Peter B Becker

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc Cumulative contributions of weak DNA determinants to targeting the Drosophila dosage compensation complex
    Gregor D Gilfillan
    Adolf Butenandt Institut, Molekularbiologie, Ludwig Maximilian Universität, Schillerstrasse 44, 80336 Munich, Germany
    Nucleic Acids Res 35:3561-72. 2007
  2. pmc Nucleosome sliding: facts and fiction
    Peter B Becker
    Adolf Butenandt Institut, Molekularbiologie, Ludwig Maximilians Universitat, D 80336 MUnchen, Germany
    EMBO J 21:4749-53. 2002
  3. ncbi request reprint ATP-dependent nucleosome remodeling
    Peter B Becker
    Adolf Butenandt Institut, Molekularbiologie, 80336 Munich, Germany
    Annu Rev Biochem 71:247-73. 2002
  4. pmc Site-specific acetylation of ISWI by GCN5
    Roger Ferreira
    Adolf Butenandt Institut, Molekularbiologie, 80336 Munchen, Germany
    BMC Mol Biol 8:73. 2007
  5. doi request reprint The activation potential of MOF is constrained for dosage compensation
    Matthias Prestel
    Adolf Butenandt Institute and Centre for Integrated Protein Science, Ludwig Maximilians University, 80336 Munich, Germany
    Mol Cell 38:815-26. 2010
  6. ncbi request reprint Lifting a chromosome: dosage compensation in Drosophila melanogaster
    Gregor D Gilfillan
    Adolf Butenandt Institut, Molekularbiologie Schillerstrasse 44, 80336 Munich, Germany
    FEBS Lett 567:8-14. 2004
  7. pmc The DNA binding CXC domain of MSL2 is required for faithful targeting the Dosage Compensation Complex to the X chromosome
    Torsten Fauth
    Adolf Butenandt Institute and Centre for Integrated Protein Science, Ludwig Maximilians University, 80336 Munich, Germany
    Nucleic Acids Res 38:3209-21. 2010
  8. pmc The MRG domain mediates the functional integration of MSL3 into the dosage compensation complex
    Violette Morales
    Adolf Butenandt Institut, Molekularbiologie, Schillerstr 44, 80336 Munchen, Germany
    Mol Cell Biol 25:5947-54. 2005
  9. pmc Drosophila ISWI regulates the association of histone H1 with interphase chromosomes in vivo
    Giorgia Siriaco
    Adolf Butenandt Institute, Molecular Biology, Munich Center of Integrated Protein Science, Ludwig Maximilians University, 80336 Munich, Germany
    Genetics 182:661-9. 2009
  10. ncbi request reprint Dosage compensation: the beginning and end of generalization
    Tobias Straub
    Adolf Butenandt Institute, Department of Molecular Biology, Ludwig Maximilians University, 80336 Munich, Germany
    Nat Rev Genet 8:47-57. 2007

Collaborators

Detail Information

Publications52

  1. pmc Cumulative contributions of weak DNA determinants to targeting the Drosophila dosage compensation complex
    Gregor D Gilfillan
    Adolf Butenandt Institut, Molekularbiologie, Ludwig Maximilian Universität, Schillerstrasse 44, 80336 Munich, Germany
    Nucleic Acids Res 35:3561-72. 2007
    ..The results support a model for MSL2 recruitment according to which several different, degenerate sequence motifs of variable affinity cluster and synergise to form a high affinity site...
  2. pmc Nucleosome sliding: facts and fiction
    Peter B Becker
    Adolf Butenandt Institut, Molekularbiologie, Ludwig Maximilians Universitat, D 80336 MUnchen, Germany
    EMBO J 21:4749-53. 2002
    ..This review discusses the possible roles for nucleosome sliding in the assembly and maintenance of dynamic chromatin and for the regulation of diverse functions in eukaryotic nuclei...
  3. ncbi request reprint ATP-dependent nucleosome remodeling
    Peter B Becker
    Adolf Butenandt Institut, Molekularbiologie, 80336 Munich, Germany
    Annu Rev Biochem 71:247-73. 2002
    ....
  4. pmc Site-specific acetylation of ISWI by GCN5
    Roger Ferreira
    Adolf Butenandt Institut, Molekularbiologie, 80336 Munchen, Germany
    BMC Mol Biol 8:73. 2007
    ..The diversity of nucleosome remodelling factors is reflected by a multitude of ATPase complexes with distinct subunit composition...
