Justo Lorenzo Bermejo

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis
    Justo Lorenzo Bermejo
    Institute of Medical Biometry and Informatics, University Hospital Heidelberg, INF 305, 69120 Heidelberg, Germany
    BMC Proc 3:S10. 2009
  2. pmc Bladder cancer in cancer patients: population-based estimates from a large Swedish study
    J Lorenzo Bermejo
    Institute of Medical Biometry and Informatics IMBI, University Hospital Heidelberg, 69120 Heidelberg, Germany
    Br J Cancer 101:1091-9. 2009
  3. doi request reprint Genetic variation in adipokine genes and risk of colorectal cancer
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Eur J Endocrinol 160:933-40. 2009
  4. ncbi request reprint Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk
    Annika Vaclavicek
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Breast Cancer Res Treat 106:205-13. 2007
  5. ncbi request reprint Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer
    Annika Vaclavicek
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Endocr Relat Cancer 14:267-77. 2007
  6. doi request reprint Familial risks of breast and prostate cancers: does the definition of the at risk period matter?
    Andreas Brandt
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, 69120 Heidelberg, Germany
    Eur J Cancer 46:752-7. 2010
  7. ncbi request reprint Sex-specific familial risks of urinary bladder cancer and associated neoplasms in Sweden
    Justo Lorenzo Bermejo
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, 69120 Heidelberg, Germany
    Int J Cancer 124:2166-71. 2009
  8. ncbi request reprint Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Endocr Relat Cancer 14:733-40. 2007
  9. doi request reprint Melanocortin receptor 1 variants and melanoma risk: a study of 2 European populations
    Dominique Scherer
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Int J Cancer 125:1868-75. 2009
  10. ncbi request reprint Biological subtypes of triple-negative breast cancer are associated with distinct morphological changes and clinical behaviour
    Zeinab Elsawaf
    Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany
    Breast 22:986-92. 2013

