A Bierhaus

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Central sympatholytics prolong survival in experimental sepsis
    Stefan Hofer
    Department of Anaesthesiology, University Hospital Heidelberg, Heidelberg, Germany
    Crit Care 13:R11. 2009
  2. pmc Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis
    Christian Bopp
    Department of Anesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Crit Care 12:201. 2008
  3. pmc Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products
    Philipp Ehlermann
    Universitat Heidelberg, Abteilung Innere Medizin III, Heidelberg, Germany
    Cardiovasc Diabetol 5:6. 2006
  4. pmc Associations of fetuin-A levels with vascular disease in type 2 diabetes patients with early diabetic nephropathy
    Marcel Roos
    Department of Nephrology, Klinikum rechts der Isar, Munich, Germany
    Cardiovasc Diabetol 9:48. 2010
  5. pmc Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes
    Per M Humpert
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Germany
    Cardiovasc Diabetol 6:9. 2007
  6. pmc RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner
    David Frommhold
    Department of Neonatology, University of Heidelberg, 20 Heidelberg, Germany
    BMC Immunol 12:56. 2011
  7. pmc Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation
    Astrid Riehl
    Signal Transduction and Growth Control, German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, Heidelberg, Germany
    BMC Genomics 11:537. 2010
  8. doi Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications
    A Bierhaus
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Diabetologia 52:2251-63. 2009
  9. pmc A mechanism converting psychosocial stress into mononuclear cell activation
    Angelika Bierhaus
    Department of Medicine I, University of Heidelberg, Otto Meyerhof Zentrum, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 100:1920-5. 2003
  10. ncbi A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetes
    G Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 116:14-7. 2008

Collaborators

Detail Information

Publications98

  1. pmc Central sympatholytics prolong survival in experimental sepsis
    Stefan Hofer
    Department of Anaesthesiology, University Hospital Heidelberg, Heidelberg, Germany
    Crit Care 13:R11. 2009
    ....
  2. pmc Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis
    Christian Bopp
    Department of Anesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Crit Care 12:201. 2008
    ..Understanding the basic signal transduction events triggered by this multi-ligand receptor may offer new diagnostic and therapeutic options in patients with sepsis...
  3. pmc Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products
    Philipp Ehlermann
    Universitat Heidelberg, Abteilung Innere Medizin III, Heidelberg, Germany
    Cardiovasc Diabetol 5:6. 2006
    ..As recently S100 proteins have been identified as ligands of RAGE, we sought to determine the effects of the proinflammatory heterodimer of S100A8/S100A9 on the RAGE-NFkappaB mediated induction of proinflammatory gene expression...
  4. pmc Associations of fetuin-A levels with vascular disease in type 2 diabetes patients with early diabetic nephropathy
    Marcel Roos
    Department of Nephrology, Klinikum rechts der Isar, Munich, Germany
    Cardiovasc Diabetol 9:48. 2010
    ..This study aims to define the role of fetuin-A as marker for micro- and macrovascular disease in a high risk population of patients with type 2 diabetes mellitus and early diabetic nephropathy...
  5. pmc Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes
    Per M Humpert
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Germany
    Cardiovasc Diabetol 6:9. 2007
    ..Since previous data were partly divergent, the aim of this study was to compare sRAGE and esRAGE in a head-to-head analysis in patients with type 2 diabetes (T2DM) with albuminuria...
  6. pmc RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner
    David Frommhold
    Department of Neonatology, University of Heidelberg, 20 Heidelberg, Germany
    BMC Immunol 12:56. 2011
    ....
  7. pmc Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation
    Astrid Riehl
    Signal Transduction and Growth Control, German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, Heidelberg, Germany
    BMC Genomics 11:537. 2010
    ....
  8. doi Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications
    A Bierhaus
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Diabetologia 52:2251-63. 2009
    ....
  9. pmc A mechanism converting psychosocial stress into mononuclear cell activation
    Angelika Bierhaus
    Department of Medicine I, University of Heidelberg, Otto Meyerhof Zentrum, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 100:1920-5. 2003
    ..Activation of NF-kappaB represents a downstream effector for the neuroendocrine response to stressful psychosocial events and links changes in the activity of the neuroendocrine axis to the cellular response...
