Justo Lorenzo Bermejo

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Above and beyond state-of-the-art approaches to investigate sequence data: summary of methods and results from the population-based association group at the Genetic Analysis Workshop 19
    Justo Lorenzo Bermejo
    Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany
    BMC Genet 17:2. 2016
  2. pmc Bladder cancer in cancer patients: population-based estimates from a large Swedish study
    J Lorenzo Bermejo
    Institute of Medical Biometry and Informatics IMBI, University Hospital Heidelberg, 69120 Heidelberg, Germany
    Br J Cancer 101:1091-9. 2009
  3. pmc Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis
    Justo Lorenzo Bermejo
    Institute of Medical Biometry and Informatics, University Hospital Heidelberg, INF 305, 69120 Heidelberg, Germany
    BMC Proc 3:S10. 2009
  4. doi request reprint Polymorphisms in the UBC9 and PIAS3 genes of the SUMO-conjugating system and breast cancer risk
    Thomas Dünnebier
    Molecular Genetics of Breast Cancer B055, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Breast Cancer Res Treat 121:185-94. 2010
  5. doi request reprint Single nucleotide polymorphisms in DNA repair genes XRCC1 and APEX1 in progression and survival of primary cutaneous melanoma patients
    Adina Figl
    Skin Cancer Unit, German Cancer Research Center, Heidelberg, Germany
    Mutat Res 661:78-84. 2009
  6. ncbi request reprint MC1R variants associated susceptibility to basal cell carcinoma of skin: interaction with host factors and XRCC3 polymorphism
    Dominique Scherer
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 122:1787-93. 2008
  7. doi request reprint Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma
    Adina Figl
    Skin Cancer Unit, German Cancer Research Center, Heidelberg, Germany
    Mutat Res 702:8-16. 2010
  8. ncbi request reprint Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Carcinogenesis 28:1442-5. 2007
  9. doi request reprint Genetic variation in adipokine genes and risk of colorectal cancer
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Eur J Endocrinol 160:933-40. 2009
  10. ncbi request reprint The single nucleotide polymorphism IVS1+309 in mouse double minute 2 does not affect risk of familial breast cancer
    Stefan Wilkening
    Department of Molecular Genetic Epidemiology, German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Res 66:646-8. 2006

Detail Information

Publications66

  1. doi request reprint Above and beyond state-of-the-art approaches to investigate sequence data: summary of methods and results from the population-based association group at the Genetic Analysis Workshop 19
    Justo Lorenzo Bermejo
    Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany
    BMC Genet 17:2. 2016
    ..This paper reports on the experience of members of the Population-Based Association group with several novel, promising approaches to preprocessing and analyzing sequence data, and to following up identified association signals. ..
  2. pmc Bladder cancer in cancer patients: population-based estimates from a large Swedish study
    J Lorenzo Bermejo
    Institute of Medical Biometry and Informatics IMBI, University Hospital Heidelberg, 69120 Heidelberg, Germany
    Br J Cancer 101:1091-9. 2009
    ..This study quantified the risk of urinary bladder neoplasms in cancer patients taking into account the age at first diagnosis, the gender of the patients and the lead time between diagnoses...
  3. pmc Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis
    Justo Lorenzo Bermejo
    Institute of Medical Biometry and Informatics, University Hospital Heidelberg, INF 305, 69120 Heidelberg, Germany
    BMC Proc 3:S10. 2009
    ....
  4. doi request reprint Polymorphisms in the UBC9 and PIAS3 genes of the SUMO-conjugating system and breast cancer risk
    Thomas Dünnebier
    Molecular Genetics of Breast Cancer B055, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Breast Cancer Res Treat 121:185-94. 2010
    ..Imputation of polymorphisms in a 300-kb region around the genotyped polymorphisms identified no variants with stronger associations. Our findings suggest that genetic variation in UBC9 may affect the risk of grade 1 breast tumors...
  5. doi request reprint Single nucleotide polymorphisms in DNA repair genes XRCC1 and APEX1 in progression and survival of primary cutaneous melanoma patients
    Adina Figl
    Skin Cancer Unit, German Cancer Research Center, Heidelberg, Germany
    Mutat Res 661:78-84. 2009
    ....
