Peter B Becker
Affiliation: University of Munich
Prabu J, MÃ¼ller M, Thomae A, SchÃ¼ssler S, Bonneau F, Becker P, et al
. Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling. Mol Cell. 2015;60:487-99 pubmed publisher
..The structure visualizes a transition-state mimic of the reaction and suggests how eukaryotic DEAH/RHA helicases couple ATP hydrolysis to RNA translocation. ..
Jain D, Baldi S, Zabel A, Straub T, Becker P. Active promoters give rise to false positive 'Phantom Peaks' in ChIP-seq experiments. Nucleic Acids Res. 2015;43:6959-68 pubmed publisher
..These profiles and other ChIP-seq data featuring prominent Phantom Peaks must be validated with chromatin from cells in which the protein of interest has been depleted. ..
BÃ¶rner K, Jain D, Vazquez Pianzola P, Vengadasalam S, Steffen N, Fyodorov D, et al
. A role for tuned levels of nucleosome remodeler subunit ACF1 during Drosophila oogenesis. Dev Biol. 2016;411:217-230 pubmed publisher
..Remarkably, a two-fold overexpression of CHRAC (ACF1 and CHRAC-16) leads to increased apoptosis and packaging defects. Evidently, finely tuned CHRAC levels are required for proper oogenesis. ..
Becker P, Workman J. Nucleosome remodeling and epigenetics. Cold Spring Harb Perspect Biol. 2013;5: pubmed publisher
..Remodeling processes participate in every aspect of genome function. Remodeling activities are commonly integrated with other mechanisms such as histone modifications or RNA metabolism to assemble stable, epigenetic states. ..
Feller C, FornÃ© I, Imhof A, Becker P. Global and specific responses of the histone acetylome to systematic perturbation. Mol Cell. 2015;57:559-71 pubmed publisher
..Conceivably, the acetylation level is adjusted to maintain the global charge neutralization of chromatin and the stability of nuclei. ..
Börner K, Becker P. Splice variants of the SWR1-type nucleosome remodeling factor Domino have distinct functions during Drosophila melanogaster oogenesis. Development. 2016;143:3154-67 pubmed publisher
..By contrast, DOM-A promotes the removal of H2A.V from stage 5 nurse cells. Remarkably, therefore, the two DOM isoforms have distinct functions in cell type-specific development and H2A.V exchange. ..