Research Topics
| Cg BienSummaryAffiliation: University of Bonn Country: Germany Publications
| Collaborators
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Detail Information
Publications
Slowly progressive hemiparesis in childhood as a consequence of Rasmussen encephalitis without or with delayed-onset seizuresC G Bien
Department of Epileptology, University of Bonn, Bonn, Germany
Eur J Neurol 14:387-90. 2007..Long-term immunotherapy is recommended in order to prevent further tissue loss and functional decline...- T-cells in human encephalitisChristian G Bien
University of Bonn, Department of Epileptology, Bonn, Germany
Neuromolecular Med 7:243-53. 2005..In all of them, T-cells play a major role in disease pathogenesis, mainly mediated by major histocompatiblity complex class I-restricted CD8+ T-lymphocytes... - [Recent insights into Rasmussen encephalitis]C G Bien
Klinik für Epileptologie, Universitat Bonn
Nervenarzt 76:1470, 1472-4, 1477-80, 1484-7. 2005..This article summarizes the current research results on the background of older data and gives recommendations regarding diagnostic and therapeutic procedures in RE patients... - Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: a European consensus statementC G Bien
Department of Epileptology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
Brain 128:454-71. 2005..Based on these data, we propose formal diagnostic criteria and a therapeutic pathway for the management of RE patients... - Assessment of the long-term effects of epilepsy surgery with three different reference groupsChristian G Bien
University of Bonn, Department of Epileptology, Bonn, Germany
Epilepsia 47:1865-9. 2006.... - The natural history of Rasmussen's encephalitisChristian G Bien
Department of Epileptology, University of Bonn, Bonn, Germany
Brain 125:1751-9. 2002..These findings should be taken into consideration when future therapeutic approaches to RE are evaluated... - Limbic encephalitis: a cause of temporal lobe epilepsy with onset in adult lifeChristian G Bien
Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Epilepsy Behav 10:529-38. 2007..A general consensus on formal diagnostic criteria for all LE subsyndromes has not yet been reached. This article proposes such diagnostic criteria and formulates suggestions for treatment... - Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsyC G Bien
Department of Epileptology, University of Bonn, Bonn, Germany
Neurology 69:1236-44. 2007..There have been few studies of adult-onset disease. We recognized that some adult individuals have evidence of limbic encephalitis (LE), an autoimmune condition of adult life, which we proposed might lead directly to this syndrome... 
Epilepsia partialis continua: semiology and differential diagnosesChristian G Bien
Dept of Epileptology, University of Bonn, Germany
Epileptic Disord 10:3-7. 2008..Published with video sequences]...- Treatment of Rasmussen encephalitis half a century after its initial description: promising prospects and a dilemmaChristian G Bien
University of Bonn, Department of Epileptology, Sigmund Freud Str 25, 53105 Bonn, Germany
Epilepsy Res 86:101-12. 2009..It does, however, mostly not improve the epilepsy. Whereas for many patients unequivocal treatment proposals can be readily made, a dilemma may emerge in those with severe epilepsy but still preserved hemispheric function... - Characteristics and surgical outcomes of patients with refractory magnetic resonance imaging-negative epilepsiesChristian G Bien
Department of Epileptology, University of Bonn, Bonn, Germany
Arch Neurol 66:1491-9. 2009..To explore several characteristics of patients with pharmacoresistant epilepsy without distinct lesions on magnetic resonance images (MRI(-)), who account for a relevant proportion of presurgical patient cohorts... - Causes, presentation and outcome of lesional adult onset mediotemporal lobe epilepsyB M Soeder
University of Bonn, Department of Epileptology, Sigmund Freud Str 25, 53105 Bonn, Germany
J Neurol Neurosurg Psychiatry 80:894-9. 2009..MTLE usually starts before adulthood and is most frequently associated with hippocampal sclerosis (HS). Here, aetiologies, disease courses and outcomes of adult onset MTLE patients treated at this tertiary epilepsy centre are studied... - Limbic encephalitis in children and adolescentsE Haberlandt
Medical University of Innsbruck, Clinical Department of Pediatrics IV, Division of Neuropediatrics and Inherited Metabolic Diseases, Innsbruck, Austria
Arch Dis Child 96:186-91. 2011..Limbic encephalitis is rare in people <18 years of age and rarely given a formal diagnosis... - Localizing value of epileptic visual aurasC G Bien
Department of Epileptology, University of Bonn, Germany
Brain 123:244-53. 2000..Complex hallucinations and tunnel vision, however, should be considered concordant only with the assumption of an anteromedial temporal or occipitotemporal seizure onset... - Transient splenium lesions in presurgical epilepsy patients: incidence and pathogenesisM Nelles
Department of Radiology Neuroradiology, University of Bonn Medical Center, Sigmund Freud Str 25, 53105 Bonn, Germany
Neuroradiology 48:443-8. 2006..Transient splenium corporis callosi (SCC) lesions are related to rapid reduction of antiepileptic drugs (AEDs). The range of substances with predilection for SCC changes, their pathophysiology and their occurrence are still unknown... - Diagnosis and staging of Rasmussen's encephalitis by serial MRI and histopathologyC G Bien
Department of Epileptology, University of Bonn, Germany
Neurology 58:250-7. 2002..To correlate MRI and histopathologic findings in patients with Rasmussen's encephalitis (RE)... - Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsyC G Bien
Departments of Epileptology, University of Bonn, Germany
Neurology 55:1823-8. 2000..To describe four patients with temporal lobe epilepsy with limbic encephalitis unrelated to neoplasm... - MRI brain volumetry in Rasmussen encephalitis: the fate of affected and "unaffected" hemispheresS Larionov
Department of Neuropathology, University of Bonn, Bonn, Germany
