H K Berthold

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. pmc A randomized controlled trial on the efficacy of carbohydrate-reduced or fat-reduced diets in patients attending a telemedically guided weight loss program
    Sabine Frisch
    Klinik für Thorax und Kardiovaskularchirurgie, Herzzentrum NRW, Ruhr Universitat Bochum, Bad Oeynhausen, Germany
    Cardiovasc Diabetol 8:36. 2009
  2. ncbi request reprint Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism: a randomized controlled trial
    H K Berthold
    Department of Clinical Pharmacology, University of Bonn, Germany
    JAMA 279:1900-2. 1998
  3. ncbi request reprint Effect of policosanol on lipid levels among patients with hypercholesterolemia or combined hyperlipidemia: a randomized controlled trial
    Heiner K Berthold
    Department of Clinical Pharmacology, Institute for Clinical Research, Center for Cardiovascular Diseases, Rotenburg an der Fulda, Germany
    JAMA 295:2262-9. 2006
  4. ncbi request reprint Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial
    Heiner K Berthold
    Drug Commission of the German Medical Association, Berlin, Germany
    Drug Saf 29:703-12. 2006
  5. ncbi request reprint Policosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent
    Ioanna Gouni-Berthold
    Medical Policlinic, University of Bonn, Bonn, Germany
    Am Heart J 143:356-65. 2002
  6. doi request reprint Effect of a cellulose-containing weight-loss supplement on gastric emptying and sensory functions
    Heiner K Berthold
    Department of Clinical Pharmacology, Institute for Clinical Research, Rotenburg an der Fulda, Germany
    Obesity (Silver Spring) 16:2272-80. 2008
  7. ncbi request reprint Garlic preparations for prevention of atherosclerosis
    H K Berthold
    Department of Clinical Pharmacology, University of Bonn, Germany
    Curr Opin Lipidol 9:565-9. 1998
  8. ncbi request reprint Influence of protease inhibitor therapy on lipoprotein metabolism
    H K Berthold
    Department of Internal Medicine I, University of Bonn, Germany
    J Intern Med 246:567-75. 1999
  9. ncbi request reprint Physiologic fluctuations of serum estradiol levels influence biochemical markers of bone resorption in young women
    A Zittermann
    Department of Nutrition Science, University of Bonn, Germany
    J Clin Endocrinol Metab 85:95-101. 2000
  10. ncbi request reprint SREBP-1c gene polymorphism is associated with increased inhibition of cholesterol-absorption in response to ezetimibe treatment
    H K Berthold
    Medical Faculty of the University of Bonn, Clinical Pharmacology, Bonn, Germany
    Exp Clin Endocrinol Diabetes 116:262-7. 2008

Collaborators

Detail Information

Publications51

  1. pmc A randomized controlled trial on the efficacy of carbohydrate-reduced or fat-reduced diets in patients attending a telemedically guided weight loss program
    Sabine Frisch
    Klinik für Thorax und Kardiovaskularchirurgie, Herzzentrum NRW, Ruhr Universitat Bochum, Bad Oeynhausen, Germany
    Cardiovasc Diabetol 8:36. 2009
    ..We investigated whether macronutrient composition of energy-restricted diets influences the efficacy of a telemedically guided weight loss program...
  2. ncbi request reprint Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism: a randomized controlled trial
    H K Berthold
    Department of Clinical Pharmacology, University of Bonn, Germany
    JAMA 279:1900-2. 1998
    ..Garlic-containing drugs have been used in the treatment of hypercholesterolemia even though their efficacy is not generally established. Little is known about the mechanisms of action of the possible effects on cholesterol in humans...
  3. ncbi request reprint Effect of policosanol on lipid levels among patients with hypercholesterolemia or combined hyperlipidemia: a randomized controlled trial
    Heiner K Berthold
    Department of Clinical Pharmacology, Institute for Clinical Research, Center for Cardiovascular Diseases, Rotenburg an der Fulda, Germany
    JAMA 295:2262-9. 2006
    ..More than 80 placebo-controlled or comparative trials, performed mostly by a single research institute, suggest that policosanol at doses of 5 to 40 mg/d has lipoprotein-lowering effects comparable with statins...
