Thomas Bieber

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi Pathogenesis of atopic dermatitis: new developments
    Thomas Bieber
    Department of Dermatology and Allergy, Rheinische Friedrich Wilhelms University Bonn, Bonn, Germany
    Curr Allergy Asthma Rep 9:291-4. 2009
  2. ncbi [Personalised medicine. Aims and challenges]
    T Bieber
    Klinik und Poliklinik fur Dermatologie und Allergologie, Universitäts klinikum Bonn, Sigmund Freud Str 25, 53105, Bonn, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56:1468-72. 2013
  3. doi Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine
    Th Bieber
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 67:1475-82. 2012
  4. doi Atopic dermatitis: a candidate for disease-modifying strategy
    T Bieber
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 67:969-75. 2012
  5. pmc Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
  6. doi Role of dendritic cells in atopic dermatitis: an update
    Thomas Bieber
    Department of Dermatology and Allergy, University of Bonn Medical Center, Germany
    Clin Rev Allergy Immunol 41:254-8. 2011
  7. ncbi The pro- and anti-inflammatory properties of human antigen-presenting cells expressing the high affinity receptor for IgE (Fc epsilon RI)
    Thomas Bieber
    Department of Dermatology and Allergy, University of Bonn, Sigmund Freud Street 25, 53105 Bonn, Germany
    Immunobiology 212:499-503. 2007
  8. doi Atopic dermatitis
    Thomas Bieber
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    N Engl J Med 358:1483-94. 2008
  9. doi Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells
    Manuela Brenk
    Department of Dermatology and Allergy, Friedrich Wilhelms University of Bonn, Germany
    J Immunol 183:145-54. 2009
  10. ncbi FcepsilonRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro
    Natalija Novak
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Allergy Clin Immunol 113:949-57. 2004

Detail Information

Publications106 found, 100 shown here

  1. ncbi Pathogenesis of atopic dermatitis: new developments
    Thomas Bieber
    Department of Dermatology and Allergy, Rheinische Friedrich Wilhelms University Bonn, Bonn, Germany
    Curr Allergy Asthma Rep 9:291-4. 2009
    ..This review aims to summarize the most recent findings in this field...
  2. ncbi [Personalised medicine. Aims and challenges]
    T Bieber
    Klinik und Poliklinik fur Dermatologie und Allergologie, Universitäts klinikum Bonn, Sigmund Freud Str 25, 53105, Bonn, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56:1468-72. 2013
    ..Thus, it provides the basement for an ultimate paradigm shift of modern medicine, away from a "reactive" medicine to a more "proactive" and personalised health care, so-called "P4 medicine". ..
  3. doi Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine
    Th Bieber
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 67:1475-82. 2012
    ..The consequences in terms of personalized prevention and management are delineated...
  4. doi Atopic dermatitis: a candidate for disease-modifying strategy
    T Bieber
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 67:969-75. 2012
    ....
  5. pmc Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
    ..This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems...
  6. doi Role of dendritic cells in atopic dermatitis: an update
    Thomas Bieber
    Department of Dermatology and Allergy, University of Bonn Medical Center, Germany
    Clin Rev Allergy Immunol 41:254-8. 2011
    ..This review will focus on the recent and relevant findings in the field of immunobiology of DCs and their role in AD...
  7. ncbi The pro- and anti-inflammatory properties of human antigen-presenting cells expressing the high affinity receptor for IgE (Fc epsilon RI)
    Thomas Bieber
    Department of Dermatology and Allergy, University of Bonn, Sigmund Freud Street 25, 53105 Bonn, Germany
    Immunobiology 212:499-503. 2007
    ..In contrast, the production of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) as well as IL-10 and TGFss may contribute to the tolerogenic properties of DC...
  8. doi Atopic dermatitis
    Thomas Bieber
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    N Engl J Med 358:1483-94. 2008
  9. doi Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells
    Manuela Brenk
    Department of Dermatology and Allergy, Friedrich Wilhelms University of Bonn, Germany
    J Immunol 183:145-54. 2009
    ..The impact of IDO thus extends beyond local immune suppression to a systemic control of the immune response...
  10. ncbi FcepsilonRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro
    Natalija Novak
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Allergy Clin Immunol 113:949-57. 2004
    ....
  11. pmc Indoleamine 2,3-dioxygenase (IDO): the antagonist of type I interferon-driven skin inflammation?
