Research Topics
Genomes and Genes | Marek BartkuhnSummaryAffiliation: University of Giessen Country: Germany Publications
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Detail Information
Publications
Active promoters and insulators are marked by the centrosomal protein 190Marek Bartkuhn
Institute for Genetics, Justus Liebig University Giessen, Giessen, Germany
EMBO J 28:877-88. 2009..Loss of either dCTCF or CP190 causes an increase of H3 and H3K27 trimethylation at these sites. Thus, for both types of cis-regulatory elements, domain borders and promoters, the chromatin structure is dependent on CP190...
Hand is a direct target of the forkhead transcription factor Biniou during Drosophila visceral mesoderm differentiationDmitry Popichenko
Department of Biology, University of Osnabruck, Zoology, Osnabruck, Germany
BMC Dev Biol 7:49. 2007..In our report we focus on the analysis of the transcriptional control of the highly conserved transcription factor Hand in circular visceral muscle cells, providing evidence that the hand gene is a direct target of Biniou...
The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterningMan Mohan
Institute for Genetics, Justus Liebig University Giessen, Heinrich Buff Ring, Giessen, Germany
EMBO J 26:4203-14. 2007..A short pulse of dCTCF expression during larval development rescues the dCTCF loss of function phenotype. Overall, we demonstrate the importance of dCTCF in fly development and in the regulation of abdominal segmentation...
Modular insulators: genome wide search for composite CTCF/thyroid hormone receptor binding sitesOliver Weth
Institute for Genetics, Justus Liebig University Giessen, Giessen, Germany
PLoS ONE 5:e10119. 2010..Thus, a number of composite CTCF/TR binding sites may represent a subset of other modular CTCF composite sites, such as groups of multiple CTCF sites or of CTCF/Oct4, CTCF/Kaiso or CTCF/Yy1 combinations...
Long range chromatin interactions involved in gene regulationMarek Bartkuhn
Institute for Genetics, Justus Liebig University Giessen, Heinrich Buff Ring 58 62, 35392 Giessen, Germany
Biochim Biophys Acta 1783:2161-6. 2008..With more sophisticated and sensitive methods combined with deep sequencing and array technology, a huge number of long range interactions can expected to be characterized in the near future...
The interaction of modified histones with the bromodomain testis-specific (BRDT) gene and its mRNA level in sperm of fertile donors and subfertile menCornelia Steilmann
Department of Urology, Pediatric Urology and Andrology, Rudolf Buchheim Strasse 7, Justus Liebig University, 35385 Giessen, Germany
Reproduction 140:435-43. 2010..Our data suggest that reduced histone methylation in the promoter of BRDT may be associated with increased transcript levels in subfertile patients...
CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatinLes J Burke
Institute for Genetics, Justus Liebig Universitaet Giessen, Giessen, Germany
EMBO J 24:3291-300. 2005..In contrast, the enhancer/promoter loop of the same locus is lost in mitosis. This may provide a novel form of epigenetic memory during cell division...
The chromatin insulator CTCF and the emergence of metazoan diversityPeter Heger
Institute for Genetics, Cologne Biocenter, University of Cologne, 50674 Cologne, Germany
Proc Natl Acad Sci U S A 109:17507-12. 2012..Such a kernel could explain (i) the formation of Hox clusters in Bilateria, (ii) the diversity of bilaterian body plans, and (iii) the uniqueness and time of onset of the Cambrian explosion...