  10. ncbi A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetes
    G Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 116:14-7. 2008
    ..We studied the association between a functionally relevant M55V polymorphism in the SUMO4 gene with microvascular diabetic complications in patients with type 1 diabetes...
  11. doi The -174G>C IL-6 gene promoter polymorphism and diabetic microvascular complications
    G Rudofsky
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Horm Metab Res 41:308-13. 2009
    ..In conclusion these data suggest no major influence of the -174G>C variant in the promoter region of the IL-6 gene on the development of microvascular complications in patients with diabetes...
  12. ncbi Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB
    A Bierhaus
    Department of Medicine I and Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Diabetes 50:2792-808. 2001
    ....
  13. ncbi Improved vascular function upon pioglitazone treatment in type 2 diabetes is not associated with changes in mononuclear NF-kappaB binding activity
    G Rudofsky
    Department Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Horm Metab Res 39:665-71. 2007
    ....
  14. doi Rosiglitazone reduces angiotensin II and advanced glycation end product-dependent sustained nuclear factor-kappaB activation in cultured human proximal tubular epithelial cells
    M Morcos
    Department of Internal Medicine 1 Endocrinology, Metabolism and Clinical Chemistry, University of Heidelberg, Germany
    Horm Metab Res 40:752-9. 2008
    ..Most importantly, rosiglitazone effects on NFkappaB activation were maximal at later time points, indicating that rosiglitazone treatment confers long lasting renoprotective effects...
  15. ncbi Postprandial mononuclear NF-kappaB activation is independent of the AGE-content of a single meal
    S Schiekofer
    Department of Medicine I, University of Heidelberg, Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 114:160-7. 2006
    ..The aim of this study was to analyze the postprandial effects of a casein meal with low or high AGE content on postprandial NF-kappaB activation in peripheral blood mononuclear cells (pBMC) of healthy volunteers...
  16. ncbi Promoter polymorphisms of UCP1, UCP2, and UCP3 are not associated with diabetic microvascular complications in type 2 diabetes
    G Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Heidelberg, Germany
    Horm Metab Res 39:306-9. 2007
  17. ncbi The DG10S478 variant in the TCF7L2 gene is not associated with microvascular complications in type 2 diabetes
    S Buchbinder
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 116:211-4. 2008
    ..However, no data exist about the influence of DG10S478 variants on manifestation of diabetes and development of diabetic complications...
  18. ncbi No association of the 94T/G polymorphism in the adiponectin gene with diabetic complications
    G Rudofsky
    Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Heidelberg, Germany
    Diabetes Obes Metab 7:455-9. 2005
    ..This study examined a possible association of the T/G polymorphism at nucleotide 94 in the adiponectin gene with the prevalence of diabetic complications...
  19. doi Maturity-Onset Diabetes of the Young (MODY) caused by a novel nonsense mutation E41X in the HNF-1α gene
    S Buchbinder
    University of Heidelberg, Department of Internal Medicine 1 and Clinical Chemistry, Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 119:182-5. 2011
    ..In spite of the severe gene defect, which truncates the protein behind the dimerization domain, the phenotype of E41X was relatively benign without frequent diabetic complications...
  20. ncbi Levels of three distinct p75 neurotrophin receptor forms found in human plasma are altered in type 2 diabetic patients
    P M Humpert
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Diabetologia 50:1517-22. 2007
    ....
  21. ncbi Reduction of postprandial hyperglycemia in patients with type 2 diabetes reduces NF-kappaB activation in PBMCs
    G Rudofsky
    Department of Medicine I, University of Heidelberg, Germany
    Horm Metab Res 36:630-8. 2004
    ....
  22. doi C332C genotype of glyoxalase 1 and its association with late diabetic complications
    J B Groener
    Department of Medicine, Division of Endocrinology and Clinical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany heidelberg de
    Exp Clin Endocrinol Diabetes 121:436-9. 2013
    ..Here, we examine a possible association of a single nucleotide polymorphism of glyoxalase 1 gene (Glo1 A332C, rs4746 or rs2736654) with the prevalence of microvascular diabetic complications in patients with type 1 and type 2 diabetes...
