Reinhard Berner

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. ncbi request reprint Cytokine expression of cord and adult blood mononuclear cells in response to Streptococcus agalactiae
    Reinhard Berner
    University Children s Hospital, D 79106 Freiburg, Germany
    Pediatr Res 51:304-9. 2002
  2. ncbi request reprint Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis
    Andrea Heinzmann
    University Children s Hospital, University of Freiburg, 79106 Freiburg, Germany
    J Allergy Clin Immunol 114:671-6. 2004
  3. pmc Enterococcal colonization of infants in a neonatal intensive care unit: associated predictors, risk factors and seasonal patterns
    Markus Hufnagel
    Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Mathildenstr, 1, D 79106 Freiburg, Germany
    BMC Infect Dis 7:107. 2007
  4. pmc Interaction of neonatal phagocytes with group B streptococcus: recognition and response
    Philipp Henneke
    Zentrum für Kinderheilkunde und Jugendmedizin, Albert Ludwigs Universitat Freiburg, Mathildenstr 1, 79106 Freiburg, Germany
    Infect Immun 74:3085-95. 2006
  5. ncbi request reprint SIRS and group-B streptococcal sepsis in newborns: pathogenesis and perspectives in adjunctive therapy
    Philipp Henneke
    Zentrum für Kinderheilkunde und Jugendmedizin, Albert Ludwigs Universitat Freiburg, Mathildenstr 1, 79106 Freiburg, Germany
    Semin Fetal Neonatal Med 11:333-42. 2006
  6. ncbi request reprint Incidence and clinical presentation of invasive neonatal group B streptococcal infections in Germany
    Kirsten Fluegge
    Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg, Germany
    Pediatrics 117:e1139-45. 2006
  7. ncbi request reprint Clinical, radiographic, and genetic diagnosis of progressive pseudorheumatoid dysplasia in a patient with severe polyarthropathy
    Stephan Ehl
    Center for Pediatrics and Adolescent Medicine, University Clinic, Mathildenstrasse 1, 79106 Freiburg, Germany
    Rheumatol Int 24:53-6. 2004
  8. ncbi request reprint Fatal Haemophilus influenzaetype b sepsis in a 10-month-old infant despite complete vaccination and adequate Hib antibodies
    Marcus Krueger
    Department of Paediatrics, University Hospital of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany
    Eur J Pediatr 163:412-3. 2004
  9. ncbi request reprint Group B streptococci during pregnancy and infancy
    Reinhard Berner
    Department of Pediatrics, University Hospital Freiburg, Freiburg, Germany
    Curr Opin Infect Dis 15:307-13. 2002
  10. ncbi request reprint Role of lipoteichoic acid in the phagocyte response to group B streptococcus
    Philipp Henneke
    Zentrum für Kinderheilkunde und Jugendmedizin, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    J Immunol 174:6449-55. 2005

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Cytokine expression of cord and adult blood mononuclear cells in response to Streptococcus agalactiae
    Reinhard Berner
    University Children s Hospital, D 79106 Freiburg, Germany
    Pediatr Res 51:304-9. 2002
    ..GBS in particular proves to be a potent activator of the neonatal immune system when compared with LPS and LTA. CD14 seems not to be a crucial molecule for activation of cord blood cells by GBS...
  2. ncbi request reprint Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis
    Andrea Heinzmann
    University Children s Hospital, University of Freiburg, 79106 Freiburg, Germany
    J Allergy Clin Immunol 114:671-6. 2004
    ..Furthermore, epidemiologic studies have demonstrated an increased risk for the development of asthma after RSV bronchiolitis, and a common genetic background for the 2 diseases is currently being discussed...
  3. pmc Enterococcal colonization of infants in a neonatal intensive care unit: associated predictors, risk factors and seasonal patterns
    Markus Hufnagel
    Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Mathildenstr, 1, D 79106 Freiburg, Germany
    BMC Infect Dis 7:107. 2007
    ..This study analyzes predictors for early enterococcal colonization of infants in a neonatal intensive care unit and describes risk factors associated with multidrugresistant enterococci colonization and its seasonal patterns...