  4. ncbi request reprint Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial
    Heiner K Berthold
    Drug Commission of the German Medical Association, Berlin, Germany
    Drug Saf 29:703-12. 2006
    ....
  5. ncbi request reprint Policosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent
    Ioanna Gouni-Berthold
    Medical Policlinic, University of Bonn, Bonn, Germany
    Am Heart J 143:356-65. 2002
    ..The mixture has been shown to lower cholesterol in animal models, healthy volunteers, and patients with type II hypercholesterolemia...
  6. doi request reprint Effect of a cellulose-containing weight-loss supplement on gastric emptying and sensory functions
    Heiner K Berthold
    Department of Clinical Pharmacology, Institute for Clinical Research, Rotenburg an der Fulda, Germany
    Obesity (Silver Spring) 16:2272-80. 2008
    ..In obese subjects, acute administration of the weight-loss supplement CM3 does not delay gastric emptying and does not influence subjective appetite sensations...
  7. ncbi request reprint Garlic preparations for prevention of atherosclerosis
    H K Berthold
    Department of Clinical Pharmacology, University of Bonn, Germany
    Curr Opin Lipidol 9:565-9. 1998
    ....
  8. ncbi request reprint Influence of protease inhibitor therapy on lipoprotein metabolism
    H K Berthold
    Department of Internal Medicine I, University of Bonn, Germany
    J Intern Med 246:567-75. 1999
    ....
  9. ncbi request reprint Physiologic fluctuations of serum estradiol levels influence biochemical markers of bone resorption in young women
    A Zittermann
    Department of Nutrition Science, University of Bonn, Germany
    J Clin Endocrinol Metab 85:95-101. 2000
    ..The data suggest that normal menstrual cycling in young women is associated with monthly fluctuations in bone turnover. This physiological effect of the menstrual cycle is most probably related to variations in serum E2 concentrations...
  10. ncbi request reprint SREBP-1c gene polymorphism is associated with increased inhibition of cholesterol-absorption in response to ezetimibe treatment
    H K Berthold
    Medical Faculty of the University of Bonn, Clinical Pharmacology, Bonn, Germany
    Exp Clin Endocrinol Diabetes 116:262-7. 2008
    ....
  11. ncbi request reprint Immunoglobulins and IgG subclasses in patients with inflammatory bowel disease
    I Gouni-Berthold
    Medizinische Poliklinik, Department of Clinical Pharmacology, University of Bonn, Germany
    Hepatogastroenterology 46:1720-3. 1999
    ....
  12. ncbi request reprint Atherosclerotic disease location and disparities in the control and treatment of cardiovascular risk factors in patients with Type 2 diabetes
    H K Berthold
    Lipid Clinic at the Interdisciplinary Metabolism Center, Charite University Medicine Berlin, Berlin, Germany
    Diabet Med 27:303-8. 2010
    ....
  13. ncbi request reprint Low serum levels of intact osteocalcin in patients with congestive heart failure
    Stefanie Schulze Schleithoff
    Department of Nutrition Science, University of Bonn, Endenicher Allee 11 13, 53115 Bonn, Germany
    J Bone Miner Metab 21:247-52. 2003
    ..However, the low serum levels of intact osteocalcin and the high ratio of undercarboxylated-to-intact osteocalcin deserve further consideration...
  14. doi request reprint The Leu72Met polymorphism of the ghrelin gene is associated with a decreased risk for type 2 diabetes
    Heiner K Berthold
    Department of Clinical Pharmacology, University of Bonn, Bonn, Germany
    Clin Chim Acta 399:112-6. 2009
    ..The Leu72Met polymorphism of its gene was associated with an increased risk of type 2 diabetes (DM2) in some, but not all studies. Its association with atherosclerosis is not known...
