Holger M Becker

Summary

Affiliation: University of Kaiserslautern
Country: Germany

Publications

  1. ncbi request reprint Carbonic anhydrases and their interplay with acid/base-coupled membrane transporters
    Holger M Becker
    Division of Zoology Membrane Transport, Department of Biology, University of Kaiserslautern, Kaiserslautern, Germany
    Subcell Biochem 75:105-34. 2014
  2. pmc Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II
    Holger M Becker
    AG Zoologie Membrantransport and Abteilung für Allgemeine Zoologie, FB Biologie, University of Kaiserslautern, D 67653 Kaiserslautern, Germany
    Proc Natl Acad Sci U S A 108:3071-6. 2011
  3. doi request reprint Nonenzymatic augmentation of lactate transport via monocarboxylate transporter isoform 4 by carbonic anhydrase II
    Holger M Becker
    Arbeitsgruppe Zoologie Membrantransport, FB Biologie, TU Kaiserslautern, P O Box 3049, 67653, Kaiserslautern, Germany
    J Membr Biol 234:125-35. 2010
  4. ncbi request reprint Carbonic anhydrase II increases the activity of the human electrogenic Na+/HCO3- cotransporter
    Holger M Becker
    Abteilung fur Allgemeine Zoologie, Fachbereich Biologie, Technische Universitat Kaiserslautern, P O Box 3049, D 67653 Kaiserslautern, Germany
    J Biol Chem 282:13508-21. 2007
  5. ncbi request reprint The sodium-bicarbonate cotransporter NBCe1 supports glutamine efflux via SNAT3 (SLC38A3) co-expressed in Xenopus oocytes
    Christina Wendel
    Abteilung fur Allgemeine Zoologie, FB Biologie, TU Kaiserslautern, P O Box 3049, 67653 Kaiserslautern, Germany
    Pflugers Arch 455:885-93. 2008
  6. pmc GPI-anchored carbonic anhydrase IV displays both intra- and extracellular activity in cRNA-injected oocytes and in mouse neurons
    Hans Peter Schneider
    Abteilung fur Allgemeine Zoologie, Fachbereich Biologie, University of Kaiserslautern, D 67653 Kaiserslautern, Germany
    Proc Natl Acad Sci U S A 110:1494-9. 2013
  7. doi request reprint Nonenzymatic proton handling by carbonic anhydrase II during H+-lactate cotransport via monocarboxylate transporter 1
    Holger M Becker
    Abteilung fur Allgemeine Zoologie, FB Biologie, Technische Universitat Kaiserslautern, Kaiserslautern, Germany
    J Biol Chem 283:21655-67. 2008
  8. ncbi request reprint Transport activity of MCT1 expressed in Xenopus oocytes is increased by interaction with carbonic anhydrase
    Holger M Becker
    Abteilungen, Allgemeine Zoologie, Fachbereich Biologie, Technische Universitat Kaiserslautern, D 67653 Kaiserslautern, Germany
    J Biol Chem 280:39882-9. 2005
  9. pmc Transport activity of the sodium bicarbonate cotransporter NBCe1 is enhanced by different isoforms of carbonic anhydrase
    Christina Schueler
    Abteilung fur Allgemeine Zoologie, FB Biologie, TU Kaiserslautern, Kaiserslautern, Germany
    PLoS ONE 6:e27167. 2011
  10. pmc Enzymatic suppression of the membrane conductance associated with the glutamine transporter SNAT3 expressed in Xenopus oocytes by carbonic anhydrase II
    Alexandra Weise
    Abteilung fur Allgemeine Zoologie, FB Biologie, Universitaet Kaiserslautern, D 67653 Kaiserslautern, Germany
    J Gen Physiol 130:203-15. 2007