    Marina Scheler
    Department of Dermatology, Friedrich Wilhelms University, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Am J Pathol 171:1936-43. 2007
    ..These findings reveal that both proinflammatory and counterregulatory mechanisms are operative in cutaneous lesions of LP. We propose that the balance of these mechanisms may be involved in the pathogenesis of this disorder...
  12. ncbi Role of the chemokine receptor CCR4 and its ligand thymus- and activation-regulated chemokine/CCL17 for lymphocyte recruitment in cutaneous lupus erythematosus
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Invest Dermatol 124:1241-8. 2005
    ..Our investigations suggest that CCR4 and TARC/CCL17 play a role in the pathophysiology of CLE. In particular, cytotoxic CD8+ T cells expressing CCR4 appear to be involved in scarring subtypes of CLE...
  13. ncbi Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells
    Jean Pierre Allam
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 121:368-374.e1. 2008
    ..Bacterial antigens like LPSs are recognized by innate immunity receptors such as Toll-like receptor 4 (TLR4), associated with LPS receptor (CD14)...
  14. doi CXCR3 <-> ligand-mediated skin inflammation in cutaneous lichenoid graft-versus-host disease
    Joerg Wenzel
    Department of Dermatology at the Universitie of Bonn, Bonn, Germany
    J Am Acad Dermatol 58:437-42. 2008
    ....
  15. ncbi Human epidermal langerhans cells express the immunoregulatory enzyme indoleamine 2,3-dioxygenase
    Dagmar von Bubnoff
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    J Invest Dermatol 123:298-304. 2004
    ..These results indicate that LC not only have the capacity to stimulate but also to inhibit T cells, and suggest that LC possess an immunoregulatory function in promoting T cell tolerance by production of IDO...
  16. doi Tacrolimus and TGF-beta act synergistically on the generation of Langerhans cells
    Bartlomiej Kwiek
    Department of Dermatology and Allergology, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 122:126-32, 132.e1. 2008
    ....
  17. doi Human myeloid dendritic cells are refractory to tryptophan metabolites
    Dagmar von Bubnoff
    Department of Dermatology and Allergology, Friedrich Wilhelms University, Bonn, Germany
    Hum Immunol 72:791-7. 2011
    ....
  18. ncbi Type I interferon-associated recruitment of cytotoxic lymphocytes: a common mechanism in regressive melanocytic lesions
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    Am J Clin Pathol 124:37-48. 2005
    ..We believe this cytotoxic immune response represents an evolutionarily conserved pathway against intracellular pathogens...
  19. ncbi Skin homing of Langerhans cell precursors: adhesion, chemotaxis, and migration
    Susanne Koch
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    J Allergy Clin Immunol 117:163-8. 2006
    ..Matrix metalloproteinases also execute an important role in modulating inflammatory and immune responses by processing chemokines, which turns them into dual players for the immigration of LC precursors into the epidermis...
  20. ncbi Expression of chemokines and chemokine receptors in lesional and nonlesional upper skin of patients with atopic dermatitis
    Eva Gros
    Department of Dermatology and Allergy, University of Bonn Medical Center, Bonn, Germany
    J Allergy Clin Immunol 124:753-60.e1. 2009
    ..Trafficking of dendritic cell (DC) subtypes to and from the skin plays a pivotal role in atopic dermatitis (AD)...
  21. ncbi Type I interferon-associated cytotoxic inflammation in lichen planus
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Cutan Pathol 33:672-8. 2006
    ..Here, we investigated whether type I IFNs are also involved in the pathogenesis of LP...
  22. ncbi Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta1 and IL-10-producing properties
    Jean Pierre Allam
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 126:638-45.e1. 2010
    ..Oral mucosal Langerhans cells (oLCs) play a central role. However, little is known about allergen binding by oLCs during mucosal allergen resorption and its impact on oLC functions...
  23. ncbi Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation
    Chun Feng Yu
    Department of Dermatology and Allergy, University Hospital, University of Bonn, Bonn, Germany
    J Immunol 184:1159-67. 2010
    ....
  24. doi Transcriptional profiling identifies an interferon-associated host immune response in invasive squamous cell carcinoma of the skin
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    Int J Cancer 123:2605-15. 2008
    ..Collectively, our findings support the concept that IFN-associated host responses play an important role in tumor immunosurveillance in the skin...
  25. ncbi Indoleamine 2,3-dioxygenase-expressing antigen-presenting cells and peripheral T-cell tolerance: another piece to the atopic puzzle?
