Research Topics
Species | Christian G BienSummaryAffiliation: University of Bonn Country: Germany Publications
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Detail Information
Publications
Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsyC G Bien
Departments of Epileptology, University of Bonn, Germany
Neurology 55:1823-8. 2000..To describe four patients with temporal lobe epilepsy with limbic encephalitis unrelated to neoplasm...- Diagnosis and staging of Rasmussen's encephalitis by serial MRI and histopathologyC G Bien
Department of Epileptology, University of Bonn, Germany
Neurology 58:250-7. 2002..To correlate MRI and histopathologic findings in patients with Rasmussen's encephalitis (RE)... - Long-term seizure outcome and antiepileptic drug treatment in surgically treated temporal lobe epilepsy patients: a controlled studyC G Bien
Department of Epileptology, University of Bonn, Bonn, Germany
Epilepsia 42:1416-21. 2001..To evaluate the long-term impact of surgical treatment on seizure outcome and antiepileptic drug (AED) use in patients with pharmacoresistant temporal lobe epilepsy (TLE)... - Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen's encephalitisChristian G Bien
Department of Epileptology, University of Bonn, Bonn, Germany
Ann Neurol 51:311-8. 2002..This study directly shows, for what we believe is the first time, that a cytotoxic T-cell mechanism contributes to loss of neurons in human brain disease... - An open study of tacrolimus therapy in Rasmussen encephalitisC G Bien
Department of Epileptology, University of Bonn, Germany
Neurology 62:2106-9. 2004..No treated patient, but 7 of 12 control patients, became eligible for hemispherectomy. Tacrolimus did not have any major side effects... 
Presence of temporal gray-white matter abnormalities does not influence epilepsy surgery outcome in temporal lobe epilepsy with hippocampal sclerosisOlaf E M G Schijns
Department of Neurosurgery, University of Bonn, Bonn, Germany
Neurosurgery 68:98-106; discussion 107. 2011..Temporal lobe gray-white matter abnormalities (GWMA) are frequent morphological aberrances observed on MRI in patients with temporal lobe epilepsy (TLE) in addition to hippocampal sclerosis (HS)...- Two P300 generators in the hippocampal formationEva Ludowig
Department of Epileptology, University of Bonn, Bonn, Germany
Hippocampus 20:186-95. 2010..Hippocampus and subiculum are essential parts of the MTL-memory system. Their function within target detection might be to maintain a template of previous stimuli for a comparison with incoming sensory stimuli... - Automated 3D MRI volumetry reveals regional atrophy differences in Rasmussen encephalitisJan Wagner
Department of Epileptology, University of Bonn, Bonn, Germany
Epilepsia 53:613-21. 2012..Furthermore, regional atrophy differences cannot be evaluated with the previously published methods. In this study we present a fully automated volumetric approach applied to serial MRI scans of 12 patients with Rasmussen encephalitis... - Sensory gating in epilepsy - effects of the lateralization of hippocampal sclerosisTimm Rosburg
Department of Epileptology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
Clin Neurophysiol 119:1310-9. 2008..The role of the hippocampus in sensory gating is unresolved as yet. The current study was conducted in order to examine the effects of hippocampal lesions on the function of auditory sensory gating... - Active suppression in the mediotemporal lobe during directed forgettingEva Ludowig
Department of Epileptology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
Neurobiol Learn Mem 93:352-61. 2010..The increased rhinal activity in response to the TBF cue might indicate an active involvement of this structure in the suppression of hippocampal memory formation... - Presence of human herpes virus 6 DNA exclusively in temporal lobe epilepsy brain tissue of patients with history of encephalitisPitt Niehusmann
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
Epilepsia 51:2478-83. 2010..Our data argue against HHV-6 as a major local pathogenetic factor in MTS hippocampi after CFS. The high detection rate of HHV-6 DNA suggests a potential pathogenetic role of HHV-6 in TLE patients with a history of encephalitis... - The cognitive consequence of resecting nonlesional tissues in epilepsy surgery--results from MRI- and histopathology-negative patients with temporal lobe epilepsyChristoph Helmstaedter
Department of Epileptology, University of Bonn Medical Centre, Bonn, Germany