  5. doi request reprint The activation potential of MOF is constrained for dosage compensation
    Matthias Prestel
    Adolf Butenandt Institute and Centre for Integrated Protein Science, Ludwig Maximilians University, 80336 Munich, Germany
    Mol Cell 38:815-26. 2010
    ....
  6. ncbi request reprint Lifting a chromosome: dosage compensation in Drosophila melanogaster
    Gregor D Gilfillan
    Adolf Butenandt Institut, Molekularbiologie Schillerstrasse 44, 80336 Munich, Germany
    FEBS Lett 567:8-14. 2004
    ..Deciphering the principles of X chromosome recognition and the nature of the chromatin configuration, that allows fine-tuning of transcription, remain the most interesting challenges...
  7. pmc The DNA binding CXC domain of MSL2 is required for faithful targeting the Dosage Compensation Complex to the X chromosome
    Torsten Fauth
    Adolf Butenandt Institute and Centre for Integrated Protein Science, Ludwig Maximilians University, 80336 Munich, Germany
    Nucleic Acids Res 38:3209-21. 2010
    ..Reporter gene assays and localization of GFP-fusion proteins confirm the important contribution of the CXC domain for DCC targeting in vivo...
  8. pmc The MRG domain mediates the functional integration of MSL3 into the dosage compensation complex
    Violette Morales
    Adolf Butenandt Institut, Molekularbiologie, Schillerstr 44, 80336 Munchen, Germany
    Mol Cell Biol 25:5947-54. 2005
    ..An N-terminal truncation that lacks the chromo-related domain and all nucleic acid binding activity is able to trigger de novo assembly of the DCC and establishment of an acetylated X-chromosome territory...
  9. pmc Drosophila ISWI regulates the association of histone H1 with interphase chromosomes in vivo
    Giorgia Siriaco
    Adolf Butenandt Institute, Molecular Biology, Munich Center of Integrated Protein Science, Ludwig Maximilians University, 80336 Munich, Germany
    Genetics 182:661-9. 2009
    ..Our findings suggest that ISWI regulates higher-order chromatin structure by modulating the interaction of H1 with interphase chromosomes...
  10. ncbi request reprint Dosage compensation: the beginning and end of generalization
    Tobias Straub
    Adolf Butenandt Institute, Department of Molecular Biology, Ludwig Maximilians University, 80336 Munich, Germany
    Nat Rev Genet 8:47-57. 2007
    ....
  11. doi request reprint The ATPase domain of ISWI is an autonomous nucleosome remodeling machine
    Felix Mueller-Planitz
    Adolf Butenandt Institut, Ludwig Maximilians Universitat, Munich, Germany
    Nat Struct Mol Biol 20:82-9. 2013
    ..Nucleosome-remodeling enzymes may thus have evolved directly from ancestral helicase-type motors, and peripheral domains have furnished regulatory capabilities that bias the remodeling reaction toward different structural outcomes...
  12. pmc Targeting determinants of dosage compensation in Drosophila
    Ina K Dahlsveen
    Adolf Butenandt Institut, Molekularbiologie, Ludwig Maximilians Universitat Munchen, Munich, Germany
    PLoS Genet 2:e5. 2006
    ..Our bioinformatics analysis suggests that DCC binding sites may be composed of variable combinations of degenerate motifs...
  13. pmc Functional integration of the histone acetyltransferase MOF into the dosage compensation complex
    Violette Morales
    Adolf Butenandt Institut, Molekularbiologie, Munich, Germany
    EMBO J 23:2258-68. 2004
    ..Activation of MOF's HAT activity upon integration into the DCC may serve to restrict the critical histone modification to the male X chromosome...
  14. pmc The dosage compensation complex shapes the conformation of the X chromosome in Drosophila
    Charlotte Grimaud
    Adolf Butenandt Institute and Centre for Integrated Protein Science CiPSM, Ludwig Maximilians University, 80336 Munich, Germany
    Genes Dev 23:2490-5. 2009
    ..We propose that nuclear organization of HAS is central to the faithful distribution of the DCC along the X chromosome...
  15. pmc Chromosome-wide gene-specific targeting of the Drosophila dosage compensation complex
    Gregor D Gilfillan
    Adolf Butenandt Institut, Molekularbiologie, Ludwig Maximilians Universitat Munchen, 80336 Munchen, Germany
    Genes Dev 20:858-70. 2006
    ..Within the targeted genes, the DCC exhibits a strong preference for exons and coding sequences. Our results demonstrate gene-specific binding of the DCC, and identify several sequence elements that may partly direct its targeting...
