Research Topics
Species | Reinhard BernerSummaryAffiliation: University of Freiburg Country: Germany Publications
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Detail Information
Publications
Cytokine expression of cord and adult blood mononuclear cells in response to Streptococcus agalactiaeReinhard Berner
University Children s Hospital, D 79106 Freiburg, Germany
Pediatr Res 51:304-9. 2002..GBS in particular proves to be a potent activator of the neonatal immune system when compared with LPS and LTA. CD14 seems not to be a crucial molecule for activation of cord blood cells by GBS...- Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitisAndrea Heinzmann
University Children s Hospital, University of Freiburg, 79106 Freiburg, Germany
J Allergy Clin Immunol 114:671-6. 2004..Furthermore, epidemiologic studies have demonstrated an increased risk for the development of asthma after RSV bronchiolitis, and a common genetic background for the 2 diseases is currently being discussed... 
Enterococcal colonization of infants in a neonatal intensive care unit: associated predictors, risk factors and seasonal patternsMarkus Hufnagel
Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Mathildenstr, 1, D 79106 Freiburg, Germany
BMC Infect Dis 7:107. 2007..This study analyzes predictors for early enterococcal colonization of infants in a neonatal intensive care unit and describes risk factors associated with multidrugresistant enterococci colonization and its seasonal patterns...- Interaction of neonatal phagocytes with group B streptococcus: recognition and responsePhilipp Henneke
, , Mathildenstr. 1, 79106 Freiburg, Germany
Infect Immun 74:3085-95. 2006 - SIRS and group-B streptococcal sepsis in newborns: pathogenesis and perspectives in adjunctive therapyPhilipp Henneke
Zentrum für Kinderheilkunde und Jugendmedizin, Albert Ludwigs Universitat Freiburg, Mathildenstr 1, 79106 Freiburg, Germany
Semin Fetal Neonatal Med 11:333-42. 2006..This article summarises the pathophysiological events leading to sepsis and suggests molecular targets for adjunctive therapy... - Incidence and clinical presentation of invasive neonatal group B streptococcal infections in GermanyKirsten Fluegge
Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg, Germany
Pediatrics 117:e1139-45. 2006..So far, there have been no published data on the incidence, morbidity, and mortality of invasive neonatal group B Streptococcus infections in Germany... - Clinical, radiographic, and genetic diagnosis of progressive pseudorheumatoid dysplasia in a patient with severe polyarthropathyStephan Ehl
Center for Pediatrics and Adolescent Medicine, University Clinic, Mathildenstrasse 1, 79106 Freiburg, Germany
Rheumatol Int 24:53-6. 2004..The patient carries a novel homozygous two-nucleotide deletion in exon 4 of the WISP3 gene. This genetic disorder is an important differential diagnosis of sicca polyarthritis... - Fatal Haemophilus influenzaetype b sepsis in a 10-month-old infant despite complete vaccination and adequate Hib antibodiesMarcus Krueger
Department of Paediatrics, University Hospital of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany
Eur J Pediatr 163:412-3. 2004 - Group B streptococci during pregnancy and infancyReinhard Berner
Department of Pediatrics, University Hospital Freiburg, Freiburg, Germany
Curr Opin Infect Dis 15:307-13. 2002.... - Role of lipoteichoic acid in the phagocyte response to group B streptococcusPhilipp Henneke
Zentrum für Kinderheilkunde und Jugendmedizin, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
J Immunol 174:6449-55. 2005..In conclusion, LTA from GBS is a TLR2/TLR6 ligand that might contribute to secreted GBS activity, but does not contribute significantly to GBS cell wall mediated macrophage activation... - Hospital admission with neonatal sepsis and development of atopic disease: Is there a link?Matthias Volkmar Kopp
University Children s Hospital, Freiburg, Germany
Pediatr Allergy Immunol 16:630-6. 2005..Our data failed to show a possible link between hospital admission with SS and development of atopic disease... - Enterococcus casseliflavus septicaemia in a preterm neonateMichael Ruess
University Children s Hospital, Freiburg, Germany
Scand J Infect Dis 34:471-2. 2002..Precise identification of Enterococcus species is difficult but is of significant clinical interest because of the intrinsic low-level resistance to vancomycin of species such as E. casseliflavus and E. gallinarum... - Elevated levels of lipopolysaccharide-binding protein and soluble CD14 in plasma in neonatal early-onset sepsisReinhard Berner
University Children s Hospital, D 79106 Freiburg, Germany
Clin Diagn Lab Immunol 9:440-5. 2002.... - Significance, management and prevention of Streptococcus agalactiae infection during the perinatal periodReinhard Berner
Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Mathildenstrasse 1, D 79106 Freiburg, Germany