  6. ncbi request reprint MC1R variants associated susceptibility to basal cell carcinoma of skin: interaction with host factors and XRCC3 polymorphism
    Dominique Scherer
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 122:1787-93. 2008
    ..However, the mechanism through which the variants influence the risk likely involves complex interactions with other genetic and host risk factors...
  7. doi request reprint Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma
    Adina Figl
    Skin Cancer Unit, German Cancer Research Center, Heidelberg, Germany
    Mutat Res 702:8-16. 2010
    ..We conclude that 13 non-synonymous polymorphisms in eight DNA-repair genes that are frequently investigated with respect to modulation of cancer risk in populations are not associated with susceptibility to cutaneous melanoma...
  8. ncbi request reprint Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Carcinogenesis 28:1442-5. 2007
    ..37-0.90, P = 0.01 and OR = 0.41, 95% CI = 0.23-0.74, P = 0.003), supporting its role in human cancer. To our knowledge, the present study is the first to determine the impact of a CNV in a tumor suppressor gene on cancer risk...
  9. doi request reprint Genetic variation in adipokine genes and risk of colorectal cancer
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Eur J Endocrinol 160:933-40. 2009
    ..We hypothesized that potentially functional polymorphisms in the adipokine genes leptin (LEP), leptin receptor (LEPR), resistin (RETN), and adiponectin (ADIPOQ) may be associated with CRC...
  10. ncbi request reprint The single nucleotide polymorphism IVS1+309 in mouse double minute 2 does not affect risk of familial breast cancer
    Stefan Wilkening
    Department of Molecular Genetic Epidemiology, German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Res 66:646-8. 2006
    ..These results suggest that the SNP IVS1+309 alone affects neither the risk nor the age of onset of heritable breast cancer...
  11. ncbi request reprint Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk
    Annika Vaclavicek
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Breast Cancer Res Treat 106:205-13. 2007
    ..Therefore, our results indicate that the investigated SNPs in the mitotic checkpoint genes do not affect the risk of familial BC...
  12. ncbi request reprint Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer
    Annika Vaclavicek
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Endocr Relat Cancer 14:267-77. 2007
    ..88, 95% CI 1.13-3.14). The observed genetic variation may also influence the inter-individual variation in response to STAT-signalling targeted therapy...
  13. pmc Variants at the 9p21 locus and melanoma risk
    Livia Maccioni
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 580, D 69120, Heidelberg, Germany
    BMC Cancer 13:325. 2013
    ..The influence of variants at the 9p21 locus on melanoma risk has been reported through investigation of CDKN2A variants through candidate gene approach as well as by genome wide association studies (GWAS)...
  14. pmc TP53-binding protein variants and breast cancer risk: a case-control study
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Breast Cancer Res 7:R502-5. 2005
    ..We have therefore examined the effects of 53BP1 single nucleotide polymorphisms (D353E, G412S, and K1136Q) and the novel 53BP1 6bp deletion (1347_1352delTATCCC) on breast cancer risk...
  15. doi request reprint Melanocortin receptor 1 variants and melanoma risk: a study of 2 European populations
    Dominique Scherer
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Int J Cancer 125:1868-75. 2009
    ..In conclusion, our data underscored the unambiguous importance of the MC1R variants towards the population burden of melanoma. However, the variants that are associated with the disease differ between the investigated populations...
  16. pmc Influence of genetic variants in type I interferon genes on melanoma survival and therapy
    Romina Elizabeth Lenci
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 7:e50692. 2012
    ..94, 95%CI 1.16-3.26, P = 0.01). In conclusion, our results identified genetic variants in interferon genes that influence melanoma progression and survival with modulation of effect due to treatment status...
  17. doi request reprint Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families
    Bernd Frank
    Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Cancer Lett 271:153-7. 2008
    ..No associations of any of the 10 nsSNPs with colorectal cancer could be replicated. The combined analyses indicated that further research based on additional independent samples is required...