Epilepsia 52:1402-8. 2011.... - Antibodies to glutamic acid decarboxylase define a form of limbic encephalitisMichael P Malter
Department of Epileptology, University of Bonn Medical Center, Bonn, Germany
Ann Neurol 67:470-8. 2010..We studied a cohort of patients with recent-onset temporal lobe epilepsy caused by LE to test for GAD antibody positivity and response to immunotherapies... - The natural history of Rasmussen's encephalitisChristian G Bien
Department of Epileptology, University of Bonn, Bonn, Germany
Brain 125:1751-9. 2002..These findings should be taken into consideration when future therapeutic approaches to RE are evaluated... - Genetic analysis of tuberous-sclerosis genes 1 and 2 in nonlesional focal epilepsyAnna Schönberger
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
Epilepsy Behav 21:233-7. 2011..0% vs controls 14%, P=0.0132), which previously was reported to be increased in gangliogliomas and mineralized focal cortical dysplasia as well. Our data suggest allelic imbalances of TSC2 in nonlesional focal epileptic tissue... - Treatment of Rasmussen encephalitis half a century after its initial description: promising prospects and a dilemmaChristian G Bien
University of Bonn, Department of Epileptology, Sigmund Freud Str 25, 53105 Bonn, Germany
Epilepsy Res 86:101-12. 2009..It does, however, mostly not improve the epilepsy. Whereas for many patients unequivocal treatment proposals can be readily made, a dilemma may emerge in those with severe epilepsy but still preserved hemispheric function... - Electric stimulation of periventricular heterotopia: participation in higher cerebral functionsJan Wagner
Department of Epileptology, University of Bonn, Bonn, Germany
Epilepsy Behav 14:425-8. 2009.... - Characteristics and surgical outcomes of patients with refractory magnetic resonance imaging-negative epilepsiesChristian G Bien
Department of Epileptology, University of Bonn, Bonn, Germany
Arch Neurol 66:1491-9. 2009..To explore several characteristics of patients with pharmacoresistant epilepsy without distinct lesions on magnetic resonance images (MRI(-)), who account for a relevant proportion of presurgical patient cohorts... - Thalamus lesions in chronic and acute seizure disordersHenriette J Tschampa
Department of Radiology Neuroradiology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
Neuroradiology 53:245-54. 2011..However, we observed persistent thalamus changes after seizures. The purpose of this study was to characterize thalamus changes in patients with seizure disorders and to correlate imaging findings with clinical features... - Diagnostic value of N-methyl-D-aspartate receptor antibodies in women with new-onset epilepsyPitt Niehusmann
Department of Epileptology, University of Bonn, Bonn, Germany
Arch Neurol 66:458-64. 2009..Most patients have antibodies to NR1/NR2 heteromers of the N-methyl-D-aspartate receptor (NMDAR)... - Continuous motor monitoring enhances functional preservation and seizure-free outcome in surgery for intractable focal epilepsyGeorg Neuloh
Department of Neurosurgery, University Hospital, University of Bonn, D 53105, Bonn, Germany
Acta Neurochir (Wien) 152:1307-14. 2010..g., through vascular compromise. Here, we explore for the first time the feasibility, safety, and the clinical value of continuous motor-evoked potential (MEP) monitoring in focal epilepsy surgery... - Assessment of the long-term effects of epilepsy surgery with three different reference groupsChristian G Bien
University of Bonn, Department of Epileptology, Bonn, Germany
Epilepsia 47:1865-9. 2006.... - Limbic encephalitis: a cause of temporal lobe epilepsy with onset in adult lifeChristian G Bien
Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Epilepsy Behav 10:529-38. 2007..A general consensus on formal diagnostic criteria for all LE subsyndromes has not yet been reached. This article proposes such diagnostic criteria and formulates suggestions for treatment... - Mitochondrial dysfunction due to Leber's hereditary optic neuropathy as a cause of visual loss during assessment for epilepsy surgeryPitt Niehusmann
Department of Neuropathology, University of Bonn, Bonn, Germany
Epilepsy Behav 20:38-43. 2011..Mitochondrial dysfunction has been reported in epilepsy. Thus, the presence of LHON mutations can be a rare cause of visual disturbances in patients with epilepsy and may have predisposed to development of epilepsy... - Advances in pathogenic concepts and therapeutic agents in Rasmussen's encephalitisChristian G Bien
