Christoph Becker

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. pmc STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    Geethanjali Pickert
    Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, 55131 Mainz, Germany
    J Exp Med 206:1465-72. 2009
  2. ncbi TGF-beta as a T cell regulator in colitis and colon cancer
    Christoph Becker
    Laboratory of Clinical Immunology, I Department of Medicine, University of Mainz, Obere Zahlbacher Str 63, 55131 Mainz, Germany
    Cytokine Growth Factor Rev 17:97-106. 2006
  3. pmc The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
    Jonas Mudter
    1st Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 118:2415-26. 2008
  4. ncbi Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells
    Sabine Dominitzki
    Laboratory of Immunology, Medical Clinic I, University of Mainz, Mainz, Germany
    J Immunol 179:2041-5. 2007
  5. doi Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer
    Maximilian J Waldner
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Inflamm Bowel Dis 16:559-67. 2010
  6. doi RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F
    Moritz Leppkes
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Gastroenterology 136:257-67. 2009
  7. ncbi Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis
    Christoph Becker
    Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
    J Immunol 177:2760-4. 2006
  8. ncbi TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    Christoph Becker
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Immunity 21:491-501. 2004
  9. pmc Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins
    Daniela Poppe
    Laboratory of Immunology, I Department of Medicine, University of Mainz, Mainz, Germany
    J Immunol 176:640-51. 2006
  10. ncbi EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation
    Stefan Wirtz
    Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
    J Immunol 174:2814-24. 2005