Expert Rev Anti Infect Ther 2:427-37. 2004..Development of effective vaccines and implementation of vaccination strategies will be one of the key challenges in the future for prevention of neonatal group B Streptococcus infections... - Polymorphisms in the cell wall-spanning domain of the C protein beta-antigen in clinical Streptococcus agalactiae isolates are caused by genetic instability of repeating DNA sequencesReinhard Berner
University Children s Hospital, D 79106 Freiburg, Germany
Pediatr Res 51:106-11. 2002..08). We hypothesize that polymorphisms in the cell wall-spanning domain of the Cbeta-protein are of functional relevance with regard to maternofetal transmission of the pathogen... - Association study of the IL13 variant Arg110Gln in atopic diseases and juvenile idiopathic arthritisAndrea Heinzmann
University Children s Hospital, University of Freiburg, Freiburg, Germany
J Allergy Clin Immunol 112:735-9. 2003..Chronic inflammatory disorders can be subdivided by their predominant immune response, either TH1 or TH2. For example, juvenile idiopathic arthritis (JIA) is a TH1 disease, and bronchial asthma is a TH2 disease... - Hemolytic uremic syndrome due to an altered factor H triggered by neonatal pertussisReinhard Berner
University Children s Hospital, Mathildenstrasse 1, 79106 Freiburg, Germany
Pediatr Nephrol 17:190-2. 2002..A factor H protein with abnormal mobility was found in the serum of the patient as analyzed by Western blotting, indicating that B. pertussis infection might have triggered HUS in a genetically predisposed patient... - Streptococcus agalactiae Cbeta protein gene (bac) sequence types, based on the repeated region of the cell-wall-spanning domain: relationship to virulence and a proposed standardized nomenclatureFanrong Kong
Centre for Infectious Diseases and Microbiology (CIDM, Institute of Clinical Pathology and Medical Research (ICPMR, Westmead Hospital, Darcy Road, Westmead, New South Wales 2145, Australia
J Med Microbiol 55:829-37. 2006..bac sequence typing is a useful addition to the previously described genotyping system, and will help to predict relative virulence among S. agalactiae serotype Ib strains... - Lipopolysaccharide binding protein is a potential marker for invasive bacterial infections in childrenKatja M Ubenauf
Centre for Pediatrics and Adolescent Medicine, University Hospital of Freiburg, Freiburg, Germany
Pediatr Infect Dis J 26:159-62. 2007..We measured LBP in serum and cerebrospinal fluid (CSF) of children with proven invasive infection caused by Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis... - Performance of Interleukin-6 and Interleukin-8 serum levels in pediatric oncology patients with neutropenia and fever for the assessment of low-riskMiriam Diepold
Department of Pediatric Oncology and Hematology, University Hospital of Bern, 3010 Bern, Switzerland
BMC Infect Dis 8:28. 2008..We aimed to analyze whether IL-6 and IL-8 could define a group of patients at low risk of septicemia... - Antibiotic resistance patterns among respiratory pathogens at a German university children's hospital over a period of 10 yearsSandra J Arri
Department of Paediatrics and Adolescent Medicine, University of Freiburg, Mathildenstrasse 1, 79106, Freiburg, Germany
Eur J Pediatr 165:9-13. 2006..pneumoniae, and H. influenzae, but an alarming increase in resistance to erythromycin, and in H. influenzae a significant increase in cefaclor resistance was observed over the 10-year period in South-Western Germany... - Heterogeneity of genotype-phenotype correlation among macrolide-resistant Streptococcus agalactiae isolatesUlrich von Both
Department of Pediatrics and Adolescent Medicine, University Hospital of Freiburg, Mathildenstrasse 1, D-79106 Freiburg, Germany
Antimicrob Agents Chemother 49:3080-2. 2005..ermB and ermTR were the most frequent genotypes (80%). The most prevalent serotype III showed great phenotypic variability while serotype V was strongly associated only with two different phenotypes... - Association between resistance to erythromycin and the presence of the fibronectin binding protein F1 gene, prtF1, in Streptococcus pyogenes isolates from German pediatric patientsMaria Haller
Department of Pediatrics and Adolescent Medicine, University Hospital of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany
Antimicrob Agents Chemother 49:2990-3. 2005..The prtF1 gene was present significantly more often among macrolide-resistant isolates. The majority of these were not clonally related... - A serotype V clone is predominant among erythromycin-resistant Streptococcus agalactiae isolates in a southwestern region of GermanyUlrich von Both
University Children's Hospital, D-79106 Freiburg, Germany
J Clin Microbiol 41:2166-9. 2003..Comparative pulsed-field gel electrophoresis analysis revealed genetic clustering of resistant strains and predominance of a single clone family within an otherwise heterogeneous serotype V population... 