  4. pmc Interaction of neonatal phagocytes with group B streptococcus: recognition and response
    Philipp Henneke
    Zentrum für Kinderheilkunde und Jugendmedizin, Albert Ludwigs Universitat Freiburg, Mathildenstr 1, 79106 Freiburg, Germany
    Infect Immun 74:3085-95. 2006
  5. ncbi request reprint SIRS and group-B streptococcal sepsis in newborns: pathogenesis and perspectives in adjunctive therapy
    Philipp Henneke
    Zentrum für Kinderheilkunde und Jugendmedizin, Albert Ludwigs Universitat Freiburg, Mathildenstr 1, 79106 Freiburg, Germany
    Semin Fetal Neonatal Med 11:333-42. 2006
    ..This article summarises the pathophysiological events leading to sepsis and suggests molecular targets for adjunctive therapy...
  6. ncbi request reprint Incidence and clinical presentation of invasive neonatal group B streptococcal infections in Germany
    Kirsten Fluegge
    Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg, Germany
    Pediatrics 117:e1139-45. 2006
    ..So far, there have been no published data on the incidence, morbidity, and mortality of invasive neonatal group B Streptococcus infections in Germany...
  7. ncbi request reprint Clinical, radiographic, and genetic diagnosis of progressive pseudorheumatoid dysplasia in a patient with severe polyarthropathy
    Stephan Ehl
    Center for Pediatrics and Adolescent Medicine, University Clinic, Mathildenstrasse 1, 79106 Freiburg, Germany
    Rheumatol Int 24:53-6. 2004
    ..The patient carries a novel homozygous two-nucleotide deletion in exon 4 of the WISP3 gene. This genetic disorder is an important differential diagnosis of sicca polyarthritis...
  8. ncbi request reprint Fatal Haemophilus influenzaetype b sepsis in a 10-month-old infant despite complete vaccination and adequate Hib antibodies
    Marcus Krueger
    Department of Paediatrics, University Hospital of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany
    Eur J Pediatr 163:412-3. 2004
  9. ncbi request reprint Group B streptococci during pregnancy and infancy
    Reinhard Berner
    Department of Pediatrics, University Hospital Freiburg, Freiburg, Germany
    Curr Opin Infect Dis 15:307-13. 2002
    ....
  10. ncbi request reprint Role of lipoteichoic acid in the phagocyte response to group B streptococcus
    Philipp Henneke
    Zentrum für Kinderheilkunde und Jugendmedizin, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    J Immunol 174:6449-55. 2005
    ..In conclusion, LTA from GBS is a TLR2/TLR6 ligand that might contribute to secreted GBS activity, but does not contribute significantly to GBS cell wall mediated macrophage activation...
  11. ncbi request reprint Hospital admission with neonatal sepsis and development of atopic disease: Is there a link?
    Matthias Volkmar Kopp
    University Children s Hospital, Freiburg, Germany
    Pediatr Allergy Immunol 16:630-6. 2005
    ..Our data failed to show a possible link between hospital admission with SS and development of atopic disease...
  12. ncbi request reprint Enterococcus casseliflavus septicaemia in a preterm neonate
    Michael Ruess
    University Children s Hospital, Freiburg, Germany
    Scand J Infect Dis 34:471-2. 2002
    ..Precise identification of Enterococcus species is difficult but is of significant clinical interest because of the intrinsic low-level resistance to vancomycin of species such as E. casseliflavus and E. gallinarum...
  13. pmc Elevated levels of lipopolysaccharide-binding protein and soluble CD14 in plasma in neonatal early-onset sepsis
    Reinhard Berner
    University Children s Hospital, D 79106 Freiburg, Germany
    Clin Diagn Lab Immunol 9:440-5. 2002
    ....
  14. ncbi request reprint Significance, management and prevention of Streptococcus agalactiae infection during the perinatal period
    Reinhard Berner
    Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Mathildenstrasse 1, D 79106 Freiburg, Germany
    Expert Rev Anti Infect Ther 2:427-37. 2004
    ..Development of effective vaccines and implementation of vaccination strategies will be one of the key challenges in the future for prevention of neonatal group B Streptococcus infections...
  15. ncbi request reprint Polymorphisms in the cell wall-spanning domain of the C protein beta-antigen in clinical Streptococcus agalactiae isolates are caused by genetic instability of repeating DNA sequences
    Reinhard Berner
    University Children s Hospital, D 79106 Freiburg, Germany
    Pediatr Res 51:106-11. 2002
    ..08). We hypothesize that polymorphisms in the cell wall-spanning domain of the Cbeta-protein are of functional relevance with regard to maternofetal transmission of the pathogen...