  23. doi Aryl hydrocarbon receptor interacting protein gene (AIP) mutations are rare in patients with hormone secreting or non-secreting pituitary adenomas
    S Buchbinder
    University of Heidelberg, Department of Internal Medicine, Endocrinology, Metabolism and Clinical Chemistry Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 116:625-8. 2008
    ..Recent data suggest that mutations in the aryl hydrocarbon receptor interacting protein gene (AIP) are associated with pituitary adenomas. AIP is considered to be a tumour suppressor gene...
  24. ncbi Long-term treatment of central Cushing's syndrome with rosiglitazone
    M Morcos
    University of Heidelberg, Department of Internal Medicine, Endocrinology, Metabolism and Clinical Chemistry Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 115:292-7. 2007
    ..Some studies revealed beneficial effects of the PPARgamma (Peroxisome-Proliferator-Activator- Receptor-gamma)-agonist rosiglitazone (RG) in in vitro studies, animal models and short term clinical studies...
  25. doi HMGB1 as a predictor of infarct transmurality and functional recovery in patients with myocardial infarction
    M Andrassy
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Intern Med 270:245-53. 2011
    ..The aim of this study was to analyse serum HMGB1 concentration and its correlation with infarct transmurality and functional recovery in patients with ST-elevation (STEMI) and non-ST-elevation myocardial infarction (NSTEMI)...
  26. doi Is diabetes an acquired disorder of reactive glucose metabolites and their intermediates?
    T Fleming
    Department of Medicine and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Diabetologia 55:1151-5. 2012
    ....
  27. ncbi Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patient
    P M Humpert
    Department of Medicine I, University Clinics Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 113:538-40. 2005
    ..Locally applied mBMC could, therefore, provide a treatment option in end stage diabetic wound healing disorders...
  28. ncbi sRAGE and esRAGE are not associated with peripheral or autonomic neuropathy in type 2 diabetes
    P M Humpert
    Universitätsklinikum Heidelberg Medizinische Klinik 1 und Klinische Chemie, Heidelberg, Germany
    Horm Metab Res 39:899-902. 2007
    ..01) and presence of retinopathy (beta=-0.19, p<0.05). In contrast to classical risk factors, plasma soluble RAGE and endogenous secretory RAGE are not associated with measures of diabetic neuropathy in type 2 diabetes patients...
  29. ncbi Clinical benefit of a short term dietary oatmeal intervention in patients with type 2 diabetes and severe insulin resistance: a pilot study
    A Lammert
    V Medizinische Klinik, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
    Exp Clin Endocrinol Diabetes 116:132-4. 2008
    ..To evaluate the potential effectiveness of 'carbohydrate days' as a dietary intervention to overcome insulin resistance in type 2 diabetes...
  30. ncbi [Non-enzymatic glycation and oxidative stress in chronic illnesses and diabetes mellitus]
    P P Nawroth
    Abteilung Innere Medizin I, Endokrinologie und Stoffwechsel, Universitat Heidelberg
    Med Klin (Munich) 94:29-38. 1999
    ....
  31. ncbi [Coagulation, inflammation and immune response -- an evolutionary conserved plan as cause for disseminated intravasal coagulation?]
    A Bierhaus
    Universitat Heidelberg, Medizin I, Im Neuenheimer Feld 410, 69120 Heidelberg E Mail
    Hamostaseologie 25:23-32. 2005
    ..The close connection between coagulation, inflammation, and immune defense has been conserved during evolution and can still be found in humans in a number of physiologic reactions to potentially detrimental effects...
  32. doi [The unsolved problem of diabetes mellitus type 2 and associated complications]
    M Morcos
    Medizinische Klinik Krehl Klinik, Abteilung Innere Medizin 1 und Klinische Chemie, Universitatsklinikum Heidelberg, INF 410, 69120 Heidelberg, Deutschland
    Chirurg 80:398, 400-4, 406-9. 2009
    ..Finally, generating treatment guidelines is extremely difficult as clinical studies targeting vascular endpoints need more than 10 years to become informative, partly due to the so-called glycaemic memory...
  33. doi Depletion of the receptor for advanced glycation end products (RAGE) sensitizes towards apoptosis via p53 and p73 posttranslational regulation
    M Brune
    Department of Internal Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Oncogene 32:1460-8. 2013
    ..Thus, the RAGE-mediated posttranslational regulation of p53 and p73 orchestrates a sequence of events culminating in control of intrinsic and extrinsic apoptosis signaling pathways...
