Christian G Bien

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsy
    C G Bien
    Departments of Epileptology, University of Bonn, Germany
    Neurology 55:1823-8. 2000
  2. ncbi request reprint Diagnosis and staging of Rasmussen's encephalitis by serial MRI and histopathology
    C G Bien
    Department of Epileptology, University of Bonn, Germany
    Neurology 58:250-7. 2002
  3. ncbi request reprint Long-term seizure outcome and antiepileptic drug treatment in surgically treated temporal lobe epilepsy patients: a controlled study
    C G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsia 42:1416-21. 2001
  4. ncbi request reprint Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen's encephalitis
    Christian G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Ann Neurol 51:311-8. 2002
  5. ncbi request reprint An open study of tacrolimus therapy in Rasmussen encephalitis
    C G Bien
    Department of Epileptology, University of Bonn, Germany
    Neurology 62:2106-9. 2004
  6. doi request reprint Outcome after epilepsy surgery in patients with MRI features of bilateral ammon's horn sclerosis
    Michael P Malter
    Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Strase 25, 53105 Bonn, Germany
    Epilepsy Res 105:150-7. 2013
  7. doi request reprint Presence of temporal gray-white matter abnormalities does not influence epilepsy surgery outcome in temporal lobe epilepsy with hippocampal sclerosis
    Olaf E M G Schijns
    Department of Neurosurgery, University of Bonn, Bonn, Germany
    Neurosurgery 68:98-106; discussion 107. 2011
  8. doi request reprint Rasmussen encephalitis: incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins
    Christian G Bien
    Department of Epileptology, University of Bonn Medical Center, Bonn, Germany
    Epilepsia 54:543-50. 2013
  9. doi request reprint Two P300 generators in the hippocampal formation
    Eva Ludowig
    Department of Epileptology, University of Bonn, Bonn, Germany
    Hippocampus 20:186-95. 2010
  10. doi request reprint Automated 3D MRI volumetry reveals regional atrophy differences in Rasmussen encephalitis
    Jan Wagner
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsia 53:613-21. 2012

Detail Information

Publications42

  1. ncbi request reprint Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsy
    C G Bien
    Departments of Epileptology, University of Bonn, Germany
    Neurology 55:1823-8. 2000
    ..To describe four patients with temporal lobe epilepsy with limbic encephalitis unrelated to neoplasm...
  2. ncbi request reprint Diagnosis and staging of Rasmussen's encephalitis by serial MRI and histopathology
    C G Bien
    Department of Epileptology, University of Bonn, Germany
    Neurology 58:250-7. 2002
    ..To correlate MRI and histopathologic findings in patients with Rasmussen's encephalitis (RE)...
  3. ncbi request reprint Long-term seizure outcome and antiepileptic drug treatment in surgically treated temporal lobe epilepsy patients: a controlled study
    C G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsia 42:1416-21. 2001
    ..To evaluate the long-term impact of surgical treatment on seizure outcome and antiepileptic drug (AED) use in patients with pharmacoresistant temporal lobe epilepsy (TLE)...
  4. ncbi request reprint Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen's encephalitis
    Christian G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Ann Neurol 51:311-8. 2002
    ..This study directly shows, for what we believe is the first time, that a cytotoxic T-cell mechanism contributes to loss of neurons in human brain disease...
  5. ncbi request reprint An open study of tacrolimus therapy in Rasmussen encephalitis
    C G Bien
    Department of Epileptology, University of Bonn, Germany
    Neurology 62:2106-9. 2004
    ..No treated patient, but 7 of 12 control patients, became eligible for hemispherectomy. Tacrolimus did not have any major side effects...
  6. doi request reprint Outcome after epilepsy surgery in patients with MRI features of bilateral ammon's horn sclerosis
    Michael P Malter
    Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Strase 25, 53105 Bonn, Germany
    Epilepsy Res 105:150-7. 2013
    ..However, due to the large number of bAHS patients not undergoing formal presurgical evaluation, the results cannot be extrapolated to bAHS patients in general...
  7. doi request reprint Presence of temporal gray-white matter abnormalities does not influence epilepsy surgery outcome in temporal lobe epilepsy with hippocampal sclerosis
    Olaf E M G Schijns
    Department of Neurosurgery, University of Bonn, Bonn, Germany
    Neurosurgery 68:98-106; discussion 107. 2011
    ..Temporal lobe gray-white matter abnormalities (GWMA) are frequent morphological aberrances observed on MRI in patients with temporal lobe epilepsy (TLE) in addition to hippocampal sclerosis (HS)...
