Bogdan Beirowski

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. pmc The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves
    Bogdan Beirowski
    Center for Molecular Medicine Cologne CMMC and Institute for Genetics, University of Cologne, Zuelpicher Strasse 47, D 50647 Cologne, Germany
    BMC Neurosci 6:6. 2005
  2. ncbi Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice
    Bogdan Beirowski
    Center for Molecular Medicine Cologne and Institute for Genetics, University of Cologne, Zuelpicher Strasse 47, D 50674 Cologne, Germany
    J Neurosci Methods 134:23-35. 2004
  3. pmc The slow Wallerian degeneration protein, WldS, binds directly to VCP/p97 and partially redistributes it within the nucleus
    Heike Laser
    Institute for Genetics and Center for Molecular Medicine, University of Cologne, D 50674 Cologne, Germany
    Mol Biol Cell 17:1075-84. 2006
  4. ncbi The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice
    Weiqian Mi
    ZMMK and Institute for Genetics, University of Cologne, Cologne, Germany
    Brain 128:405-16. 2005
  5. ncbi Antifibrotic, nephroprotective potential of ACE inhibitor vs AT1 antagonist in a murine model of renal fibrosis
    Oliver Gross
    Medical Faculty University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Nephrol Dial Transplant 19:1716-23. 2004
  6. ncbi Nephroprotection by antifibrotic and anti-inflammatory effects of the vasopeptidase inhibitor AVE7688
    Oliver Gross
    Department of Internal Medicine I, Medical Faculty University of Cologne, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Kidney Int 68:456-63. 2005
  7. ncbi Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive renal fibrosis in Alport syndrome
    Marie Louise Koepke
    Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, and Department of Anatomy I, University of Cologne, Germany
    Nephrol Dial Transplant 22:1062-9. 2007
  8. ncbi DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria
    Oliver Gross
    Medical Faculty, University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Kidney Int 66:102-11. 2004
  9. ncbi Neuroprotective strategies in MS: lessons from C57BL/Wld(S) mice
    Michael P Coleman
    The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    J Neurol Sci 233:133-8. 2005
  10. ncbi A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses
    Robert Adalbert
    The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Eur J Neurosci 21:271-7. 2005

Collaborators

Detail Information

Publications12

  1. pmc The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves
    Bogdan Beirowski
    Center for Molecular Medicine Cologne CMMC and Institute for Genetics, University of Cologne, Zuelpicher Strasse 47, D 50647 Cologne, Germany
    BMC Neurosci 6:6. 2005
    ..Here, we apply this method to study the progressive nature of Wallerian degeneration in both wild-type and slow Wallerian degeneration (WldS) mutant mice...
  2. ncbi Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice
    Bogdan Beirowski
    Center for Molecular Medicine Cologne and Institute for Genetics, University of Cologne, Zuelpicher Strasse 47, D 50674 Cologne, Germany
    J Neurosci Methods 134:23-35. 2004
    ..9 cm exploiting confocal fluorescence imaging. Altogether transgenic YFP-H mice prove to be a valuable tool to study mechanisms of Wallerian degeneration in vivo and in vitro...
  3. pmc The slow Wallerian degeneration protein, WldS, binds directly to VCP/p97 and partially redistributes it within the nucleus
    Heike Laser
    Institute for Genetics and Center for Molecular Medicine, University of Cologne, D 50674 Cologne, Germany
    Mol Biol Cell 17:1075-84. 2006
    ..We conclude that N-terminal sequences of Wld(S) protein influence the intranuclear location of both ubiquitin proteasome and NAD(+) synthesis machinery and that an evolutionary recent sequence mediates binding of mammalian Ube4b to VCP...
  4. ncbi The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice
    Weiqian Mi
    ZMMK and Institute for Genetics, University of Cologne, Cologne, Germany
    Brain 128:405-16. 2005
    ..We conclude that axon degeneration mechanisms are more closely related than previously thought and that a link exists in gad between spheroid pathology and Wallerian degeneration that could hold for other disorders...
  5. ncbi Antifibrotic, nephroprotective potential of ACE inhibitor vs AT1 antagonist in a murine model of renal fibrosis
    Oliver Gross
    Medical Faculty University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Nephrol Dial Transplant 19:1716-23. 2004
    ..We used this animal model to compare the potential of ACE inhibitor vs AT1 antagonist to prevent renal fibrosis irrespective of blood pressure-dependent involvement by the renin system...
  6. ncbi Nephroprotection by antifibrotic and anti-inflammatory effects of the vasopeptidase inhibitor AVE7688
    Oliver Gross
    Department of Internal Medicine I, Medical Faculty University of Cologne, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Kidney Int 68:456-63. 2005
    ..In the present study, we investigated the nephroprotective potential of the vasopeptidase inhibitor AVE7688 beyond its antihypertensive effects in a mouse model of progressive renal fibrosis...
  7. ncbi Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive renal fibrosis in Alport syndrome
    Marie Louise Koepke
    Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, and Department of Anatomy I, University of Cologne, Germany
    Nephrol Dial Transplant 22:1062-9. 2007
    ..The aim of this study was to examine the anti-fibrotic effect of the HMG-CoA-reductase-inhibitor, cerivastatin, in COL4A3 knockout mice, an animal model of Alport syndrome with progressive renal fibrosis...
  8. ncbi DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria
    Oliver Gross
    Medical Faculty, University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Kidney Int 66:102-11. 2004
    ..The interaction between type IV collagen and cell surface receptors is believed important for normal renal function as well as significant in chronic renal diseases and we therefore analyzed mice with a targeted deletion of DDR1...
  9. ncbi Neuroprotective strategies in MS: lessons from C57BL/Wld(S) mice
    Michael P Coleman
    The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    J Neurol Sci 233:133-8. 2005
    ..Similar morphologies have been described in MS, stroke, and other disorders, again suggesting a uniformity of axon degeneration mechanisms...
  10. ncbi A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses
    Robert Adalbert
    The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Eur J Neurosci 21:271-7. 2005
    ..Thus, the slow Wallerian degeneration phenotype can be transferred to another mammalian species and synapses may be more effectively preserved after axotomy in species with longer axons...
  11. ncbi Chronic renal failure and shortened lifespan in COL4A3+/- mice: an animal model for thin basement membrane nephropathy
    Bogdan Beirowski
    Medical Faculty University of Cologne, Medicine Clinic I, Hospital Merheim, Ostmerheimer Strasse 200, D 51109 Cologne, Germany
    J Am Soc Nephrol 17:1986-94. 2006
    ..Therefore, the COL4A3(+/-) mouse model will help in the understanding of the pathogenesis of TBMN in humans and in the evaluation of potential therapies...
  12. ncbi Preemptive ramipril therapy delays renal failure and reduces renal fibrosis in COL4A3-knockout mice with Alport syndrome
    Oliver Gross
    Medical Faculty University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Kidney Int 63:438-46. 2003
    ..Molecular genetics allows early diagnosis, however, no preventive strategy can be offered. Using the COL4A3 -/- mouse, an animal model for human AS, we evaluated therapy with ramipril in mice...