  18. doi request reprint Sex-specific familial risks of urinary bladder cancer and associated neoplasms in Sweden
    Justo Lorenzo Bermejo
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, 69120 Heidelberg, Germany
    Int J Cancer 124:2166-71. 2009
    ..The present data may guide the design of forthcoming gene identification studies and the interpretation of the genome-wide association studies that are about to be published...
  19. pmc Aberrant expression of retinoic acid signaling molecules influences patient survival in astrocytic gliomas
    Benito Campos
    Division of Neurological Research, Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany
    Am J Pathol 178:1953-64. 2011
    ..CRBP1 and ALDH1A1 were independent prognostic markers for adverse patient survival. Our data indicate a complex and clinically relevant deregulation of RA signaling, which seems to be a central event in glioma pathogenesis...
  20. doi request reprint Variants at chromosome 20 (ASIP locus) and melanoma risk
    Livia Maccioni
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    Int J Cancer 132:42-54. 2013
    ..Our data confirmed the association of different variants at chromosome 20q11 with melanoma risk...
  21. ncbi request reprint Polymorphisms in the growth hormone receptor: a case-control study in breast cancer
    Kerstin Wagner
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 118:2903-6. 2006
    ..Neither did the 3 most common haplotypes influence breast cancer risk. However, a rare haplotype (dGGC), containing the GHRd3 allele, was associated with a decreased breast cancer risk (OR 0.30, 95% CI 0.11-0.80)...
  22. ncbi request reprint Association of NCOA3 polymorphisms with breast cancer risk
    Barbara Burwinkel
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Clin Cancer Res 11:2169-74. 2005
    ..79; 95% confidence interval, 0.67-0.93; P = 0.004). Because of the impact of NCOA3 in antiestrogen therapy resistance, these polymorphisms might also influence therapy outcome in breast cancer...
  23. ncbi request reprint The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study
    Bernd Frank
    Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Breast Cancer Res Treat 111:139-44. 2008
    ..The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans...
  24. doi request reprint Familial risks of breast and prostate cancers: does the definition of the at risk period matter?
    Andreas Brandt
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, 69120 Heidelberg, Germany
    Eur J Cancer 46:752-7. 2010
    ..The aim of this study was to compare familial breast and prostate cancer risks according to the two definitions...
  25. pmc Association of inherited variation in Toll-like receptor genes with malignant melanoma susceptibility and survival
    Andreas Gast
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 6:e24370. 2011
    ..The polymorphic amino acid residue, located in the ectodomain of TLR4, can have functional consequences...
  26. ncbi request reprint Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Endocr Relat Cancer 14:733-40. 2007
    ..28, 95% CI 0.11-0.70). SNPs in the INS, IGFBPI, and IRS2 genes did not affect the risk of CRC. In conclusion, genetic variation in the insulin signaling pathway genes may affect the risk of CRC...
  27. doi request reprint LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells
    Susumu Nakata
    Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany
    Brain Pathol 23:60-72. 2013
    ..Our findings suggest that LGR5 plays a role in maintenance and/or survival of brain CSCs...
  28. doi request reprint A case-control study of childhood acute lymphoblastic leukaemia and polymorphisms in the TGF-beta and receptor genes
    Liping Dai
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Pediatr Blood Cancer 52:819-23. 2009
    ..Inherited genetic variants in critical genes can putatively modulate susceptibility to childhood acute lymphoblastic leukemia (ALL)...
  29. doi request reprint Association of stem cell-related markers and survival in astrocytic gliomas
    Feng Wan
    Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    Biomarkers 16:136-43. 2011
    ..Our findings suggest that immature glioma cells are involved in tumour growth and tumour progression and significantly impact on patient prognosis...
  30. doi request reprint Clustering of concordant and discordant cancer types in Swedish couples is rare
    Marianne Weires
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Eur J Cancer 47:98-106. 2011
    ..Spouses are exposed to common environmental cancer risk factors during adulthood. Investigating the aggregation of cancer in couples might provide valuable insights into cancer development...
  31. doi request reprint Exploring the association between genetic variation in the SUMO isopeptidase gene USPL1 and breast cancer through integration of data from the population-based GENICA study and external genetic databases
    Justo Lorenzo Bermejo
    Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    Int J Cancer 133:362-72. 2013
    ..The provided information may facilitate the design of independent studies to validate the association between USPL1 rs7984952 and risk of Grade 3 breast tumors...