  8. doi request reprint Rasmussen encephalitis: incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins
    Christian G Bien
    Department of Epileptology, University of Bonn Medical Center, Bonn, Germany
    Epilepsia 54:543-50. 2013
    ..Rasmussen encephalitis (RE) leads to progressive tissue and function loss of one brain hemisphere and often intractable epilepsy. This is the first randomized prospective treatment trial in RE...
  9. doi request reprint Two P300 generators in the hippocampal formation
    Eva Ludowig
    Department of Epileptology, University of Bonn, Bonn, Germany
    Hippocampus 20:186-95. 2010
    ..Hippocampus and subiculum are essential parts of the MTL-memory system. Their function within target detection might be to maintain a template of previous stimuli for a comparison with incoming sensory stimuli...
  10. doi request reprint Automated 3D MRI volumetry reveals regional atrophy differences in Rasmussen encephalitis
    Jan Wagner
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsia 53:613-21. 2012
    ..Furthermore, regional atrophy differences cannot be evaluated with the previously published methods. In this study we present a fully automated volumetric approach applied to serial MRI scans of 12 patients with Rasmussen encephalitis...
  11. doi request reprint Presence of human herpes virus 6 DNA exclusively in temporal lobe epilepsy brain tissue of patients with history of encephalitis
    Pitt Niehusmann
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Epilepsia 51:2478-83. 2010
    ..Our data argue against HHV-6 as a major local pathogenetic factor in MTS hippocampi after CFS. The high detection rate of HHV-6 DNA suggests a potential pathogenetic role of HHV-6 in TLE patients with a history of encephalitis...
  12. doi request reprint Sensory gating in epilepsy - effects of the lateralization of hippocampal sclerosis
    Timm Rosburg
    Department of Epileptology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Clin Neurophysiol 119:1310-9. 2008
    ..The role of the hippocampus in sensory gating is unresolved as yet. The current study was conducted in order to examine the effects of hippocampal lesions on the function of auditory sensory gating...
  13. doi request reprint Active suppression in the mediotemporal lobe during directed forgetting
    Eva Ludowig
    Department of Epileptology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Neurobiol Learn Mem 93:352-61. 2010
    ..The increased rhinal activity in response to the TBF cue might indicate an active involvement of this structure in the suppression of hippocampal memory formation...
  14. doi request reprint The cognitive consequence of resecting nonlesional tissues in epilepsy surgery--results from MRI- and histopathology-negative patients with temporal lobe epilepsy
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn Medical Centre, Bonn, Germany
    Epilepsia 52:1402-8. 2011
    ....
  15. doi request reprint Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis
    Michael P Malter
    Department of Epileptology, University of Bonn Medical Center, Bonn, Germany
    Ann Neurol 67:470-8. 2010
    ..We studied a cohort of patients with recent-onset temporal lobe epilepsy caused by LE to test for GAD antibody positivity and response to immunotherapies...
  16. ncbi request reprint The natural history of Rasmussen's encephalitis
    Christian G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Brain 125:1751-9. 2002
    ..These findings should be taken into consideration when future therapeutic approaches to RE are evaluated...
  17. doi request reprint Trends in presurgical evaluation and surgical treatment of epilepsy at one centre from 1988-2009
    Christian G Bien
    Department of Epileptology, University of Bonn Medical Centre, Bonn, Germany
    J Neurol Neurosurg Psychiatry 84:54-61. 2013
    ..Here, we report on presurgical patients grouped according to their underlying pathology by giving results of presurgical evaluation, surgical therapy and long-term follow-up between 1989-2009 and describe trends over this period...
  18. doi request reprint Genetic analysis of tuberous-sclerosis genes 1 and 2 in nonlesional focal epilepsy
    Anna Schönberger
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Epilepsy Behav 21:233-7. 2011
    ..0% vs controls 14%, P=0.0132), which previously was reported to be increased in gangliogliomas and mineralized focal cortical dysplasia as well. Our data suggest allelic imbalances of TSC2 in nonlesional focal epileptic tissue...