  34. ncbi Distinct roles of Mac-1 and its counter-receptors in neonatal obstructive nephropathy
    B Lange-Sperandio
    Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
    Kidney Int 69:81-8. 2006
    ..ICAM-1 and its new ligands RAGE and JAM-C are sequentially activated in UUO. Blocking of Mac-1 and its ligands may confer synergistic renoprotective effects in neonatal obstructive nephropathy...
  35. doi Glycated and carbamylated albumin are more "nephrotoxic" than unmodified albumin in the amphibian kidney
    M L Gross
    Institute of Pathology, University of Heidelberg, Germany
    Am J Physiol Renal Physiol 301:F476-85. 2011
    ..The data indicate that carbamylation and glycation increase the capacity of albumin to cause tubular cell damage and peritubular fibrosis...
  36. ncbi A 63bp deletion in the promoter of rage correlates with a decreased risk for nephropathy in patients with type 2 diabetes
    G Rudofsky
    Department of Medicine I, Otto Meyerhof Zentrum and Department of Nephrology, University of Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 112:135-41. 2004
    ..The observed difference between type 1 and type 2 diabetes might point to diverse pathomechanisms of nephropathy in both types of diabetes...
  37. doi Critical evaluation of mouse models used to study pain and loss of pain perception in diabetic neuropathy
    A Bierhaus
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 120:188-90. 2012
    ....
  38. ncbi Posttranslational modification of lipoproteins--a fatal attraction in metabolic disease?
    A Bierhaus
    Department of Medicine I, University of Heidelberg, Heidelberg, Germany
    J Alzheimers Dis 7:315-7. 2005
  39. pmc Expression of receptors for advanced glycation end products in peripheral occlusive vascular disease
    U Ritthaler
    Department of Medicine, University of Heidelberg, Germany
    Am J Pathol 146:688-94. 1995
    ..Taken together, our findings suggest that RAGE may contribute to the pathogenesis of a range of vascular disorders...
  40. ncbi Glimepiride reduces mononuclear activation of the redox-sensitive transcription factor nuclear factor-kappa B
    S Schiekofer
    Department of Medicine I, University of Heidelberg, Heidelberg, Germany
    Diabetes Obes Metab 5:251-61. 2003
    ..This prompted us to study in vitro and in vivo in a placebo-controlled study the effect of glimepiride on the redox-sensitive transcription factor nuclear factor-kappa B (NF-kappaB)...
  41. ncbi Tissue factor-dependent pathway is not involved in exercise-induced formation of thrombin and fibrin
    Claus Weiss
    Department of Internal Medicine VII Sportsmedicine, University Hospital, 69115 Heidelberg, Germany
    J Appl Physiol (1985) 92:211-8. 2002
    ....
  42. doi High-mobility group box-1 in ischemia-reperfusion injury of the heart
    Martin Andrassy
    Department of Medicine III, University of Heidelberg, Heidelberg, Germany
    Circulation 117:3216-26. 2008
    ..Although HMGB1 has been implicated in ischemia/reperfusion (I/R) injury of the liver and lung, its role in I/R injury of the heart remains unclear...
  43. pmc Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes
    Aino Soro-Paavonen
    Albert Einstein Juvenile Diabetes Research Foundation Centre for Diabetes Complications, Diabetes Metabolism Division, Baker Heart Research Institute, Melbourne, Australia
    Diabetes 57:2461-9. 2008
    ..This study examines the effects of deletion of RAGE on the development of atherosclerosis in the diabetic apoE(-/-) model of accelerated atherosclerosis...
  44. ncbi Tuning the volume of the immune response: strength and persistence of stimulation determine migration and cytokine secretion of dendritic cells
    Thomas Luft
    The German Cancer Research Center, Department of Molecular Oncology Hematology, Heidelberg, Germany
    Blood 104:1066-74. 2004
    ..Thus, a novel concept emerges in which the type of immune response induced by DCs is tuned by the strength and persistence of DC activating signals...
  45. pmc Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs
    Christos Tikellis
    Baker Medical Research Institute, Melbourne, Victoria 8008, Australia
    Am J Physiol Endocrinol Metab 295:E323-30. 2008
    ..These data point to the potential utility of AGE-reducing strategies in the prevention and management of cardiac disease...