  16. ncbi request reprint Association study of the IL13 variant Arg110Gln in atopic diseases and juvenile idiopathic arthritis
    Andrea Heinzmann
    University Children s Hospital, University of Freiburg, Freiburg, Germany
    J Allergy Clin Immunol 112:735-9. 2003
    ..Chronic inflammatory disorders can be subdivided by their predominant immune response, either TH1 or TH2. For example, juvenile idiopathic arthritis (JIA) is a TH1 disease, and bronchial asthma is a TH2 disease...
  17. ncbi request reprint Hemolytic uremic syndrome due to an altered factor H triggered by neonatal pertussis
    Reinhard Berner
    University Children s Hospital, Mathildenstrasse 1, 79106 Freiburg, Germany
    Pediatr Nephrol 17:190-2. 2002
    ..A factor H protein with abnormal mobility was found in the serum of the patient as analyzed by Western blotting, indicating that B. pertussis infection might have triggered HUS in a genetically predisposed patient...
  18. ncbi request reprint Streptococcus agalactiae Cbeta protein gene (bac) sequence types, based on the repeated region of the cell-wall-spanning domain: relationship to virulence and a proposed standardized nomenclature
    Fanrong Kong
    Centre for Infectious Diseases and Microbiology CIDM, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, Darcy Road, Westmead, New South Wales 2145, Australia
    J Med Microbiol 55:829-37. 2006
    ..bac sequence typing is a useful addition to the previously described genotyping system, and will help to predict relative virulence among S. agalactiae serotype Ib strains...
  19. ncbi request reprint Lipopolysaccharide binding protein is a potential marker for invasive bacterial infections in children
    Katja M Ubenauf
    Centre for Pediatrics and Adolescent Medicine, University Hospital of Freiburg, Freiburg, Germany
    Pediatr Infect Dis J 26:159-62. 2007
    ..We measured LBP in serum and cerebrospinal fluid (CSF) of children with proven invasive infection caused by Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis...
  20. pmc Performance of Interleukin-6 and Interleukin-8 serum levels in pediatric oncology patients with neutropenia and fever for the assessment of low-risk
    Miriam Diepold
    Department of Pediatric Oncology and Hematology, University Hospital of Bern, 3010 Bern, Switzerland
    BMC Infect Dis 8:28. 2008
    ..We aimed to analyze whether IL-6 and IL-8 could define a group of patients at low risk of septicemia...
  21. ncbi request reprint Antibiotic resistance patterns among respiratory pathogens at a German university children's hospital over a period of 10 years
    Sandra J Arri
    Department of Paediatrics and Adolescent Medicine, University of Freiburg, Mathildenstrasse 1, 79106, Freiburg, Germany
    Eur J Pediatr 165:9-13. 2006
    ..catarrhalis isolates were beta-lactamase positive, the minimal inhibitory concentration to ampicillin, however, exceeded only in 3% of all strains the cut-off of 1.5 mg/l. The erythromycin resistance rate of M. catarrhalis was 0.3%...
  22. pmc Heterogeneity of genotype-phenotype correlation among macrolide-resistant Streptococcus agalactiae isolates
    Ulrich von Both
    Department of Pediatrics and Adolescent Medicine, University Hospital of Freiburg, Mathildenstrasse 1, D 79106 Freiburg, Germany
    Antimicrob Agents Chemother 49:3080-2. 2005
    ..ermB and ermTR were the most frequent genotypes (80%). The most prevalent serotype III showed great phenotypic variability while serotype V was strongly associated only with two different phenotypes...
  23. pmc Association between resistance to erythromycin and the presence of the fibronectin binding protein F1 gene, prtF1, in Streptococcus pyogenes isolates from German pediatric patients
    Maria Haller
    Department of Pediatrics and Adolescent Medicine, University Hospital of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany
    Antimicrob Agents Chemother 49:2990-3. 2005
    ..The prtF1 gene was present significantly more often among macrolide-resistant isolates. The majority of these were not clonally related...
  24. pmc A serotype V clone is predominant among erythromycin-resistant Streptococcus agalactiae isolates in a southwestern region of Germany
    Ulrich von Both
    University Children s Hospital, D 79106 Freiburg, Germany
    J Clin Microbiol 41:2166-9. 2003
    ..Comparative pulsed-field gel electrophoresis analysis revealed genetic clustering of resistant strains and predominance of a single clone family within an otherwise heterogeneous serotype V population...
