Peter Bartsch

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Clinical practice: Acute high-altitude illnesses
    Peter Bartsch
    University Clinic, Department of Internal Medicine, Division VII Sports Medicine, Heidelberg, Germany
    N Engl J Med 368:2294-302. 2013
  2. ncbi request reprint Effect of altitude on the heart and the lungs
    Peter Bartsch
    Department of Internal Medicine VII, Division of Sports Medicine, Medical University Clinic, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Circulation 116:2191-202. 2007
  3. ncbi request reprint K+ channel activation with minoxidil stimulates nasal-epithelial ion transport and blunts exaggerated hypoxic pulmonary hypertension
    Simon Peth
    Medical Clinic VII, Sports Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    High Alt Med Biol 7:54-63. 2006
  4. doi request reprint No correlation between plasma levels of vascular endothelial growth factor or its soluble receptor and acute mountain sickness
    Kai Schommer
    Department of Internal Medicine, Division VII Sports Medicine, Medical Clinic, University Hospital Heidelberg, Heidelberg, Germany
    High Alt Med Biol 12:323-7. 2011
  5. doi request reprint Exercise intensity typical of mountain climbing does not exacerbate acute mountain sickness in normobaric hypoxia
    Kai Schommer
    Department of Internal Medicine VII, Division of Sports Medicine, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
    J Appl Physiol (1985) 113:1068-74. 2012
  6. ncbi request reprint Hypoxia-induced inhibition of whole cell membrane currents and ion transport of A549 cells
    Christoph Karle
    Section III Cardiology, Department of Internal Medicine, Medical Clinic and Policlinic, University of Heidelberg, Germany
    Am J Physiol Lung Cell Mol Physiol 286:L1154-60. 2004
  7. doi request reprint Training in normobaric hypoxia and its effects on acute mountain sickness after rapid ascent to 4559 m
    Kai Schommer
    Department of Sports Medicine, Medical Clinic, University Hospital Heidelberg, Heidelberg, Germany
    High Alt Med Biol 11:19-25. 2010
  8. ncbi request reprint No association between high-altitude tolerance and the ACE I/D gene polymorphism
    Christoph Dehnert
    Division of Sports Medicine, Department of Internal Medicine, University Hospital, Heidelberg, Germany
    Med Sci Sports Exerc 34:1928-33. 2002
  9. doi request reprint The effect of endothelin-1 on alveolar fluid clearance and pulmonary edema formation in the rat
    Marc Moritz Berger
    Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany
    Anesth Analg 108:225-31. 2009
  10. ncbi request reprint High altitude pulmonary edema: a pressure-induced leak
    Christoph Dehnert
    Medical University Clinic, Department of Internal Medicine, Div of Sports Medicine, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Respir Physiol Neurobiol 158:266-73. 2007

Collaborators

Detail Information

Publications43

  1. doi request reprint Clinical practice: Acute high-altitude illnesses
    Peter Bartsch
    University Clinic, Department of Internal Medicine, Division VII Sports Medicine, Heidelberg, Germany
    N Engl J Med 368:2294-302. 2013
    ..He wants to know how he can prevent becoming ill at high altitude and whether training or sleeping under normobaric hypoxic conditions in the weeks before the ascent would be helpful. What would you advise?..
  2. ncbi request reprint Effect of altitude on the heart and the lungs
    Peter Bartsch
    Department of Internal Medicine VII, Division of Sports Medicine, Medical University Clinic, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Circulation 116:2191-202. 2007
  3. ncbi request reprint K+ channel activation with minoxidil stimulates nasal-epithelial ion transport and blunts exaggerated hypoxic pulmonary hypertension
    Simon Peth
    Medical Clinic VII, Sports Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    High Alt Med Biol 7:54-63. 2006
    ..These results show that the K+ ATP activator minoxidil prevents the decrease in nasal-epithelial potential by hypoxia and seems to blunt an exaggerated increase in PAP in acute hypoxia...
