Cg Bien

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi Slowly progressive hemiparesis in childhood as a consequence of Rasmussen encephalitis without or with delayed-onset seizures
    C G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Eur J Neurol 14:387-90. 2007
  2. ncbi T-cells in human encephalitis
    Christian G Bien
    University of Bonn, Department of Epileptology, Bonn, Germany
    Neuromolecular Med 7:243-53. 2005
  3. ncbi [Recent insights into Rasmussen encephalitis]
    C G Bien
    Klinik für Epileptologie, Universitat Bonn
    Nervenarzt 76:1470, 1472-4, 1477-80, 1484-7. 2005
  4. ncbi Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: a European consensus statement
    C G Bien
    Department of Epileptology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Brain 128:454-71. 2005
  5. ncbi Assessment of the long-term effects of epilepsy surgery with three different reference groups
    Christian G Bien
    University of Bonn, Department of Epileptology, Bonn, Germany
    Epilepsia 47:1865-9. 2006
  6. ncbi The natural history of Rasmussen's encephalitis
    Christian G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Brain 125:1751-9. 2002
  7. ncbi Limbic encephalitis: a cause of temporal lobe epilepsy with onset in adult life
    Christian G Bien
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Epilepsy Behav 10:529-38. 2007
  8. ncbi Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsy
    C G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Neurology 69:1236-44. 2007
  9. doi Epilepsia partialis continua: semiology and differential diagnoses
    Christian G Bien
    Dept of Epileptology, University of Bonn, Germany
    Epileptic Disord 10:3-7. 2008
  10. doi Treatment of Rasmussen encephalitis half a century after its initial description: promising prospects and a dilemma
    Christian G Bien
    University of Bonn, Department of Epileptology, Sigmund Freud Str 25, 53105 Bonn, Germany
    Epilepsy Res 86:101-12. 2009

Detail Information

Publications36

  1. ncbi Slowly progressive hemiparesis in childhood as a consequence of Rasmussen encephalitis without or with delayed-onset seizures
    C G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Eur J Neurol 14:387-90. 2007
    ..Long-term immunotherapy is recommended in order to prevent further tissue loss and functional decline...
  2. ncbi T-cells in human encephalitis
    Christian G Bien
    University of Bonn, Department of Epileptology, Bonn, Germany
    Neuromolecular Med 7:243-53. 2005
    ..In all of them, T-cells play a major role in disease pathogenesis, mainly mediated by major histocompatiblity complex class I-restricted CD8+ T-lymphocytes...
  3. ncbi [Recent insights into Rasmussen encephalitis]
    C G Bien
    Klinik für Epileptologie, Universitat Bonn
    Nervenarzt 76:1470, 1472-4, 1477-80, 1484-7. 2005
    ..This article summarizes the current research results on the background of older data and gives recommendations regarding diagnostic and therapeutic procedures in RE patients...
  4. ncbi Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: a European consensus statement
    C G Bien
    Department of Epileptology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Brain 128:454-71. 2005
    ..Based on these data, we propose formal diagnostic criteria and a therapeutic pathway for the management of RE patients...
  5. ncbi Assessment of the long-term effects of epilepsy surgery with three different reference groups
    Christian G Bien
    University of Bonn, Department of Epileptology, Bonn, Germany
    Epilepsia 47:1865-9. 2006
    ....
  6. ncbi The natural history of Rasmussen's encephalitis
    Christian G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Brain 125:1751-9. 2002
    ..These findings should be taken into consideration when future therapeutic approaches to RE are evaluated...
  7. ncbi Limbic encephalitis: a cause of temporal lobe epilepsy with onset in adult life
    Christian G Bien
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Epilepsy Behav 10:529-38. 2007
    ..A general consensus on formal diagnostic criteria for all LE subsyndromes has not yet been reached. This article proposes such diagnostic criteria and formulates suggestions for treatment...
  8. ncbi Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsy
    C G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Neurology 69:1236-44. 2007
    ..There have been few studies of adult-onset disease. We recognized that some adult individuals have evidence of limbic encephalitis (LE), an autoimmune condition of adult life, which we proposed might lead directly to this syndrome...
  9. doi Epilepsia partialis continua: semiology and differential diagnoses
    Christian G Bien
    Dept of Epileptology, University of Bonn, Germany
    Epileptic Disord 10:3-7. 2008
    ..Published with video sequences]...
  10. doi Treatment of Rasmussen encephalitis half a century after its initial description: promising prospects and a dilemma
    Christian G Bien
    University of Bonn, Department of Epileptology, Sigmund Freud Str 25, 53105 Bonn, Germany
    Epilepsy Res 86:101-12. 2009
    ..It does, however, mostly not improve the epilepsy. Whereas for many patients unequivocal treatment proposals can be readily made, a dilemma may emerge in those with severe epilepsy but still preserved hemispheric function...