  46. doi Receptor for advanced glycation end product expression in experimental diabetic retinopathy
    Yumei Wang
    5th Medical Clinic, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Ann N Y Acad Sci 1126:42-5. 2008
    ....
  47. pmc Insulin stimulates the clonogenic potential of angiogenic endothelial progenitor cells by IGF-1 receptor-dependent signaling
    Per M Humpert
    Department of Medicine I and Clinical Chemistry, University Clinics Heidelberg, Germany
    Mol Med 14:301-8. 2008
    ..In conclusion, this is the first study showing an insulin-mediated activation of the IGF-1 receptor leading to an increased clonogenic and angiogenic potential of EPCs in vitro...
  48. ncbi Receptor for advanced glycation endproduct (RAGE)-mediated nuclear factor-kappaB activation in vasculitic neuropathy
    Karl Matthias Haslbeck
    Department of Neurology, University of Erlangen Nurnberg, Erlangen, Germany
    Muscle Nerve 29:853-60. 2004
    ..Controls showed only weak staining. These data suggest that the RAGE pathway plays a critical proinflammatory role in vasculitic neuropathy...
  49. pmc A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis
    Judson M Englert
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Pathol 172:583-91. 2008
    ..Combined with data from other studies on mouse models of pulmonary fibrosis and human IPF tissues indicate that loss of RAGE contributes to IPF pathogenesis...
  50. pmc Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
    Birgit Liliensiek
    Department of Molecular Immunology, Division of Tumor Immunology, German Cancer Research Center, Heidelberg, Germany
    J Clin Invest 113:1641-50. 2004
    ..These results indicate that the innate immune response is controlled by pattern-recognition receptors not only at the initiating steps but also at the phase of perpetuation...
  51. pmc RAGE signaling sustains inflammation and promotes tumor development
    Christoffer Gebhardt
    Division of Signal Transduction and Growth Control, German Cancer Research Center, 69120 Heidelberg, Germany
    J Exp Med 205:275-85. 2008
    ..We show that RAGE signaling drives the strength and maintenance of an inflammatory reaction during tumor promotion and provide direct genetic evidence for a novel role for RAGE in linking chronic inflammation and cancer...
  52. doi The RAGE pathway: activation and perpetuation in the pathogenesis of diabetic neuropathy
    Ivan K Lukic
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Ann N Y Acad Sci 1126:76-80. 2008
    ..Identifying RAGE-dependent inflammation as one pathomechanism underlying neuronal dysfunction might provide the basis for new therapeutic approaches...
  53. doi A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)
    Angela Raucci
    San Raffaele Scientific Institute, Milan, Italy
    FASEB J 22:3716-27. 2008
    ..Our data do not disprove the interpretation that high levels of soluble forms of RAGE protect against chronic inflammation, but rather suggest that they correlate with high levels of ongoing inflammation...
  54. pmc RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
    Olga Turovskaya
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Carcinogenesis 29:2035-43. 2008
    ..These findings show that RAGE, carboxylated glycans and S100A8/A9 play essential roles in tumor-stromal interactions, leading to inflammation-associated colon carcinogenesis...
  55. ncbi Activation of tubular epithelial cells in diabetic nephropathy
    Michael Morcos
    Department of Internal Medicine 1, University of Heidelberg, Bergheimerstrasse 58, 69115 Heidelberg, Germany
    Diabetes 51:3532-44. 2002
    ....
  56. ncbi Modulation of the vascular endothelium during infection--the role of NF-kappa B activation
    Angelika Bierhaus
    Department of Medicine I, University of Heidelberg, Heidelberg, Germany
    Contrib Microbiol 10:86-105. 2003
  57. ncbi Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy
    Hans Peter Hammes
    Medical Clinic V, School of Clinical Medicine, Mannheim, Germany
    Nat Med 9:294-9. 2003
    ..The ability of benfotiamine to inhibit three major pathways simultaneously might be clinically useful in preventing the development and progression of diabetic complications...
  58. ncbi Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs
    Stephan Schiekofer
    Department of Medicine I, University of Heidelberg, Bergheimerstrasse 58, 69115 Heidelberg, Germany
    Diabetes 52:621-33. 2003
    ....
  59. pmc RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy
    Thoralf M Wendt
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Am J Pathol 162:1123-37. 2003
    ....
