Research Topics
Genomes and Genes
| Justo Lorenzo BermejoSummaryAffiliation: University of Heidelberg Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Bladder cancer in cancer patients: population-based estimates from a large Swedish studyJ Lorenzo Bermejo
Institute of Medical Biometry and Informatics IMBI, University Hospital Heidelberg, 69120 Heidelberg, Germany
Br J Cancer 101:1091-9. 2009..This study quantified the risk of urinary bladder neoplasms in cancer patients taking into account the age at first diagnosis, the gender of the patients and the lead time between diagnoses...- Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritisJusto Lorenzo Bermejo
Institute of Medical Biometry and Informatics, University Hospital Heidelberg, INF 305, 69120 Heidelberg, Germany
BMC Proc 3:S10. 2009.... 
Genetic variation in adipokine genes and risk of colorectal cancerSonali Pechlivanis
Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Eur J Endocrinol 160:933-40. 2009..We hypothesized that potentially functional polymorphisms in the adipokine genes leptin (LEP), leptin receptor (LEPR), resistin (RETN), and adiponectin (ADIPOQ) may be associated with CRC...
Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer riskAnnika Vaclavicek
Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Breast Cancer Res Treat 106:205-13. 2007..Therefore, our results indicate that the investigated SNPs in the mitotic checkpoint genes do not affect the risk of familial BC...- Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancerAnnika Vaclavicek
Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Endocr Relat Cancer 14:267-77. 2007..88, 95% CI 1.13-3.14). The observed genetic variation may also influence the inter-individual variation in response to STAT-signalling targeted therapy... - Familial risks of breast and prostate cancers: does the definition of the at risk period matter?Andreas Brandt
Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, 69120 Heidelberg, Germany
Eur J Cancer 46:752-7. 2010..The aim of this study was to compare familial breast and prostate cancer risks according to the two definitions... - Sex-specific familial risks of urinary bladder cancer and associated neoplasms in SwedenJusto Lorenzo Bermejo
Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, 69120 Heidelberg, Germany
Int J Cancer 124:2166-71. 2009..The present data may guide the design of forthcoming gene identification studies and the interpretation of the genome-wide association studies that are about to be published... - Melanocortin receptor 1 variants and melanoma risk: a study of 2 European populationsDominique Scherer
Division of Molecular Genetic Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
Int J Cancer 125:1868-75. 2009..In conclusion, our data underscored the unambiguous importance of the MC1R variants towards the population burden of melanoma. However, the variants that are associated with the disease differ between the investigated populations... - Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effectSonali Pechlivanis
Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Endocr Relat Cancer 14:733-40. 2007..28, 95% CI 0.11-0.70). SNPs in the INS, IGFBPI, and IRS2 genes did not affect the risk of CRC. In conclusion, genetic variation in the insulin signaling pathway genes may affect the risk of CRC... - MDM2 SNP309 and cancer risk: a combined analysisStefan Wilkening
Department of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Carcinogenesis 28:2262-7. 2007..27, 95% CI = 1.12-1.44). The data show that SNP309 alone has little or no effect on the risk of common cancers, but it might modify the time of tumor onset and prognosis... - Single nucleotide polymorphisms in DNA repair genes and basal cell carcinoma of skinRanjit Kumar Thirumaran
Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Carcinogenesis 27:1676-81. 2006..10-36.8), compared with the genotype TT (XRCC3)/GG (NBS1). The data from this study show overall risk modulation of BCC by variant allele for T241M polymorphism in XRCC3 and gender-specific effect by E185Q polymorphism in NBS1... - Clustering of concordant and discordant cancer types in Swedish couples is rareMarianne Weires
Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Eur J Cancer 47:98-106. 2011..Spouses are exposed to common environmental cancer risk factors during adulthood. Investigating the aggregation of cancer in couples might provide valuable insights into cancer development... - Is there still a need for candidate gene approaches in the era of genome-wide association studies?Stefan Wilkening
German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Genomics 93:415-9. 2009..However, depending on the gene or the population, there may still be a need for candidate gene approaches, especially when looking at polymorphisms with low allele frequencies... - Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosisMarta Faryna
German Cancer Research Center DKFZ, Division of Epigenomics and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
FASEB J 26:4937-50. 2012..In summary, early methylation changes are frequent in the low-grade pathway of breast cancer and may be useful in the development of differential diagnostic and possibly also prognostic markers... - Endometrial cancer: population attributable risks from reproductive, familial and socioeconomic factorsKari Hemminki
Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Eur J Cancer 41:2155-9. 2005..84%. Although the present analysis lacked data on some important risk factors for endometrial cancer, the results suggest that a large proportion of the etiology of endometrial cancer can be defined by known epidemiological risk factors... - The single nucleotide polymorphism IVS1+309 in mouse double minute 2 does not affect risk of familial breast cancerStefan Wilkening
Department of Molecular Genetic Epidemiology, German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Cancer Res 66:646-8. 2006..These results suggest that the SNP IVS1+309 alone affects neither the risk nor the age of onset of heritable breast cancer... - Comparison of measures for haplotype similarityVivien Marquard
Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
BMC Proc 1:S128. 2007..While it yielded a much lower power, Yu's measure had 80% power around the disease locus... - Death receptor 4 variants and colorectal cancer riskBernd Frank
Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Cancer Epidemiol Biomarkers Prev 15:2002-5. 2006..37; 95% CI, 0.98-5.76). The score statistic yielded an empirical P of 0.03 of the haplotype-specific test for 626C-683C based on 20,000 simulations, suggesting that DR4 626C-683C may affect colorectal cancer predisposition... - Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortiumFederico Canzian
German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Hum Mol Genet 19:3873-84. 2010..Although previous studies have shown that variations in these genes can influence endogenous hormone levels, the magnitude of the effect of single SNPs does not appear to be sufficient to alter breast cancer risk... - Carcinogen metabolism, cigarette smoking, and breast cancer risk: a Bayes model averaging approachNadine Stephenson
Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
Epidemiol Perspect Innov 7:10. 2010..We explore the use of a Bayes Model Averaging approach as an alternative to analyze the influence of genetic variants, environmental effects and their interactions on disease...