  15. pmc Patterns and predictors of statin prescription in patients with type 2 diabetes
    Heiner K Berthold
    Charite University Medicine Berlin, Virchow Clinic Campus, Lipid Clinic at the Interdisciplinary Metabolism Center, Berlin, Germany
    Cardiovasc Diabetol 8:25. 2009
    ..The aim of the study was to identify patient-related factors predicting statin prescription...
  16. ncbi request reprint The Pro387Leu variant of protein tyrosine phosphatase-1B is not associated with diabetes mellitus type 2 in a German population
    I Gouni-Berthold
    Department of Internal Medicine II, University of Cologne and Center of Molecular Medicine Cologne CMMC, Cologne, Germany
    J Intern Med 257:272-80. 2005
    ..Recently a Pro387Leu variant of the PTP-1B gene has been associated with an increased risk of DM-2 in a Danish population. Reports from China and Finland failed to confirm this association...
  17. ncbi request reprint Resistin gene 3'-untranslated region +62G-->A polymorphism is associated with hypertension but not diabetes mellitus type 2 in a German population
    I Gouni-Berthold
    Department of Internal Medicine II, University of Cologne and Center of Molecular Medicine Cologne, Germany
    J Intern Med 258:518-26. 2005
    ..Purpose of the present study was to examine for the first time in a German Caucasian population the possible association between this polymorphism and DM-2, hypertension, lipoprotein levels, resistin levels as well as atherosclerosis...
  18. ncbi request reprint The K121Q polymorphism of the plasma cell glycoprotein-1 gene is not associated with diabetes mellitus type 2 in German Caucasians
    I Gouni-Berthold
    Department of Internal Medicine II, University of Cologne and Center of Molecular Medicine Cologne CMMC, Germany
    Horm Metab Res 38:524-9. 2006
    ..Our data suggest that the K121Q polymorphism of the PC-1 gene is not associated with diabetes, obesity, hypertension or atherosclerosis in a German Caucasian population...
  19. ncbi request reprint Association of the promoter polymorphism -232C/G of the phosphoenolpyruvate carboxykinase gene (PCK1) with Type 2 diabetes mellitus
    I Gouni-Berthold
    Department of Internal Medicine II, University of Cologne, Cologne, Germany
    Diabet Med 23:419-25. 2006
    ..A -232C/G promoter polymorphism of PCK1 has been associated with an increased risk of Type 2 diabetes in a Canadian population. The purpose of the present study was to examine this association in a German Caucasian population...
  20. ncbi request reprint Body mass index and disease duration are predictors of disturbed bone turnover in anorexia nervosa. A case-control study
    T Weinbrenner
    Department of Clinical Pharmacology, University of Bonn, Germany
    Eur J Clin Nutr 57:1262-7. 2003
    ..To characterize the influence of body mass index (BMI), body composition, hormonal factors and disease duration on bone metabolism markers in anorexia nervosa (AN) patients...
  21. ncbi request reprint Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?
    Armin Zittermann
    Department of Nutrition Science, University of Bonn, Germany
    J Am Coll Cardiol 41:105-12. 2003
    ..This study was designed to evaluate the association between vitamin D status and congestive heart failure (CHF)...
  22. ncbi request reprint The peroxisome proliferator-activated receptor delta +294T/C polymorphism in relation to lipoprotein metabolism in patients with diabetes mellitus type 2 and in non-diabetic controls
    Ioanna Gouni-Berthold
    Department of Internal Medicine II, University of Cologne and Center of Molecular Medicine Cologne CMMC, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Atherosclerosis 183:336-41. 2005
    ..Furthermore, a possible gene-gene interaction between the PPARdelta +294T/C polymorphism and the PPARalpha L162V polymorphism was examined...
  23. ncbi request reprint Influence of simvastatin on apoB-100 secretion in non-obese subjects with mild hypercholesterolemia
    Heiner K Berthold
    Department of Clinical Pharmacology, University of Bonn, Bonn, Germany
    Lipids 45:491-500. 2010
    ..s.)]. The data indicate that simvastatin does not influence the secretion of apoB-100-containing lipoproteins in non-obese subjects with near-normal LDL cholesterol concentrations...