  60. ncbi Glucose, glycation, and RAGE: implications for amplification of cellular dysfunction in diabetic nephropathy
    Thoralf Wendt
    Department of Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Am Soc Nephrol 14:1383-95. 2003
    ..A new paradigm is proposed in glomerular injury, and it is suggested that blockade of the RAGE axis may provide a novel means to prevent irreparable glomerular injury in diabetes and other sclerosing glomerulopathies...
  61. ncbi New aspects of integrin-mediated leukocyte adhesion in inflammation: regulation by haemostatic factors and bacterial products
    Joong Sup Rhee
    Institute for Biochemistry, Medical Faculty, Justus Liebig University, Giessen, Germany
    Curr Mol Med 3:387-92. 2003
    ..The better understanding of the interactions between vascular cells and particularly of integrin-dependent leukocyte adhesion may lead to the development of novel therapeutical concepts in inflammatory vascular disorders...
  62. ncbi New treatments for diabetic neuropathy: pathogenetically oriented treatment
    Angelika Bierhaus
    Department of Medicine I, University of Heidelberg, Germany
    Curr Diab Rep 3:452-8. 2003
    ....
  63. pmc The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment
    Triantafyllos Chavakis
    Department of Internal Medicine I, University Heidelberg, Bergheimer Strasse 58, D 69115 Heidelberg, Germany
    J Exp Med 198:1507-15. 2003
    ....
  64. pmc Posttranslationally modified proteins as mediators of sustained intestinal inflammation
    Martin Andrassy
    Department of Medicine I, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Am J Pathol 169:1223-37. 2006
    ..Thus, CML-mps generated in inflammatory lesions have the capacity to elicit a RAGE-dependent intestinal inflammatory response...
  65. ncbi Maturing dendritic cells depend on RAGE for in vivo homing to lymph nodes
    Angelo A Manfredi
    Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 48, Milan, Italy
    J Immunol 180:2270-5. 2008
    ..Thus the HMGB1-RAGE pathway is a checkpoint in DC maturation and function and a candidate for targeted therapies...
  66. ncbi Pharmacologic cholinesterase inhibition improves survival in experimental sepsis
    Stefan Hofer
    Department of Anaesthesiology, University of Heidelberg, Heidelberg, Germany
    Crit Care Med 36:404-8. 2008
    ..Here we studied whether the cholinergic anti-inflammatory pathway can be activated by pharmacologic cholinesterase inhibition in vivo...
  67. ncbi Angiostatin is a novel anti-inflammatory factor by inhibiting leukocyte recruitment
    Triantafyllos Chavakis
    Department of Internal Medicine, Universitat Heidelberg, Germany
    Blood 105:1036-43. 2005
    ..These observations could provide the basis for new therapeutic applications of angiostatin to target chronic inflammatory processes in different pathologic situations...
  68. pmc A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin
    Valeria V Orlova
    Experimental Immunology Branch, NCI, NIH, Bethesda, MD 20892, USA
    EMBO J 26:1129-39. 2007
    ..Together, a novel HMGB1-dependent pathway for inflammatory cell recruitment and activation that requires the functional interplay between Mac-1 and RAGE is described here...
  69. ncbi Activation of the RAGE pathway: a general mechanism in the pathogenesis of polyneuropathies?
    Karl Matthias Haslbeck
    Department of Neurology, University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neurol Res 29:103-10. 2007
    ..We wanted to investigate whether the newly discovered RAGE pathway also contributes to the pathogenesis of various other PNP...
  70. ncbi Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
    Jane Tian
    Inflammation and Autoimmune Group, Research Department, MedImmune, Gaithersburg, Maryland 20878, USA
    Nat Immunol 8:487-96. 2007
    ..Our data demonstrate a mechanism by which HMGB1 and RAGE activate plasmacytoid dendritic cells and B cells in response to DNA and contribute to autoimmune pathogenesis...
  71. ncbi SDF-1 genotype influences insulin-dependent mobilization of adult progenitor cells in type 2 diabetes
    Per M Humpert
    Medizinische Klinik 1, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Diabetes Care 28:934-6. 2005
  72. pmc Regulation of osteoclast function and bone mass by RAGE
    Zheng Zhou
    Institute of Molecular Medicine and Genomics and Department of Neurology, Medical College of Georgia, Augusta, GA, 30912, USA
    J Exp Med 203:1067-80. 2006
    ....