  4. doi request reprint No correlation between plasma levels of vascular endothelial growth factor or its soluble receptor and acute mountain sickness
    Kai Schommer
    Department of Internal Medicine, Division VII Sports Medicine, Medical Clinic, University Hospital Heidelberg, Heidelberg, Germany
    High Alt Med Biol 12:323-7. 2011
    ..These data provide no evidence for a role of plasma VEGF and sFlt-1 in the pathophysiology of AMS. They do, however, not exclude paracrine effects of VEGF in the brain...
  5. doi request reprint Exercise intensity typical of mountain climbing does not exacerbate acute mountain sickness in normobaric hypoxia
    Kai Schommer
    Department of Internal Medicine VII, Division of Sports Medicine, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
    J Appl Physiol (1985) 113:1068-74. 2012
    ..We conclude that moderate exercise at ~50% maximal oxygen uptake does not increase AMS in normobaric hypoxia. These data do not exclude that considerably higher exercise intensities exacerbate AMS...
  6. ncbi request reprint Hypoxia-induced inhibition of whole cell membrane currents and ion transport of A549 cells
    Christoph Karle
    Section III Cardiology, Department of Internal Medicine, Medical Clinic and Policlinic, University of Heidelberg, Germany
    Am J Physiol Lung Cell Mol Physiol 286:L1154-60. 2004
    ..It appears, therefore, that a hypoxia-induced change in membrane conductance and membrane potential might be a link between hypoxia and alveolar ion transport inhibition...
  7. doi request reprint Training in normobaric hypoxia and its effects on acute mountain sickness after rapid ascent to 4559 m
    Kai Schommer
    Department of Sports Medicine, Medical Clinic, University Hospital Heidelberg, Heidelberg, Germany
    High Alt Med Biol 11:19-25. 2010
    ..Whether such a program would prevent AMS at higher altitudes, but with slower ascent, remains to be tested...
  8. ncbi request reprint No association between high-altitude tolerance and the ACE I/D gene polymorphism
    Christoph Dehnert
    Division of Sports Medicine, Department of Internal Medicine, University Hospital, Heidelberg, Germany
    Med Sci Sports Exerc 34:1928-33. 2002
    ....
  9. doi request reprint The effect of endothelin-1 on alveolar fluid clearance and pulmonary edema formation in the rat
    Marc Moritz Berger
    Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany
    Anesth Analg 108:225-31. 2009
    ..Therefore, we performed this study to clarify effects of ET-1 on alveolar reabsorption and fluid balance in the rat lung...
  10. ncbi request reprint High altitude pulmonary edema: a pressure-induced leak
    Christoph Dehnert
    Medical University Clinic, Department of Internal Medicine, Div of Sports Medicine, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Respir Physiol Neurobiol 158:266-73. 2007
    ..Lower levels of exhaled NO in hypoxia before and during HAPE suggest that this abnormality also occurs in the lungs and polymorphisms of the eNOS gene are associated with susceptibility to HAPE in the Indian and Japanese population...
  11. ncbi request reprint Physiological aspects of high-altitude pulmonary edema
    Peter Bartsch
    Department of Internal Medicine VII, Division of Sports Medicine, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    J Appl Physiol (1985) 98:1101-10. 2005
    ..The combination of high flow at higher pressure results in pressures, which exceed the structural and dynamic capacity of the alveolar capillary barrier to maintain normal alveolar fluid balance...
  12. ncbi request reprint Nasal epithelium potential difference at high altitude (4,559 m): evidence for secretion
    Heimo Mairbäurl
    Division of Sports Medicine, Department of Medicine, University of Heidelberg, Luisenstrasse 5, Geb 4100, 69115 Heidelberg, Germany
    Am J Respir Crit Care Med 167:862-7. 2003
    ..It is therefore uncertain whether similar changes also occur at the alveolar epithelium...
  13. doi request reprint Alveolar but not intravenous S-ketamine inhibits alveolar sodium transport and lung fluid clearance in rats
    Marc M Berger
    Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany
    Anesth Analg 111:164-70. 2010
    ..We studied the effects of alveolar and IV S-ketamine on transalveolar Na+ transport and AFC, and investigated whether IV S-ketamine enters the alveolar space in response to endotoxemia-induced pulmonary inflammation...
