Wolfgang G Bessler

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. ncbi request reprint Lipopeptide adjuvants in combination treatment
    Wolfgang G Bessler
    Institut für Molekulare Medizin und Zellforschung, Universitatsklinikum Freiburg, Stefan Meier Str 8, D 79104 Fribourg, Germany
    Int Immunopharmacol 3:1217-24. 2003
  2. doi request reprint Immunomodulating effects of OM-89, a bacterial extract from Escherichia coli, in murine and human leukocytes
    Wolfgang G Bessler
    Institut für Molekulare Medizin und Zellforschung, Freiburg University Hospital, Freiburg, Germany
    Arzneimittelforschung 59:571-7. 2009
  3. doi request reprint The bacterial extract OM-85 BV protects mice against influenza and Salmonella infection
    Wolfgang G Bessler
    Institute for Molecular Medicine and Cell Research, University Clinic, Freiburg, Germany
    Int Immunopharmacol 10:1086-90. 2010
  4. doi request reprint Immunostimulatory properties of the bacterial extract OM-89 in vitro and in vivo
    Wolfgang G Bessler
    Institute for Molecular Medicine and Cell Research, University Clinic, Freiburg, Germany
    Arzneimittelforschung 60:324-9. 2010
  5. ncbi request reprint Triacyl-lipopentapeptide adjuvants: TLR2-dependent activation of macrophages and modulation of receptor-mediated cell activation by altering acyl-moieties
    Silke D C Müller
    Institut für Molekulare Medizin und Zellforschung der Universität, AK Tumorimmunologie Vakzine, Stefan Meier Str 8, D 79104 Freiburg, Germany
    Int Immunopharmacol 4:1287-300. 2004
  6. ncbi request reprint A fetal sheep liver extract containing immunostimulatory substances including LPS acts as leukocyte activator in cells of LPS responder and non responder mice
    Silke Müller
    AK Tumorimmunologie Vakzine, Institut für Molekulare Medizin und Zellforschung, Universitatsklinikum Freiburg, Stefan Meier Strasse 8, D 79104 Freiburg, Germany
    Int Immunopharmacol 5:1809-19. 2005
  7. ncbi request reprint Modulation of the Th1/Th2 bias by lipopeptide and saponin adjuvants in orally immunized mice
    Maria Huber
    Institut für Molekulare Medizin und Zellforschung, AK Tumorimmunologie Vakzine, Universitäts klinikum Freiburg, Germany
    Immunobiology 205:61-73. 2002
  8. doi request reprint Passive vaccination with a human monoclonal antibody: generation of antibodies and studies for efficacy in Bacillus anthracis infections
    Ulrich vor dem Esche
    Institut für Molekulare Medizin und Zellforschung, Universitatsklinikum Freiburg, Freiburg, Germany
    Immunobiology 216:847-53. 2011

Collaborators

  • H Wagner
  • Ulrich Zahringer
  • Reginald M Gorczynski
  • K Mittenbühler
  • Roland Grunow
  • Maria Huber
  • Ulrich vor dem Esche
  • Silke Müller
  • Silke D C Müller
  • Wolfgang Beyer
  • Ulrike Hahn
  • Andrea Zgaga-Griesz
  • Ulrich V D Esche
  • Christian Alexander
  • Otto Westphal
  • Petra Hoffmann
  • Jean Pierre Mach
  • Thierry Waelli
  • Ernst T Rietschel
  • Carsten J Kirschning
  • Ulrich v d Esche Uv
  • Markus R Müller
  • Lutz Heinevetter
  • Wiltrud Baier

Detail Information

Publications8

  1. ncbi request reprint Lipopeptide adjuvants in combination treatment
    Wolfgang G Bessler
    Institut für Molekulare Medizin und Zellforschung, Universitatsklinikum Freiburg, Stefan Meier Str 8, D 79104 Fribourg, Germany
    Int Immunopharmacol 3:1217-24. 2003
    ..The chemically well-defined lipopeptides can be synthesized with high purity and reproducibility and constitute ideal agents to be combined with antigens/vaccines or antitumor treatment...
  2. doi request reprint Immunomodulating effects of OM-89, a bacterial extract from Escherichia coli, in murine and human leukocytes
    Wolfgang G Bessler
    Institut für Molekulare Medizin und Zellforschung, Freiburg University Hospital, Freiburg, Germany
    Arzneimittelforschung 59:571-7. 2009
    ..The activation of immune cells is likely to be mediated via Toll like receptors (TLRs); thus, the binding of components of the extract to TLR-4 and marginally to TLR-2 could be shown...
  3. doi request reprint The bacterial extract OM-85 BV protects mice against influenza and Salmonella infection
    Wolfgang G Bessler
    Institute for Molecular Medicine and Cell Research, University Clinic, Freiburg, Germany
    Int Immunopharmacol 10:1086-90. 2010
    ..Our findings demonstrate the antimicrobial activity of OM-85 BV against infections, as also has been shown in clinical studies...
  4. doi request reprint Immunostimulatory properties of the bacterial extract OM-89 in vitro and in vivo
    Wolfgang G Bessler
    Institute for Molecular Medicine and Cell Research, University Clinic, Freiburg, Germany
    Arzneimittelforschung 60:324-9. 2010
    ..5 ml once a day for 10 consecutive days). The extract proved to be effective: 90% of the OM-89-treated animals survived compared to 58% of the untreated control group...
  5. ncbi request reprint Triacyl-lipopentapeptide adjuvants: TLR2-dependent activation of macrophages and modulation of receptor-mediated cell activation by altering acyl-moieties
    Silke D C Müller
    Institut für Molekulare Medizin und Zellforschung der Universität, AK Tumorimmunologie Vakzine, Stefan Meier Str 8, D 79104 Freiburg, Germany
    Int Immunopharmacol 4:1287-300. 2004
    ....
  6. ncbi request reprint A fetal sheep liver extract containing immunostimulatory substances including LPS acts as leukocyte activator in cells of LPS responder and non responder mice
    Silke Müller
    AK Tumorimmunologie Vakzine, Institut für Molekulare Medizin und Zellforschung, Universitatsklinikum Freiburg, Stefan Meier Strasse 8, D 79104 Freiburg, Germany
    Int Immunopharmacol 5:1809-19. 2005
    ..Our results may help to explain the beneficial effect of the extract in patients which has been observed clinically...
  7. ncbi request reprint Modulation of the Th1/Th2 bias by lipopeptide and saponin adjuvants in orally immunized mice
    Maria Huber
    Institut für Molekulare Medizin und Zellforschung, AK Tumorimmunologie Vakzine, Universitäts klinikum Freiburg, Germany
    Immunobiology 205:61-73. 2002
    ..Our findings are of importance for the improvement of mucosal immunizations, and might be a tool for the immunotheraphy of food allergies...
  8. doi request reprint Passive vaccination with a human monoclonal antibody: generation of antibodies and studies for efficacy in Bacillus anthracis infections
    Ulrich vor dem Esche
    Institut für Molekulare Medizin und Zellforschung, Universitatsklinikum Freiburg, Freiburg, Germany
    Immunobiology 216:847-53. 2011
    ..In general, our studies show the applicability of the CB-F7 line to create fully human monoclonal antibodies for vaccination...