  32. doi request reprint Risk of subsequent solid tumors after non-Hodgkin's lymphoma: effect of diagnostic age and time since diagnosis
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Im Neuenheimer Feld 580, Heidelberg, Germany
    J Clin Oncol 26:1850-7. 2008
    ..Quantitative data on solid tumors are limited. We focus on survivors of non-Hodgkin's lymphoma (NHL) because the disease is diagnosed at a wide range of ages and treated uniformly primarily with chemotherapy...
  33. doi request reprint Common variants in the UBC9 gene encoding the SUMO-conjugating enzyme are associated with breast tumor grade
    Thomas Dünnebier
    Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 125:596-602. 2009
    ..0003). The present results underline the value of genetic variation in UBC9 for breast cancer prognosis...
  34. doi request reprint Age-specific risk of incident prostate cancer and risk of death from prostate cancer defined by the number of affected family members
    Andreas Brandt
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 580, Heidelberg, Germany
    Eur Urol 58:275-80. 2010
    ..The thorough assessment of familial prostate cancer (PCa) risk is as important as ever to provide a basis for clinical counselling and screening recommendations...
  35. pmc Nuclear expression of the deubiquitinase CYLD is associated with improved survival in human hepatocellular carcinoma
    Stefan Welte
    National Center for Tumor Diseases, Department of Medical Oncology, Internal Medicine VI, Heidelberg University Hospital, Heidelberg, Germany
    PLoS ONE 9:e110591. 2014
    ..This study aimed to assess subcellular CYLD expression in tumor tissues and its prognostic significance in HCC patients undergoing liver resection or liver transplantation...
  36. ncbi request reprint Single nucleotide polymorphisms in DNA repair genes and basal cell carcinoma of skin
    Ranjit Kumar Thirumaran
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Carcinogenesis 27:1676-81. 2006
    ..10-36.8), compared with the genotype TT (XRCC3)/GG (NBS1). The data from this study show overall risk modulation of BCC by variant allele for T241M polymorphism in XRCC3 and gender-specific effect by E185Q polymorphism in NBS1...
  37. ncbi request reprint Endometrial cancer: population attributable risks from reproductive, familial and socioeconomic factors
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Eur J Cancer 41:2155-9. 2005
    ..84%. Although the present analysis lacked data on some important risk factors for endometrial cancer, the results suggest that a large proportion of the etiology of endometrial cancer can be defined by known epidemiological risk factors...
  38. doi request reprint Is there still a need for candidate gene approaches in the era of genome-wide association studies?
    Stefan Wilkening
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Genomics 93:415-9. 2009
    ..However, depending on the gene or the population, there may still be a need for candidate gene approaches, especially when looking at polymorphisms with low allele frequencies...
  39. ncbi request reprint MDM2 SNP309 and cancer risk: a combined analysis
    Stefan Wilkening
    Department of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Carcinogenesis 28:2262-7. 2007
    ..27, 95% CI = 1.12-1.44). The data show that SNP309 alone has little or no effect on the risk of common cancers, but it might modify the time of tumor onset and prognosis...
  40. pmc The 'common disease-common variant' hypothesis and familial risks
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 3:e2504. 2008
    ..However, the population attributable fractions of the two alleles are equal. The penetrance mode of the causative locus may be very difficult to deduce from the apparent penetrance mode of the marker locus...
  41. doi request reprint Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis
    Marta Faryna
    German Cancer Research Center DKFZ, Division of Epigenomics and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    FASEB J 26:4937-50. 2012
    ..In summary, early methylation changes are frequent in the low-grade pathway of breast cancer and may be useful in the development of differential diagnostic and possibly also prognostic markers...
  42. doi request reprint Biological subtypes of triple-negative breast cancer are associated with distinct morphological changes and clinical behaviour
    Zeinab Elsawaf
    Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany
    Breast 22:986-92. 2013
    ..Basal (A or B) tumours showed a substantially better outcome compared with basoluminal and luminal tumours. Our data underline the heterogeneity of TNBC and characterise potentially relevant biological subtypes. ..