  11. doi Characteristics and surgical outcomes of patients with refractory magnetic resonance imaging-negative epilepsies
    Christian G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Arch Neurol 66:1491-9. 2009
    ..To explore several characteristics of patients with pharmacoresistant epilepsy without distinct lesions on magnetic resonance images (MRI(-)), who account for a relevant proportion of presurgical patient cohorts...
  12. doi Causes, presentation and outcome of lesional adult onset mediotemporal lobe epilepsy
    B M Soeder
    University of Bonn, Department of Epileptology, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Neurol Neurosurg Psychiatry 80:894-9. 2009
    ..MTLE usually starts before adulthood and is most frequently associated with hippocampal sclerosis (HS). Here, aetiologies, disease courses and outcomes of adult onset MTLE patients treated at this tertiary epilepsy centre are studied...
  13. doi Limbic encephalitis in children and adolescents
    E Haberlandt
    Medical University of Innsbruck, Clinical Department of Pediatrics IV, Division of Neuropediatrics and Inherited Metabolic Diseases, Innsbruck, Austria
    Arch Dis Child 96:186-91. 2011
    ..Limbic encephalitis is rare in people <18 years of age and rarely given a formal diagnosis...
  14. ncbi Localizing value of epileptic visual auras
    C G Bien
    Department of Epileptology, University of Bonn, Germany
    Brain 123:244-53. 2000
    ..Complex hallucinations and tunnel vision, however, should be considered concordant only with the assumption of an anteromedial temporal or occipitotemporal seizure onset...
  15. ncbi Transient splenium lesions in presurgical epilepsy patients: incidence and pathogenesis
    M Nelles
    Department of Radiology Neuroradiology, University of Bonn Medical Center, Sigmund Freud Str 25, 53105 Bonn, Germany
    Neuroradiology 48:443-8. 2006
    ..Transient splenium corporis callosi (SCC) lesions are related to rapid reduction of antiepileptic drugs (AEDs). The range of substances with predilection for SCC changes, their pathophysiology and their occurrence are still unknown...
  16. ncbi Diagnosis and staging of Rasmussen's encephalitis by serial MRI and histopathology
    C G Bien
    Department of Epileptology, University of Bonn, Germany
    Neurology 58:250-7. 2002
    ..To correlate MRI and histopathologic findings in patients with Rasmussen's encephalitis (RE)...
  17. ncbi Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsy
    C G Bien
    Departments of Epileptology, University of Bonn, Germany
    Neurology 55:1823-8. 2000
    ..To describe four patients with temporal lobe epilepsy with limbic encephalitis unrelated to neoplasm...
  18. ncbi MRI brain volumetry in Rasmussen encephalitis: the fate of affected and "unaffected" hemispheres
    S Larionov
    Department of Neuropathology, University of Bonn, Bonn, Germany
    Neurology 64:885-7. 2005
    ..Correlation of the planimetrically and volumetrically assessed hemispheric ratios (HRs) was significant. The results support the concept of RE as a basically unilateral disease. Planimetric HR assessment is valid and time efficient...
  19. ncbi An open study of tacrolimus therapy in Rasmussen encephalitis
    C G Bien
    Department of Epileptology, University of Bonn, Germany
    Neurology 62:2106-9. 2004
    ..No treated patient, but 7 of 12 control patients, became eligible for hemispherectomy. Tacrolimus did not have any major side effects...
  20. ncbi Long-term seizure outcome and antiepileptic drug treatment in surgically treated temporal lobe epilepsy patients: a controlled study
    C G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsia 42:1416-21. 2001
    ..To evaluate the long-term impact of surgical treatment on seizure outcome and antiepileptic drug (AED) use in patients with pharmacoresistant temporal lobe epilepsy (TLE)...
  21. ncbi [VGKC antibodies associated with limbic encephalitis]
    B M Soeder
    Klinik für Epileptologie, Universitat Bonn
    Nervenarzt 76:760-2. 2005
    ..The diagnostic workup of such a case and the apparently typical good response to long-term immunotherapy of this LE subform are described...
  22. doi Intracranially recorded memory-related potentials reveal higher posterior than anterior hippocampal involvement in verbal encoding and retrieval
    Eva Ludowig
    Department of Epileptology, University of Bonn, Bonn, Germany
    J Cogn Neurosci 20:841-51. 2008
    ..Both effects were larger the further posterior an electrode was located in the hippocampus. Findings are suggestive for a predominant posterior hippocampal involvement in both verbal encoding and retrieval...