  24. ncbi request reprint Peroxisome proliferator-activated receptor-gamma2 Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are not associated with hypertension in diabetes mellitus type 2
    Ioanna Gouni-Berthold
    Department of Internal Medicine II, University of Cologne and Center of Molecular Medicine Cologne CMMC, Cologne, Germany
    J Hypertens 23:301-8. 2005
    ..The purpose of this study was to investigate the association between these polymorphisms and hypertension in patients with diabetes mellitus type 2 (DM2)...
  25. ncbi request reprint Association between the PPARalpha L162V polymorphism, plasma lipoprotein levels, and atherosclerotic disease in patients with diabetes mellitus type 2 and in nondiabetic controls
    Ioanna Gouni-Berthold
    Second Department of Internal Medicine, University of Cologne and Center of Molecular Medicine Cologne CMMC, Cologne, Germany
    Am Heart J 147:1117-24. 2004
    ..The present study was performed to evaluate the association between the PPARalpha polymorphism L162V and the presence of dyslipidemia and/or atherosclerotic disease in patients with DM-2 in comparison with nondiabetic controls...
  26. ncbi request reprint Short-term effects of high soy supplementation on sex hormones, bone markers, and lipid parameters in young female adults
    Armin Zittermann
    Department of Nutrition Science, University of Bonn, Endenicher Allee 11 13, 53115 Bonn, Germany
    Eur J Nutr 43:100-8. 2004
    ..High intake of soy products has been suggested to prevent breast cancer, osteoporosis, and cardiovascular diseases...
  27. ncbi request reprint Neutrophil-elastase in chronic inflammatory bowel disease: a marker of disease activity?
    I Gouni-Berthold
    Medizinische Poliklinik, University of Bonn, Germany
    Hepatogastroenterology 46:2315-20. 1999
    ..The purpose of this study was to examine whether plasma elastase represents a reliable laboratory marker for establishing the activity of chronic inflammatory bowel disease...
  28. doi request reprint Physician gender is associated with the quality of type 2 diabetes care
    H K Berthold
    Clinical Pharmacology Division, Medical Faculty, University of Bonn, Bonn, Germany
    J Intern Med 264:340-50. 2008
    ..Patient gender influences the quality of medical care whilst the role of physician gender is not well established. To investigate the influence of physician gender on quality of care in patients with type 2 diabetes...
  29. ncbi request reprint Troglitazone and rosiglitazone inhibit the low density lipoprotein-induced vascular smooth muscle cell growth
    I Gouni-Berthold
    , Bonn, Germany
    Exp Clin Endocrinol Diabetes 109:203-9. 2001
    ..We conclude that thiazolidinediones are potent inhibitors of LDL-induced VSMC growth acting downstream of the cytoplasmic activation of MAPK...
  30. ncbi request reprint Combined calcium and vitamin D supplementation is not superior to calcium supplementation alone in improving disturbed bone metabolism in patients with congestive heart failure
    S S Schleithoff
    Institute of Nutrition and Food Sciences, University of Bonn, Germany
    Eur J Clin Nutr 62:1388-94. 2008
    ..To clarify the potential role of vitamin D supplementation on bone metabolism in congestive heart failure (CHF) patients with low vitamin D status and insufficient dietary calcium intake...
  31. ncbi request reprint Lipoprotein metabolism in patients with anorexia nervosa: a case-control study investigating the mechanisms leading to hypercholesterolaemia
    T Weinbrenner
    Department of Clinical Pharmacology, University of Bonn, Bonn, Germany
    Br J Nutr 91:959-69. 2004
    ..The clinical subtype of AN plays a major role in the mechanisms leading to hypercholesterolaemia...
  32. ncbi request reprint Oral contraceptives moderately effect bone resorption markers and serum-soluble interleukin-6 receptor concentrations
    A Zittermann
    Department of Nutrition Science, University of Bonn, Endenicher Allee 11 13, 53115 Bonn, Germany
    Calcif Tissue Int 70:11-21. 2002
    ..Results are a further indication that monthly fluctuations of bone resorption in young women are mediated by sex hormones and that osteoclastic activity is stimulated by cytokines in vivo...
