Christian Behl

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint Estrogen can protect neurons: modes of action
    Christian Behl
    MPI of Psychiatry, D 80804 Munich, Germany
    J Steroid Biochem Mol Biol 83:195-7. 2002
  2. doi request reprint Oxidative stress resistance in hippocampal cells is associated with altered membrane fluidity and enhanced nonamyloidogenic cleavage of endogenous amyloid precursor protein
    Angela B Clement
    Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, 55099 Mainz, Germany
    Free Radic Biol Med 48:1236-41. 2010
  3. ncbi request reprint Mitochondrially encoded cysteine predicts animal lifespan
    Bernd Moosmann
    Evolutionary Pathobiochemistry Group, Institute for Physiological Chemistry and Pathological Biochemistry, Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
    Aging Cell 7:32-46. 2008
  4. ncbi request reprint Adaptation of neuronal cells to chronic oxidative stress is associated with altered cholesterol and sphingolipid homeostasis and lysosomal function
    Angela B Clement
    Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University Mainz, Germany
    J Neurochem 111:669-82. 2009
  5. ncbi request reprint Inhibition of the myosin light chain kinase prevents hypoxia-induced blood-brain barrier disruption
    Christoph R W Kuhlmann
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Neurochem 102:501-7. 2007
  6. ncbi request reprint The search for novel avenues for the therapy and prevention of Alzheimer's disease
    Christian Behl
    Institute for Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Mainz, Medical School, Mainz, Germany
    Drug News Perspect 19:5-12. 2006
  7. ncbi request reprint Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells--implications for neuroprotection against Ca-mediated excitotoxicity
    Martin Gamerdinger
    Department of Pathobiochemistry, Medical School, Johannes Gutenberg University, Mainz, Germany
    J Neurochem 97:57-68. 2006
  8. ncbi request reprint Inhibition of glycogen synthase kinase 3 beta is involved in the resistance to oxidative stress in neuronal HT22 cells
    Monika Schäfer
    Independent Research Group Neurodegeneration, Max Planck Institute for Psychiatry, Munich, Germany
    Brain Res 1005:84-9. 2004
  9. ncbi request reprint The neuroprotective actions of corticotropin releasing hormone
    Nadhim Bayatti
    Neural Development, Plasticity and Repair, Sir James Spence Institute Child Health, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 4LP, UK
    Ageing Res Rev 4:258-70. 2005
  10. ncbi request reprint Oxidative stress in Alzheimer's disease: implications for prevention and therapy
    Christian Behl
    Institute for Physiological Chemistry and Pathobiochemistry, Faculty of Medicine, Johannes Gutenberg University, Mainz, D 55099 Mainz, Germany
    Subcell Biochem 38:65-78. 2005

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Estrogen can protect neurons: modes of action
    Christian Behl
    MPI of Psychiatry, D 80804 Munich, Germany
    J Steroid Biochem Mol Biol 83:195-7. 2002
    ..The various modes of action of estrogen via receptor activation and in a non-receptor fashion are currently under intensive investigation...
  2. doi request reprint Oxidative stress resistance in hippocampal cells is associated with altered membrane fluidity and enhanced nonamyloidogenic cleavage of endogenous amyloid precursor protein
    Angela B Clement
    Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, 55099 Mainz, Germany
    Free Radic Biol Med 48:1236-41. 2010
    ..Thus our -data provide a link between chronic oxidative stress, alterations in membrane fluidity and composition of membrane subdomains, stress adaptation, and APP processing...
  3. ncbi request reprint Mitochondrially encoded cysteine predicts animal lifespan
    Bernd Moosmann
    Evolutionary Pathobiochemistry Group, Institute for Physiological Chemistry and Pathological Biochemistry, Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
    Aging Cell 7:32-46. 2008
    ..These results provide distinct support for the free radical theory of aging...
  4. ncbi request reprint Adaptation of neuronal cells to chronic oxidative stress is associated with altered cholesterol and sphingolipid homeostasis and lysosomal function
    Angela B Clement
    Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University Mainz, Germany
    J Neurochem 111:669-82. 2009
    ..These findings suggest an important role of the cell type-specific lipid profile for differential vulnerabilities of different brain areas toward chronic oxidative stress...
  5. ncbi request reprint Inhibition of the myosin light chain kinase prevents hypoxia-induced blood-brain barrier disruption
    Christoph R W Kuhlmann
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Neurochem 102:501-7. 2007
    ..Furthermore, ML-7 and apocynin blocked hypoxia-dependent phosphorylation of MLC. Our data demonstrate that hypoxia causes a breakdown of the BBB in vitro and in vivo involving ROS and the contractile machinery...
