Katharina Biermann

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. pmc Cancer stem cells as targets for cancer therapy: selected cancers as examples
    Sabine Hombach-Klonisch
    Department Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Canada
    Arch Immunol Ther Exp (Warsz) 56:165-80. 2008
  2. ncbi request reprint Genome-wide expression profiling reveals new insights into pathogenesis and progression of testicular germ cell tumors
    Katharina Biermann
    Department of Pathology, University of Bonn, Bonn, Germany
    Cancer Genomics Proteomics 4:359-67. 2007
  3. ncbi request reprint Uterine tumor resembling an ovarian sex cord tumor associated with metastasis
    Katharina Biermann
    Department of Pathology, University of Bonn, Bonn, Germany
    Int J Gynecol Pathol 27:58-60. 2008
  4. ncbi request reprint Diagnostic value of markers M2A, OCT3/4, AP-2gamma, PLAP and c-KIT in the detection of extragonadal seminomas
    K Biermann
    Institute of Pathology, Department of Developmental Pathology, University of Bonn, Germany
    Histopathology 49:290-7. 2006
  5. ncbi request reprint Gene expression profiling identifies new biological markers of neoplastic germ cells
    Katharina Biermann
    Institute of Pathology, University Hospital Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Anticancer Res 27:3091-100. 2007
  6. ncbi request reprint c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminoma
    K Biermann
    Institute of Pathology, University of Bonn, Germany
    J Pathol 213:311-8. 2007
  7. doi request reprint The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expression
    Daniel Nettersheim
    Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, Germany
    Genes Chromosomes Cancer 50:1033-42. 2011
  8. doi request reprint Critical function of AP-2 gamma/TCFAP2C in mouse embryonic germ cell maintenance
    Susanne Weber
    Institute of Pathology, Department of Developmental Pathology, University of Bonn, Bonn, Germany
    Biol Reprod 82:214-23. 2010
  9. pmc NANOG promoter methylation and expression correlation during normal and malignant human germ cell development
    Daniel Nettersheim
    Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, Germany
    Epigenetics 6:114-22. 2011
  10. pmc Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors
    Dawid Eckert
    Department of Developmental Pathology, Institute of Pathology, University of Bonn, Germany
    BMC Dev Biol 8:106. 2008