  19. doi request reprint Treatment of Rasmussen encephalitis half a century after its initial description: promising prospects and a dilemma
    Christian G Bien
    University of Bonn, Department of Epileptology, Sigmund Freud Str 25, 53105 Bonn, Germany
    Epilepsy Res 86:101-12. 2009
    ..It does, however, mostly not improve the epilepsy. Whereas for many patients unequivocal treatment proposals can be readily made, a dilemma may emerge in those with severe epilepsy but still preserved hemispheric function...
  20. doi request reprint Thalamus lesions in chronic and acute seizure disorders
    Henriette J Tschampa
    Department of Radiology Neuroradiology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Neuroradiology 53:245-54. 2011
    ..However, we observed persistent thalamus changes after seizures. The purpose of this study was to characterize thalamus changes in patients with seizure disorders and to correlate imaging findings with clinical features...
  21. ncbi request reprint Assessment of the long-term effects of epilepsy surgery with three different reference groups
    Christian G Bien
    University of Bonn, Department of Epileptology, Bonn, Germany
    Epilepsia 47:1865-9. 2006
    ....
  22. doi request reprint Continuous motor monitoring enhances functional preservation and seizure-free outcome in surgery for intractable focal epilepsy
    Georg Neuloh
    Department of Neurosurgery, University Hospital, University of Bonn, D 53105, Bonn, Germany
    Acta Neurochir (Wien) 152:1307-14. 2010
    ..g., through vascular compromise. Here, we explore for the first time the feasibility, safety, and the clinical value of continuous motor-evoked potential (MEP) monitoring in focal epilepsy surgery...
  23. doi request reprint Characteristics and surgical outcomes of patients with refractory magnetic resonance imaging-negative epilepsies
    Christian G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Arch Neurol 66:1491-9. 2009
    ..To explore several characteristics of patients with pharmacoresistant epilepsy without distinct lesions on magnetic resonance images (MRI(-)), who account for a relevant proportion of presurgical patient cohorts...
  24. doi request reprint Electric stimulation of periventricular heterotopia: participation in higher cerebral functions
    Jan Wagner
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsy Behav 14:425-8. 2009
    ..Interestingly, the anterior-to-posterior representation of these functions is comparable to the normal anterior-to-posterior representation in a normal neocortex (similar to a periventricular "minicortex" in early developmental stages)...
  25. doi request reprint Diagnostic value of N-methyl-D-aspartate receptor antibodies in women with new-onset epilepsy
    Pitt Niehusmann
    Department of Epileptology, University of Bonn, Bonn, Germany
    Arch Neurol 66:458-64. 2009
    ..Most patients have antibodies to NR1/NR2 heteromers of the N-methyl-D-aspartate receptor (NMDAR)...
  26. doi request reprint Mitochondrial dysfunction due to Leber's hereditary optic neuropathy as a cause of visual loss during assessment for epilepsy surgery
    Pitt Niehusmann
    Department of Neuropathology, University of Bonn, Bonn, Germany
    Epilepsy Behav 20:38-43. 2011
    ..Mitochondrial dysfunction has been reported in epilepsy. Thus, the presence of LHON mutations can be a rare cause of visual disturbances in patients with epilepsy and may have predisposed to development of epilepsy...
  27. ncbi request reprint Advances in pathogenic concepts and therapeutic agents in Rasmussen's encephalitis
    Christian G Bien
    University of Bonn, Department of Epileptology, Germany
    Expert Opin Investig Drugs 11:981-9. 2002
    ..An opinion on symptomatic treatment with anticonvulsive drugs is included...
  28. ncbi request reprint Limbic encephalitis: a cause of temporal lobe epilepsy with onset in adult life
    Christian G Bien
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Epilepsy Behav 10:529-38. 2007
    ..A general consensus on formal diagnostic criteria for all LE subsyndromes has not yet been reached. This article proposes such diagnostic criteria and formulates suggestions for treatment...
  29. ncbi request reprint Serial MRI of limbic encephalitis
    Horst Urbach
    Department of Radiology, University of Bonn Medical Center, Sigmund Freud Str 25, 53105 Bonn, Germany
    Neuroradiology 48:380-6. 2006
    ..The aim of the study was to analyze serial magnetic resonance imaging (MRI) scans in patients with various forms of limbic encephalitis (LE) in order to evaluate whether, and at what time point, MRI findings support the diagnosis of LE...