  6. ncbi request reprint The search for novel avenues for the therapy and prevention of Alzheimer's disease
    Christian Behl
    Institute for Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Mainz, Medical School, Mainz, Germany
    Drug News Perspect 19:5-12. 2006
    ....
  7. ncbi request reprint Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells--implications for neuroprotection against Ca-mediated excitotoxicity
    Martin Gamerdinger
    Department of Pathobiochemistry, Medical School, Johannes Gutenberg University, Mainz, Germany
    J Neurochem 97:57-68. 2006
    ....
  8. ncbi request reprint Inhibition of glycogen synthase kinase 3 beta is involved in the resistance to oxidative stress in neuronal HT22 cells
    Monika Schäfer
    Independent Research Group Neurodegeneration, Max Planck Institute for Psychiatry, Munich, Germany
    Brain Res 1005:84-9. 2004
    ....
  9. ncbi request reprint The neuroprotective actions of corticotropin releasing hormone
    Nadhim Bayatti
    Neural Development, Plasticity and Repair, Sir James Spence Institute Child Health, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 4LP, UK
    Ageing Res Rev 4:258-70. 2005
    ..Taken together, an impressive amount of evidence has accumulated recently, highlighting this new and potentially important function of CRH...
  10. ncbi request reprint Oxidative stress in Alzheimer's disease: implications for prevention and therapy
    Christian Behl
    Institute for Physiological Chemistry and Pathobiochemistry, Faculty of Medicine, Johannes Gutenberg University, Mainz, D 55099 Mainz, Germany
    Subcell Biochem 38:65-78. 2005
    ..Nevertheless, the exact molecular mechanisms and the real impact of oxidative stress on the development and progression of Alzheimer's Disease as well as of other neurodegenerative disorders still needs to be further investigated...
  11. ncbi request reprint High-throughput functional genomics identifies genes that ameliorate toxicity due to oxidative stress in neuronal HT-22 cells: GFPT2 protects cells against peroxide
    Jürgen Zitzler
    Xantos Biomedicine AG, Max Lebsche Platz 31, D 81377 Munich, Germany
    Mol Cell Proteomics 3:834-40. 2004
    ..Thus, GFPT appears to be conserved among yeast and men as a critical target of methylmercury and ROS-induced cytotoxicity...
  12. ncbi request reprint Oestrogen as a neuroprotective hormone
    Christian Behl
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Nat Rev Neurosci 3:433-42. 2002
    ..Understanding the mechanisms of oestrogen action will be crucial to determine its potential as a therapeutic agent, particularly in the elderly...
  13. ncbi request reprint Functional interaction of estrogen receptor alpha and caveolin isoforms in neuronal SK-N-MC cells
    Jürgen Zschocke
    Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University, 55099 Mainz, Germany
    J Steroid Biochem Mol Biol 84:167-70. 2003
    ..In conclusion, our observations provide a possible mechanism of negative feedback regulation of ERalpha co-activator caveolin by the steroid receptor itself in this cellular model...
  14. ncbi request reprint Sex hormones, neuroprotection and cognition
    Christian Behl
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Prog Brain Res 138:135-42. 2002
  15. ncbi request reprint Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells
    Jürgen Zschocke
    Neurodegeneration Group, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Biol Chem 277:38772-80. 2002
    ..The observed mechanism of gene silencing by ER alpha may have implications for the transcriptional regulation of further ER alpha target genes...
  16. ncbi request reprint Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach
    Christian Behl
    Max Planck Institute of Psychiatry, Munich, Germany
    Free Radic Biol Med 33:182-91. 2002
    ....
  17. ncbi request reprint Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1
    Giovanni Marsicano
    Department of Molecular Genetics of Behavior, Max Planck Institute of Psychiatry, Munich, Germany
    J Neurochem 80:448-56. 2002
    ..The results strongly suggest that CB1 is not involved in the cellular antioxidant neuroprotective effects of cannabinoids...
  18. ncbi request reprint Oxidative nerve cell death in Alzheimer's disease and stroke: antioxidants as neuroprotective compounds
    Christian Behl
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Chem 383:521-36. 2002
    ..Finally, an outlook is given on the neuroprotective potential of aromatic amines and imines, which may comprise novel lead structures for antioxidant drug design...
  19. ncbi request reprint Differential promotion of glutamate transporter expression and function by glucocorticoids in astrocytes from various brain regions
    Jürgen Zschocke
    Department of Pathobiochemistry, Johannes Gutenberg University Mainz, 55099 Mainz, Germany
    J Biol Chem 280:34924-32. 2005
    ..Taken together, our data highlight a potential role for glucocorticoids in regulating GLT-1 gene expression during central nervous system development or pathophysiological processes including stress...
