M F Bauer

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Protein translocation into mitochondria: the role of TIM complexes
    M F Bauer
    Institut fur Klinische Chemie, Molekulare Diagnostik und Institut für Klinische Chemie, Akad Krankenhaus München Schwabing, D 80804 München, Germany
    Trends Cell Biol 10:25-31. 2000
  2. ncbi Genetic and structural characterization of the human mitochondrial inner membrane translocase
    M F Bauer
    Institut für Klinische Chemie Molekularbiologische Diagnostik und Mitochondriale Genetik und Institut für Diabetesforschung, Akad, Krankenhaus München Schwabing, Kolner Platz 1, Munchen, D 80804, Germany
    J Mol Biol 289:69-82. 1999
  3. ncbi Mitochondrial disorders. A diagnostic challenge in clinical chemistry
    M F Bauer
    Institute of Clinical Chemistry, Molecular Diagnostics and Mitochondrial Genetics, Diabetes Research Group, Academic Hospital Munich Schwabing, Germany
    Clin Chem Lab Med 37:855-76. 1999
  4. ncbi Import of proteins into mitochondria: a novel pathomechanism for progressive neurodegeneration
    M F Bauer
    Institut fur Klinische Chemie, Molekulare Diagnostik und Mitochondriale Genetik am Akad Lehrkrankenhaus München Schwabing, Germany
    J Inherit Metab Dis 24:166-80. 2001
  5. ncbi The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom
    M F Bauer
    Institut fur Klinische Chemie, Molekular Diagnostik und Mitochondriale Genetik und Institut für Diabetesforschung, Akad Krankenhaus München Schwabing, Kolner Platz 1, D 80804, Munich, Germany
    FEBS Lett 464:41-7. 1999
  6. ncbi Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria
    U Rothbauer
    Institut fur Klinische Chemie, Molekulare Diagnostik und Mitochondriale Genetik, Akademisches Lehrkrankenhaus München Schwabing, Koelner Platz 1, München 80804, Germany
    J Biol Chem 276:37327-34. 2001
  7. ncbi Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria
    M F Bauer
    Institut für Physiologische Chemie der Universität, Munchen, Germany
    Cell 87:33-41. 1996
  8. ncbi Yeast mitochondrial F1F0-ATPase: the novel subunit e is identical to Tim11
    I Arnold
    Institut für Physiologische Chemie der Universität München, Munich, Germany
    FEBS Lett 411:195-200. 1997
  9. ncbi Detection of neonatal argininosuccinate lyase deficiency by serum tandem mass spectrometry
    S Stadler
    Institut fur Klinische Chemie, Molekulare Diagnostik und Mitochondriale Genetik, Krankenhaus München Schwabing, Germany
    J Inherit Metab Dis 24:370-8. 2001
  10. ncbi "Adult" form of muscular carnitine palmitoyltransferase II deficiency: manifestation in a 2-year-old child
    K Gempel
    Institute for Clinical Chemistry, Molecular Diagnostics and Mitochondrial Genetics, Academic Hospital Schwabing, Munich, Germany
    Eur J Pediatr 160:548-51. 2001