  33. ncbi request reprint Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial
    Stefanie S Schleithoff
    Institute of Nutrition and Food Science, University of Bonn, Bonn, Germany
    Am J Clin Nutr 83:754-9. 2006
    ..In vitro studies suggest that vitamin D suppresses proinflammatory cytokines and increases antiinflammatory cytokines...
  34. ncbi request reprint Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults
    Susanne Brämswig
    Department of Clinical Pharmacology, University of Bonn, 53105 Bonn, Germany
    Am J Physiol Heart Circ Physiol 282:H704-16. 2002
    ..The increase is neither related to increased ApoB production nor to decreased catabolism but is rather due to changes in the conversion cascade of IDL particles, most likely as an indirect effect through a decrease in thyroid hormones...
  35. ncbi request reprint Decrease of elevated N,N-dimethylglycine and N-methylglycine in human immunodeficiency virus infection during short-term highly active antiretroviral therapy
    M P Look
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Metabolism 50:1275-81. 2001
    ....
  36. pmc Comparison of the hepatic clearances of campesterol, sitosterol, and cholesterol in healthy subjects suggests that efflux transporters controlling intestinal sterol absorption also regulate biliary secretion
    T Sudhop
    Department of Clinical Pharmacology, University of Bonn, Germany
    Gut 51:860-3. 2002
    ..Recently identified ABCG5/8 transporters are responsible in part for the different absorption rates of campesterol, sitosterol, and cholesterol. These transporters are also expressed in the liver and might regulate biliary sterol secretion...
  37. ncbi request reprint 5,10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women
    Iris P Fohr
    Department of Pathophysiology of Human Nutrition, Institute of Nutritional Science, University of Bonn, Germany
    Am J Clin Nutr 75:275-82. 2002
    ..Supplementation with folic acid (FA) decreases plasma tHcy, but limited data are available on the effect of 5-methyltetrahydrofolate (MTHF)...
  38. ncbi request reprint Age-dependent effects of atorvastatin on biochemical bone turnover markers: a randomized controlled trial in postmenopausal women
    Heiner K Berthold
    Institute for Clinical Research and Department Clinical Pharmacology, Center for Cardiovascular Diseases, Rotenburg an der Fulda, Germany
    Osteoporos Int 15:459-67. 2004
    ..gt;63 years). In summary, the present data suggest that short-term treatment with atorvastatin may have age-dependent effects on biochemical markers of bone turnover in postmenopausal women...
  39. doi request reprint Supplementation with a multivitamin containing 800 microg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women
    Susanne Brämswig
    Institute of Nutrition and Food Science, Human Nutrition II Pathophysiology of Nutrition, University of Bonn, Endenicher Allee 11 13, D 53 115 Bonn, Germany
    Int J Vitam Nutr Res 79:61-70. 2009
    ..With respect to NTD prevention, we suggest the re-evaluation of the current recommendation of folic acid supplementation...
  40. doi request reprint Influence of ghrelin gene polymorphisms on hypertension and atherosclerotic disease
    Heiner K Berthold
    Lipid Clinic, Interdisciplinary Metabolism Center, Charite University Medicine Berlin, Virchow Clinic Campus, Berlin, Germany
    Hypertens Res 33:155-60. 2010
    ..No association of GHRL SNPs or haplotypes with atherosclerotic disease was observed. In conclusion, we observed statistical evidence for association between GHRL SNPs and risk of hypertension...
  41. ncbi request reprint Body fat distribution, serum leptin, and cardiovascular risk factors in men with obstructive sleep apnea
    Harald Schäfer
    Department of Medicine II, University of Bonn, Germany
    Chest 122:829-39. 2002
    ..To determine whether there are interrelationships between body fat, serum leptin levels, and the degree of OSA...
  42. ncbi request reprint Lipoprotein(a) concentration increases during treatment with carbamazepine
    Suzanne Brämswig
    Department of Clinical Pharmacology, University of Bonn, Bonn, Germany
    Epilepsia 44:457-60. 2003
    ..We investigated prospectively the effect of CBZ on lipoprotein(a) concentration in normolipidemic healthy adults...
