Jürgen Behrens

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint The Wnt connection to tumorigenesis
    Jürgen Behrens
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen N rnberg, 91054 Erlangen, Germany
    Int J Dev Biol 48:477-87. 2004
  2. doi request reprint One hit, two outcomes for VHL-mediated tumorigenesis
    Jürgen Behrens
    Jürgen Behrens is at the Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen, Glückstr 6, 91341 Erlangen, Germany
    Nat Cell Biol 10:1127-8. 2008
  3. ncbi request reprint The role of the Wnt signalling pathway in colorectal tumorigenesis
    J Behrens
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glueckstr 6, D 91054 Erlangen, Germany
    Biochem Soc Trans 33:672-5. 2005
  4. pmc Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration
    Astrid S Pfister
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 287:35333-40. 2012
  5. pmc Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation
    Kristina Tanneberger
    Nikolaus Fiebiger Center, University Erlangen Nurnberg, Erlangen, Germany
    EMBO J 30:1433-43. 2011
  6. doi request reprint Wnt signaling inhibits Forkhead box O3a-induced transcription and apoptosis through up-regulation of serum- and glucocorticoid-inducible kinase 1
    Manuel Dehner
    Department of Experimental Medicine II, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen, Glueckstrasse 6, 91054 Erlangen, Germany
    J Biol Chem 283:19201-10. 2008
  7. pmc A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation
    Shree Harsha Vijaya Chandra
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nurnberg, Glückstrasse, Erlangen, Germany
    PLoS ONE 7:e34479. 2012
  8. ncbi request reprint Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 16:199-209. 2007
  9. ncbi request reprint E-cadherin modulates Wnt-dependent transcription in colorectal cancer cells but does not alter Wnt-independent gene expression in fibroblasts
    Felix Kuphal
    Department of Experimental Medicine II, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen, Glueckstr 6, 91054 Erlangen, Germany
    Exp Cell Res 312:457-67. 2006
  10. pmc Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor
    Ingrid Wacker
    Nikolaus Fiebiger Center, University Erlangen Nurnberg, Glückstr 6, 91054 Erlangen, Germany
    Mol Cell Biol 29:1707-18. 2009