  20. ncbi request reprint P-glycoprotein has negligible effects on estradiol and testosterone in mice
    Martin Ebinger
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Neurosci Lett 427:6-9. 2007
    ..The organ/plasma quotients showed no significant group effects. We concluded that P-gp does not influence the penetration of testosterone and estradiol to a biologically significant extent...
  21. ncbi request reprint O-glycosylation of the tail domain of neurofilament protein M in human neurons and in spinal cord tissue of a rat model of amyotrophic lateral sclerosis (ALS)
    Nina Lüdemann
    Department of Neurobiology, University of Osnabruck, Barbarastrasse 11, D 49076 Osnabrück
    J Biol Chem 280:31648-58. 2005
    ....
  22. pmc Concepts for the treatment of Alzheimer's disease: molecular mechanisms and clinical application
    Claus Pietrzik
    Department of Molecular Neurodegeneration, Institute for Physiological Chemistry and Pathochemistry, Johannes Gutenberg University Mainz, Medical School, 55099 Mainz, Germany
    Int J Exp Pathol 86:173-85. 2005
    ..Additionally, we summarize some of the experimental approaches in AD therapy, which might lead to the development of more promising drugs in the future...
  23. ncbi request reprint Antioxidants as treatment for neurodegenerative disorders
    Bernd Moosmann
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA
    Expert Opin Investig Drugs 11:1407-35. 2002
    ..Finally, an outlook as to which direction antioxidant drug development and clinical practice may be leading to in the near future will be provided...
  24. ncbi request reprint Neuroprotective strategies in Alzheimer's disease
    Christian Behl
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Adv Exp Med Biol 513:475-96. 2002
  25. ncbi request reprint Brain region-specific neuroprotective action and signaling of corticotropin-releasing hormone in primary neurons
    Nadhim Bayatti
    Independent Research Group Neurodegeneration, Max Planck Institute of Psychiatry, 80804 Munich, Germany Chemistry and Pathobiochemistry, Johannes Gutenberg University Mainz, 55099 Mainz, Germany
    Endocrinology 144:4051-60. 2003
    ..Differences in signaling were found to be independent of receptor expression levels because RT-PCR analysis indicated no region-specific differences in CRHR1 mRNA expression...
  26. ncbi request reprint CB1 cannabinoid receptors and on-demand defense against excitotoxicity
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, 80804 Munich, Germany
    Science 302:84-8. 2003
    ..These protective mechanisms could not be triggered in mutant mice. The endogenous cannabinoid system thus provides on-demand protection against acute excitotoxicity in central nervous system neurons...
  27. ncbi request reprint Estrogen receptor (ER)-mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERalpha and ERbeta
    Anja van de Stolpe
    Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Mol Endocrinol 18:2908-23. 2004
    ....
  28. ncbi request reprint Inactivation of glycogen synthase kinase-3beta protects against kainic acid-induced neurotoxicity in vivo
    Sharon Goodenough
    Department of Pathobiochemistry, Johannes Gutenberg University, Mainz, Germany
    Brain Res 1026:116-25. 2004
    ..This work supports a role for GSK-3beta in cell death in response to excitotoxins in vivo and further confirms that GSK-3beta plays a role in cell death/cell survival pathways...
  29. ncbi request reprint Caveolin and GLT-1 gene expression is reciprocally regulated in primary astrocytes: association of GLT-1 with non-caveolar lipid rafts
    Jürgen Zschocke
    Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University, Mainz, Germany
    Glia 49:275-87. 2005
    ..We also provide strong evidence that GLT-1 itself is concentrated in lipid rafts, inferring an important role for glial glutamate transporter function...
  30. ncbi request reprint Corticotropin-releasing hormone-mediated induction of intracellular signaling pathways and brain-derived neurotrophic factor expression is inhibited by the activation of the endocannabinoid system
    Nadhim Bayatti
    Department of Pathobiochemistry, Johannes Gutenberg University Mainz Medical School, 55099 Mainz, Germany
    Endocrinology 146:1205-13. 2005
    ..Thus, these data highlight an interaction between the CRH and the cannabinoid system in the regulation of BDNF expression by influencing cAMP and Ca2+ signaling pathways...
  31. ncbi request reprint Secretory peptide hormones are biochemical antioxidants: structure-activity relationship
    Bernd Moosmann
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Pharmacol 61:260-8. 2002
    ....