    Dagmar von Bubnoff
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    J Allergy Clin Immunol 112:854-60. 2003
    ..We introduce the hypothesis that tryptophan degradation might add to the ability to control and downregulate allergen-specific T-cell responses in atopic individuals...
  26. ncbi The immune privilege of the oral mucosa
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Trends Mol Med 14:191-8. 2008
    ....
  27. doi Role of high-resolution ultrasound and PET/CT imaging for preoperative characterization of sentinel lymph nodes in cutaneous melanoma
    Torsten Hinz
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Ultrasound Med Biol 39:30-6. 2013
    ....
  28. doi Sentinel lymph node status as most important prognostic factor in patients with high-risk cutaneous melanomas (tumour thickness >4.00 mm): outcome analysis from a single institution
    Torsten Hinz
    Department of Dermatology and Allergology, Center of Integrated Oncology Cologne Bonn University of Bonn, Bonn, Germany
    Eur J Nucl Med Mol Imaging 39:1316-25. 2012
    ..The purpose of the current study was to determine the prognostic value of SLNB in patients with thick cutaneous melanomas (tumour thickness >4.0 mm) in terms of progression-free survival (PFS) and overall survival (OS)...
  29. doi Indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells and macrophages in infectious and noninfectious cutaneous granulomas
    Dagmar von Bubnoff
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    J Am Acad Dermatol 65:819-32. 2011
    ..In this study we undertook an analysis of IDO expression in granulomas of infectious and noninfectious origin in the human skin...
  30. ncbi Gene expression profiling of lichen planus reflects CXCL9+-mediated inflammation and distinguishes this disease from atopic dermatitis and psoriasis
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Invest Dermatol 128:67-78. 2008
    ..Gene expression profiling might complement the diagnostic spectrum in dermatology and may provide new pathogenetic insights...
  31. ncbi Characterization of FcepsilonRI-bearing CD123 blood dendritic cell antigen-2 plasmacytoid dendritic cells in atopic dermatitis
    Natalija Novak
    Department of Dermatology, University of Bonn, Germany
    J Allergy Clin Immunol 114:364-70. 2004
    ..Plasmacytoid dendritic cells (pDCs), which are instrumental in the defense of viral infections, are present in reduced amounts in the skin of patients with AD, which is characterized by a high susceptibility to viral infections...
  32. doi Type I interferon-associated cytotoxic inflammation in cutaneous lupus erythematosus
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Arch Dermatol Res 301:83-6. 2009
    ..These and other studies suggest that a complex network of IFN-associated cytokines, chemokines and adhesion molecules orchestrates and promotes tissue injury observed in LE skin...
  33. doi The immunoglobulin E-Toll-like receptor network
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn Medical Center, Bonn, Germany
    Int Arch Allergy Immunol 151:1-7. 2010
    ..Current knowledge about the cross talk of TLRs with FcepsilonRI- and IgE-related immune responses is discussed herein...
  34. ncbi Kinetics of gene induction after FcepsilonRI ligation of atopic monocytes identified by suppression subtractive hybridization
    Dagmar von Bubnoff
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    J Immunol 169:6170-7. 2002
    ..These results demonstrate that the analysis of the profile of gene induction following activation of FcepsilonRI on atopic monocytes may reveal how these cells might participate in the regulation of atopic disorders...
  35. doi Real-time tissue elastography as promising diagnostic tool for diagnosis of lymph node metastases in patients with malignant melanoma: a prospective single-center experience
    Torsten Hinz
    Department of Dermatology and Allergology, Center of Integrated Oncology CIO Cologne Bonn, University of Bonn, Bonn, Germany
    Dermatology 226:81-90. 2013
    ....
  36. pmc Inhibitory oligodeoxynucleotides downregulate herpes simplex virus-induced plasmacytoid dendritic cell type I interferon production and modulate cell function
    Wen Ming Peng
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Hum Immunol 68:879-87. 2007
    ....
  37. doi γ-Interferon-regulated chaperone governs human lymphocyte antigen class II expression
    Nadine Kämper
    Institute of Genetics, University of Bonn, Bonn, Germany
    FASEB J 26:104-16. 2012
    ..We present a mechanism explaining how parallel IFNγ-mediated regulation of CIITA and of its chaperone BAT3 controls the level of components of the HLA class II processing pathway...
  38. ncbi Subpopulations of human dendritic cells display a distinct phenotype and bind differentially to proteins of the extracellular matrix
    Kristine Kohl
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Eur J Cell Biol 86:719-30. 2007
    ..In summary, subpopulations of CD34DCs and MoDCs are phenotypically related to each other, but not identical and display differential binding to components of the extracellular matrix...