Molecular epidemiology of invasive neonatal Streptococcus agalactiae isolates in GermanyUlrich von Both
Centre for Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg, Germany
Pediatr Infect Dis J 27:903-6. 2008..A comprehensive nationwide active surveillance study over 2 years was performed in Germany to describe the molecular epidemiology among 296 invasive neonatal GBS isolates...- Antibiotic susceptibility in neonatal invasive isolates of Streptococcus agalactiae in a 2-year nationwide surveillance study in GermanyKirsten Fluegge
Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany
Antimicrob Agents Chemother 48:4444-6. 2004..Erythromycin and clindamycin resistance was found in 10.1 and 5.7%, respectively. The ermB, ermTR, or mefA gene was detected in all but one of the erythromycin-resistant isolates... - Antimicrobial resistance in Escherichia coli sepsisOlaf Dammann
Pediatr Infect Dis J 23:978-9; author reply 979-80. 2004 - Serotype distribution of invasive group B streptococcal isolates in infants: results from a nationwide active laboratory surveillance study over 2 years in GermanyKirsten Fluegge
Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg, Germany
Clin Infect Dis 40:760-3. 2005..Use of a trivalent GBS vaccine in Germany could theoretically provide protection against 84% and 94% of invasive early-onset and late-onset infections, respectively... - Two siblings with lethal pneumococcal meningitis in a family with a mutation in Interleukin-1 receptor-associated kinase 4Anselm Enders
Center for Pediatrics and Adolescent Medicine, University of Freiburg, Germany
J Pediatr 145:698-700. 2004..Interleukin-1-related kinase 4 deficiency is a potentially lethal immunodeficiency characterized by a poor inflammatory response to pyogenic infections... - Prospective population-based study of viral lower respiratory tract infections in children under 3 years of age (the PRI.DE study)Johannes Forster
St Josefs Hospital, Sautier Strasse 1, 79104 Freiburg, Germany
Eur J Pediatr 163:709-16. 2004..Conclusion: Hospitalisation rates due to lower respiratory tract infections in healthy children were similar to those reported elsewhere; the rates for outpatient visits were approximately ten times higher... - A boy with a mediastinal massUlrich von Both
Department of Pediatrics, University Hospital Freiburg, Institute of Medical Microbiology, D-79104, Freiburg, Germany
Lancet 364:474. 2004 - Ten years' experience with year-round active surveillance of up to 19 respiratory pathogens in childrenJosef A I Weigl
Pediatric Infectious Diseases, Children s Hospital Kiel, Schwanenweg 20, Kiel, Germany
Eur J Pediatr 166:957-66. 2007..Surveillance systems for acute respiratory infections (ARI) in children currently are often limited in terms of the panel of pathogens and the age range investigated or are only syndromic and at times only active in the winter season... - Diagnostic performance of a rapid antigen test for RSV in comparison with a 19-valent multiplex RT-PCR ELISA in children with acute respiratory tract infectionsHeike Schützle
Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Mathildenstr 1, 79106 Freiburg, Germany
Eur J Pediatr 167:745-9. 2008..For older patients a positive test raised disease probability from 23 to 45% during the RSV season. Negative test results did not markedly change disease probability... - Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleenStephanie Kruetzmann
Max-Plank Institute for Immunology, Department of Developmental Immunology, D-79108 Freiburg, Germany
J Exp Med 197:939-45. 2003..IgM memory B cells, therefore, require the spleen for their generation and/or survival and are responsible for the protection against encapsulated bacteria... - Low prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in a southwestern region of GermanyKirsten Fluegge
Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Mathildenstrasse 1, 79106, Freiburg, Germany
Eur J Pediatr 165:688-90. 2006..aureus. The prevalence of MRSA among healthy as well as hospitalized children colonized with S. aureus is still extremely rare in this region...