Affiliation: University of Mainz
- Estrogen can protect neurons: modes of actionChristian Behl
MPI of Psychiatry, D 80804 Munich, Germany
J Steroid Biochem Mol Biol 83:195-7. 2002..The various modes of action of estrogen via receptor activation and in a non-receptor fashion are currently under intensive investigation...
- Oxidative stress resistance in hippocampal cells is associated with altered membrane fluidity and enhanced nonamyloidogenic cleavage of endogenous amyloid precursor proteinAngela B Clement
Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, 55099 Mainz, Germany
Free Radic Biol Med 48:1236-41. 2010..Thus our -data provide a link between chronic oxidative stress, alterations in membrane fluidity and composition of membrane subdomains, stress adaptation, and APP processing...
- Mitochondrially encoded cysteine predicts animal lifespanBernd Moosmann
Evolutionary Pathobiochemistry Group, Institute for Physiological Chemistry and Pathological Biochemistry, Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
Aging Cell 7:32-46. 2008..These results provide distinct support for the free radical theory of aging...
- Adaptation of neuronal cells to chronic oxidative stress is associated with altered cholesterol and sphingolipid homeostasis and lysosomal functionAngela B Clement
Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University Mainz, Germany
J Neurochem 111:669-82. 2009..These findings suggest an important role of the cell type-specific lipid profile for differential vulnerabilities of different brain areas toward chronic oxidative stress...
- Inhibition of the myosin light chain kinase prevents hypoxia-induced blood-brain barrier disruptionChristoph R W Kuhlmann
Institute of Physiology and Pathophysiology, Johannes Gutenberg University of Mainz, Mainz, Germany
J Neurochem 102:501-7. 2007..Furthermore, ML-7 and apocynin blocked hypoxia-dependent phosphorylation of MLC. Our data demonstrate that hypoxia causes a breakdown of the BBB in vitro and in vivo involving ROS and the contractile machinery...
- The search for novel avenues for the therapy and prevention of Alzheimer's diseaseChristian Behl
Institute for Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Mainz, Medical School, Mainz, Germany
Drug News Perspect 19:5-12. 2006....
- Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells--implications for neuroprotection against Ca-mediated excitotoxicityMartin Gamerdinger
Department of Pathobiochemistry, Medical School, Johannes Gutenberg University, Mainz, Germany
J Neurochem 97:57-68. 2006....
- Inhibition of glycogen synthase kinase 3 beta is involved in the resistance to oxidative stress in neuronal HT22 cellsMonika Schäfer
Independent Research Group Neurodegeneration, Max Planck Institute for Psychiatry, Munich, Germany
Brain Res 1005:84-9. 2004....
- The neuroprotective actions of corticotropin releasing hormoneNadhim Bayatti
Neural Development, Plasticity and Repair, Sir James Spence Institute (Child Health, School of Clinical Medical Sciences, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, NE1 4LP, UK
Ageing Res Rev 4:258-70. 2005..Taken together, an impressive amount of evidence has accumulated recently, highlighting this new and potentially important function of CRH...
- Oxidative stress in Alzheimer's disease: implications for prevention and therapyChristian Behl
Institute for Physiological Chemistry and Pathobiochemistry, Faculty of Medicine, Johannes Gutenberg University, Mainz, D-55099 Mainz, Germany
Subcell Biochem 38:65-78. 2005..Nevertheless, the exact molecular mechanisms and the real impact of oxidative stress on the development and progression of Alzheimer's Disease as well as of other neurodegenerative disorders still needs to be further investigated...
- High-throughput functional genomics identifies genes that ameliorate toxicity due to oxidative stress in neuronal HT-22 cells: GFPT2 protects cells against peroxideJürgen Zitzler
Xantos Biomedicine AG, Max Lebsche Platz 31, D 81377 Munich, Germany
Mol Cell Proteomics 3:834-40. 2004..Thus, GFPT appears to be conserved among yeast and men as a critical target of methylmercury and ROS-induced cytotoxicity...
- Oestrogen as a neuroprotective hormoneChristian Behl
Max Planck Institute of Psychiatry, 80804 Munich, Germany
Nat Rev Neurosci 3:433-42. 2002..Understanding the mechanisms of oestrogen action will be crucial to determine its potential as a therapeutic agent, particularly in the elderly...
- Functional interaction of estrogen receptor alpha and caveolin isoforms in neuronal SK-N-MC cellsJürgen Zschocke
Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University, 55099 Mainz, Germany
J Steroid Biochem Mol Biol 84:167-70. 2003..In conclusion, our observations provide a possible mechanism of negative feedback regulation of ERalpha co-activator caveolin by the steroid receptor itself in this cellular model...
- Sex hormones, neuroprotection and cognitionChristian Behl
Max-Planck-Institute of Psychiatry, 80804 Munich, Germany
Prog Brain Res 138:135-42. 2002
- Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cellsJürgen Zschocke
Neurodegeneration Group, Max Planck Institute of Psychiatry, 80804 Munich, Germany
J Biol Chem 277:38772-80. 2002..The observed mechanism of gene silencing by ER alpha may have implications for the transcriptional regulation of further ER alpha target genes...
- Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approachChristian Behl
Max Planck Institute of Psychiatry, Munich, Germany
Free Radic Biol Med 33:182-91. 2002....
- Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1Giovanni Marsicano
Department of Molecular Genetics of Behavior, Max Planck Institute of Psychiatry, Munich, Germany
J Neurochem 80:448-56. 2002..The results strongly suggest that CB1 is not involved in the cellular antioxidant neuroprotective effects of cannabinoids...
- Oxidative nerve cell death in Alzheimer's disease and stroke: antioxidants as neuroprotective compoundsChristian Behl
Max-Planck-Institute of Psychiatry, Munich, Germany
Biol Chem 383:521-36. 2002..Finally, an outlook is given on the neuroprotective potential of aromatic amines and imines, which may comprise novel lead structures for antioxidant drug design...
- Differential promotion of glutamate transporter expression and function by glucocorticoids in astrocytes from various brain regionsJürgen Zschocke
Department of Pathobiochemistry, Johannes Gutenberg University Mainz, 55099 Mainz, Germany
J Biol Chem 280:34924-32. 2005..Taken together, our data highlight a potential role for glucocorticoids in regulating GLT-1 gene expression during central nervous system development or pathophysiological processes including stress...
- P-glycoprotein has negligible effects on estradiol and testosterone in miceMartin Ebinger
Max Planck Institute of Psychiatry, 80804 Munich, Germany
Neurosci Lett 427:6-9. 2007..The organ/plasma quotients showed no significant group effects. We concluded that P-gp does not influence the penetration of testosterone and estradiol to a biologically significant extent...
- O-glycosylation of the tail domain of neurofilament protein M in human neurons and in spinal cord tissue of a rat model of amyotrophic lateral sclerosis (ALS)Nina Lüdemann
Department of Neurobiology, University of Osnabruck, Barbarastrasse 11, D 49076 Osnabrück
J Biol Chem 280:31648-58. 2005....
- Concepts for the treatment of Alzheimer's disease: molecular mechanisms and clinical applicationClaus Pietrzik
Department of Molecular Neurodegeneration, Institute for Physiological Chemistry and Pathochemistry, Johannes Gutenberg-University Mainz, Medical School, 55099 Mainz, Germany
Int J Exp Pathol 86:173-85. 2005..Additionally, we summarize some of the experimental approaches in AD therapy, which might lead to the development of more promising drugs in the future...
- Antioxidants as treatment for neurodegenerative disordersBernd Moosmann
Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA
Expert Opin Investig Drugs 11:1407-35. 2002..Finally, an outlook as to which direction antioxidant drug development and clinical practice may be leading to in the near future will be provided...
- Neuroprotective strategies in Alzheimer's diseaseChristian Behl
Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany
Adv Exp Med Biol 513:475-96. 2002
- Brain region-specific neuroprotective action and signaling of corticotropin-releasing hormone in primary neuronsNadhim Bayatti
Independent Research Group Neurodegeneration, Max Planck Institute of Psychiatry, 80804 Munich, Germany Chemistry and Pathobiochemistry, Johannes Gutenberg University Mainz, 55099 Mainz, Germany
Endocrinology 144:4051-60. 2003..Differences in signaling were found to be independent of receptor expression levels because RT-PCR analysis indicated no region-specific differences in CRHR1 mRNA expression...
- CB1 cannabinoid receptors and on-demand defense against excitotoxicityGiovanni Marsicano
Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, 80804 Munich, Germany
Science 302:84-8. 2003..These protective mechanisms could not be triggered in mutant mice. The endogenous cannabinoid system thus provides on-demand protection against acute excitotoxicity in central nervous system neurons...
- Estrogen receptor (ER)-mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERalpha and ERbetaAnja van de Stolpe
Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Mol Endocrinol 18:2908-23. 2004....
- Inactivation of glycogen synthase kinase-3beta protects against kainic acid-induced neurotoxicity in vivoSharon Goodenough
Department of Pathobiochemistry, Johannes Gutenberg University, Mainz, Germany
Brain Res 1026:116-25. 2004..This work supports a role for GSK-3beta in cell death in response to excitotoxins in vivo and further confirms that GSK-3beta plays a role in cell death/cell survival pathways...
- Caveolin and GLT-1 gene expression is reciprocally regulated in primary astrocytes: association of GLT-1 with non-caveolar lipid raftsJürgen Zschocke
Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University, Mainz, Germany
Glia 49:275-87. 2005..We also provide strong evidence that GLT-1 itself is concentrated in lipid rafts, inferring an important role for glial glutamate transporter function...
- Corticotropin-releasing hormone-mediated induction of intracellular signaling pathways and brain-derived neurotrophic factor expression is inhibited by the activation of the endocannabinoid systemNadhim Bayatti
Department of Pathobiochemistry, Johannes Gutenberg University Mainz Medical School, 55099 Mainz, Germany
Endocrinology 146:1205-13. 2005..Thus, these data highlight an interaction between the CRH and the cannabinoid system in the regulation of BDNF expression by influencing cAMP and Ca2+ signaling pathways...
- Secretory peptide hormones are biochemical antioxidants: structure-activity relationshipBernd Moosmann
Max Planck Institute of Psychiatry, Munich, Germany
Mol Pharmacol 61:260-8. 2002....