  14. ncbi request reprint Hypoxic ventilatory response, ventilation, gas exchange, and fluid balance in acute mountain sickness
    Peter Bartsch
    Department of Internal Medicine, Division of Sports Medicine, Medical University Clinic, Heidelberg, Germany
    High Alt Med Biol 3:361-76. 2002
    ....
  15. ncbi request reprint Effects of acute moderate hypoxia on anaerobic capacity in endurance-trained runners
    Birgit Friedmann
    Department of Internal Medicine VII Sports Medicine, University Hospital, Im Neuenheimer Feld 710, 69120, Heidelberg, Germany
    Eur J Appl Physiol 101:67-73. 2007
    ..The performance reduction during all-out exercise of short duration has to be attributed to the decrement in aerobic capacity...
  16. doi request reprint Health risk for athletes at moderate altitude and normobaric hypoxia
    Kai Schommer
    Department of Internal Medicine, Division of Sports Medicine, University Hospital Heidelberg, Germany
    Br J Sports Med 46:828-32. 2012
    ..Moderate altitudes may also lead to splenic infarctions in healthy athletes with sickle cell trait...
  17. doi request reprint Insufficient control of exercise intensity by heart rate monitoring in cardiac patients
    Falko Frese
    Department of Sports Medicine, Medical Clinic, University Hospital Heidelberg, Im Neuenheimer Feld 710, Heidelberg, Germany
    Eur J Prev Cardiol 19:436-43. 2012
    ..To test the reliability of heart rate (HR) recommendations for cardiac rehabilitation training obtained from different treadmill tests...
  18. ncbi request reprint Role of hemolysis in red cell adenosine triphosphate release in simulated exercise conditions in vitro
    Heimo Mairbäurl
    Medical Clinic VII, Sports Medicine, University of Heidelberg, Heidelberg, Germany
    Med Sci Sports Exerc 45:1941-7. 2013
    ....
  19. ncbi request reprint Hypoxia decreases cellular ATP demand and inhibits mitochondrial respiration of a549 cells
    Kristin Heerlein
    Medical Clinic VII, Sports Medicine, University of Heidelberg, Heidelberg, Germany
    Am J Respir Cell Mol Biol 32:44-51. 2005
    ..Our findings indicate that inhibition of the Na/K-ATPase by hypoxia contributes little to energy preservation in hypoxia. It remains unclear to what extent hypoxic inhibition of mitochondrial metabolism affects ATP-consuming processes...
  20. doi request reprint Total haemoglobin mass and red blood cell profile in endurance-trained and non-endurance-trained adolescent athletes
    Gert Ulrich
    Department of Sports Medicine, Medical Clinic, University Hospital Heidelberg, Im Neuenheimer Feld 710, 69120, Heidelberg, Germany
    Eur J Appl Physiol 111:2855-64. 2011
    ..At the age of 15-17 years, 18 months of regular training did not induce significant changes in tHb mass beyond alterations explained by physical growth and also variables of red blood cell profile did not change significantly...
  21. doi request reprint Beta2-adrenergic stimulation blunts inhibition of epithelial ion transport by hypoxia of rat alveolar epithelial cells
    Benjamin Loeh
    Medical Clinic VII, Sports Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Cell Physiol Biochem 25:123-34. 2010
    ..These results indicate that beta(2) adrenergic stimulation increased Na(+)- and Cl(-) transport in ATII cells even in hypoxia thus restoring normal reabsorption...
  22. ncbi request reprint High altitude pulmonary oedema
    Peter Bartsch
    Department of Internal Medicine, Medical University Clinic Heidelberg, Germany
    Swiss Med Wkly 133:377-84. 2003
    ..Even susceptible individuals can avoid HAPE if they ascend slowly with an average gain of altitude not exceeding 300-350 m/day above an altitude of 2500 m...
  23. ncbi request reprint Altered ion transporter expression in bronchial epithelium in mountaineers with high-altitude pulmonary edema
    Heimo Mairbäurl
    Division of Sports Medicine, Department of Medicine, University of Heidelberg, Germany
    J Appl Physiol (1985) 95:1843-50. 2003
    ..It is therefore unclear whether these differences are related to the pathophysiology of HAPE...