Collaborators

Detail Information

Publications14

  1. ncbi Protein translocation into mitochondria: the role of TIM complexes
    M F Bauer
    Institut fur Klinische Chemie, Molekulare Diagnostik und Institut für Klinische Chemie, Akad Krankenhaus München Schwabing, D 80804 München, Germany
    Trends Cell Biol 10:25-31. 2000
    ....
  2. ncbi Genetic and structural characterization of the human mitochondrial inner membrane translocase
    M F Bauer
    Institut für Klinische Chemie Molekularbiologische Diagnostik und Mitochondriale Genetik und Institut für Diabetesforschung, Akad, Krankenhaus München Schwabing, Kolner Platz 1, Munchen, D 80804, Germany
    J Mol Biol 289:69-82. 1999
    ..Both TIM complexes display a native molecular mass of 110 kDa. We suggest that the structural organization of TIM23.17 preprotein translocases is conserved from low to high eukaryotes...
  3. ncbi Mitochondrial disorders. A diagnostic challenge in clinical chemistry
    M F Bauer
    Institute of Clinical Chemistry, Molecular Diagnostics and Mitochondrial Genetics, Diabetes Research Group, Academic Hospital Munich Schwabing, Germany
    Clin Chem Lab Med 37:855-76. 1999
    ..In addition, an overview on recently identified genetic defects and their pathogenic molecular mechanisms will be given...
  4. ncbi Import of proteins into mitochondria: a novel pathomechanism for progressive neurodegeneration
    M F Bauer
    Institut fur Klinische Chemie, Molekulare Diagnostik und Mitochondriale Genetik am Akad Lehrkrankenhaus München Schwabing, Germany
    J Inherit Metab Dis 24:166-80. 2001
    ..This contribution briefly summarizes the current knowledge of the pathways of protein import and proposes a mechanism to explain how defective import leads to neurodegeneration...
  5. ncbi The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom
    M F Bauer
    Institut fur Klinische Chemie, Molekular Diagnostik und Mitochondriale Genetik und Institut für Diabetesforschung, Akad Krankenhaus München Schwabing, Kolner Platz 1, D 80804, Munich, Germany
    FEBS Lett 464:41-7. 1999
    ..We report the identification, chromosomal localization and expressional analysis of six human family members which represent further candidate genes for neurodegenerative diseases...
  6. ncbi Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria
    U Rothbauer
    Institut fur Klinische Chemie, Molekulare Diagnostik und Mitochondriale Genetik, Akademisches Lehrkrankenhaus München Schwabing, Koelner Platz 1, München 80804, Germany
    J Biol Chem 276:37327-34. 2001
    ..Thus, the pathomechanism underlying the Mohr-Tranebjaerg syndrome may involve an impaired biogenesis of the human TIM23 complex causing severe pleiotropic mitochondrial dysfunction...
  7. ncbi Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria
    M F Bauer
    Institut für Physiologische Chemie der Universität, Munchen, Germany
    Cell 87:33-41. 1996
    ..The ensuring dissociation of Tim23 dimer triggers opening of the TIM channel and insertion of the preprotein...
  8. ncbi Yeast mitochondrial F1F0-ATPase: the novel subunit e is identical to Tim11
    I Arnold
    Institut für Physiologische Chemie der Universität München, Munich, Germany
    FEBS Lett 411:195-200. 1997
    ..Subunit e had been previously identified as Tim11 and was proposed to be involved in the process of sorting of proteins to the mitochondrial inner membrane...
  9. ncbi Detection of neonatal argininosuccinate lyase deficiency by serum tandem mass spectrometry
    S Stadler
    Institut fur Klinische Chemie, Molekulare Diagnostik und Mitochondriale Genetik, Krankenhaus München Schwabing, Germany
    J Inherit Metab Dis 24:370-8. 2001
    ..We propose MS-MS as a diagnostic tool suitable for the rapid detection of specific alterations in the amino acid spectra caused by ASL deficiency...
  10. ncbi "Adult" form of muscular carnitine palmitoyltransferase II deficiency: manifestation in a 2-year-old child
    K Gempel
    Institute for Clinical Chemistry, Molecular Diagnostics and Mitochondrial Genetics, Academic Hospital Schwabing, Munich, Germany
    Eur J Pediatr 160:548-51. 2001
    ..The diagnosis was confirmed by impaired in-vitro palmitate oxidation in blood and the detection of a homozygous substitution S113L in the carnitine palmitoyltransferase-II gene...
  11. ncbi Functional cooperation and stoichiometry of protein translocases of the outer and inner membranes of mitochondria
    C Sirrenberg
    Institut für Physiologische Chemie der Universität München, Goethestrasse 33, 80336 Munchen, Germany
    J Biol Chem 272:29963-6. 1997
    ..The stoichiometry of Tom40, Tim23, and Tim22 in mitochondria was determined to be 5:1:0.22. We conclude that translocases of the outer membrane are present in excess over translocases of the inner membrane...
  12. ncbi The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-Hsp70/ATP driving system
    J Berthold
    Institut fur Physiologische Chemie, Universitat Munchen, Federal Republic of Germany
    Cell 81:1085-93. 1995
    ....
  13. pmc The role of the TIM8-13 complex in the import of Tim23 into mitochondria
    S A Paschen
    Institut für Physiologische Chemie der Universität München, Goethestrasse 33, 80336 Munchen, Germany
    EMBO J 19:6392-400. 2000
    ..It is demonstrated that import of human Tim23 is dependent on a high membrane potential. A mechanism to explain the pathology of MTS is discussed...
  14. ncbi Mitochondrial Hsp70/MIM44 complex facilitates protein import
    H C Schneider
    Institut für Physiologische Chemie der Universität München, Germany
    Nature 371:768-74. 1994
    ..The complex appears to act as a molecular ratchet which is energetically driven by the hydrolysis of ATP...