Henryk Barthel

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi Florbetaben to trace amyloid-β in the Alzheimer brain by means of PET
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Alzheimers Dis 26:117-21. 2011
  2. ncbi Individualized quantification of brain β-amyloid burden: results of a proof of mechanism phase 0 florbetaben PET trial in patients with Alzheimer's disease and healthy controls
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 38:1702-14. 2011
  3. ncbi Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Lancet Neurol 10:424-35. 2011
  4. ncbi Dissociating behavioral disorders in early dementia-An FDG-PET study
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
    Psychiatry Res 194:235-44. 2011
  5. ncbi Effects of subthalamic nucleus stimulation on striatal dopaminergic transmission in patients with Parkinson's disease within one-year follow-up
    Swen Hesse
    Dept of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    J Neurol 255:1059-66. 2008
  6. ncbi Monoamine transporter availability in Parkinson's disease patients with or without depression
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 36:428-35. 2009
  7. ncbi Serotonin transporter imaging with [123I]beta-CIT SPECT before and after one year of citalopram treatment of obsessive-compulsive disorder
    Katarina Stengler-Wenzke
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Neuropsychobiology 53:40-5. 2006
  8. ncbi Executive deficits are related to the inferior frontal junction in early dementia
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstr 1a, 04103 Leipzig, Germany
    Brain 135:201-15. 2012
  9. ncbi Dopamine transporter imaging in adult patients with attention-deficit/hyperactivity disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Psychiatry Res 171:120-8. 2009
  10. ncbi Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, D 04103 Leipzig, Germany
    Psychiatry Res 140:63-72. 2005