Collaborators

Detail Information

Publications22

  1. pmc STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    Geethanjali Pickert
    Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, 55131 Mainz, Germany
    J Exp Med 206:1465-72. 2009
    ..In summary, our data suggest that intestinal epithelial STAT3 activation regulates immune homeostasis in the gut by promoting IL-22-dependent mucosal wound healing...
  2. ncbi TGF-beta as a T cell regulator in colitis and colon cancer
    Christoph Becker
    Laboratory of Clinical Immunology, I Department of Medicine, University of Mainz, Obere Zahlbacher Str 63, 55131 Mainz, Germany
    Cytokine Growth Factor Rev 17:97-106. 2006
    ..TGF-beta not only mediates the suppression of effector T cells by Tregs, recent evidence also reveals a role for TGF-beta along with TCR stimulation in the peripheral induction of regulatory T cells from naïve CD4+CD25- cells...
  3. pmc The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
    Jonas Mudter
    1st Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 118:2415-26. 2008
    ..Taken together, our data identify IRF4 as a key regulator of mucosal IL-6 production in T cell-dependent experimental colitis and suggest that IRF4 might provide a therapeutic target for IBDs...
  4. ncbi Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells
    Sabine Dominitzki
    Laboratory of Immunology, Medical Clinic I, University of Mainz, Mainz, Germany
    J Immunol 179:2041-5. 2007
    ....
  5. doi Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer
    Maximilian J Waldner
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Inflamm Bowel Dis 16:559-67. 2010
    ..In the present study we aimed at assessing the role of perforin-dependent effector mechanisms in the immune response in a murine model of colitis-associated colon cancer...
  6. doi RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F
    Moritz Leppkes
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Gastroenterology 136:257-67. 2009
    ..We analyzed the roles of Th17 cells and the transcription factor retinoic acid receptor-related organ receptor (ROR)gamma, which regulates Th17 differentiation, in chronic intestinal inflammation...
  7. ncbi Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis
    Christoph Becker
    Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
    J Immunol 177:2760-4. 2006
    ..Taken together, our data identify cross-regulation of IL-12 expression by IL-23 as novel key regulatory pathway during initiation of T cell dependent colitis...
  8. ncbi TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    Christoph Becker
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Immunity 21:491-501. 2004
    ..Taken together, our data provide novel insights into TGF-beta signaling in colorectal cancer and suggest novel therapeutic approaches for colorectal cancer based on inhibition of TGF-beta-dependent IL-6 trans-signaling...
  9. pmc Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins
    Daniela Poppe
    Laboratory of Immunology, I Department of Medicine, University of Mainz, Mainz, Germany
    J Immunol 176:640-51. 2006
    ..These findings provide novel insights into the immunosuppressive effects of azathioprine and suggest that antagonists of the Vav-Rac signaling pathway may be useful for suppression of T cell-dependent pathogenic immune responses...
  10. ncbi EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation
    Stefan Wirtz
    Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
    J Immunol 174:2814-24. 2005
    ..Thus, EBI3 gene transcription in DCs is induced rapidly by TLR signaling during innate immune responses preceding cytokine driven Th cell development...
  11. ncbi Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
    Massimo C Fantini
    Laboratory of Immunology, I Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Immunol 172:5149-53. 2004
    ..In summary, we demonstrate that TGF-beta induces a regulatory phenotype in CD4(+)CD25(-) T cells through the induction of Foxp3 and a positive autoregulatory loop of TGF-beta signaling due to the absence of Smad7...
  12. ncbi IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1
    Clemens Neufert
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Mainz, Germany
    Eur J Immunol 37:1809-16. 2007
    ..Our data thus demonstrate that IL-27 controls the development of Th17 and iTreg cells via differential effects on STAT1...
  13. ncbi A critical regulatory role of leucin zipper transcription factor c-Maf in Th1-mediated experimental colitis
    Benno Weigmann
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    J Immunol 173:3446-55. 2004
    ..Targeting of c-Maf in memory T cells in CD appears to be an attractive target for therapeutic interventions...
  14. doi A variant of Smurf2 protects mice against colitis-associated colon cancer by inducing transforming growth factor β signaling
    Heike Dornhoff
    Department of Medicine, University of Erlangen Nuremberg, Erlangen and Nuremberg, Germany
    Gastroenterology 142:1183-1194.e4. 2012
    ..We identified a splice variant of Smurf2 (ΔE2Smurf2) and investigated its role in colon carcinogenesis in mice...
  15. pmc The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer
    Imke Atreya
    I Department of Medicine, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Gut 56:1572-8. 2007
    ..Furthermore, TGF-beta and IL4 could be identified as important inducer of eomesodermin expression...
  16. ncbi An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression
    Clemens Neufert
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    Nat Protoc 2:1998-2004. 2007
    ..Different scoring systems including number of tumors and tumor size identify factors promoting or inhibiting tumor initiation and/or tumor progression, respectively...
  17. pmc Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
    Christoph Becker
    Laboratory of Immunology I, Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 112:693-706. 2003
    ....
  18. ncbi Stepwise regulation of TH1 responses in autoimmunity: IL-12-related cytokines and their receptors
    Christoph Becker
    Laboratory of Immunology, I Department of Medicine, University of Mainz, Germany
    Inflamm Bowel Dis 11:755-64. 2005
    ..This review focuses on these novel cytokines and their role in cell-mediated immune responses and discusses differences and common features within the family of IL-12-related cytokines...
  19. ncbi Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue
    Benno Weigmann
    I Med Clinic, Immunological Laboratory, Johannes Gutenberg University, Obere Zahlbacherstrasse 63, 55131 Mainz, Germany
    Nat Protoc 2:2307-11. 2007
    ..Finally, the isolated cells can be used for further investigations like comparative studies of mRNA expression, cell-proliferation assay or protein analysis. This protocol can be completed within 6-7 h...
  20. pmc CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
    Imke Tiede
    Laboratory of Immunology, Department of Medicine, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    J Clin Invest 111:1133-45. 2003
    ..These findings explain the immunosuppressive effects of azathioprine and suggest that 6-Thio-GTP derivates may be useful as potent immunosuppressive agents in autoimmune diseases and organ transplantation...
  21. ncbi Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, Mainz, Germany
    J Immunol 168:411-20. 2002
    ....
  22. ncbi Angiogenesis, immune system and growth factors: new targets in colorectal cancer therapy
    Massimo C Fantini
    Laboratory of Immunology, I Medical Clinic, Johannes Gutenberg University, 55131 Mainz, Obere Zahlbacher Str 63, Germany
    Expert Rev Anticancer Ther 5:681-94. 2005
    ..Tumor-induced angiogenesis, the cancer-immune system crosstalk and the effect of growth factors on dysplastic cells represent new fields of investigation for anticancer therapy...