Sascha Beneke

Summary

Affiliation: University of Konstanz
Country: Germany

Publications

  1. doi request reprint Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span
    Sascha Beneke
    Molecular Toxicology Group, Department of Biology, University of Konstanz, Universitaetsstr 10, 78457 Konstanz, Germany
    Mech Ageing Dev 131:366-9. 2010
  2. pmc Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1
    Sascha Beneke
    Molecular Toxicology Group, Department of Biology, University of Konstanz, 78457 Konstanz, Germany
    Nucleic Acids Res 36:6309-17. 2008
  3. doi request reprint Poly(ADP-ribose) polymerase activity in different pathologies--the link to inflammation and infarction
    Sascha Beneke
    University of Konstanz, Molecular Toxicology Group, Universiteatsstr 10, Box X911, 78457 Konstanz, Germany
    Exp Gerontol 43:605-14. 2008
  4. ncbi request reprint Ageing and PARP
    Alexander Burkle
    Molecular Toxicology Group, Box X911, University of Konstanz, D 78457 Konstanz, Germany
    Pharmacol Res 52:93-9. 2005
  5. doi request reprint Ex vivo supplementation with nicotinic acid enhances cellular poly(ADP-ribosyl)ation and improves cell viability in human peripheral blood mononuclear cells
    Kathrin Weidele
    Molecular Toxicology Group, Department of Biology, University of Konstanz, Konstanz, Germany
    Biochem Pharmacol 80:1103-12. 2010
  6. pmc Poly(ADP-ribosyl)ation in mammalian ageing
    Sascha Beneke
    Molecular Toxicology Group, Department of Biology, University of Konstanz, D 78457 Konstanz, Germany
    Nucleic Acids Res 35:7456-65. 2007
  7. ncbi request reprint Poly(ADP-ribosyl)ation inhibitors: promising drug candidates for a wide variety of pathophysiologic conditions
    Sascha Beneke
    Molecular Toxicology Group, University of Konstanz, Konstanz, Germany
    Int J Cancer 111:813-8. 2004
  8. ncbi request reprint Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity
    Alexander Burkle
    Department of Gerontology, Institute for Ageing and Health, Wolfson Research Centre, University of Newcastle, NGH, Westgate Road, IHE, Newcastle upon Tyne NE4 6BE, UK
    Exp Gerontol 37:1203-5. 2002
  9. ncbi request reprint Poly(ADP-ribosyl)ation and aging
    Alexander Burkle
    Department of Gerontology, University of Newcastle, Newcastle upon Tyne, UK
    Exp Gerontol 39:1599-601. 2004
  10. pmc Chromatin composition is changed by poly(ADP-ribosyl)ation during chromatin immunoprecipitation
    Sascha Beneke
    Molecular Toxicology, University of Konstanz, Konstanz, Germany
    PLoS ONE 7:e32914. 2012