  43. pmc Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro
    Bruno Christian Koehler
    National Center for Tumor Diseases, Department of Medical Oncology, Internal Medicine VI, Heidelberg University Hospital, Heidelberg, Germany
    PLoS ONE 8:e76446. 2013
    ..Thus, our study illustrates novel antitumoral mechanisms of Bcl-2 protein targeting. ..
  44. doi request reprint Electroplated and cast double crown-retained removable dental prostheses: 6-year results from a randomized clinical trial
    Thomas Stober
    Department of Prosthodontics, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Clin Oral Investig 19:1129-36. 2015
    ..The purpose of this study was to evaluate the clinical performance of removable dental prostheses (RDP) supported by either electroplated (EP-RDP) or cast (C-RDP) double crowns...
  45. ncbi request reprint Determination of allele frequency in pooled DNA: comparison of three PCR-based methods
    Stefan Wilkening
    German Cancer Research Center, Molecular Genetic Epidemiology, Heidelberg, Germany
    Biotechniques 39:853-8. 2005
    ..44%, SD = 4.2%). Real-time PCR with TaqMan probes, a convenient but very expensive method, had an MD of 1.47% and the lowest variation between replicates (SD = 3.18%)...
  46. ncbi request reprint Cancer characteristics in Swedish families fulfilling criteria for hereditary nonpolyposis colorectal cancer
    Justo Lorenzo Bermejo
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Gastroenterology 129:1889-99. 2005
    ....
  47. ncbi request reprint Gene-environment interactions in cancer: do they exist?
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120, Heidelberg, Germany
    Ann N Y Acad Sci 1076:137-48. 2006
    ..Enhancing the likelihood that the disease causation is genetic, for example, by selecting familial cases, may increase the power of the studies, and the rareness of those cases calls for collaborative networks...
  48. pmc Socio-economic status and overall and cause-specific mortality in Sweden
    Marianne Weires
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg, Germany
    BMC Public Health 8:340. 2008
    ..Another aim was to investigate possible gender differences...
  49. ncbi request reprint Differential gene expression in melanocytic nevi with the V600E BRAF mutation
    Sandra Bloethner
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Genes Chromosomes Cancer 46:1019-27. 2007
    ..Moreover, nevi with mutations showed over-expression of genes involved in melanocytic senescence and cell cycle inhibition...
  50. pmc The updated Swedish family-cancer database used to assess familial risks of prostate cancer during rapidly increasing incidence
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Hered Cancer Clin Pract 4:186-92. 2006
    ..Increased surveillance and the availability of PSA screening are the likely reasons for the overestimated familial relative risk shortly after the first diagnosis. This lead time bias should be considered in clinical counselling...
  51. doi request reprint Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients
    Christine Jungk
    Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany
    BMC Cancer 16:81. 2015
    ..To address these issues, we performed a retrospective analysis on clinical outcome and side effects of BCNU-based chemotherapy in recurrent glioma...
  52. ncbi request reprint Familial risk for non-Hodgkin lymphoma and other lymphoproliferative malignancies by histopathologic subtype: the Swedish Family-Cancer Database
    Andrea Altieri
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    Blood 106:668-72. 2005
    ..The patterns of risks in parents and siblings support the hypothesis of an autosomal-dominant component for diffuse large B-cell NHL and a recessive one for follicular NHL...
  53. ncbi request reprint The rare ERBB2 variant Ile654Val is associated with an increased familial breast cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Carcinogenesis 26:643-7. 2005
    ..We hypothesize that ERBB2 Val654 represents an oncogenic variant which might, in addition, influence clinical outcome and predict a worse prognosis...
  54. doi request reprint Comparison of incidence of complications and aesthetic performance for posterior metal-free polymer crowns and metal-ceramic crowns: results from a randomized clinical trial
    Brigitte Ohlmann
    Department of Prosthodontics, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany Electronic address
    J Dent 42:671-6. 2014
    ..The purpose of this randomized clinical study was to evaluate the clinical performance of posterior, metal-free polymer crowns after follow-up for up to six years, and to compare it with the performance of metal-ceramic crowns...
