse 25, 53105, Bonn
Urologe A 45:735-8. 2006..We represent two cases of metastatic renal PNET in a 28- and 39-year-old patient. Due to the multimodal treatment a partial and a complete remission was achieved, respectively... - TCam-2 but not JKT-1 cells resemble seminoma in cell cultureD Eckert
Abteilung für Entwicklungspathologie, Institut fur Pathologie, Universitat Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
Cell Tissue Res 331:529-38. 2008..The data represent the first genome-wide expression analysis of the two cell lines and comparison/clustering with subgroups of germ cell tumors. Only TCam-2 seems to represent a suitable in vitro model for seminoma... - DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancerOlufunmilade A Omisanjo
Department of Urology and Pediatric Urology, Giessen, Germany
Histochem Cell Biol 127:175-81. 2007..This holds true also in testicular tumors, where HDAC1 has been demonstrated in embryonal carcinoma, seminoma and teratoma. Interestingly, DNMT1 was not expressed in seminoma, but upregulated in embryonal carcinoma... - Novel germ cell markers characterize testicular seminoma and fetal testisIsabella Gashaw
Institute of Anatomy, University of Duisburg Essen, Essen, Germany
Mol Hum Reprod 13:721-7. 2007.... - Primitive neuroectodermal tumor: rare, highly aggressive differential diagnosis in urologic malignanciesJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
Urology 68:257-62. 2006..It is characterized by the expression of MIC2 and neural markers (eg, neuron-specific enolase, synaptophysin, S-100, vimentin, Leu-7), and the presence of the EWS-FLI1 translocation... - Pathological consequences of VCP mutations on human striated muscleChristian U Hübbers
Institute of Biochemistry I, University of Cologne, Cologne, Germany
Brain 130:381-93. 2007..The latter findings provide a novel link to VCP carbohydrate interactions in the complex pathology of IBMPFD... - Epigenetics in male germ cellsKatharina Biermann
, , Standort Giessen, , Rudolf-Buchheim-Strasse 7, 35383 Giessen, Germany
J Androl 28:466-80. 2007