  73. ncbi Plasma sRAGE is independently associated with urinary albumin excretion in type 2 diabetes
    Per M Humpert
    Department of Medicine 1, University of Heidelberg, Heidelberg, Germany
    Diabetes Care 29:1111-3. 2006
  74. ncbi Tissue factor as a link between wounding and tissue repair
    Jiang Chen
    University of Heidelberg, Department of Medicine I, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Diabetes 54:2143-54. 2005
    ..These data establish TF expression as an important link between the early inflammatory response to cutaneous wounding and reparative processes...
  75. ncbi RAGE in inflammation: a new therapeutic target?
    Angelika Bierhaus
    Department of Medicine I, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Curr Opin Investig Drugs 7:985-91. 2006
    ....
  76. ncbi Effects of supplementation with alpha-lipoic acid on exercise-induced activation of coagulation
    Claus Weiss
    Department of Internal Medicine VII Sportsmedicine, University Hospital Heidelberg, 69120 Heidelberg, Germany
    Metabolism 54:815-20. 2005
    ..The role of oxidative stress for exercise-induced activation of coagulation has to be defined in further studies...
  77. ncbi Adipocytokines as a novel target for the anti-inflammatory effect of atorvastatin in patients with type 2 diabetes
    Maximilian von Eynatten
    Diabetes Care 28:754-5. 2005
  78. ncbi Atherosclerosis and restenosis: is there a role for RAGE?
    Peter Nawroth
    Dean s Office, AA152, School of Medicine, Medical College of Georgia, 1120 Fifteenth Street, Augusta, GA 30912, USA
    Curr Diab Rep 5:11-6. 2005
    ..In the diabetic milieu, two classes of RAGE ligands, products of nonenzymatic glycoxidation and S100 proteins, appear to drive receptor-mediated cellular activation and, potentially, acceleration of vascular disease...
  79. ncbi Advanced glycation end product receptor-mediated cellular dysfunction
    Angelika Bierhaus
    University of Heidelberg, Department of Medicine I, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Ann N Y Acad Sci 1043:676-80. 2005
    ..Furthermore, RAGE-/- mice can be protected by sRAGE in certain settings of the adaptive immune response. This finding implies that abounding RAGE ligands overworking the RAGE pathway might also activate other receptors...
  80. ncbi High-molecular weight adiponectin is independently associated with the extent of coronary artery disease in men
    Maximilian von Eynatten
    Department of Nephrology, Technical University Munich, Ismaningerstr 22, 81675 Munich, Germany
    Atherosclerosis 199:123-8. 2008
    ..We therefore investigated whether HMW adiponectin is associated with the extent of coronary artery disease (CAD) in men...
  81. ncbi Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
    Berend Isermann
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Nat Med 13:1349-58. 2007
    ..Conversely, maintaining high APC levels during long-term diabetes protects against diabetic nephropathy...
  82. ncbi sRAGE is elevated in septic patients and associated with patients outcome
    Christian Bopp
    Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany
    J Surg Res 147:79-83. 2008
    ....
  83. ncbi RAGE (receptor for advanced glycation end products): a central player in the inflammatory response
    Triantafyllos Chavakis
    Department of Internal Medicine I, University Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Microbes Infect 6:1219-25. 2004
    ..These different aspects are discussed in the present review...
  84. ncbi Damage to the peritoneal membrane by glucose degradation products is mediated by the receptor for advanced glycation end-products
    Vedat Schwenger
    Department of Medicine Division of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    J Am Soc Nephrol 17:199-207. 2006
    ..Peritoneal damage by GDP in PDF is dependent at least in part on AGE-RAGE interaction...
  85. ncbi Decreased plasma lipoprotein lipase in hypoadiponectinemia: an association independent of systemic inflammation and insulin resistance
    Maximilian von Eynatten
    Department of Medicine I Endocrinology and Metabolism, University of Heidelberg, INF 410, D 69120 Heidelberg, Germany
    Diabetes Care 27:2925-9. 2004
    ..Recently, dramatically increased LPL activity was reported in mice overexpressing adiponectin. We therefore speculated that adiponectin may directly affect LPL in humans...