University of Bonn, Department of Epileptology, Germany
Expert Opin Investig Drugs 11:981-9. 2002..An opinion on symptomatic treatment with anticonvulsive drugs is included... - Serial MRI of limbic encephalitisHorst Urbach
Department of Radiology, University of Bonn Medical Center, Sigmund Freud Str 25, 53105 Bonn, Germany
Neuroradiology 48:380-6. 2006..The aim of the study was to analyze serial magnetic resonance imaging (MRI) scans in patients with various forms of limbic encephalitis (LE) in order to evaluate whether, and at what time point, MRI findings support the diagnosis of LE... - Intracranially recorded memory-related potentials reveal higher posterior than anterior hippocampal involvement in verbal encoding and retrievalEva Ludowig
Department of Epileptology, University of Bonn, Bonn, Germany
J Cogn Neurosci 20:841-51. 2008..Both effects were larger the further posterior an electrode was located in the hippocampus. Findings are suggestive for a predominant posterior hippocampal involvement in both verbal encoding and retrieval... - Correlation of MRI and histopathology in epileptogenic parietal and occipital lobe lesionsHorst Urbach
Department of Radiology, University of Bonn Medical Center, Bonn, Germany
Seizure 16:608-14. 2007..To analyze the diagnostic accuracy of MRI in patients undergoing parietal and occipital lobe epilepsy surgery... - T-cells in human encephalitisChristian G Bien
University of Bonn, Department of Epileptology, Bonn, Germany
Neuromolecular Med 7:243-53. 2005..In all of them, T-cells play a major role in disease pathogenesis, mainly mediated by major histocompatiblity complex class I-restricted CD8+ T-lymphocytes... - Epilepsia partialis continua: semiology and differential diagnosesChristian G Bien
Dept of Epileptology, University of Bonn, Germany
Epileptic Disord 10:3-7. 2008..Published with video sequences]... - Rasmussen's encephalitis: a role for autoimmune cytotoxic T lymphocytesJan Bauer
Brain Research Institute, Division of Neuroimmunology, University of Vienna, Vienna, Austria
Curr Opin Neurol 15:197-200. 2002..Specific attention is given to the recent recognition of cytotoxicity by CD8+/granzyme-B-positive T lymphocytes as a new pathogenic mechanism of neuronal damage... - Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitisAngela Vincent
Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
Brain 127:701-12. 2004..Establishing the frequency of this new syndrome, the full range of clinical presentations and means of early recognition, and optimal immunotherapy, should now be the aim... - Mesial frontal epilepsy and ictal body turning along the horizontal body axisHowan Leung
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, NT, Hong Kong SAR, The People s Republic of China
Arch Neurol 65:71-7. 2008..To evaluate the clinical utility of mesial frontal semiology... - Temporal lobe seizures, amnesia and autoantibodies - identifying a potentially reversible form of non-paraneoplastic limbic encephalitisAngela Vincent
Epileptic Disord 7:177-9. 2005 - Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitisElena Alvaréz-Baron
Department of Neuropathology, University Bonn Medical School, Sigmund Freud Str 25, 53105 Bonn, Germany
Epilepsy Res 80:93-7. 2008.... - Spinal algetic-tonic seizures manifesting as paroxysmal "positive" Brown-Séquard syndromeAnne Kirchner
Dept of Epileptology, University of Boon, Germany
Epileptic Disord 9:182-5. 2007..For the first time, this rare type of seizure is published with a video documentation. It may deserve consideration in the differential diagnosis of otherwise unexplained paroxysmal events that present in an "epileptic" manner... - Astrocytes are a specific immunological target in Rasmussen's encephalitisJan Bauer
Division of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
Ann Neurol 62:67-80. 2007..An in vitro study, however, suggested glutamate receptor 3 (GluR3) antibody-mediated astrocytic loss. Therefore, we investigated astrocytic apoptosis and loss in situ... 
Limbic encephalitis: extension of the diagnostic armamentariumChristian G Bien
J Neurol Neurosurg Psychiatry 78:332-3. 2007- Surgical treatment of occipital lobe epilepsyDevin K Binder
Department of Neurological Surgery, University of California, Irvine, Orange, California 92868 3298, USA
J Neurosurg 109:57-69. 2008..Preoperative findings, surgical strategies, histopathological bases, and postoperative outcomes for OLE remain to be elucidated...