R Besch

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc Selective induction of cell death in melanoma cell lines through targeting of Mcl-1 and A1
    Daniela Senft
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany
    PLoS ONE 7:e30821. 2012
  2. pmc The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival
    Tobias Hohenauer
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany
    EMBO Mol Med 5:919-34. 2013
  3. doi request reprint POU transcription factors in melanocytes and melanoma
    Robert Besch
    Department of Dermatology and Allergology, Ludwig Maximilian University, 80337 Munich, Germany Electronic address
    Eur J Cell Biol 93:55-60. 2014
  4. pmc Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1
    Henry Zall
    Institute for Medical Microbiology, Technische Universitat Munchen, Trogerstr, Munich, Germany
    Mol Cancer 9:164. 2010
  5. ncbi request reprint Inhibition of urokinase-type plasminogen activator receptor induces apoptosis in melanoma cells by activation of p53
    R Besch
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany
    Cell Death Differ 14:818-29. 2007
  6. pmc Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells
    Robert Besch
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany
    J Clin Invest 119:2399-411. 2009
  7. pmc In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-XL and Mcl-1 but in the absence of active BH3-only proteins
    D Senft
    Department of Dermatology and Allergology, Ludwig Maximilian University, 80337 Munich, Germany
    Cell Death Dis 6:e1996. 2015
  8. doi request reprint Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells
    A Weber
    Institute for Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Munich, Germany
    Cell Death Differ 17:942-51. 2010
  9. ncbi request reprint Differential expression of melanoma-associated growth factors in keratinocytes and fibroblasts by ultraviolet A and ultraviolet B radiation
    M Brenner
    Department of Dermatology, Ludwig Maximilian University, Frauenlobstrasse 9 11, D 80337 Munich, Germany
    Br J Dermatol 153:733-9. 2005

Collaborators

Detail Information

Publications9

  1. pmc Selective induction of cell death in melanoma cell lines through targeting of Mcl-1 and A1
    Daniela Senft
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany
    PLoS ONE 7:e30821. 2012
    ..Together, these results identify antiapoptotic proteins on which specifically melanoma cells rely on and, thus, provide a basis for the development of new Bcl-2 protein-targeting therapies...
  2. pmc The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival
    Tobias Hohenauer
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany
    EMBO Mol Med 5:919-34. 2013
    ..Together, these results identify Brn3a as a new factor in melanoma that is essential for melanoma cell survival and that promotes melanocytic transformation and tumourigenesis...
  3. doi request reprint POU transcription factors in melanocytes and melanoma
    Robert Besch
    Department of Dermatology and Allergology, Ludwig Maximilian University, 80337 Munich, Germany Electronic address
    Eur J Cell Biol 93:55-60. 2014
    ..Here, the POU transcription factor family and its role in melanocytic transformation and melanoma are reviewed. ..
  4. pmc Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1
    Henry Zall
    Institute for Medical Microbiology, Technische Universitat Munchen, Trogerstr, Munich, Germany
    Mol Cancer 9:164. 2010
    ..Human renal cell carcinoma (RCC) is very resistant to chemotherapy. ABT-737 is a novel inhibitor of anti-apoptotic proteins of the Bcl-2 family that has shown promise in various preclinical tumour models...
  5. ncbi request reprint Inhibition of urokinase-type plasminogen activator receptor induces apoptosis in melanoma cells by activation of p53
    R Besch
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany
    Cell Death Differ 14:818-29. 2007
    ..Inhibition of uPAR induces a pro-apoptotic signalling pathway via p53 that is independent of ERK or FAK signalling. These findings may offer new treatment strategies for metastatic melanoma...
  6. pmc Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells
    Robert Besch
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany
    J Clin Invest 119:2399-411. 2009
    ..Due to their immunostimulatory and proapoptotic activity, RIG-I and MDA-5 ligands have therapeutic potential due to their ability to overcome the characteristic resistance of melanoma cells to apoptosis...
  7. pmc In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-XL and Mcl-1 but in the absence of active BH3-only proteins
    D Senft
    Department of Dermatology and Allergology, Ludwig Maximilian University, 80337 Munich, Germany
    Cell Death Dis 6:e1996. 2015
    ..These findings argue for auto-activation of Bak in the absence of anti-apoptotic Bcl-2 proteins and provide evidence of profound differences in the activation of Bax and Bak. ..
  8. doi request reprint Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells
    A Weber
    Institute for Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Munich, Germany
    Cell Death Differ 17:942-51. 2010
    ..These results indicate that the proapoptotic activity of TLR3/TRIF/caspase-8 in melanoma cells is under the control of IAPs, and the use of novel Smac mimetics might be a feasible approach to target melanoma...
  9. ncbi request reprint Differential expression of melanoma-associated growth factors in keratinocytes and fibroblasts by ultraviolet A and ultraviolet B radiation
    M Brenner
    Department of Dermatology, Ludwig Maximilian University, Frauenlobstrasse 9 11, D 80337 Munich, Germany
    Br J Dermatol 153:733-9. 2005
    ..A stimulation of growth factor production by cells in the immediate environment of melanocytes may lead to a paracrine activation and proliferation of melanocytes that in turn become more susceptible to transformation...