Collaborators

Detail Information

Publications30

  1. ncbi request reprint The Wnt connection to tumorigenesis
    Jürgen Behrens
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen N rnberg, 91054 Erlangen, Germany
    Int J Dev Biol 48:477-87. 2004
    ..Here we will describe the biochemical interactions which shape the Wnt pathway and focus on its role in tumorigenesis...
  2. doi request reprint One hit, two outcomes for VHL-mediated tumorigenesis
    Jürgen Behrens
    Jürgen Behrens is at the Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen, Glückstr 6, 91341 Erlangen, Germany
    Nat Cell Biol 10:1127-8. 2008
  3. ncbi request reprint The role of the Wnt signalling pathway in colorectal tumorigenesis
    J Behrens
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glueckstr 6, D 91054 Erlangen, Germany
    Biochem Soc Trans 33:672-5. 2005
    ..Here I will summarize the biochemical interactions occurring in Wnt signalling and describe how alterations in Wnt pathway components lead to CRC...
  4. pmc Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration
    Astrid S Pfister
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 287:35333-40. 2012
    ....
  5. pmc Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation
    Kristina Tanneberger
    Nikolaus Fiebiger Center, University Erlangen Nurnberg, Erlangen, Germany
    EMBO J 30:1433-43. 2011
    ..We propose a mechanism for Wnt receptor activation by which generation of PtdIns(4,5)P(2) leads to recruitment of Amer1 to the plasma membrane, which acts as a scaffold protein to stimulate phosphorylation of LRP6...
  6. doi request reprint Wnt signaling inhibits Forkhead box O3a-induced transcription and apoptosis through up-regulation of serum- and glucocorticoid-inducible kinase 1
    Manuel Dehner
    Department of Experimental Medicine II, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen, Glueckstrasse 6, 91054 Erlangen, Germany
    J Biol Chem 283:19201-10. 2008
    ..Finally, we show that induction of Wnt signaling inhibits FoxO3a-induced apoptosis. Collectively our results indicate that evasion of apoptosis is another feature employed by an overactive Wnt signaling...
  7. pmc A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation
    Shree Harsha Vijaya Chandra
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nurnberg, Glückstrasse, Erlangen, Germany
    PLoS ONE 7:e34479. 2012
    ..Thus, truncated APC is an essential component of colorectal cancer cells, required for cell proliferation, possibly by adjusting β-catenin signalling to the "just right" level...
  8. ncbi request reprint Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 16:199-209. 2007
    ....
  9. ncbi request reprint E-cadherin modulates Wnt-dependent transcription in colorectal cancer cells but does not alter Wnt-independent gene expression in fibroblasts
    Felix Kuphal
    Department of Experimental Medicine II, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen, Glueckstr 6, 91054 Erlangen, Germany
    Exp Cell Res 312:457-67. 2006
    ..Our data indicate that E-cadherin may modulate Wnt-dependent gene expression by regulating the availability of beta-catenin but has a surprisingly small impact on gene expression in the absence of Wnt signaling...
  10. pmc Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor
    Ingrid Wacker
    Nikolaus Fiebiger Center, University Erlangen Nurnberg, Glückstr 6, 91054 Erlangen, Germany
    Mol Cell Biol 29:1707-18. 2009
    ..Finally, knockdown of activin B reduces tumor growth of RCC cells in nude mice. Our data indicate that activin B is a key mediator of VHL/HIF-induced transformation in RCC...
  11. doi request reprint Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours
    Eva Maria Kohler
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 18:213-26. 2009
    ..The CID is a direct target of the selective pressure acting on APC during tumourigenesis. It explains the interdependence of both APC mutations, not only in colorectal but also in duodenal and desmoid tumours...
  12. pmc Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 8:e68072. 2013
    ....
  13. pmc Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20
    Michel V Hadjihannas
    Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen, Glueckstrasse 6, 91054 Erlangen, Germany
    EMBO Rep 13:347-54. 2012
    ..CDC20-resistant conductin inhibits Wnt signalling and attenuates colony formation of colorectal cancer cells. We propose that CDC20-mediated degradation of conductin regulates Wnt/β-catenin signalling for maximal activity during G1/S...
  14. ncbi request reprint Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention
    Eva Krieghoff
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nurnberg, Glückstr 6, 91054 Erlangen, Germany
    J Cell Sci 119:1453-63. 2006
    ....
  15. ncbi request reprint CIN By WNT: growth pathways, mitotic control and chromosomal instability in cancer
    Michel V Hadjihannas
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Erlangen, Germany
    Cell Cycle 5:2077-81. 2006
    ..We speculate that aberrant activation of these pathways, as observed in cancer can result in chromosomal instability thus explaining the widespread appearance of CIN in human cancers...
  16. doi request reprint APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nu rnberg, Glu ckstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 20:3554-64. 2011
    ..This suggests that the sensitivity of truncated APC to oligomerization by CtBP constitutes an essential facet of tumour development...
  17. ncbi request reprint Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours
    Eva Maria Kohler
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 17:1978-87. 2008
    ..Thus, our data provide a functional definition of the MCR: the APC fragments typical of colon cancer are selected for the presence of a single functional 20R, the first one, and are therefore equivalent relative to beta-catenin binding...
  18. doi request reprint Liprin-α4 is a new hypoxia-inducible target gene required for maintenance of cell-cell contacts
    Sandra Mattauch
    Nikolaus Fiebiger Center, University Erlangen Nurnberg, Glückstrasse 6, Erlangen, Germany
    Exp Cell Res 316:2883-92. 2010
    ..Our data describe for the first time liprin-α4 as a hypoxia-induced gene potentially involved in cell-cell adhesion...
  19. ncbi request reprint AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane
    Annette Grohmann
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nuremberg, Glückstr 6, 91054 Erlangen, Germany
    J Cell Sci 120:3738-47. 2007
    ..These data indicate that AMER1 controls the subcellular distribution of APC between membrane- and microtubule-associated pools, and might thereby regulate APC-dependent cellular morphogenesis, cell migration and cell-cell adhesion...
  20. pmc Conductin/axin2 and Wnt signalling regulates centrosome cohesion
    Michel V Hadjihannas
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glueckstrasse 6, Erlangen 91054, Germany
    EMBO Rep 11:317-24. 2010
    ..These data indicate that Wnt/beta-catenin signalling and conductin regulate centrosomal cohesion by altering the phosphorylation status of beta-catenin at the centrosomes...
  21. ncbi request reprint Expression profiling reveals genes associated with transendothelial migration of tumor cells: a functional role for alphavbeta3 integrin
    Katja Bauer
    Nikolaus Fiebiger Zentrum, University Erlangen Nuernberg, Glueckstr 6, 91054 Erlangen, Germany
    Int J Cancer 121:1910-8. 2007
    ..Our gene expression analysis of a defined collection of tumor cell lines can be used as a starting point to identify further genes functionally involved in transendothelial migration...
  22. pmc The canonical Wnt signalling pathway and its APC partner in colon cancer development
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstr 6, 91054 Erlangen, Germany
    Gut 56:417-25. 2007
  23. pmc The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1
    Ruth Schietke
    Interdisciplinary Centre for Clinical Research, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 285:6658-69. 2010
    ..Lysyl oxidases could be an attractive molecular target for cancers of epithelial origin, in particular because they are partly extracellular...
  24. pmc Amer2 protein is a novel negative regulator of Wnt/β-catenin signaling involved in neuroectodermal patterning
    Astrid S Pfister
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 287:1734-41. 2012
    ..Our data characterize Amer2 for the first time as a negative regulator of Wnt signaling both in cell lines and in vivo and define Amer proteins as a novel family of Wnt pathway regulators...
  25. pmc different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 9:e94413. 2014
    ....
  26. pmc Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer
    Michel V Hadjihannas
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nuernberg, Glueckstrasse 6, 91054 Erlangen, Germany
    Proc Natl Acad Sci U S A 103:10747-52. 2006
    ..Knock-down of conductin by small interfering RNA in colon carcinoma cells or gene ablation in mouse embryo fibroblasts enforces the checkpoint...
  27. ncbi request reprint Truncated APC is required for cell proliferation and DNA replication
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Erlangen, Germany
    Int J Cancer 119:74-9. 2006
    ..Thus, our data suggest that colon cancer cells retain a truncated APC fragment because it is essential for cell proliferation...
  28. ncbi request reprint Common denominator genes that distinguish colorectal carcinoma from normal mucosa
    Roland S Croner
    Department of Surgery, University of Erlangen, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Int J Colorectal Dis 20:353-62. 2005
    ..On the basis of our own and other investigators' microarray data, our goal was to identify a common denominator gene cluster distinguishing CRC from MC...
  29. doi request reprint Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients
    E M Kohler
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nurnberg, Erlangen, Bayern, Germany
    Oncogene 29:1663-71. 2010
    ..The analysis of the distribution of truncating mutations along the APC sequence in colorectal tumours from FAP patients revealed that the first 15R is one target of the positive selection of mutations that lead to tumour development...
  30. doi request reprint Snail promotes Wnt target gene expression and interacts with beta-catenin
    V Stemmer
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Erlangen, Germany
    Oncogene 27:5075-80. 2008
    ..Our data indicate a positive feedback stimulation of the Wnt pathway by activation of snail...