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Carbonic anhydrases and their interplay with acid/base-coupled membrane transporters
    Holger M Becker
    Division of Zoology Membrane Transport, Department of Biology, University of Kaiserslautern, Kaiserslautern, Germany
    Subcell Biochem 75:105-34. 2014
    ..Furthermore, we discuss recent findings that indicate the significance of these 'transport metabolons' for normal cell functions. ..
  2. pmc Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II
    Holger M Becker
    AG Zoologie Membrantransport and Abteilung für Allgemeine Zoologie, FB Biologie, University of Kaiserslautern, D 67653 Kaiserslautern, Germany
    Proc Natl Acad Sci U S A 108:3071-6. 2011
    ....
  3. doi request reprint Nonenzymatic augmentation of lactate transport via monocarboxylate transporter isoform 4 by carbonic anhydrase II
    Holger M Becker
    Arbeitsgruppe Zoologie Membrantransport, FB Biologie, TU Kaiserslautern, P O Box 3049, 67653, Kaiserslautern, Germany
    J Membr Biol 234:125-35. 2010
    ....
  4. ncbi request reprint Carbonic anhydrase II increases the activity of the human electrogenic Na+/HCO3- cotransporter
    Holger M Becker
    Abteilung fur Allgemeine Zoologie, Fachbereich Biologie, Technische Universitat Kaiserslautern, P O Box 3049, D 67653 Kaiserslautern, Germany
    J Biol Chem 282:13508-21. 2007
    ..Our results show that the transport capacity of NBCe1 is enhanced by the catalytic activity of CAII, in line with the notion that CAII forms a transport metabolon with NBCe1...
  5. ncbi request reprint The sodium-bicarbonate cotransporter NBCe1 supports glutamine efflux via SNAT3 (SLC38A3) co-expressed in Xenopus oocytes
    Christina Wendel
    Abteilung fur Allgemeine Zoologie, FB Biologie, TU Kaiserslautern, P O Box 3049, 67653 Kaiserslautern, Germany
    Pflugers Arch 455:885-93. 2008
    ..A model is presented that attempts to explain the role of intracellular pH, bicarbonate transport, and buffering capacity mediated by NBCe1 for uptake and efflux of glutamine via SNAT3...
  6. pmc GPI-anchored carbonic anhydrase IV displays both intra- and extracellular activity in cRNA-injected oocytes and in mouse neurons
    Hans Peter Schneider
    Abteilung fur Allgemeine Zoologie, Fachbereich Biologie, University of Kaiserslautern, D 67653 Kaiserslautern, Germany
    Proc Natl Acad Sci U S A 110:1494-9. 2013
    ..Our results suggest that membrane-associated CA IV contributes robust catalytic activity intracellularly, and that this activity participates in regulating H(+) dynamics in the cytosol, both in injected oocytes and in mouse neurons...
  7. doi request reprint Nonenzymatic proton handling by carbonic anhydrase II during H+-lactate cotransport via monocarboxylate transporter 1
    Holger M Becker
    Abteilung fur Allgemeine Zoologie, FB Biologie, Technische Universitat Kaiserslautern, Kaiserslautern, Germany
    J Biol Chem 283:21655-67. 2008
    ..We present a hypothetical model in which the effective movement of H(+) into the bulk cytosol is increased by CAII, thus slowing the dissipation of the H(+) gradient across the cell membrane, which drives MCT1 activity...
  8. ncbi request reprint Transport activity of MCT1 expressed in Xenopus oocytes is increased by interaction with carbonic anhydrase
    Holger M Becker
    Abteilungen, Allgemeine Zoologie, Fachbereich Biologie, Technische Universitat Kaiserslautern, D 67653 Kaiserslautern, Germany
    J Biol Chem 280:39882-9. 2005
    ..Our results suggest that CA enhances MCT1 transport activity, independent of its enzymatic reaction center, presumably by binding to MCT1...
  9. pmc Transport activity of the sodium bicarbonate cotransporter NBCe1 is enhanced by different isoforms of carbonic anhydrase
    Christina Schueler
    Abteilung fur Allgemeine Zoologie, FB Biologie, TU Kaiserslautern, Kaiserslautern, Germany
    PLoS ONE 6:e27167. 2011
    ....
  10. pmc Enzymatic suppression of the membrane conductance associated with the glutamine transporter SNAT3 expressed in Xenopus oocytes by carbonic anhydrase II
    Alexandra Weise
    Abteilung fur Allgemeine Zoologie, FB Biologie, Universitaet Kaiserslautern, D 67653 Kaiserslautern, Germany
    J Gen Physiol 130:203-15. 2007
    ..This study also emphasizes the importance of carbonic anhydrase activity and the presence of CO(2)-bicarbonate buffers for membrane transport processes...
  11. ncbi request reprint Voltage dependence of H+ buffering mediated by sodium bicarbonate cotransport expressed in Xenopus oocytes
    Holger M Becker
    Abteilung fur Allgemeine Zoologie, Fachbereich Biologie, Technische Universitat Kaiserslautern, D 67653 Kaiserslautern, Germany
    J Biol Chem 279:28057-62. 2004
    ..Our results indicate that the electrogenic NBCe1 renders the cell membrane potential an effective regulator of intracellular H(+) buffering and acid/base-coupled metabolite transport...
  12. pmc Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II
    Malin H Stridh
    Division of General Zoology, Department of Biology, University of Kaiserslautern, PO Box 3049, D 67653 Kaiserslautern, Germany
    J Physiol 590:2333-51. 2012
    ..By this mechanism CAII could enhance transfer of lactate between astrocytes and neurons and thus provide the neurons with an increased supply of energy substrate...
  13. pmc Transport activity of the high-affinity monocarboxylate transporter MCT2 is enhanced by extracellular carbonic anhydrase IV but not by intracellular carbonic anhydrase II
    Michael Klier
    Abteilung fur Allgemeine Zoologie, Fachbereich Biologie, Technische Universitat Kaiserslautern, P O Box 3049, 67653 Kaiserslautern, Germany
    J Biol Chem 286:27781-91. 2011
    ..The data suggest that extracellular membrane-bound CAIV, but not cytosolic CAII, augments transport activity of MCT2 in a non-catalytic manner, possibly by facilitating a proton pathway other than His-88...
  14. pmc Facilitated lactate transport by MCT1 when coexpressed with the sodium bicarbonate cotransporter (NBC) in Xenopus oocytes
    Holger M Becker
    Abteilung für Zoologie, FB Biologie, Universitat Kaiserslautern, D 67653 Kaiserslautern, Germany
    Biophys J 86:235-47. 2004
    ..Hence these membrane transporters functionally cooperate and are able to increase ion/metabolite transport activity...