  39. ncbi Enhanced type I interferon signaling and recruitment of chemokine receptor CXCR3-expressing lymphocytes into the skin following treatment with the TLR7-agonist imiquimod
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Cutan Pathol 32:257-62. 2005
    ..We hypothesize that TLR7-signaling strongly induces the production of interferon (IFN) alpha, which is able to enhance Th1-mediated cellular antiviral and antitumor immunity...
  40. ncbi Transforming growth factor-beta1 regulates the expression of the high-affinity receptor for IgE on CD34 stem cell-derived CD1a dendritic cells in vitro
    Jean Pierre Allam
    Department of Dermatology, Rheinische Friedrich Wilhelms University of Bonn, Bonn, Germany
    J Invest Dermatol 123:676-82. 2004
    ..In view of these data, a picture emerges that FcepsilonRI+ on DC is finely modified by the TGF-beta1 concentration in the microenvironment and could be of primary relevance in the context of atopic diseases...
  41. ncbi Toll-like receptor 7 agonists and skin
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Drug News Perspect 21:158-65. 2008
    ..This review summarizes the current knowledge about the immunological mechanisms induced by the TLR7 agonist imiquimod as well as established clinical therapies and putative applications of TLR7 agonists in the near future...
  42. doi Molecular pathogenesis and clinical implications of eczema herpeticum
    Caroline Bussmann
    Department of Dermatology and Allergology, University of Bonn, Bonn, Germany
    Expert Rev Mol Med 10:e21. 2008
    ..In this review, we summarise the current knowledge of the molecular pathogenesis of eczema herpeticum...
  43. ncbi A reducing microenvironment leads to the generation of FcepsilonRIhigh inflammatory dendritic epidermal cells (IDEC)
    Natalija Novak
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    J Invest Dermatol 119:842-9. 2002
    ....
  44. pmc Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus
    Stephan Weidinger
    Department of Dermatology and Allergy, Technische Universitat Munchen, Munchen, Germany
    PLoS Genet 4:e1000166. 2008
    ..Our data furthermore confirm association of STAT6 variation with serum IgE levels...
  45. ncbi Superimposed linear lichen planopilaris: another polygenic disorder exemplifying a new genetic concept
    Caroline Bussmann
    Department of Dermatology and Allergy, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Eur J Dermatol 20:269-70. 2010
    ..This is to our knowledge the first described case of a superimposed lichen planopilaris...
  46. pmc Evidence for a differential expression of the FcepsilonRIgamma chain in dendritic cells of atopic and nonatopic donors
    Natalija Novak
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    J Clin Invest 111:1047-56. 2003
    ..We propose that enhanced Fc epsilon RI on DCs from atopic donors is driven by enhanced expression of otherwise limiting amounts of Fc epsilon RI gamma and is preserved by increased IgE levels...
  47. doi Identification of IDO-positive and IDO-negative human dendritic cells after activation by various proinflammatory stimuli
    Dagmar von Bubnoff
    Department of Dermatology and Allergy, Friedrich Wilhelms University of Bonn, 53105 Bonn, Germany
    J Immunol 186:6701-9. 2011
    ..It seems likely that the IDO-positive DC subset possesses a regulatory function and might skew a T cell response toward tolerance...
  48. doi Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFNλ) in cutaneous lupus erythematosus
    Sabine Zahn
    Department of Dermatology and Allergology, University of Bonn, Bonn, Germany
    J Invest Dermatol 131:133-40. 2011
    ..Our results provide evidence for a role of type III IFNs in not only antiviral immunity but also autoimmune diseases of the skin...
  49. doi Indoleamine 2,3-dioxygenase expression in early keratocyte neoplasia of the lower lip correlates to the degree of cell atypia
    Dagmar von Bubnoff
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    Pathol Int 62:105-11. 2012
    ..0005) but not to the extent of inflammation (P=0.4283). Expression of IDO in early atypic skin epithelial conditions might be a predictor to promote carcinogenesis...
  50. doi Reduced IFN-γ receptor expression and attenuated IFN-γ response by dendritic cells in patients with atopic dermatitis
    Eva Gros
    Department of Dermatology and Allergy, University of Bonn Medical Center, Bonn, Germany
    J Allergy Clin Immunol 128:1015-21. 2011
    ..Atopic dermatitis (AD) is characterized by a predominance of T(H)2 immune reactions but weaker T(H)1 immune responses in acute skin lesions...