  86. ncbi Understanding RAGE, the receptor for advanced glycation end products
    Angelika Bierhaus
    J Mol Med (Berl) 83:876-86. 2005
    ..These data suggest that, just as RAGE is a multiligand receptor, its ligands are also likely to recognize several receptors in mediating their biologic effects...
  87. pmc Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily
    Angelika Bierhaus
    University of Heidelberg, Department of Medicine I, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    J Clin Invest 114:1741-51. 2004
    ..These data demonstrate, for the first time to our knowledge, that the RAGE-NF-kappaB axis operates in diabetic neuropathy, by mediating functional sensory deficits, and that its inhibition may provide new therapeutic approaches...
  88. ncbi Linking stress to inflammation
    Angelika Bierhaus
    Department of Medicine I, INF 410, University of Heidelberg, Heidelberg 69120, Germany
    Anesthesiol Clin 24:325-40. 2006
    ..Because the neuroimmunologic axis can be seen as a system connecting mental states with inflammatory reactions, pro-inflammatory mediators and anti-inflammatory strategies should be studied as such in experimental settings...
  89. ncbi Chronic corticosterone-induced deterioration in rat behaviour is not paralleled by changes in hippocampal NF-kappaB-activation
    Konstanze Plaschke
    Clinic of Anaesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, D 69120, Heidelberg, Germany
    Stress 9:97-106. 2006
    ..Thus, cognitive alterations in rats seen after chronic corticosterone exposure are not paralleled by hippocampal NF-kappaB modulation...
  90. ncbi [Osteoporosis and cardiovascular disease--two sides of the same coin?]
    Peter Nawroth
    Abteilung Innere Medizin I und Sektion Osteologie, Universitat Heidelberg
    Med Klin (Munich) 98:437-46. 2003
    ....
  91. ncbi Differential effect of Rhizoma coptidis and its main alkaloid compound berberine on TNF-alpha induced NFkappaB translocation in human keratinocytes
    Ronny Enk
    Medizinische Klinik III, Universitat Heidelberg, Germany
    J Ethnopharmacol 109:170-5. 2007
    ..Rhizoma coptidis extract therefore appears to be a potent inhibitor of TNF-alpha induced inflammation in dermatological conditions...
  92. ncbi Androgen receptor isoforms AR-A and AR-B display functional differences in cultured human bone cells and genital skin fibroblasts
    Ute M Liegibel
    Division of Osteology, Department of Medicine, Ruprecht Karls University, Luisenstr 5, 69115 Heidelberg, Germany
    Steroids 68:1179-87. 2003
    ....
  93. ncbi Evidence of left ventricular contractile asynchrony by echocardiographic phase imaging in patients with type 2 diabetes mellitus and without clinically evident heart disease
    Grigorios Korosoglou
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Am J Cardiol 98:1525-30. 2006
    ..05) and showed higher intraobserver variability (5.6% vs 3.2%, p <0.05). In conclusion, this is the first study showing increased left ventricular asynchrony in patients with DM and no clinical evidence of heart disease...
  94. ncbi Antiangiogenic properties of low molecular weight heparin - does tissue factor provide the answer?
    Angelika Bierhaus
    Thromb Haemost 92:438-9. 2004
  95. ncbi Lack of association between polymorphisms of the toll-like receptor 4 gene and cerebral ischemia
    Peter Reismann
    Department Medicine I, University of Heidelberg, Germany
    J Neurol 251:853-8. 2004
    ..This implies that the Asp299Gly TLR4-allele might have a protective role in carotid atherosclerosis, but not in cerebral ischemia...
  96. ncbi Comment on: Lin et al. (2007) SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes: Diabetes 56: 1177-1180
    Gottfried Rudofsky
    Diabetes 56:e11; author reply e12-3. 2007
  97. ncbi Low levels of sRAGE are associated with increased risk for mortality in renal transplant recipients
    Sascha Gross
    Kidney Center, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 84:659-63. 2007
    ..In this study we investigated determinants of endogenous sRAGE in renal transplant recipients and whether sRAGE was associated with mortality and graft loss...
  98. ncbi Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes
    Gottfried Rudofsky
    Department Medicine I, University of Heidelberg, Heidelberg, Germany
    Diabetes Care 27:179-83. 2004
    ..To establish whether single nucleotide polymorphisms (Asp299Gly and Thr399Ile) of the toll-like receptor 4 have an association with late diabetic complications...