Detail Information

Publications23

  1. pmc Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis
    Justo Lorenzo Bermejo
    Institute of Medical Biometry and Informatics, University Hospital Heidelberg, INF 305, 69120 Heidelberg, Germany
    BMC Proc 3:S10. 2009
    ....
  2. pmc Bladder cancer in cancer patients: population-based estimates from a large Swedish study
    J Lorenzo Bermejo
    Institute of Medical Biometry and Informatics IMBI, University Hospital Heidelberg, 69120 Heidelberg, Germany
    Br J Cancer 101:1091-9. 2009
    ..This study quantified the risk of urinary bladder neoplasms in cancer patients taking into account the age at first diagnosis, the gender of the patients and the lead time between diagnoses...
  3. doi request reprint Genetic variation in adipokine genes and risk of colorectal cancer
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Eur J Endocrinol 160:933-40. 2009
    ..We hypothesized that potentially functional polymorphisms in the adipokine genes leptin (LEP), leptin receptor (LEPR), resistin (RETN), and adiponectin (ADIPOQ) may be associated with CRC...
  4. ncbi request reprint Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk
    Annika Vaclavicek
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Breast Cancer Res Treat 106:205-13. 2007
    ..Therefore, our results indicate that the investigated SNPs in the mitotic checkpoint genes do not affect the risk of familial BC...
  5. ncbi request reprint Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer
    Annika Vaclavicek
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Endocr Relat Cancer 14:267-77. 2007
    ..88, 95% CI 1.13-3.14). The observed genetic variation may also influence the inter-individual variation in response to STAT-signalling targeted therapy...
  6. doi request reprint Familial risks of breast and prostate cancers: does the definition of the at risk period matter?
    Andreas Brandt
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, 69120 Heidelberg, Germany
    Eur J Cancer 46:752-7. 2010
    ..The aim of this study was to compare familial breast and prostate cancer risks according to the two definitions...
  7. ncbi request reprint Sex-specific familial risks of urinary bladder cancer and associated neoplasms in Sweden
    Justo Lorenzo Bermejo
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, 69120 Heidelberg, Germany
    Int J Cancer 124:2166-71. 2009
    ..The present data may guide the design of forthcoming gene identification studies and the interpretation of the genome-wide association studies that are about to be published...
  8. ncbi request reprint Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Endocr Relat Cancer 14:733-40. 2007
    ..28, 95% CI 0.11-0.70). SNPs in the INS, IGFBPI, and IRS2 genes did not affect the risk of CRC. In conclusion, genetic variation in the insulin signaling pathway genes may affect the risk of CRC...
  9. doi request reprint Melanocortin receptor 1 variants and melanoma risk: a study of 2 European populations
    Dominique Scherer
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Int J Cancer 125:1868-75. 2009
    ..In conclusion, our data underscored the unambiguous importance of the MC1R variants towards the population burden of melanoma. However, the variants that are associated with the disease differ between the investigated populations...
  10. ncbi request reprint Biological subtypes of triple-negative breast cancer are associated with distinct morphological changes and clinical behaviour
    Zeinab Elsawaf
    Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany
    Breast 22:986-92. 2013
    ..Basal (A or B) tumours showed a substantially better outcome compared with basoluminal and luminal tumours. Our data underline the heterogeneity of TNBC and characterise potentially relevant biological subtypes. ..
  11. ncbi request reprint MDM2 SNP309 and cancer risk: a combined analysis
    Stefan Wilkening
    Department of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Carcinogenesis 28:2262-7. 2007
    ..27, 95% CI = 1.12-1.44). The data show that SNP309 alone has little or no effect on the risk of common cancers, but it might modify the time of tumor onset and prognosis...
  12. ncbi request reprint Single nucleotide polymorphisms in DNA repair genes and basal cell carcinoma of skin
    Ranjit Kumar Thirumaran
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Carcinogenesis 27:1676-81. 2006
    ..10-36.8), compared with the genotype TT (XRCC3)/GG (NBS1). The data from this study show overall risk modulation of BCC by variant allele for T241M polymorphism in XRCC3 and gender-specific effect by E185Q polymorphism in NBS1...
  13. doi request reprint Clustering of concordant and discordant cancer types in Swedish couples is rare
    Marianne Weires
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Eur J Cancer 47:98-106. 2011
    ..Spouses are exposed to common environmental cancer risk factors during adulthood. Investigating the aggregation of cancer in couples might provide valuable insights into cancer development...
  14. doi request reprint Is there still a need for candidate gene approaches in the era of genome-wide association studies?
    Stefan Wilkening
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Genomics 93:415-9. 2009
    ..However, depending on the gene or the population, there may still be a need for candidate gene approaches, especially when looking at polymorphisms with low allele frequencies...
  15. doi request reprint Exploring the association between genetic variation in the SUMO isopeptidase gene USPL1 and breast cancer through integration of data from the population-based GENICA study and external genetic databases
    Justo Lorenzo Bermejo
    Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    Int J Cancer 133:362-72. 2013
    ..The provided information may facilitate the design of independent studies to validate the association between USPL1 rs7984952 and risk of Grade 3 breast tumors...
  16. doi request reprint Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis
    Marta Faryna
    German Cancer Research Center DKFZ, Division of Epigenomics and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    FASEB J 26:4937-50. 2012
    ..In summary, early methylation changes are frequent in the low-grade pathway of breast cancer and may be useful in the development of differential diagnostic and possibly also prognostic markers...
  17. ncbi request reprint Endometrial cancer: population attributable risks from reproductive, familial and socioeconomic factors
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Eur J Cancer 41:2155-9. 2005
    ..84%. Although the present analysis lacked data on some important risk factors for endometrial cancer, the results suggest that a large proportion of the etiology of endometrial cancer can be defined by known epidemiological risk factors...
  18. ncbi request reprint Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - a systematic review and meta-analysis
    Lorenz K Thomas
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany Clinical Cooperation Unit, German Cancer Research Center DKFZ, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany
    Eur J Cancer 50:85-98. 2014
    ..These regions might be relevant for carcinogenesis and could serve as diagnostic markers to identify premalignant lesions with high progression risk towards invasive cancer...
  19. ncbi request reprint The single nucleotide polymorphism IVS1+309 in mouse double minute 2 does not affect risk of familial breast cancer
    Stefan Wilkening
    Department of Molecular Genetic Epidemiology, German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Res 66:646-8. 2006
    ..These results suggest that the SNP IVS1+309 alone affects neither the risk nor the age of onset of heritable breast cancer...
  20. pmc Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium
    Federico Canzian
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Hum Mol Genet 19:3873-84. 2010
    ..Although previous studies have shown that variations in these genes can influence endogenous hormone levels, the magnitude of the effect of single SNPs does not appear to be sufficient to alter breast cancer risk...
  21. pmc Carcinogen metabolism, cigarette smoking, and breast cancer risk: a Bayes model averaging approach
    Nadine Stephenson
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Epidemiol Perspect Innov 7:10. 2010
    ..We explore the use of a Bayes Model Averaging approach as an alternative to analyze the influence of genetic variants, environmental effects and their interactions on disease...
  22. pmc Comparison of measures for haplotype similarity
    Vivien Marquard
    Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    BMC Proc 1:S128. 2007
    ..While it yielded a much lower power, Yu's measure had 80% power around the disease locus...
  23. ncbi request reprint Death receptor 4 variants and colorectal cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:2002-5. 2006
    ..37; 95% CI, 0.98-5.76). The score statistic yielded an empirical P of 0.03 of the haplotype-specific test for 626C-683C based on 20,000 simulations, suggesting that DR4 626C-683C may affect colorectal cancer predisposition...