  16. pmc ACF1 improves the effectiveness of nucleosome mobilization by ISWI through PHD-histone contacts
    Anton Eberharter
    Adolf Butenandt Institut, Molekularbiologie, Munchen, Germany
    EMBO J 23:4029-39. 2004
    ..Connecting ACF to histones may be prerequisite for efficient conversion of ATP-dependent conformational changes of ISWI into translocation of DNA relative to the histones during nucleosome mobilization...
  17. ncbi request reprint Dosage compensation in flies: mechanism, models, mystery
    Tobias Straub
    Adolf Butenandt Institut, Molekularbiologie, Schillerstrasse 44, 80336 Munchen, Germany
    FEBS Lett 579:3258-63. 2005
    ..We discuss the prevalent models in the context of recent experimental observations...
  18. doi request reprint MSL2 combines sensor and effector functions in homeostatic control of the Drosophila dosage compensation machinery
    Raffaella Villa
    Molecular Biology Unit, Adolf Butenandt Institute and Center for Integrated Protein Science, Ludwig Maximilians University, 80336 Munich, Germany
    Mol Cell 48:647-54. 2012
    ..Furthermore, systematic mapping of modification sites by mass spectrometry and chromatin interaction studies on the target protein MSL1 suggest that the role of MSL2-mediated ubiquitylation goes beyond proteolysis...
  19. pmc The Drosophila MSL complex activates the transcription of target genes
    Tobias Straub
    Adolf Butenandt Institute, Molecular Biology Unit, Ludwig Maximilians University, 80336 Munich, Germany
    Genes Dev 19:2284-8. 2005
    ..The results unequivocally document an approximate twofold activation of target genes by the MSL complex...
  20. pmc ACF catalyses chromatosome movements in chromatin fibres
    Verena K Maier
    Molekularbiologie, Adolf Butenandt Institut, Ludwig Maximilian Universität, Munich, Germany
    EMBO J 27:817-26. 2008
    ..This first demonstration of catalysed chromatosome movements suggests that the bulk of interphase euchromatin may be rendered dynamic by dedicated nucleosome-remodelling factors...
  21. ncbi request reprint Nucleosome remodeling: one mechanism, many phenomena?
    Gernot Längst
    Adolf Butenandt Institut, Molekularbiologie, Ludwig Maximilians University Munchen, Schillerstrasse 44, D 80336 Munich, Germany
    Biochim Biophys Acta 1677:58-63. 2004
    ..This review explores the alternative possibility that the rich phenomenology of nucleosome remodeling may be brought about by variations of one basic remodeling reaction...
  22. ncbi request reprint A nucleosome sliding assay for chromatin remodeling factors
    Anton Eberharter
    Adolf Butenandt Institut, Molekularbiologie, München D 80336, Germany
    Methods Enzymol 377:344-53. 2004
  23. pmc The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding
    Tiziana Bonaldi
    Adolf Butenandt Institut, Molekularbiologie, Schillerstrasse 44, D 80336 MUnchen, Germany
    EMBO J 21:6865-73. 2002
    ..By contrast, an HMGB1 mutant with increased binding affinity was inhibitory. These observations are consistent with a role for HMGB1 as a DNA chaperone facilitating the rate-limiting DNA distortion during nucleosome remodelling...
  24. ncbi request reprint ATP-dependent nucleosome remodelling: factors and functions
    Anton Eberharter
    Adolf Butenandt Institut, Molekularbiologie, Schillerstr 44, 80336 Munchen, Germany
    J Cell Sci 117:3707-11. 2004
  25. pmc The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization
    Karim Bouazoune
    Adolf Butenandt Institut, Molekularbiologie, Ludwig Maximilians Universitat, Schillerstrasse 44, D 80336 MUnchen, Germany
    EMBO J 21:2430-40. 2002
    ..Furthermore, we identify DNA binding as a novel chromodomain-associated activity...
  26. ncbi request reprint The many colours of chromodomains
    Alexander Brehm
    Adolf Butenandt Institut, Molekularbiologie, Munchen, Germany
    Bioessays 26:133-40. 2004
    ....
  27. doi request reprint ATP-dependent chromatosome remodeling
    Verena K Maier
    Adolf Butenandt Institut, Abt Molekularbiologie, and Münchner Zentrum für Integrierte Proteinforschung, Ludwig Maximilian Universitat Munchen, Schillerstrasse 44, D 80336 MUnchen, Germany
    Biol Chem 389:345-52. 2008
    ..Recent findings suggest that some remodeling machines can reorganize even folded chromatin fibers containing the linker histone H1, extending the potential scope of remodeling reactions to the bulk of euchromatin...