  25. doi request reprint Molecular epidemiology of invasive neonatal Streptococcus agalactiae isolates in Germany
    Ulrich von Both
    Centre for Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg, Germany
    Pediatr Infect Dis J 27:903-6. 2008
    ..A comprehensive nationwide active surveillance study over 2 years was performed in Germany to describe the molecular epidemiology among 296 invasive neonatal GBS isolates...
  26. pmc Antibiotic susceptibility in neonatal invasive isolates of Streptococcus agalactiae in a 2-year nationwide surveillance study in Germany
    Kirsten Fluegge
    Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany
    Antimicrob Agents Chemother 48:4444-6. 2004
    ..Erythromycin and clindamycin resistance was found in 10.1 and 5.7%, respectively. The ermB, ermTR, or mefA gene was detected in all but one of the erythromycin-resistant isolates...
  27. ncbi request reprint Antimicrobial resistance in Escherichia coli sepsis
    Olaf Dammann
    Pediatr Infect Dis J 23:978-9; author reply 979-80. 2004
  28. ncbi request reprint Serotype distribution of invasive group B streptococcal isolates in infants: results from a nationwide active laboratory surveillance study over 2 years in Germany
    Kirsten Fluegge
    Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg, Germany
    Clin Infect Dis 40:760-3. 2005
    ..Use of a trivalent GBS vaccine in Germany could theoretically provide protection against 84% and 94% of invasive early-onset and late-onset infections, respectively...
  29. ncbi request reprint Two siblings with lethal pneumococcal meningitis in a family with a mutation in Interleukin-1 receptor-associated kinase 4
    Anselm Enders
    Center for Pediatrics and Adolescent Medicine, University of Freiburg, Germany
    J Pediatr 145:698-700. 2004
    ..Interleukin-1-related kinase 4 deficiency is a potentially lethal immunodeficiency characterized by a poor inflammatory response to pyogenic infections...
  30. ncbi request reprint Prospective population-based study of viral lower respiratory tract infections in children under 3 years of age (the PRI.DE study)
    Johannes Forster
    St Josefs Hospital, Sautier Strasse 1, 79104 Freiburg, Germany
    Eur J Pediatr 163:709-16. 2004
    ..Conclusion: Hospitalisation rates due to lower respiratory tract infections in healthy children were similar to those reported elsewhere; the rates for outpatient visits were approximately ten times higher...
  31. ncbi request reprint A boy with a mediastinal mass
    Ulrich von Both
    Department of Pediatrics, University Hospital Freiburg, Institute of Medical Microbiology, D 79104, Freiburg, Germany
    Lancet 364:474. 2004
  32. ncbi request reprint Ten years' experience with year-round active surveillance of up to 19 respiratory pathogens in children
    Josef A I Weigl
    Pediatric Infectious Diseases, Children s Hospital Kiel, Schwanenweg 20, Kiel, Germany
    Eur J Pediatr 166:957-66. 2007
    ..Surveillance systems for acute respiratory infections (ARI) in children currently are often limited in terms of the panel of pathogens and the age range investigated or are only syndromic and at times only active in the winter season...
  33. ncbi request reprint Diagnostic performance of a rapid antigen test for RSV in comparison with a 19-valent multiplex RT-PCR ELISA in children with acute respiratory tract infections
    Heike Schützle
    Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Mathildenstr 1, 79106 Freiburg, Germany
    Eur J Pediatr 167:745-9. 2008
    ..For older patients a positive test raised disease probability from 23 to 45% during the RSV season. Negative test results did not markedly change disease probability...
  34. pmc Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen
    Stephanie Kruetzmann
    Max Plank Institute for Immunology, Department of Developmental Immunology, D 79108 Freiburg, Germany
    J Exp Med 197:939-45. 2003
    ..IgM memory B cells, therefore, require the spleen for their generation and/or survival and are responsible for the protection against encapsulated bacteria...
  35. ncbi request reprint Low prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in a southwestern region of Germany
    Kirsten Fluegge
    Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Mathildenstrasse 1, 79106, Freiburg, Germany
    Eur J Pediatr 165:688-90. 2006
    ..aureus. The prevalence of MRSA among healthy as well as hospitalized children colonized with S. aureus is still extremely rare in this region...