  51. ncbi Characterization of dendritic cells from human oral mucosa: a new Langerhans' cell type with high constitutive FcepsilonRI expression
    Jean Pierre Allam
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    J Allergy Clin Immunol 112:141-8. 2003
    ..Although Langerhans' cells (LC), known to play a crucial role in initiating allergen-dependent immune responses in the skin, have also been detected in the oral mucosa, little is known about their phenotype and exact physiologic role...
  52. ncbi IP10/CXCL10 - CXCR3 interaction: a potential self-recruiting mechanism for cytotoxic lymphocytes in lichen sclerosus et atrophicus
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Germany
    Acta Derm Venereol 87:112-7. 2007
    ..Infiltrating lymphocytes, containing IP10 in their granules, could provide an important self-perpetuating mechanism...
  53. ncbi The role of cytotoxic skin-homing CD8+ lymphocytes in cutaneous cytotoxic T-cell lymphoma and pityriasis lichenoides
    Joerg Wenzel
    Department of Dermatology, Institute of Pathology, University of Bonn, Bonn, Germany
    J Am Acad Dermatol 53:422-7. 2005
    ..This case prompted us to reinvestigate the role of cytotoxic T lymphocytes in PL and its relationship to antiviral immunity...
  54. ncbi The role of dendritic cell subtypes in the pathophysiology of atopic dermatitis
    Natalija Novak
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Am Acad Dermatol 53:S171-6. 2005
    ..Compelling evidence presented here suggests that two types of dendritic cells (DC), myeloid DC (mDC) and plasmacytoid DC (pDC), are important in the pathogenesis of AD...
  55. ncbi The expression of human leukocyte antigen-DR and CD25 on circulating T cells in cutaneous lupus erythematosus and correlation with disease activity
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    Exp Dermatol 14:454-9. 2005
    ..In patients with SLE, the expression of activation markers on circulating T cells reflects disease activity. Here, we investigated whether this also holds true for patients with CLE...
  56. ncbi Biologicals dramatic advances in the treatment of psoriasis
    Dagmar Wilsmann-Theis
    Department of Dermatology, University of Bonn, Germany
    Curr Pharm Des 12:989-99. 2006
    ..Four of these agents, alefacept, efalizumab, etanercept and infliximab have already impacted on routine clinical practice. Current developments in the treatment of psoriasis with biologicals are reviewed...
  57. doi Efficacy and safety of subcutaneous allergen-specific immunotherapy with depigmented polymerized mite extract in atopic dermatitis
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 130:925-31.e4. 2012
    ..Exposure to house dust mites (HDMs) aggravates the course of atopic dermatitis (AD) in patients sensitized to HDMs...
  58. doi Prognostic value of sentinel lymph node biopsy in 121 low-risk melanomas (tumour thickness <1.00 mm) on the basis of a long-term follow-up
    Torsten Hinz
    Department of Dermatology and Allergology, Center of Integrated Oncology CIO Cologne Bonn, University of Bonn, Bonn, Germany
    Eur J Nucl Med Mol Imaging 39:581-8. 2012
    ....
  59. doi IL-23-producing CD68(+) macrophage-like cells predominate within an IL-17-polarized infiltrate in chronic periodontitis lesions
    Jean Pierre Allam
    Department of Dermatology and Allergy, University of Bonn, Germany
    J Clin Periodontol 38:879-86. 2011
    ..To analyse antigen-presenting cells (APCs), such as dendritic cells (DCs), macrophages (Mo) or B cells depending on the regional site of chronic periodontitis (CP), and to investigate their relation to Th17 cells...
  60. ncbi Immune mechanisms leading to atopic dermatitis
    Natalija Novak
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 112:S128-39. 2003
    ..The current review will examine recent advances that have been made in our understanding of the genetic and pathophysiologic prerequisites that form the basis of this common recalcitrant skin disorder...
  61. doi Facing psoriasis and atopic dermatitis: are there more similarities or more differences?
    Dagmar Wilsmann-Theis
    Department of Dermatology and Allergy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Dermatol 18:172-80. 2008
    ..Beyond that, in view of these findings, the question arises, which similarities and differences between AD and Pso exist. In order to address this point, we provide an overview about the current knowledge in the field of AD and Pso...