  24. ncbi request reprint Magnetic resonance imaging of uneven pulmonary perfusion in hypoxia in humans
    Christoph Dehnert
    University Hospital Heidelberg, Internal Medicine VII, Sports Medicine, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Am J Respir Crit Care Med 174:1132-8. 2006
    ....
  25. ncbi request reprint Cytochrome P450 enzyme-mediated drug metabolism at exposure to acute hypoxia (corresponding to an altitude of 4,500 m)
    Michael Streit
    Department of Internal Medicine VII, Sportsmedicine, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Eur J Clin Pharmacol 61:39-46. 2005
    ..To investigate the effect of acute hypoxia and concomitant changes in portal blood flow on the disposition of drugs mainly metabolized by the cytochrome P(450) enzymes (CYP) 3A4 (verapamil) and CYP1A2 (theophylline)...
  26. ncbi request reprint Dexamethasone prevents transport inhibition by hypoxia in rat lung and alveolar epithelial cells by stimulating activity and expression of Na+-K+-ATPase and epithelial Na+ channels
    Sevin Guney
    Medical Clinic VII, Sports Medicine, Univ of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Am J Physiol Lung Cell Mol Physiol 293:L1332-8. 2007
    ..These results indicate that DEX prevents inhibition of alveolar reabsorption by hypoxia and stimulates the expression of Na transporters even when it is applied in hypoxia...
  27. ncbi request reprint Skeletal muscle dysfunction in patients with idiopathic pulmonary arterial hypertension
    Ralf Bauer
    Department of Cardiology, Angiology and Pulmology, University Hospital, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Respir Med 101:2366-9. 2007
    ..30; p=0.16). The present skeletal muscle dysfunction is a novel finding in patients with IPAH. The correlation with respiratory muscle dysfunction and severity of disease might indicate a generalised "myopathy" in IPAH...
  28. ncbi request reprint Transient minor improvement of high altitude headache by sumatriptan
    Dominik Utiger
    Department of Internal Medicine, Division of Sports Medicine, Medical University Clinic Heidelberg, Germany
    High Alt Med Biol 3:387-93. 2002
    ..Because there was only a minor transient amelioration of high altitude headache with sumatriptan, we conclude that 5-HT1 receptors do not play a major role in the pathophysiology of high altitude headache...
  29. ncbi request reprint Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O(2) chemosensitivity
    Wulf Hildebrandt
    Department of Immunochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Blood 99:1552-5. 2002
    ..Results suggest the possibility that age-related changes in plasma REDST may account for the age-related changes in HVR...
  30. ncbi request reprint Acute mountain sickness: controversies and advances
    Peter Bartsch
    Medical University Clinic, Department of Internal Medicine, Division of Sports Medicine, Heidelberg, Germany
    High Alt Med Biol 5:110-24. 2004
    ....
  31. ncbi request reprint Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers
    Heimo Mairbäurl
    Medical Clinic and Polyclinic, Department of Internal Medicine VII, Sports Medicine, University of Heidelberg, Hospitalstrasse 3, Geb 4100, 69115 Heidelberg, Germany
    Am J Physiol Lung Cell Mol Physiol 282:L659-65. 2002
    ..These results demonstrate that exposure to hypoxia inhibits alveolar epithelial Na reabsorption by reducing the rates of both apical amiloride-sensitive Na entry and basolateral Na extrusion...
  32. doi request reprint Effects of strength training with eccentric overload on muscle adaptation in male athletes
    Birgit Friedmann-Bette
    Department of Sports Medicine, Medical Clinic, University Hospital Heidelberg, Im Neuenheimer Feld 710, 69120, Heidelberg, Germany
    Eur J Appl Physiol 108:821-36. 2010
    ..The enhanced eccentric load apparently led to a subtly faster gene expression pattern and induced a shift towards a faster muscle phenotype plus associated adaptations that make a muscle better suited for fast, explosive movements...
  33. ncbi request reprint [Altitude sickness]
    Marc Moritz Berger
    Klinik für Anaesthesiologie und Intensivmedizin, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg
    Med Monatsschr Pharm 27:368-72. 2004
  34. ncbi request reprint Exercise with the intensity of the individual anaerobic threshold in acute hypoxia
    Birgit Friedmann
    Department of Sports Medicine, Medical Clinic and Policlinic, University of Heidelberg, Germany
    Med Sci Sports Exerc 36:1737-42. 2004
    ..15) defines equivalent relative submaximal intensities in these environmental conditions...