Detail Information

Publications13

  1. doi request reprint Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span
    Sascha Beneke
    Molecular Toxicology Group, Department of Biology, University of Konstanz, Universitaetsstr 10, 78457 Konstanz, Germany
    Mech Ageing Dev 131:366-9. 2010
    ..e. substrate affinity and reaction velocity. In addition, we have characterized two human PARP-1 alleles and assign their activity difference to their respective initial velocity and not substrate affinity...
  2. pmc Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1
    Sascha Beneke
    Molecular Toxicology Group, Department of Biology, University of Konstanz, 78457 Konstanz, Germany
    Nucleic Acids Res 36:6309-17. 2008
    ..Our findings reinforce the link between poly(ADP-ribosyl)ation and aging/longevity and also impact on the use of poly(ADP-ribose) polymerase inhibitors in tumor therapy...
  3. doi request reprint Poly(ADP-ribose) polymerase activity in different pathologies--the link to inflammation and infarction
    Sascha Beneke
    University of Konstanz, Molecular Toxicology Group, Universiteatsstr 10, Box X911, 78457 Konstanz, Germany
    Exp Gerontol 43:605-14. 2008
    ..This review provides an introduction into the wide and complex field of poly(ADP-ribosyl)ation in different pathologies with regards of cell death regulation, inflammation and resulting tissue damage...
  4. ncbi request reprint Ageing and PARP
    Alexander Burkle
    Molecular Toxicology Group, Box X911, University of Konstanz, D 78457 Konstanz, Germany
    Pharmacol Res 52:93-9. 2005
    ..Recent research on PARPs and poly(ADP-ribose) provides several candidate mechanisms through which poly(ADP-ribosyl)ation might contribute to keeping the ageing process at slow pace...
  5. doi request reprint Ex vivo supplementation with nicotinic acid enhances cellular poly(ADP-ribosyl)ation and improves cell viability in human peripheral blood mononuclear cells
    Kathrin Weidele
    Molecular Toxicology Group, Department of Biology, University of Konstanz, Konstanz, Germany
    Biochem Pharmacol 80:1103-12. 2010
    ..In summary, ex vivo supplementation of human PBMC with NA increases cellular NAD(+) levels, boosts the cellular poly(ADP-ribosyl)ation response to genotoxic treatment, and protects from DNA-damage-induced cell death...
  6. pmc Poly(ADP-ribosyl)ation in mammalian ageing
    Sascha Beneke
    Molecular Toxicology Group, Department of Biology, University of Konstanz, D 78457 Konstanz, Germany
    Nucleic Acids Res 35:7456-65. 2007
    ..Recent research on PARPs and poly(ADP-ribose) yielded several candidate mechanisms through which poly(ADP-ribosyl)ation might act as a factor that limits the rate of ageing...
  7. ncbi request reprint Poly(ADP-ribosyl)ation inhibitors: promising drug candidates for a wide variety of pathophysiologic conditions
    Sascha Beneke
    Molecular Toxicology Group, University of Konstanz, Konstanz, Germany
    Int J Cancer 111:813-8. 2004
    ....
  8. ncbi request reprint Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity
    Alexander Burkle
    Department of Gerontology, Institute for Ageing and Health, Wolfson Research Centre, University of Newcastle, NGH, Westgate Road, IHE, Newcastle upon Tyne NE4 6BE, UK
    Exp Gerontol 37:1203-5. 2002
    ..Here we review the current state of the art concerning the relationship between DNA strand break repair, poly(ADP-ribosyl)ation, maintenance of genomic stability and mammalian life span...
  9. ncbi request reprint Poly(ADP-ribosyl)ation and aging
    Alexander Burkle
    Department of Gerontology, University of Newcastle, Newcastle upon Tyne, UK
    Exp Gerontol 39:1599-601. 2004
    ....
  10. pmc Chromatin composition is changed by poly(ADP-ribosyl)ation during chromatin immunoprecipitation
    Sascha Beneke
    Molecular Toxicology, University of Konstanz, Konstanz, Germany
    PLoS ONE 7:e32914. 2012
    ..By preventing polymer synthesis with the proposed modifications in standard ChIP protocols it is now possible to analyze the natural chromatin-composition...
  11. ncbi request reprint The emerging role of poly(ADP-ribose) polymerase-1 in longevity
    Alexander Burkle
    Department of Biology, University of Konstanz, P O Box X911, D 78457 Konstanz, Germany
    Int J Biochem Cell Biol 37:1043-53. 2005
    ....
  12. doi request reprint A caveat in mouse genetic engineering: ectopic gene targeting in ES cells by bidirectional extension of the homology arms of a gene replacement vector carrying human PARP-1
    Aswin Mangerich
    Molecular Toxicology Group, Department of Biology, University of Konstanz, Box X911, 78457, Constance, Germany
    Transgenic Res 18:261-79. 2009
    ..We provide reliable techniques to detect such ectopic gene targeting which represents an unexpected caveat in mouse genetic engineering that should be considered in the design and validation strategy of future gene knock-in approaches...
  13. ncbi request reprint Poly(ADP-ribosyl)ation, PARP, and aging
    Sascha Beneke
    Molecular Toxicology Group, Department of Biology, Box X911, University of Konstanz, D 78457 Konstanz, Germany
    Sci Aging Knowledge Environ 2004:re9. 2004
    ....