  55. doi request reprint Tailored selection of study individuals to be sequenced in order to improve the accuracy of genotype imputation
    Barbara Peil
    Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany
    Genet Epidemiol 39:114-21. 2015
    ....
  56. ncbi request reprint T-DM1 as a New Treatment Option for Patients with Metastatic HER2-positive Breast Cancer in Clinical Practice
    Laura L Michel
    National Center for Tumor Diseases, University Hospital, Heidelberg, Germany Department of Obstetrics and Gynecology, University Hospital, Heidelberg, Germany
    Anticancer Res 35:5085-90. 2015
    ..To compare results of trastuzumab-emtansine (T-DM1) treatment in our clinical practice with data from phase III clinical trials...
  57. pmc EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma
    Rossella Pellegrino
    Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
    Hepatology 59:1886-99. 2014
    ..8, P < 0.001). Noticeably, a strong activation of this cascade was associated with shorter patient survival...
  58. ncbi request reprint Clinical performance of conical and electroplated telescopic double crown-retained partial dentures: a randomized clinical study
    Thomas Stober
    Department of Prosthodontics, University Hospital, Heidelberg, Germany
    Int J Prosthodont 25:209-16. 2012
    ..The aim of this study was to quantify and compare the clinical performance of cast conical double crown-retained removable partial dentures (C-RPDs) and electroplated double crown-retained removable partial dentures (EP-RPDs)...
  59. ncbi request reprint Genetic epidemiology of cancer: from families to heritable genes
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 111:944-50. 2004
    ..Clinical genetic counseling would benefit from reviewing established familial risks on all main types of cancer...
  60. pmc Contribution of the Defective BRCA1, BRCA2 and CHEK2 Genes to the Familial Aggregation of Breast Cancer: a Simulation Study Based on the Swedish Family-Cancer Database
    Justo Lorenzo Bermejo
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Hered Cancer Clin Pract 2:185-91. 2004
    ..In contrast, roughly 85% of the familial risk of breast cancer diagnosed before the age of 69 years remained unexplained. The contribution of CHEK2 to familial breast cancer was small...
  61. doi request reprint Expression and prognostic relevance of the death receptor CD95 (Fas/APO1) in renal cell carcinomas
    Stephan Macher-Goeppinger
    Institute of Pathology, University of Heidelberg, Germany
    Cancer Lett 301:203-11. 2011
    ..In conclusion, high CD95 expression is a negative independent prognostic factor in RCCs which could be used to identify high-risk patients with a poor clinical prognosis...
  62. doi request reprint Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - a systematic review and meta-analysis
    Lorenz K Thomas
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany Clinical Cooperation Unit, German Cancer Research Center DKFZ, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany
    Eur J Cancer 50:85-98. 2014
    ..These regions might be relevant for carcinogenesis and could serve as diagnostic markers to identify premalignant lesions with high progression risk towards invasive cancer...
  63. pmc Carcinogen metabolism, cigarette smoking, and breast cancer risk: a Bayes model averaging approach
    Nadine Stephenson
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Epidemiol Perspect Innov 7:10. 2010
    ..We explore the use of a Bayes Model Averaging approach as an alternative to analyze the influence of genetic variants, environmental effects and their interactions on disease...
  64. ncbi request reprint Death receptor 4 variants and colorectal cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:2002-5. 2006
    ..37; 95% CI, 0.98-5.76). The score statistic yielded an empirical P of 0.03 of the haplotype-specific test for 626C-683C based on 20,000 simulations, suggesting that DR4 626C-683C may affect colorectal cancer predisposition...
  65. pmc Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium
    Federico Canzian
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Hum Mol Genet 19:3873-84. 2010
    ..Although previous studies have shown that variations in these genes can influence endogenous hormone levels, the magnitude of the effect of single SNPs does not appear to be sufficient to alter breast cancer risk...
  66. pmc Comparison of measures for haplotype similarity
    Vivien Marquard
    Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    BMC Proc 1:S128. 2007
    ..While it yielded a much lower power, Yu's measure had 80% power around the disease locus...