  62. ncbi Dendritic cells as potential targets for mucosal immunotherapy
    Jean Pierre Allam
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Curr Opin Allergy Clin Immunol 9:554-7. 2009
    ..Without doubt, oral mucosal antigen-presenting cells such as dendritic cells play a central role as they process antigens to initialize and modulate T-cell activation...
  63. ncbi Myeloid CD11c+ S100+ dendritic cells express indoleamine 2,3-dioxygenase at the inflammatory border to invasive lower lip squamous cell carcinoma
    Melanie Alice Kuales
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    Histol Histopathol 26:997-1006. 2011
    ..IDO expression in LL-SCC may aid immune escape and chronic inflammation to promote cancer progression. Inhibition of IDO might be a therapeutic strategy to increase the anti-tumor immune response in SCC-LL...
  64. doi High-resolution ultrasound combined with power Doppler sonography can reduce the number of sentinel lymph node biopsies in cutaneous melanoma
    Torsten Hinz
    Department of Dermatology and Allergology, Center of Integrated Oncology Cologne Bonn, University of Bonn, Bonn, Germany
    Dermatology 222:180-8. 2011
    ..Disadvantages of the SLNB procedure are the overall costs and potential side effects of the operation [J Dtsch Dermatol Ges 2009;7:318-327; J Am Dermatol 2010;62:737-748]...
  65. doi Dendritic cells: bridging innate and adaptive immunity in atopic dermatitis
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, D 53105 Bonn, Germany
    J Allergy Clin Immunol 125:50-9. 2010
    ..Therefore TLR-bearing DCs represent promising targets, which might help to improve tolerance induction during immunotherapeutic approaches in the future...
  66. ncbi Single nucleotide polymorphisms of the IL18 gene are associated with atopic eczema
    Natalija Novak
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Allergy Clin Immunol 115:828-33. 2005
    ..Human IL-18 is an inflammatory cytokine that plays a role in atopic diseases, such as atopic eczema (AE), by enhancing IL-4 and IL-13 production and stimulating the synthesis of IgE...
  67. ncbi CXCR3-mediated recruitment of cytotoxic lymphocytes in lupus erythematosus profundus
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Germany
    J Am Acad Dermatol 56:648-50. 2007
    ..Recently, we observed a case of LEP involving the lower right eyelid. Our immunohistological analyses of lesional skin biopsies revealed a type I IFN signature in the context of cytotoxic lobular panniculitis...
  68. ncbi Migration and differentiation of Langerhans cell precursors
    Kristine Kohl
    Department of Dermatology, Bonn University, Bonn, Germany
    Eur J Cell Biol 83:805-11. 2004
    ..Experiments designed to investigate the influence of signals provided by both the skin components and by the LC precursors on LC immigration into the skin are in progress...
  69. ncbi Keratitis-ichthyosis-deafness syndrome in association with follicular occlusion triad
    Laura Maintz
    Department of Dermatology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Dermatol 15:347-52. 2005
    ..To our knowledge, only one case of KID syndrome occurring in association with follicular occlusion triad has been reported before...
  70. ncbi Dendritic cells and atopic eczema/dermatitis syndrome
    Dagmar von Bubnoff
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    Curr Opin Allergy Clin Immunol 3:353-8. 2003
    ..Here, we review recent findings that underscore the importance of dendritic cells as being central to shape these proinflammatory responses...
  71. doi FcεRI-Toll-like receptor interaction in atopic dermatitis
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Curr Probl Dermatol 41:47-53. 2011
    ....
  72. ncbi Enhanced type I interferon signalling promotes Th1-biased inflammation in cutaneous lupus erythematosus
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Germany
    J Pathol 205:435-42. 2005
    ..It is proposed that type I IFNs induce a Th1-biased inflammatory immune response, with recruitment of CXCR3-expressing T-lymphocytes into the skin...
  73. doi Subcutaneous immunotherapy with a depigmented polymerized birch pollen extract--a new therapeutic option for patients with atopic dermatitis
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Int Arch Allergy Immunol 155:252-6. 2011
    ..The aim of this study was to evaluate for the first time the safety and efficacy of SIT with a depigmented polymerized birch pollen extract in AD patients...
  74. ncbi Positive lymphocyte transformation test in a patient with allergic contact dermatitis of the scalp after short-term use of topical minoxidil solution
    Tobias Hagemann
    Department of Dermatology, University of Bonn, Bonn, Germany
    Contact Dermatitis 53:53-5. 2005
    ..In contrast, patients with allergies to the active ingredient itself are no longer candidates for treatment with minoxidil and should undergo alternative therapeutic options...
