T A Bayer

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi It all sticks together--the APP-related family of proteins and Alzheimer's disease
    T A Bayer
    Department of Psychiatry, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Mol Psychiatry 4:524-8. 1999
  2. ncbi Migratory potential of transplantable neural tumor cell lines
    T A Bayer
    Department of Psychiatry, University of Bonn Medical Center, Germany
    Acta Neuropathol 97:607-12. 1999
  3. ncbi Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores
    T A Bayer
    Department of Psychiatry, University of Bonn Medical Center, Germany
    Neurosci Lett 266:213-6. 1999
  4. ncbi Evidence for activation of microglia in patients with psychiatric illnesses
    T A Bayer
    Department of Psychiatry, University of Bonn Medical Center, Germany
    Neurosci Lett 271:126-8. 1999
  5. ncbi Key factors in Alzheimer's disease: beta-amyloid precursor protein processing, metabolism and intraneuronal transport
    T A Bayer
    Department of Psychiatry, University of Bonn Medical Center, Germany
    Brain Pathol 11:1-11. 2001
  6. ncbi Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice
    O Wirths
    Department of Psychiatry, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany
    Neurosci Lett 306:116-20. 2001
  7. ncbi Gender dependent APP processing in a transgenic mouse model of Alzheimer's disease
    S Schafer
    Department of Psychiatry, Division of Neurobiology, Saarland University, Homburg Saar, Germany
    J Neural Transm 114:387-94. 2007
  8. ncbi Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice
    O Wirths
    Department of Psychiatry, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 316:145-8. 2001
  9. ncbi Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer's disease
    T A Bayer
    Department of Neuropathology, University of Bonn Medical Center, Germany
    Acta Neuropathol 94:519-24. 1997
  10. ncbi Traumatic brain injury: cause or risk of Alzheimer's disease? A review of experimental studies
    J Szczygielski
    Department of Psychiatry, Section Neurobiology, Saarland University, Homburg, Germany
    J Neural Transm 112:1547-64. 2005