Neurology 64:885-7. 2005..Correlation of the planimetrically and volumetrically assessed hemispheric ratios (HRs) was significant. The results support the concept of RE as a basically unilateral disease. Planimetric HR assessment is valid and time efficient... - An open study of tacrolimus therapy in Rasmussen encephalitisC G Bien
Department of Epileptology, University of Bonn, Germany
Neurology 62:2106-9. 2004..No treated patient, but 7 of 12 control patients, became eligible for hemispherectomy. Tacrolimus did not have any major side effects... - Long-term seizure outcome and antiepileptic drug treatment in surgically treated temporal lobe epilepsy patients: a controlled studyC G Bien
Department of Epileptology, University of Bonn, Bonn, Germany
Epilepsia 42:1416-21. 2001..To evaluate the long-term impact of surgical treatment on seizure outcome and antiepileptic drug (AED) use in patients with pharmacoresistant temporal lobe epilepsy (TLE)... - [VGKC antibodies associated with limbic encephalitis]B M Soeder
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Nervenarzt 76:760-2. 2005..The diagnostic workup of such a case and the apparently typical good response to long-term immunotherapy of this LE subform are described... - Intracranially recorded memory-related potentials reveal higher posterior than anterior hippocampal involvement in verbal encoding and retrievalEva Ludowig
Department of Epileptology, University of Bonn, Bonn, Germany
J Cogn Neurosci 20:841-51. 2008..Both effects were larger the further posterior an electrode was located in the hippocampus. Findings are suggestive for a predominant posterior hippocampal involvement in both verbal encoding and retrieval... - Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen's encephalitisChristian G Bien
Department of Epileptology, University of Bonn, Bonn, Germany
Ann Neurol 51:311-8. 2002..This study directly shows, for what we believe is the first time, that a cytotoxic T-cell mechanism contributes to loss of neurons in human brain disease... - Sensory gating in epilepsy - effects of the lateralization of hippocampal sclerosisTimm Rosburg
Department of Epileptology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
Clin Neurophysiol 119:1310-9. 2008..The role of the hippocampus in sensory gating is unresolved as yet. The current study was conducted in order to examine the effects of hippocampal lesions on the function of auditory sensory gating... - Temporal lobe seizures, amnesia and autoantibodies - identifying a potentially reversible form of non-paraneoplastic limbic encephalitisAngela Vincent
Epileptic Disord 7:177-9. 2005 - Mesial frontal epilepsy and ictal body turning along the horizontal body axisHowan Leung
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, NT, Hong Kong SAR, The People s Republic of China
Arch Neurol 65:71-7. 2008..To evaluate the clinical utility of mesial frontal semiology... - Rasmussen's encephalitis: a role for autoimmune cytotoxic T lymphocytesJan Bauer
Brain Research Institute, Division of Neuroimmunology, University of Vienna, Vienna, Austria
Curr Opin Neurol 15:197-200. 2002..Specific attention is given to the recent recognition of cytotoxicity by CD8+/granzyme-B-positive T lymphocytes as a new pathogenic mechanism of neuronal damage... - Correlation of MRI and histopathology in epileptogenic parietal and occipital lobe lesionsHorst Urbach
Department of Radiology, University of Bonn Medical Center, Bonn, Germany
Seizure 16:608-14. 2007..To analyze the diagnostic accuracy of MRI in patients undergoing parietal and occipital lobe epilepsy surgery... - Serial MRI of limbic encephalitisHorst Urbach
Department of Radiology, University of Bonn Medical Center, Sigmund Freud Str 25, 53105 Bonn, Germany
Neuroradiology 48:380-6. 2006..The aim of the study was to analyze serial magnetic resonance imaging (MRI) scans in patients with various forms of limbic encephalitis (LE) in order to evaluate whether, and at what time point, MRI findings support the diagnosis of LE... - Advances in pathogenic concepts and therapeutic agents in Rasmussen's encephalitisChristian G Bien
University of Bonn, Department of Epileptology, Germany
Expert Opin Investig Drugs 11:981-9. 2002..An opinion on symptomatic treatment with anticonvulsive drugs is included... - Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitisAngela Vincent
Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
Brain 127:701-12. 2004..Establishing the frequency of this new syndrome, the full range of clinical presentations and means of early recognition, and optimal immunotherapy, should now be the aim... - Surgical treatment of occipital lobe epilepsyDevin K Binder
Department of Neurological Surgery, University of California, Irvine, Orange, California 92868 3298, USA
J Neurosurg 109:57-69. 2008..Preoperative findings, surgical strategies, histopathological bases, and postoperative outcomes for OLE remain to be elucidated... - Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitisElena Alvaréz-Baron
Department of Neuropathology, University Bonn Medical School, Sigmund Freud Str 25, 53105 Bonn, Germany
Epilepsy Res 80:93-7. 2008.... - Astrocytes are a specific immunological target in Rasmussen's encephalitisJan Bauer
Division of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
Ann Neurol 62:67-80. 2007..An in vitro study, however, suggested glutamate receptor 3 (GluR3) antibody-mediated astrocytic loss. Therefore, we investigated astrocytic apoptosis and loss in situ... - Spinal algetic-tonic seizures manifesting as paroxysmal "positive" Brown-Séquard syndromeAnne Kirchner
Dept of Epileptology, University of Boon, Germany
Epileptic Disord 9:182-5. 2007..For the first time, this rare type of seizure is published with a video documentation. It may deserve consideration in the differential diagnosis of otherwise unexplained paroxysmal events that present in an "epileptic" manner... 
Limbic encephalitis: extension of the diagnostic armamentariumChristian G Bien
J Neurol Neurosurg Psychiatry 78:332-3. 2007