  35. doi request reprint Exercise-induced hemostatic activation in patients with dilated cardiomyopathy in sinus rhythm
    Dirk Lossnitzer
    University Hospital of Heidelberg, Department of Internal Medicine III Cardiology, Heidelberg, Germany
    Blood Coagul Fibrinolysis 19:146-52. 2008
    ..Maximal physical exercise does not induce an exaggerated formation of thrombin and fibrin in CHF patients. The fibrinolytic response to exercise in terms of plasmin formation is not compromised in patients with dilated cardiomyopathy...
  36. ncbi request reprint Effects of supplementation with alpha-lipoic acid on exercise-induced activation of coagulation
    Claus Weiss
    Department of Internal Medicine VII Sportsmedicine, University Hospital Heidelberg, 69120 Heidelberg, Germany
    Metabolism 54:815-20. 2005
    ..The role of oxidative stress for exercise-induced activation of coagulation has to be defined in further studies...
  37. ncbi request reprint Tissue factor-dependent pathway is not involved in exercise-induced formation of thrombin and fibrin
    Claus Weiss
    Department of Internal Medicine VII Sportsmedicine, University Hospital, 69115 Heidelberg, Germany
    J Appl Physiol (1985) 92:211-8. 2002
    ....
  38. ncbi request reprint Enhanced hypoxic pulmonary vasoconstriction in families of adults or children with idiopathic pulmonary arterial hypertension
    Ekkehard Grunig
    Department of Cardiology and Pneumology, University Hospital of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Chest 128:630S-633S. 2005
  39. ncbi request reprint In vitro hypoxia impairs beta2-adrenergic receptor signaling in primary rat alveolar epithelial cells
    Emel Baloglu
    1Medical Clinic VII, Sports Medicine, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany
    Am J Physiol Lung Cell Mol Physiol 296:L500-9. 2009
    ..These results indicate that despite the decrease in G(s) protein level G(s) protein was still functional and that hypoxia impairs beta(2)-AR signaling due to an increased activity of G(i/o) proteins...
  40. ncbi request reprint Unchanged anaerobic and aerobic performance after short-term intermittent hypoxia
    Vahid Tadibi
    Department of Internal Medicine, Division of Sports Medicine, Medical University Clinic Heidelberg, Heidelberg, Germany
    Med Sci Sports Exerc 39:858-64. 2007
    ..Therefore, we conducted a randomized, double-blind, placebo-controlled study to investigate the effects of this new method on both anaerobic and aerobic performance...
  41. ncbi request reprint Acute mountain sickness: influence of susceptibility, preexposure, and ascent rate
    Michael Schneider
    Department of Internal Medicine, Division of Sports Medicine, University Hospital Heidelberg, Germany
    Med Sci Sports Exerc 34:1886-91. 2002
    ..We examined the interaction of various established risk factors for acute mountain sickness (AMS) in a setting relevant for mountaineering and trekking...
  42. doi request reprint Enhanced myofiber recruitment during exhaustive squatting performed as whole-body vibration exercise
    Holger Eckhardt
    Department of Sports Medicine, Medical Clinic, University Hospital Heidelberg, Heidelberg, Germany
    J Strength Cond Res 25:1120-5. 2011
    ..The increased myoelectric activity and the enhanced exercise-induced increase in capillary lactate concentration during WBVS provide evidence for augmented recruitment of muscle tissue when WBV is added to exhaustive squatting exercise...
  43. pmc Gastrointestinal complaints in runners are not due to small intestinal bacterial overgrowth
    Kai Schommer
    Department of Internal Medicine, The University Hospital Heidelberg, 69120 Heidelberg, Germany
    J Negat Results Biomed 10:8. 2011
    ..Gastrointestinal complaints are common among long distance runners. We hypothesised that small intestinal bacterial overgrowth (SIBO) is present in long distance runners frequently afflicted with gastrointestinal complaints...