  28. pmc Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics
    Anton Eberharter
    Adolf Butenandt Institut, Molekularbiologie, Ludwig Maximilians Universitat, Schillerstrasse 44, D 80336 MUnchen, Germany
    EMBO Rep 3:224-9. 2002
    ..The targeting of enzymes that modulate the histone acetylation status of chromatin, in synergy with the effects mediated by other chromatin remodeling factors, is central to gene regulation...
  29. doi request reprint Transcription modulation chromosome-wide: universal features and principles of dosage compensation in worms and flies
    Tobias Straub
    Adolf Butenandt Institut and Center for Integrated Protein Science Munich CIPSM, Ludwig Maximilians Universitat, Schillerstrasse 44, D 80336 Munich, Germany
    Curr Opin Genet Dev 21:147-53. 2011
    ....
  30. doi request reprint Preparation of chromatin assembly extracts from preblastoderm Drosophila embryos
    Edgar Bonte
    Molekularbiologie, Adolf Butenandt Institut, Munchen, Germany
    Methods Mol Biol 523:1-10. 2009
    ..The resulting chromatin is an excellent approximation of physiological chromatin in vivo. This chapter describes the preparation of chromatin assembly extracts and the chromatin assembly reaction...
  31. doi request reprint DNA sequence and the organization of chromosomal domains
    Tobias Straub
    Adolf Butenandt Institut and Center for Integrated Protein Science Munich, Ludwig Maximilian Universität, Schillerstrasse 44, D 80336 Munich, Germany
    Curr Opin Genet Dev 18:175-80. 2008
    ..Inspiration and motivation for this discourse comes from the unresolved question of how X chromosomes are identified for dosage compensation...
  32. doi request reprint Nucleosome sliding mechanisms: new twists in a looped history
    Felix Mueller-Planitz
    1 Adolf Butenandt Institute, Ludwig Maximilians Universitat, Munich, Germany 2 Center for Integrated Protein Science Munich, Ludwig Maximilians Universitat, Munich, Germany
    Nat Struct Mol Biol 20:1026-32. 2013
    ..Such domains optimize and regulate the basic sliding reaction and exploit sliding to achieve diverse structural effects, such as nucleosome positioning or eviction, or the regular spacing of nucleosomes in chromatin. ..
  33. ncbi request reprint Gene regulation by histone H1: new links to DNA methylation
    Ralph A W Rupp
    Adolf Butenandt Institut, Molekularbiologie, Schillerstr 44 80336 München, Germany
    Cell 123:1178-9. 2005
    ..Although a 50% reduction of histone H1 levels in embryonic stem cells affects chromatin structure globally, the expression of very few genes is altered. Intriguingly, this study reveals a new link between H1 and DNA methylation...
  34. pmc A critical epitope for substrate recognition by the nucleosome remodeling ATPase ISWI
    Cedric R Clapier
    Adolf Butenandt Institut, Molekularbiologie, Ludwig Maximilians Universitat Munchen, Schillerstrasse 44, 80336 Munchen, Germany
    Nucleic Acids Res 30:649-55. 2002
    ..Consistent with this hypothesis, the ISWI ATPase is stimulated by isolated H4 tail peptides ISWI only in the presence of DNA. Acetylation of the adjacent K12 and K16 residues impairs substrate recognition by ISWI...
  35. pmc Dosage compensation and the global re-balancing of aneuploid genomes
    Matthias Prestel
    Adolf Butenandt Institute and Centre for Integrated Protein Science CiPSM, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
    Genome Biol 11:216. 2010
    ..The dosage-compensation systems that evolved along with monosomic sex chromosomes exemplify the intricacies of compensating for differences in gene copy number by transcriptional regulation...
  36. doi request reprint Nucleosome dynamics and epigenetic stability
    Philipp Korber
    Adolf Butenandt Institute, Ludwig Maximilians University, 80336 Munich, Germany
    Essays Biochem 48:63-74. 2010
    ..All of them may contribute to the assembly of heritable epigenetic structures...
  37. ncbi request reprint Wolfram Hörz 1944-2005
    Peter B Becker
    Adolf Butenandt Institut, Molekularbiologie, D 80336 MUnchen, Germany
    Cell 124:13-4. 2006
  38. ncbi request reprint Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI
    Tim Grüne
    European Molecular Biology Laboratory, Grenoble Outstation, B P 181, F 38042 Grenoble 9, France
    Mol Cell 12:449-60. 2003
    ..An integrated structural and functional analysis of these domains provides insight into how ISWI interacts with the nucleosomal substrate...