Collaborators

Detail Information

Publications24

  1. pmc Cancer stem cells as targets for cancer therapy: selected cancers as examples
    Sabine Hombach-Klonisch
    Department Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Canada
    Arch Immunol Ther Exp (Warsz) 56:165-80. 2008
    ..Finally, alternative targeted anticancer therapies arising from recently identified molecules with cancer-(semi-)selective capabilities (e.g. apoptin, Brevinin-2R) are considered...
  2. ncbi request reprint Genome-wide expression profiling reveals new insights into pathogenesis and progression of testicular germ cell tumors
    Katharina Biermann
    Department of Pathology, University of Bonn, Bonn, Germany
    Cancer Genomics Proteomics 4:359-67. 2007
    ..In summary, our data identified tumor type-specific gene signatures of GCT and provided new insights into genetic pathways driving the transition to seminomas and embryonal carcinomas from their respective precursor lesions...
  3. ncbi request reprint Uterine tumor resembling an ovarian sex cord tumor associated with metastasis
    Katharina Biermann
    Department of Pathology, University of Bonn, Bonn, Germany
    Int J Gynecol Pathol 27:58-60. 2008
    ..This case indicates that although the majority of UTROSCT are benign tumors, some of them might undergo malignant transformation and have a metastatic potency...
  4. ncbi request reprint Diagnostic value of markers M2A, OCT3/4, AP-2gamma, PLAP and c-KIT in the detection of extragonadal seminomas
    K Biermann
    Institute of Pathology, Department of Developmental Pathology, University of Bonn, Germany
    Histopathology 49:290-7. 2006
    ..To compare the suitability of new seminoma markers including transcription factors AP-2gamma, OCT3/4 and M2A for detection of metastatic and extragonadal seminomas with the two well-known markers c-KIT and PLAP...
  5. ncbi request reprint Gene expression profiling identifies new biological markers of neoplastic germ cells
    Katharina Biermann
    Institute of Pathology, University Hospital Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Anticancer Res 27:3091-100. 2007
    ..There is only limited knowledge about gene expression in human testicular germ cell tumors of adolescents and adults (TGCTs), and, in particular in its preinvasive stage intratubular germ cell neoplasia unclassified (IGCNU)...
  6. ncbi request reprint c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminoma
    K Biermann
    Institute of Pathology, University of Bonn, Germany
    J Pathol 213:311-8. 2007
    ..Furthermore, our findings show that c-KIT down-regulation occurs during the progression of IGCNU to seminoma...
  7. doi request reprint The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expression
    Daniel Nettersheim
    Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, Germany
    Genes Chromosomes Cancer 50:1033-42. 2011
    ..Hence, NANOG is not a primary target gene responsible for the inhibition of differentiation in seminomas...
  8. doi request reprint Critical function of AP-2 gamma/TCFAP2C in mouse embryonic germ cell maintenance
    Susanne Weber
    Institute of Pathology, Department of Developmental Pathology, University of Bonn, Bonn, Germany
    Biol Reprod 82:214-23. 2010
    ..Our results implicate Tcfap2c as an important effector of Prdm1 activity that is required for PGC maintenance, most likely mediating Prdm1-induced suppression of mesodermal differentiation...
  9. pmc NANOG promoter methylation and expression correlation during normal and malignant human germ cell development
    Daniel Nettersheim
    Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, Germany
    Epigenetics 6:114-22. 2011
    ..Finally, methylation of CpGs in the NANOG promoter in germ cell tumors and derived cell lines correlated to differentiation state...
  10. pmc Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors
    Dawid Eckert
    Department of Developmental Pathology, Institute of Pathology, University of Bonn, Germany
    BMC Dev Biol 8:106. 2008
    ..This imposes epigenetic modifications leading to transcriptional repression in mouse PGCs enabling them to escape the somatic differentiation program during migration, while expressing markers of pluripotency...
  11. doi request reprint First report of an unexpected blind-ending duplication of the ureter as a rare pitfall in kidney transplantation
    Stefan Hauser
    Department of Urology, University of Bonn, Bonn, Germany
    Transpl Int 21:696-7. 2008
    ..Accuracy should be ensured when exploring the exact anatomy of the donor organ...
  12. doi request reprint CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Urology 71:161-7. 2008
    ..CpG island hypermethylation causes gene silencing and could be decisive in prostate carcinogenesis and progression. We investigated its role at multiple gene sites during prostate carcinogenesis...
  13. ncbi request reprint [Aggressive course of a malignant alveolar soft tissue sarcoma]
    T Strunk
    Klinik und Poliklinik fur Urologie, Medizinische Einrichtungen der Universität Bonn, 53127 Bonn
    Urologe A 46:1422-4. 2007
    ..We report a patient's history who rapidly died of his sickness despite the low initial tumor stage...
  14. ncbi request reprint Prostate cancer tissue is masked by bicalutamide: a case report
    J Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Med Res 12:212-5. 2007
    ..Despite of detailed histological work-up and immunohistochemistry cancer suspicious lesions were not found. We think that bicalutamide may be capable of masking prostate cancer cells...
  15. ncbi request reprint Aggressive angiomyxoma of the prostate mimicking benign prostatic hyperplasia
    Patrick J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Eur J Med Res 11:167-9. 2006
    ..Only few cases in males have been reported in the literature. We describe what we think is the first case of an aggressive angiomyxoma arising in the prostate presenting with classical symptoms of benign prostatic hyperplasia...
  16. doi request reprint [Pediatric renal cell carcinoma. A rare differential diagnosis of Wilms' tumor]
    N Fischer
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Deutschland
    Urologe A 47:620-3. 2008
    ..Our objective is to discuss the difficulties in clinical diagnosis, prognosis, and therapy of this very rare disease in children and to provide a review of the current literature...
  17. doi request reprint Stem cell marker expression in small cell lung carcinoma and developing lung tissue
    Lin Kristin Koch
    Institut of Pathology, University of Bonn, Bonn, Germany
    Hum Pathol 39:1597-605. 2008
    ..Taken together, we show that small cell lung cancers and clustered epithelial cells in developing proximal bronchi share the expression of stem cell markers, suggesting a possible histogenetic link...
  18. ncbi request reprint [Primitive neuroectodermal tumor of the kidney]
    J Ellinger
    Klinik und Poliklinik fur Urologie, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Strasse 25, 53105, Bonn
    Urologe A 45:735-8. 2006
    ..We represent two cases of metastatic renal PNET in a 28- and 39-year-old patient. Due to the multimodal treatment a partial and a complete remission was achieved, respectively...
  19. ncbi request reprint TCam-2 but not JKT-1 cells resemble seminoma in cell culture
    D Eckert
    Abteilung für Entwicklungspathologie, Institut fur Pathologie, Universitat Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Cell Tissue Res 331:529-38. 2008
    ..The data represent the first genome-wide expression analysis of the two cell lines and comparison/clustering with subgroups of germ cell tumors. Only TCam-2 seems to represent a suitable in vitro model for seminoma...
  20. ncbi request reprint DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer
    Olufunmilade A Omisanjo
    Department of Urology and Pediatric Urology, Giessen, Germany
    Histochem Cell Biol 127:175-81. 2007
    ..This holds true also in testicular tumors, where HDAC1 has been demonstrated in embryonal carcinoma, seminoma and teratoma. Interestingly, DNMT1 was not expressed in seminoma, but upregulated in embryonal carcinoma...
  21. ncbi request reprint Novel germ cell markers characterize testicular seminoma and fetal testis
    Isabella Gashaw
    Institute of Anatomy, University of Duisburg Essen, Essen, Germany
    Mol Hum Reprod 13:721-7. 2007
    ....
  22. ncbi request reprint Primitive neuroectodermal tumor: rare, highly aggressive differential diagnosis in urologic malignancies
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Urology 68:257-62. 2006
    ..It is characterized by the expression of MIC2 and neural markers (eg, neuron-specific enolase, synaptophysin, S-100, vimentin, Leu-7), and the presence of the EWS-FLI1 translocation...
  23. ncbi request reprint Pathological consequences of VCP mutations on human striated muscle
    Christian U Hübbers
    Institute of Biochemistry I, University of Cologne, Cologne, Germany
    Brain 130:381-93. 2007
    ..The latter findings provide a novel link to VCP carbohydrate interactions in the complex pathology of IBMPFD...
  24. ncbi request reprint Epigenetics in male germ cells
    Katharina Biermann
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Giessen und Marburg GmbH, Standort Giessen, Justus Liebig Universitat Giessen, Rudolf Buchheim Strasse 7, 35383 Giessen, Germany
    J Androl 28:466-80. 2007