Collaborators

Detail Information

Publications21

  1. ncbi It all sticks together--the APP-related family of proteins and Alzheimer's disease
    T A Bayer
    Department of Psychiatry, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Mol Psychiatry 4:524-8. 1999
    ..We hypothesize that the functional loss of members of the APP family contributes to the gradual cognitive decline in Alzheimer's disease patients...
  2. ncbi Migratory potential of transplantable neural tumor cell lines
    T A Bayer
    Department of Psychiatry, University of Bonn Medical Center, Germany
    Acta Neuropathol 97:607-12. 1999
    ..These neural tumor cell lines provide a valuable tool for the development of strategies against strongly migrating neural tumors...
  3. ncbi Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores
    T A Bayer
    Department of Psychiatry, University of Bonn Medical Center, Germany
    Neurosci Lett 266:213-6. 1999
    ..These observations suggest that alpha-synuclein does not contribute to late neurodegenerative processes in AD brains...
  4. ncbi Evidence for activation of microglia in patients with psychiatric illnesses
    T A Bayer
    Department of Psychiatry, University of Bonn Medical Center, Germany
    Neurosci Lett 271:126-8. 1999
    ..The activation of microglia cells, which represent a major part of the brain immune response, may help to unravel the pathophysiological processes in severe psychiatric illnesses...
  5. ncbi Key factors in Alzheimer's disease: beta-amyloid precursor protein processing, metabolism and intraneuronal transport
    T A Bayer
    Department of Psychiatry, University of Bonn Medical Center, Germany
    Brain Pathol 11:1-11. 2001
    ..Beta-amyloid precursor protein has a pivotal role in Alzheimer's disease...
  6. ncbi Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice
    O Wirths
    Department of Psychiatry, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany
    Neurosci Lett 306:116-20. 2001
    ..Interestingly, intraneuronal Abeta staining was no longer detected in the brain of aged double-transgenic mice, which correlates with the typical neuropathology in the brain of chronic AD patients...
  7. ncbi Gender dependent APP processing in a transgenic mouse model of Alzheimer's disease
    S Schafer
    Department of Psychiatry, Division of Neurobiology, Saarland University, Homburg Saar, Germany
    J Neural Transm 114:387-94. 2007
    ....
  8. ncbi Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice
    O Wirths
    Department of Psychiatry, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 316:145-8. 2001
    ..This observation gives the first evidence for the association of reelin with amyloid deposits...
  9. ncbi Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer's disease
    T A Bayer
    Department of Neuropathology, University of Bonn Medical Center, Germany
    Acta Neuropathol 94:519-24. 1997
    ..Some astrocytes elicited perinuclear APLP1 staining, but this was observed in both AD and control brains. These findings raise the possibility that APLP1 may contribute to the pathogenesis of AD-associated neurodegeneration...
  10. ncbi Traumatic brain injury: cause or risk of Alzheimer's disease? A review of experimental studies
    J Szczygielski
    Department of Psychiatry, Section Neurobiology, Saarland University, Homburg, Germany
    J Neural Transm 112:1547-64. 2005
    ..We further evaluate the connection between traumatic brain insults and subsequent development of dementia and try to differentiate between primary and secondary pathological mechanisms...
  11. doi Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models
    O Wirths
    Division of Molecular Psychiatry, Department of Psychiatry, University of Goettingen, Goettingen, Germany
    Genes Brain Behav 7:1-5. 2008
    ..In addition, we summarize the state of knowledge on this phenotype in experimental mouse models, expressing AD-associated genes like tau or amyloid precursor protein...
  12. doi Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairment
    T A Bayer
    Division of Molecular Psychiatry, Department of Psychiatry, University of Goettingen, Goettingen, Germany
    Genes Brain Behav 7:6-11. 2008
    ..4) Onset of the observed behavioral alterations correlates well with robust axonal degeneration in brain and spinal cord and with abundant hippocampal CA1 neuron loss...
  13. ncbi Identification of amplified genes from SV40 large T antigen-induced rat PNET cell lines by subtractive cDNA analysis and radiation hybrid mapping
    S Weggen
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Oncogene 20:2023-31. 2001
    ..We propose that this simple cloning strategy may serve as a powerful tool for the isolation of genes implicated in known chromosomal aberrations in primary tumors and tumor cell lines...
  14. ncbi Analysis of a polymorphism in the tuberous sclerosis (TSC2) gene does not predispose to schizophrenia
    R Przkora
    Department of Neuropathology, University of Bonn Medical Center, Germany
    Eur Arch Psychiatry Clin Neurosci 248:314-5. 1998
    ..A 222-bp fragment of genomic DNA containing the TSC2 variant was analyzed by SSCP. The analysis revealed that there is no association with schizophrenia...
  15. ncbi Cholesterol synthesis rate in human hippocampus declines with aging
    K M Thelen
    Department of Clinical Pharmacology, University of Bonn Medical Center, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Neurosci Lett 403:15-9. 2006
    ..We conclude that during aging, cholesterol synthesis is decreased in the hippocampus, while absolute cholesterol content remains at a stable level...
  16. ncbi Disturbed gyrification of the prefrontal region in male schizophrenic patients: A morphometric postmortem study
    K Vogeley
    Department of Psychiatry, Freidrich Wilhelms University of Bonn, Germany
    Am J Psychiatry 157:34-9. 2000
    ..The goal was to test the hypothesis that abnormalities of gyrification are present in the prefrontal region of postmortem brains from schizophrenic patients...
  17. ncbi Review of immunological and immunopathological findings in schizophrenia
    M Rothermundt
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Brain Behav Immun 15:319-39. 2001
    ..On the basis of the findings, perspectives for future research are outlined aiming at a precise and consequent strategy to elucidate a potential involvement of immune mechanisms in the etiopathogenesis of schizophrenia...
  18. ncbi Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease
    S Scheuermann
    ZMBH, Center for Molecular Biology, University of Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    J Biol Chem 276:33923-9. 2001
    ..We suggest that dimerization could be a physiologically important mechanism for regulating the proposed signal activity of APP...
  19. ncbi A vicious circle: role of oxidative stress, intraneuronal Abeta and Cu in Alzheimer's disease
    T A Bayer
    Department of Neurobiology, Clinic of Psychiatry, University of the Saarland, Homburg, Germany
    Clin Neuropathol 25:163-71. 2006
    ..Thus, we conclude that bioavailability of Cu is a crucial point for the pathogenesis of AD...
  20. ncbi [The role of copper in the pathophysiology of Alzheimer's disease]
    H Kessler
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum des Saarlandes, Homburg Saar
    Nervenarzt 76:581-5. 2005
    ....
  21. ncbi Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer's disease
    H Kessler
    Department of Psychiatry and Psychotherapy, Saarland University, Homburg Saar, Germany
    J Neural Transm 113:1763-9. 2006
    ..Although only AD patients were included, the reduced plasma Cu and CB levels in patients with a CSF diagnosis of advanced AD supports previous observations that a mild Cu deficiency might contribute to AD progression...