  39. ncbi request reprint Sequence-specific targeting of Drosophila roX genes by the MSL dosage compensation complex
    Yongkyu Park
    Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Cell 11:977-86. 2003
    ..Our results are consistent with a model in which nascent roX RNA assembly with MSL proteins is an early step in the initiation of dosage compensation...
  40. ncbi request reprint Ran binds to chromatin by two distinct mechanisms
    Daniel Bilbao-Cortes
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Curr Biol 12:1151-6. 2002
    ..We propose that the Ran binding capacity of chromatin contributes to localized spindle and NE assembly...
  41. pmc Modulation of ISWI function by site-specific histone acetylation
    Davide F V Corona
    Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA
    EMBO Rep 3:242-7. 2002
    ..These findings suggest that H4K16 acetylation directly counteracts chromatin compaction mediated by the ISWI ATPase...
  42. ncbi request reprint Analysis of activator-dependent transcription reinitiation in vitro
    Raphael Sandaltzopoulos
    Department of Molecular Biology, Democritus University of Thrace, University Hospital at Dragana, G 68100 Alexandroupolis, Greece
    Methods Enzymol 370:487-501. 2003
  43. pmc Recruitment of the nucleolar remodeling complex NoRC establishes ribosomal DNA silencing in chromatin
    Ralf Strohner
    Adolf Butenandt Institut, Molekularbiologie, Ludwig Maximilians Universitat, 80336 Munich German
    Mol Cell Biol 24:1791-8. 2004
    ..These results reveal an important role for TTF-I in recruiting NoRC to rDNA and an active role for NoRC in the establishment of rDNA silencing...
  44. ncbi request reprint Nucleosome binding by the bromodomain and PHD finger of the transcriptional cofactor p300
    Anja Ragvin
    Department of Molecular Biology, University of Bergen, HIB, Thormohlensgt 55, N 5020 Bergen, Norway
    J Mol Biol 337:773-88. 2004
    ..Our data are consistent with a model where the two domains cooperate in nucleosome binding. In this model, both the bromodomain and the PHD finger contact the nucleosome while simultaneously interacting with each other...
  45. ncbi request reprint Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment
    Tobias Straub
    Department of Molecular Biology, Adolf Butenandt Institute, Schillerstr 44, 80336, Munich, Germany
    Chromosoma 114:352-64. 2005
    ..Our findings have profound implications for the mechanism underlying dosage compensation and furthermore provide a new, conceptual reference of stability in an otherwise highly dynamic nuclear environment...
  46. pmc Structure-function analysis of the RNA helicase maleless
    Annalisa Izzo
    Adolf Butenandt Institut and Center of integrated Protein Science, Munchen, Germany
    Nucleic Acids Res 36:950-62. 2008
    ..The C-terminal domain containing a glycine-rich heptad repeat adds potential dimerization and RNA-binding surfaces which are not required for helicase activity...
  47. pmc The histone fold subunits of Drosophila CHRAC facilitate nucleosome sliding through dynamic DNA interactions
    Klaus F Hartlepp
    European Molecular Biology Laboratory, Grenoble Outstation, France
    Mol Cell Biol 25:9886-96. 2005
    ....
  48. ncbi request reprint Gene regulation: a finger on the mark
    Peter B Becker
    Nature 442:31-2. 2006
  49. doi request reprint Combined use of RNAi and quantitative proteomics to study gene function in Drosophila
    Tiziana Bonaldi
    Max Planck Institute of Biochemistry, Department of Proteomics and Signal Transduction, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Mol Cell 31:762-72. 2008
    ..We found little overall correlation between changes in the transcriptome and proteome with many protein changes unaccompanied by message changes. However, correlation was high for those mRNAs that changed significantly by microarray...
  50. ncbi request reprint Nucleosome remodelers on track
    Peter B Becker
    Nat Struct Mol Biol 12:732-3. 2005
  51. pmc Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination
    Karl P Nightingale
    Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Nucleic Acids Res 35:6311-21. 2007
    ....
  52. ncbi request reprint Regulation of higher-order chromatin structures by nucleosome-remodelling factors
    Patrick D Varga-Weisz
    Babraham Institute, Cambridge, CB2 4AT, UK
    Curr Opin Genet Dev 16:151-6. 2006
    ..Recent observations support roles for nucleosome-remodelling factors at the supra-nucleosomal level...