Christoph G Baums
Affiliation: University of Leipzig
Seele J, Hillermann L, Beineke A, Seitz M, von Pawel Rammingen U, Valentin Weigand P, et al
. The immunoglobulin M-degrading enzyme of Streptococcus suis, IdeSsuis, is a highly protective antigen against serotype 2. Vaccine. 2015;33:2207-2212 pubmed publisher
..In conclusion, the results of this study indicate that rIdeSsuis is a highly protective antigen in pigs. ..
Seele J, Beineke A, Hillermann L, Jaschok Kentner B, von Pawel Rammingen U, Valentin Weigand P, et al
. The immunoglobulin M-degrading enzyme of Streptococcus suis, IdeSsuis, is involved in complement evasion. Vet Res. 2015;46:45 pubmed publisher
..In conclusion, this study demonstrates that Ide(Ssuis) is a novel complement evasion factor, which is important for bacterial survival in porcine blood during the early adaptive (IgM-dominated) immune response. ..
Unterweger C, Ruczizka U, Spergser J, Baums C, Hennig Pauka I. Effect of Early-Life Treatment of Piglets with Long-Acting Ceftiofur on Colonization of Streptococcus suis Serotype 7 and Elicitation of Specific Humoral Immunity in a Farm Dealing with Streptococcal Diseases. Pathogens. 2018;7: pubmed publisher
..suis or the induction of bactericidal humoral immunity in nursery and fattening pigs. The necessity of continuous usage should be reconsidered. ..
de Buhr N, Stehr M, Neumann A, Naim H, Valentin Weigand P, von KÃ¶ckritz Blickwede M, et al
. Identification of a novel DNase of Streptococcus suis (EndAsuis) important for neutrophil extracellular trap degradation during exponential growth. Microbiology. 2015;161:838-50 pubmed publisher
..As degradation of bacterial DNA caused by S. suis depended on ssnA and endAsuis, further functions of both factors in the host-pathogen interaction might be envisioned. ..
Fornefett J, Krause J, Klose K, Fingas F, Hassert R, Benga L, et al
. Comparative analysis of humoral immune responses and pathologies of BALB/c and C57BL/6 wildtype mice experimentally infected with a highly virulent Rodentibacter pneumotropicus (Pasteurella pneumotropica) strain. BMC Microbiol. 2018;18:45 pubmed publisher
..The described model is ideally suited for future vaccination studies using the natural host. ..
Rieckmann K, Seydel A, Szewczyk K, Klimke K, Rungelrath V, Baums C. Streptococcus suis cps7: an emerging virulent sequence type (ST29) shows a distinct, IgM-determined pattern of bacterial survival in blood of piglets during the early adaptive immune response after weaning. Vet Res. 2018;49:48 pubmed publisher
..suis pathotype showing high survival factors in porcine blood after weaning, but IgM-mediated killing in the blood of older growing piglets. This underlines the relevance of IgM as an important host defense mechanism against S. suis. ..
Eisenberg T, Hudemann C, Hossain H, Hewer A, Tello K, Bandorski D, et al
. Characterization of Five Zoonotic Streptococcus suis Strains from Germany, Including One Isolate from a Recent Fatal Case of Streptococcal Toxic Shock-Like Syndrome in a Hunter. J Clin Microbiol. 2015;53:3912-5 pubmed publisher
..All five zoonotic German strains were characterized by high multiplication in human blood samples ex vivo, but induction of only low levels of proinflammatory cytokines compared to a Chinese STSLS strain. ..
Warneboldt F, Sander S, Beineke A, Valentin Weigand P, Kamphues J, Baums C. Clearance of Streptococcus suis in Stomach Contents of Differently Fed Growing Pigs. Pathogens. 2016;5: pubmed publisher
..In conclusion, the porcine stomach constitutes a very efficient barrier against oro-gastrointenstinal S. suis infections. Conditions leading to the passage of S. suis through the stomach remain to be identified. ..
Rungelrath V, Wohlsein J, Siebert U, Stott J, Prenger Berninghoff E, von Pawel Rammingen U, et al
. Identification of a novel host-specific IgG protease in Streptococcus phocae subsp. phocae. Vet Microbiol. 2017;201:42-48 pubmed publisher
..phocae subsp. phocae involved in immune evasion. Furthermore, the fact that IdeP cleaves solely IgG of certain marine mammals reflects functional adaption of S. phocae subsp. phocae to grey and harbor seals as its main hosts. ..