  30. ncbi request reprint Correlation of MRI and histopathology in epileptogenic parietal and occipital lobe lesions
    Horst Urbach
    Department of Radiology, University of Bonn Medical Center, Bonn, Germany
    Seizure 16:608-14. 2007
    ..To analyze the diagnostic accuracy of MRI in patients undergoing parietal and occipital lobe epilepsy surgery...
  31. doi request reprint Intracranially recorded memory-related potentials reveal higher posterior than anterior hippocampal involvement in verbal encoding and retrieval
    Eva Ludowig
    Department of Epileptology, University of Bonn, Bonn, Germany
    J Cogn Neurosci 20:841-51. 2008
    ..Both effects were larger the further posterior an electrode was located in the hippocampus. Findings are suggestive for a predominant posterior hippocampal involvement in both verbal encoding and retrieval...
  32. ncbi request reprint T-cells in human encephalitis
    Christian G Bien
    University of Bonn, Department of Epileptology, Bonn, Germany
    Neuromolecular Med 7:243-53. 2005
    ..In all of them, T-cells play a major role in disease pathogenesis, mainly mediated by major histocompatiblity complex class I-restricted CD8+ T-lymphocytes...
  33. doi request reprint Epilepsia partialis continua: semiology and differential diagnoses
    Christian G Bien
    Dept of Epileptology, University of Bonn, Germany
    Epileptic Disord 10:3-7. 2008
    ..Published with video sequences]...
  34. ncbi request reprint Rasmussen's encephalitis: a role for autoimmune cytotoxic T lymphocytes
    Jan Bauer
    Brain Research Institute, Division of Neuroimmunology, University of Vienna, Vienna, Austria
    Curr Opin Neurol 15:197-200. 2002
    ..Specific attention is given to the recent recognition of cytotoxicity by CD8+/granzyme-B-positive T lymphocytes as a new pathogenic mechanism of neuronal damage...
  35. ncbi request reprint Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis
    Angela Vincent
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Brain 127:701-12. 2004
    ..Establishing the frequency of this new syndrome, the full range of clinical presentations and means of early recognition, and optimal immunotherapy, should now be the aim...
  36. ncbi request reprint Temporal lobe seizures, amnesia and autoantibodies - identifying a potentially reversible form of non-paraneoplastic limbic encephalitis
    Angela Vincent
    Epileptic Disord 7:177-9. 2005
  37. doi request reprint Mesial frontal epilepsy and ictal body turning along the horizontal body axis
    Howan Leung
    Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, NT, Hong Kong SAR, The People s Republic of China
    Arch Neurol 65:71-7. 2008
    ..To evaluate the clinical utility of mesial frontal semiology...
  38. pmc Limbic encephalitis: extension of the diagnostic armamentarium
    Christian G Bien
    J Neurol Neurosurg Psychiatry 78:332-3. 2007
  39. ncbi request reprint Spinal algetic-tonic seizures manifesting as paroxysmal "positive" Brown-Séquard syndrome
    Anne Kirchner
    Dept of Epileptology, University of Boon, Germany
    Epileptic Disord 9:182-5. 2007
    ..For the first time, this rare type of seizure is published with a video documentation. It may deserve consideration in the differential diagnosis of otherwise unexplained paroxysmal events that present in an "epileptic" manner...
  40. doi request reprint Surgical treatment of occipital lobe epilepsy
    Devin K Binder
    Department of Neurological Surgery, University of California, Irvine, Orange, California 92868 3298, USA
    J Neurosurg 109:57-69. 2008
    ..Preoperative findings, surgical strategies, histopathological bases, and postoperative outcomes for OLE remain to be elucidated...
  41. ncbi request reprint Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis
    Elena Alvaréz-Baron
    Department of Neuropathology, University Bonn Medical School, Sigmund Freud Str 25, 53105 Bonn, Germany
    Epilepsy Res 80:93-7. 2008
    ....
  42. ncbi request reprint Astrocytes are a specific immunological target in Rasmussen's encephalitis
    Jan Bauer
    Division of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    Ann Neurol 62:67-80. 2007
    ..An in vitro study, however, suggested glutamate receptor 3 (GluR3) antibody-mediated astrocytic loss. Therefore, we investigated astrocytic apoptosis and loss in situ...