  75. ncbi Allergic and nonallergic forms of atopic diseases
    Natalija Novak
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 112:252-62. 2003
    ....
  76. doi Natural killer cells in atopic and autoimmune diseases of the skin
    Dagmar von Bubnoff
    Department of Dermatology and Allergy, Friedrich Wilhelms University, Bonn, Germany
    J Allergy Clin Immunol 125:60-8. 2010
    ..Many details are still unclear; however, we believe that there is solid evidence that NK cells actively participate in a number of diseases that have not been traditionally linked to this type of lymphocyte...
  77. ncbi Enhanced expression and activity of protein-tyrosine kinases establishes a functional signaling pathway only in FcepsilonRIhigh Langerhans cells from atopic individuals
    Stefan Kraft
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    J Invest Dermatol 119:804-11. 2002
    ..Key words:..
  78. doi 2. Dendritic cells as regulators of immunity and tolerance
    Natalija Novak
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 121:S370-4; quiz S413. 2008
    ....
  79. ncbi Aggregation of the high-affinity IgE receptor Fc(epsilon)RI on human monocytes and dendritic cells induces NF-kappaB activation
    Stefan Kraft
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    J Invest Dermatol 118:830-7. 2002
    ..Thus NF-kappaB activation represents a novel mechanism by which Fc(epsilon)RI on monocytes and DC potentially controls inflammatory reactions...
  80. ncbi The good, the bad and the ugly--APCs of the eye
    Natalija Novak
    Department of Dermatology, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Trends Immunol 24:570-4. 2003
    ..Thus, the corneal DC, as well as the DC and the macrophages in the iris and ciliary body, have the potential of determining the outcome of immunity or tolerance within this organ...
  81. ncbi Tryptase detection in bone-marrow blood: a new diagnostic tool in systemic mastocytosis
    Julia Proelss
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Am Acad Dermatol 56:453-7. 2007
    ..The diagnosis of systemic mastocytosis is substantially based on the histologic examination of bone-marrow biopsy specimens...
  82. doi Photodynamic therapy as an alternative treatment for cutaneous sarcoidosis
    Dagmar Wilsmann-Theis
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Dermatology 217:343-6. 2008
    ..We report two cases of cutaneous sarcoidosis successfully treated with photodynamic therapy, which represents an effective alternative therapy with fewer side effects...
  83. ncbi Periodic genital pruritus caused by syringoma of the vulva
    Rainer Gerdsen
    Department of Dermatology, University of Bonn, Germany, Bonn, Germany
    Acta Obstet Gynecol Scand 81:369-70. 2002
  84. ncbi Topical treatment of pyoderma gangraenosum
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Germany
    Dermatology 205:221-3. 2002
    ..We give a review about these topically used drugs and the mechanisms probably involved...
  85. ncbi [Topical treatment of bullous pemphigoid with tacrolimus. Case report with brief literature review]
    Joerg Wenzel
    Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Bonn
    J Dtsch Dermatol Ges 3:207-10. 2005
    ..He was treated with 0.1% tacrolimus ointment, which was able to control the disease. We briefly review the literature and discuss the potential role of tacrolimus as a novel option for the topical treatment of BP...
  86. ncbi FcepsilonRI induces the tryptophan degradation pathway involved in regulating T cell responses
    Dagmar von Bubnoff
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Immunol 169:1810-6. 2002
    ..We speculate that the expression of IDO by FcepsilonRI(+) APCs in vivo allows these cells to regulate T cell responses in atopic disorders by inhibiting or stimulating T cell proliferation, depending on the metabolic environment...
  87. ncbi [Systemic treatment of cutaneous lupus erythematosus]
    Joerg Wenzel
    Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Bonn
    J Dtsch Dermatol Ges 1:694-704. 2003
    ....
  88. ncbi Infraorbital eyelid edema as the presenting sign of bronchogenic carcinoma
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Int J Dermatol 41:386-7. 2002
  89. ncbi Diagnostic performance of whole body dual modality 18F-FDG PET/CT imaging for N- and M-staging of malignant melanoma: experience with 250 consecutive patients
    Michael J Reinhardt
    Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany
    J Clin Oncol 24:1178-87. 2006
    ..To assess the diagnostic performance of positron emission tomography/computed tomography (PET/CT) using (18)F-fluorodeoxyglucose (FDG) for N- and M-staging of cutaneous melanoma...