  23. ncbi Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen's encephalitis
    Christian G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Ann Neurol 51:311-8. 2002
    ..This study directly shows, for what we believe is the first time, that a cytotoxic T-cell mechanism contributes to loss of neurons in human brain disease...
  24. doi Sensory gating in epilepsy - effects of the lateralization of hippocampal sclerosis
    Timm Rosburg
    Department of Epileptology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Clin Neurophysiol 119:1310-9. 2008
    ..The role of the hippocampus in sensory gating is unresolved as yet. The current study was conducted in order to examine the effects of hippocampal lesions on the function of auditory sensory gating...
  25. ncbi Temporal lobe seizures, amnesia and autoantibodies - identifying a potentially reversible form of non-paraneoplastic limbic encephalitis
    Angela Vincent
    Epileptic Disord 7:177-9. 2005
  26. doi Mesial frontal epilepsy and ictal body turning along the horizontal body axis
    Howan Leung
    Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, NT, Hong Kong SAR, The People s Republic of China
    Arch Neurol 65:71-7. 2008
    ..To evaluate the clinical utility of mesial frontal semiology...
  27. ncbi Rasmussen's encephalitis: a role for autoimmune cytotoxic T lymphocytes
    Jan Bauer
    Brain Research Institute, Division of Neuroimmunology, University of Vienna, Vienna, Austria
    Curr Opin Neurol 15:197-200. 2002
    ..Specific attention is given to the recent recognition of cytotoxicity by CD8+/granzyme-B-positive T lymphocytes as a new pathogenic mechanism of neuronal damage...
  28. ncbi Correlation of MRI and histopathology in epileptogenic parietal and occipital lobe lesions
    Horst Urbach
    Department of Radiology, University of Bonn Medical Center, Bonn, Germany
    Seizure 16:608-14. 2007
    ..To analyze the diagnostic accuracy of MRI in patients undergoing parietal and occipital lobe epilepsy surgery...
  29. ncbi Serial MRI of limbic encephalitis
    Horst Urbach
    Department of Radiology, University of Bonn Medical Center, Sigmund Freud Str 25, 53105 Bonn, Germany
    Neuroradiology 48:380-6. 2006
    ..The aim of the study was to analyze serial magnetic resonance imaging (MRI) scans in patients with various forms of limbic encephalitis (LE) in order to evaluate whether, and at what time point, MRI findings support the diagnosis of LE...
  30. ncbi Advances in pathogenic concepts and therapeutic agents in Rasmussen's encephalitis
    Christian G Bien
    University of Bonn, Department of Epileptology, Germany
    Expert Opin Investig Drugs 11:981-9. 2002
    ..An opinion on symptomatic treatment with anticonvulsive drugs is included...
  31. ncbi Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis
    Angela Vincent
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Brain 127:701-12. 2004
    ..Establishing the frequency of this new syndrome, the full range of clinical presentations and means of early recognition, and optimal immunotherapy, should now be the aim...
  32. doi Surgical treatment of occipital lobe epilepsy
    Devin K Binder
    Department of Neurological Surgery, University of California, Irvine, Orange, California 92868 3298, USA
    J Neurosurg 109:57-69. 2008
    ..Preoperative findings, surgical strategies, histopathological bases, and postoperative outcomes for OLE remain to be elucidated...
  33. doi Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis
    Elena Alvaréz-Baron
    Department of Neuropathology, University Bonn Medical School, Sigmund Freud Str 25, 53105 Bonn, Germany
    Epilepsy Res 80:93-7. 2008
    ....
  34. ncbi Astrocytes are a specific immunological target in Rasmussen's encephalitis
    Jan Bauer
    Division of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    Ann Neurol 62:67-80. 2007
    ..An in vitro study, however, suggested glutamate receptor 3 (GluR3) antibody-mediated astrocytic loss. Therefore, we investigated astrocytic apoptosis and loss in situ...
  35. ncbi Spinal algetic-tonic seizures manifesting as paroxysmal "positive" Brown-Séquard syndrome
    Anne Kirchner
    Dept of Epileptology, University of Boon, Germany
    Epileptic Disord 9:182-5. 2007
    ..For the first time, this rare type of seizure is published with a video documentation. It may deserve consideration in the differential diagnosis of otherwise unexplained paroxysmal events that present in an "epileptic" manner...
  36. pmc Limbic encephalitis: extension of the diagnostic armamentarium
    Christian G Bien
    J Neurol Neurosurg Psychiatry 78:332-3. 2007