  43. ncbi request reprint Carbamazepine does not alter biochemical parameters of bone turnover in healthy male adults
    S Brämswig
    Department of Clinical Pharmacology, University of Bonn, 53105 Bonn, Germany
    Calcif Tissue Int 73:356-60. 2003
    ..Variations in 25OHD levels are in line with the seasonal fluctuations in vitamin D status...
  44. doi request reprint The stable isotope ketoisocaproic acid breath test as a measure of hepatic decarboxylation capacity: a quantitative analysis in normal subjects after oral and intravenous administration
    Heiner K Berthold
    Department of Clinical Pharmacology, University of Bonn, Bonn, Germany
    Liver Int 29:1356-64. 2009
    ..There is no generally accepted kinetic evaluation method for the stable isotope [(13)C]ketoisocaproic acid (KIC) breath test. Differences found in the results between women and men are contradictory...
  45. ncbi request reprint Comparison of a silicon carbide coated stent versus a noncoated stent in humans: the Tenax- versus Nir-Stent Study (TENISS)
    Martin Unverdorben
    Center for Cardiovascular Diseases, Heinz Meise Strasse 100, Rotenburg a d Fulda, Germany
    J Interv Cardiol 16:325-33. 2003
    ..Stents coated with hypothrombogenic silicon carbide (a-SiC:H) exhibited low restenosis rates in the rabbit and in an observational study in humans. Thus, the clinical and angiographic outcome was assessed in a large multicenter study...
  46. doi request reprint Use of the lactose-[13C]ureide breath test for diagnosis of small bowel bacterial overgrowth: comparison to the glucose hydrogen breath test
    Heiner K Berthold
    Department of Clinical Pharmacology, University of Bonn, Bonn, Germany
    J Gastroenterol 44:944-51. 2009
    ..Our aim was to evaluate the lactose-[(13)C]ureide breath test (LUBT) to diagnose SBBO and to compare it with the GHBT, using cultures of intestinal aspirates as a gold standard...
  47. ncbi request reprint Adverse reactions to anticoagulants and to antiplatelet drugs recorded by the German spontaneous reporting system
    Jörg David Tiaden
    Drug Commission of the German Medical Association, Cologne, Germany
    Semin Thromb Hemost 31:371-80. 2005
    ....
  48. ncbi request reprint Comparison of a silicon carbide-coated stent versus a noncoated stent in human beings: the Tenax versus Nir Stent Study's long-term outcome
    Martin Unverdorben
    Center for Cardiovascular Diseases, Rotenburg an der Fulda, Germany
    Am Heart J 145:e17. 2003
    ..Recurrence in a-SiC:H at mid-term follow-up has been shown to be similar to a stainless steel device. The long-term outcome, however, may be different...
  49. ncbi request reprint Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: a randomized trial in healthy men
    Ioanna Gouni-Berthold
    Department of Internal Medicine II, University of Cologne, Kerpener Street 62, 50937 Cologne, Germany
    Atherosclerosis 198:198-207. 2008
    ..The molecular mechanisms underlying the pronounced lipid-lowering effects of this combination have not been fully elucidated in humans...
  50. pmc Sex disparities in the treatment and control of cardiovascular risk factors in type 2 diabetes
    Ioanna Gouni-Berthold
    Department of Internal Medicine II, University of Cologne, Cologne, Germany
    Diabetes Care 31:1389-91. 2008
    ..To assess whether sex differences exist in the effective control and medication treatment intensity of cardiovascular disease (CVD) risk factors...
  51. ncbi request reprint Comparison of sirolimus and everolimus in their effects on blood lipid profiles and haematological parameters in heart transplant recipients
    Gero Tenderich
    Department of Cardio Thoracic Surgery, Heart Center North Rhine Westfalia, Ruhr University of Bochum, Bad Oeynhausen, Germany
    Clin Transplant 21:536-43. 2007
    ....