  90. ncbi Bullous lupus erythematosus in a patient with pre-existing dermatomyositis
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Rheumatol Int 24:114-6. 2004
    ..Observations of transitions between DM and LE are extremely rare. Nevertheless, this case demonstrates the close relationship between these two disorders in the context of autoimmune connective tissue disease...
  91. doi Efficacy of ablative laser treatment in Galli-Galli disease
    Harald Voth
    Department of Dermatology and Allergy, University of Bonn, Germany
    Arch Dermatol 147:317-20. 2011
    ..To date, no convincing treatment options are known for GGD. We sought to examine the therapeutic potential of ablative laser treatment in a patient with genetically confirmed GGD...
  92. ncbi Generalized lichen nitidus with involvement of the palms following interferon alpha treatment
    Marina Scheler
    Department of Dermatology, University of Bonn, Bonn, Germany
    Dermatology 215:236-9. 2007
    ..Furthermore in our patient we could show a strong lesional expression of MxA, a protein specifically induced by type I interferon. It is tempting to speculate that interferon alpha may be involved in the pathogenesis of lichen nitidus...
  93. ncbi Steroid-sparing effect of pimecrolimus cream 1% in children with severe atopic dermatitis
    Torsten Zuberbier
    Department of Dermatology and Allergy, Allergy Centre Charité, Berlin, Germany
    Dermatology 215:325-30. 2007
    ..To investigate if pimecrolimus cream 1% reduces the need for steroids in the long-term management of severe pediatric atopic dermatitis (AD)...
  94. ncbi House dust mite allergen levels in German day-care centers
    Steffen Engelhart
    Institute of Hygiene and Public Health, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Int J Hyg Environ Health 205:453-7. 2002
    ..09-0.49) from day-care centers were significantly lower (p < 0.001). We conclude that day-care centers should be included as potential places of additional exposure to house dust mite allergens if avoidance measures are taken...
  95. ncbi Successful treatment of Dowling-Degos disease with Er:YAG laser
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    Dermatol Surg 28:748-50. 2002
    ..The typical clinical picture is a reticulate pigmentation of the flexures, genital folds, and pectoral skin areas. Many different treatment options have been tried in recent years without a convincing therapeutic benefit...
  96. ncbi [Pathogenesis of atopic eczema]
    Natalija Novak
    Klinik und Poliklinik für Dermatologie der Universität Bonn
    J Dtsch Dermatol Ges 3:994-1004; quiz 1005-6. 2005
  97. ncbi [Therapy of atopic eczema with calcineurin inhibitors]
    Thomas A Luger
    Hautklinik, Universitätsklinikkum Münster, Deutschland
    J Dtsch Dermatol Ges 3:385-91. 2005
  98. ncbi Mechanism of HBD-3 deficiency in atopic dermatitis
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Room K926, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Immunol 121:332-8. 2006
    ..These studies suggest that neutralizing the Th2 cytokine milieu in AD skin may augment the innate immune response against bacterial and viral pathogens...
  99. ncbi Tumor necrosis factor-alpha- and IL-4-independent development of Langerhans cell-like dendritic cells from M-CSF-conditioned precursors
    Jean Baptiste Barbaroux
    INSERM U255, IFR58, Centre de Recherches Biomedicales des Cordeliers, Université Pierre et Marie Curie Paris 6 et René Descartes Paris 5, Paris, France
    J Invest Dermatol 126:114-20. 2006
    ..This suggests that M-CSF-conditioned DC precursors retain the capacity to efficiently undergo a differentiation program, giving rise to LC-like DC solely through the effect of GM-CSF and TGFbeta...
  100. ncbi A randomized, double-blind, vehicle-controlled study of 1% pimecrolimus cream in adult patients with perioral dermatitis
    Thomas Schwarz
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Am Acad Dermatol 59:34-40. 2008
    ..Perioral dermatitis (POD) is a common dermatosis without standard therapy...
  101. ncbi Dichotomic nature of atopic dermatitis reflected by combined analysis of monocyte immunophenotyping and single nucleotide polymorphisms of the interleukin-4/interleukin-13 receptor gene: the dichotomy of extrinsic and intrinsic atopic dermatitis
    Natalija Novak
    Department of Dermatology, Friedrich Wilhelms University, D 53105 Bonn, Germany
    J Invest Dermatol 119:870-5. 2002
    ..Altogether our findings indicate that intrinsic atopic dermatitis patients exhibit phenotypic and immunologic features, which differ from those of patients with extrinsic atopic dermatitis or other atopic disorders...