Detail Information

Publications25

  1. ncbi Florbetaben to trace amyloid-β in the Alzheimer brain by means of PET
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Alzheimers Dis 26:117-21. 2011
    ....
  2. ncbi Individualized quantification of brain β-amyloid burden: results of a proof of mechanism phase 0 florbetaben PET trial in patients with Alzheimer's disease and healthy controls
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 38:1702-14. 2011
    ..The value of various quantitative parameters derived from the PET scans as potential surrogate markers of cognitive decline was also investigated...
  3. ncbi Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Lancet Neurol 10:424-35. 2011
    ..We aimed to assess the sensitivity and specificity of florbetaben (¹⁸F) PET in discriminating between patients with probable Alzheimer's disease and elderly healthy controls...
  4. ncbi Dissociating behavioral disorders in early dementia-An FDG-PET study
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
    Psychiatry Res 194:235-44. 2011
    ..Our study contributes to the understanding of behavioral deficits in early dementia and suggests specific diagnostic and therapeutic approaches...
  5. ncbi Effects of subthalamic nucleus stimulation on striatal dopaminergic transmission in patients with Parkinson's disease within one-year follow-up
    Swen Hesse
    Dept of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    J Neurol 255:1059-66. 2008
    ..These data show that clinical improvement and reduction of dopaminergic drugs in patients with advanced PD undergoing bilateral STN-DBS are paralleled by stable DAT and recovery of striatal D2R availability 12 months after surgery...
  6. ncbi Monoamine transporter availability in Parkinson's disease patients with or without depression
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 36:428-35. 2009
    ..Therefore, we studied PD patients with depression (PD+D) and without depression (PD-D) using high-resolution single-photon emission computed tomography (SPECT) and the monoamine transporter marker [(123)I]FP-CIT...
  7. ncbi Serotonin transporter imaging with [123I]beta-CIT SPECT before and after one year of citalopram treatment of obsessive-compulsive disorder
    Katarina Stengler-Wenzke
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Neuropsychobiology 53:40-5. 2006
    ..The neurobiological mechanisms of SSRI action and failure to respond to SSRI treatment remain to be elucidated...
  8. ncbi Executive deficits are related to the inferior frontal junction in early dementia
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstr 1a, 04103 Leipzig, Germany
    Brain 135:201-15. 2012
    ..Our study underlines the importance of the inferior frontal junction area for cognitive control in general and for executive deficits in early dementia...
  9. ncbi Dopamine transporter imaging in adult patients with attention-deficit/hyperactivity disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Psychiatry Res 171:120-8. 2009
    ..Further studies will have to deal with the question of whether these findings have the potential to influence treatment decisions in this complex disorder...
  10. ncbi Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, D 04103 Leipzig, Germany
    Psychiatry Res 140:63-72. 2005
    ..Our data provide evidence for imbalanced monoaminergic neurotransmitter modulation in OCD. Further studies with more selective DAT and SERT radiotracers are needed...
  11. ncbi Executive and behavioral deficits share common neural substrates in frontotemporal lobar degeneration - a pilot FDG-PET study
    Karolina A Raczka
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Psychiatry Res 182:274-80. 2010
    ..This hypothesis might be further explored in studies involving larger patient groups...
  12. ncbi Concordant pre- and postsynaptic deficits of dopaminergic neurotransmission in neurologic Wilson disease
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Germany
    AJNR Am J Neuroradiol 24:234-8. 2003
    ..These results could be relevant in therapeutic decision making in patients with this copper deposition disorder...
  13. ncbi Decreased cerebral α4β2* nicotinic acetylcholine receptor availability in patients with mild cognitive impairment and Alzheimer's disease assessed with positron emission tomography
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 38:515-25. 2011
    ....
  14. ncbi Is correction for age necessary in neuroimaging studies of the central serotonin transporter?
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Germany
    Eur J Nucl Med Mol Imaging 30:427-30. 2003
    ..From these results we conclude that age-related changes in SERT density need to be considered in future clinical studies...
  15. ncbi Reduced alpha4beta2*-nicotinic acetylcholine receptor binding and its relationship to mild cognitive and depressive symptoms in Parkinson disease
    Philipp M Meyer
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Arch Gen Psychiatry 66:866-77. 2009
    ..Cognitive or depressive disorders are frequently noted in patients with Parkinson disease (PD) and may be related to altered signaling through alpha4beta2*-nicotinic acetylcholine receptors (alpha4beta2*-nAChRs)...
  16. ncbi Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders
    Swen Hesse
    Department of Nuclear Medicine, University Hospital, University of Leipzig, Leipzig, Germany
    Neurosci Biobehav Rev 28:547-63. 2004
    ..We furthermore elucidate the potential of SERT imaging techniques in estimating the effect of selective serotonin reuptake-inhibitors...
  17. ncbi Influence of scan duration on the accuracy of β-amyloid PET with florbetaben in patients with Alzheimer's disease and healthy volunteers
    Solveig Tiepolt
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 40:238-44. 2013
    ..In dementia imaging, shortening of scan duration may simplify future clinical use. The aim of this retrospective study was to investigate the effect of scan duration on diagnostic accuracy...
  18. ncbi [18F]Fluoroazomycinarabinofuranoside (18FAZA) and [18F]Fluoromisonidazole (18FMISO): a comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors
    Dietlind Sorger
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Nucl Med Biol 30:317-26. 2003
    ..This advantage of a faster reduction of unspecific binding, in light of similar or marginally lower tumor uptake, warrants further investigation of (18)FAZA as a marker of regional hypoxia in tumors...
  19. ncbi Effect of progenitor cells on myocardial perfusion and metabolism in patients after recanalization of a chronically occluded coronary artery
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Nucl Med 49:557-63. 2008
    ....
  20. ncbi Different mechanisms for changes in glucose uptake of the right and left ventricular myocardium in pulmonary hypertension
    Regine Kluge
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Nucl Med 46:25-31. 2005
    ..An increased metabolic rate of glucose uptake in the right ventricle presumably indicates RV impairment, correlating with the Tei index, which is an established prognostic parameter for cardiac dysfunction and poor survival...
  21. ncbi Small-animal imaging of tumour proliferation with PET
    Henryk Barthel
    Molecular Therapy and PET Oncology, Imperial College London, Hammersmith Hospital, UK
    Lancet Oncol 5:100. 2004
  22. ncbi Combined evaluation of FDG-PET and MRI improves detection and differentiation of dementia
    Juergen Dukart
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    PLoS ONE 6:e18111. 2011
    ....
  23. ncbi Correlation between automated writing movements and striatal dopaminergic innervation in patients with Wilson's disease
    Wieland Hermann
    Department of Neurology, University of Leipzig, Liebigstr. 22a, 04107 Leipzig, Germany
    J Neurol 249:1082-7. 2002
    ..Furthermore analysis of automated handwriting movements could be useful for therapy monitoring and evaluation of striatal dopaminergic innervation...
  24. ncbi Effect of drug-induced cytotoxicity on glucose uptake in Hodgkin's lymphoma cells
    Ursula Banning
    Division of Pediatric Hematology and Oncology, Clinic and Policlinic for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Eur J Haematol 77:102-8. 2006
    ..Altogether, this study provides important in vitro evidence to clarify the mechanisms by which FDG-PET monitors the effect of anti-cancer treatment in Hodgkin's lymphoma patients...
  25. ncbi Permanent middle cerebral artery occlusion in sheep: a novel large animal model of focal cerebral ischemia
    Johannes Boltze
    Fraunhofer Institute of Cell Therapy and Immunology, Leipzig, Germany
    J Cereb Blood Flow Metab 28:1951-64. 2008
    ..This model could be used as an alternative to existing large animal models, especially for longitudinal analyses of the safety and therapeutic impact of novel therapies in the field of translational stroke research...