Henryk Barthel

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. doi request reprint PET/MR in dementia and other neurodegenerative diseases
    Henryk Barthel
    Department of Nuclear Medicine, Leipzig University Hospital, Leipzig, Germany Electronic address
    Semin Nucl Med 45:224-33. 2015
  2. doi request reprint Florbetaben to trace amyloid-β in the Alzheimer brain by means of PET
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Alzheimers Dis 26:117-21. 2011
  3. doi request reprint Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Lancet Neurol 10:424-35. 2011
  4. doi request reprint Individualized quantification of brain β-amyloid burden: results of a proof of mechanism phase 0 florbetaben PET trial in patients with Alzheimer's disease and healthy controls
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 38:1702-14. 2011
  5. doi request reprint Dissociating behavioral disorders in early dementia-An FDG-PET study
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
    Psychiatry Res 194:235-44. 2011
  6. doi request reprint Effects of subthalamic nucleus stimulation on striatal dopaminergic transmission in patients with Parkinson's disease within one-year follow-up
    Swen Hesse
    Dept of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    J Neurol 255:1059-66. 2008
  7. ncbi request reprint Serotonin transporter imaging with [123I]beta-CIT SPECT before and after one year of citalopram treatment of obsessive-compulsive disorder
    Katarina Stengler-Wenzke
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Neuropsychobiology 53:40-5. 2006
  8. doi request reprint Monoamine transporter availability in Parkinson's disease patients with or without depression
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 36:428-35. 2009
  9. doi request reprint Influence of scan duration on the accuracy of β-amyloid PET with florbetaben in patients with Alzheimer's disease and healthy volunteers
    Solveig Tiepolt
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 40:238-44. 2013
  10. doi request reprint Executive and behavioral deficits share common neural substrates in frontotemporal lobar degeneration - a pilot FDG-PET study
    Karolina A Raczka
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Psychiatry Res 182:274-80. 2010

Detail Information

Publications41

  1. doi request reprint PET/MR in dementia and other neurodegenerative diseases
    Henryk Barthel
    Department of Nuclear Medicine, Leipzig University Hospital, Leipzig, Germany Electronic address
    Semin Nucl Med 45:224-33. 2015
    ....
  2. doi request reprint Florbetaben to trace amyloid-β in the Alzheimer brain by means of PET
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Alzheimers Dis 26:117-21. 2011
    ....
  3. doi request reprint Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Lancet Neurol 10:424-35. 2011
    ..We aimed to assess the sensitivity and specificity of florbetaben (¹⁸F) PET in discriminating between patients with probable Alzheimer's disease and elderly healthy controls...
  4. doi request reprint Individualized quantification of brain β-amyloid burden: results of a proof of mechanism phase 0 florbetaben PET trial in patients with Alzheimer's disease and healthy controls
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 38:1702-14. 2011
    ..The value of various quantitative parameters derived from the PET scans as potential surrogate markers of cognitive decline was also investigated...
  5. doi request reprint Dissociating behavioral disorders in early dementia-An FDG-PET study
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
    Psychiatry Res 194:235-44. 2011
    ..Our study contributes to the understanding of behavioral deficits in early dementia and suggests specific diagnostic and therapeutic approaches...
  6. doi request reprint Effects of subthalamic nucleus stimulation on striatal dopaminergic transmission in patients with Parkinson's disease within one-year follow-up
    Swen Hesse
    Dept of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    J Neurol 255:1059-66. 2008
    ..These data show that clinical improvement and reduction of dopaminergic drugs in patients with advanced PD undergoing bilateral STN-DBS are paralleled by stable DAT and recovery of striatal D2R availability 12 months after surgery...
  7. ncbi request reprint Serotonin transporter imaging with [123I]beta-CIT SPECT before and after one year of citalopram treatment of obsessive-compulsive disorder
    Katarina Stengler-Wenzke
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Neuropsychobiology 53:40-5. 2006
    ..The neurobiological mechanisms of SSRI action and failure to respond to SSRI treatment remain to be elucidated...
  8. doi request reprint Monoamine transporter availability in Parkinson's disease patients with or without depression
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 36:428-35. 2009
    ..Therefore, we studied PD patients with depression (PD+D) and without depression (PD-D) using high-resolution single-photon emission computed tomography (SPECT) and the monoamine transporter marker [(123)I]FP-CIT...
  9. doi request reprint Influence of scan duration on the accuracy of β-amyloid PET with florbetaben in patients with Alzheimer's disease and healthy volunteers
    Solveig Tiepolt
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 40:238-44. 2013
    ..In dementia imaging, shortening of scan duration may simplify future clinical use. The aim of this retrospective study was to investigate the effect of scan duration on diagnostic accuracy...
  10. doi request reprint Executive and behavioral deficits share common neural substrates in frontotemporal lobar degeneration - a pilot FDG-PET study
    Karolina A Raczka
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Psychiatry Res 182:274-80. 2010
    ..This hypothesis might be further explored in studies involving larger patient groups...
  11. doi request reprint PET quantification of 18F-florbetaben binding to β-amyloid deposits in human brains
    Georg A Becker
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Nucl Med 54:723-31. 2013
    ..We evaluated the kinetic model-based approaches to the quantification of β-amyloid binding in the brain from dynamic PET data. The validity of the practically useful tissue ratio was also evaluated against the model-based parameters...
  12. pmc Executive deficits are related to the inferior frontal junction in early dementia
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstr 1a, 04103 Leipzig, Germany
    Brain 135:201-15. 2012
    ..Our study underlines the importance of the inferior frontal junction area for cognitive control in general and for executive deficits in early dementia...
  13. doi request reprint Dopamine transporter imaging in adult patients with attention-deficit/hyperactivity disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Psychiatry Res 171:120-8. 2009
    ..Further studies will have to deal with the question of whether these findings have the potential to influence treatment decisions in this complex disorder...
  14. ncbi request reprint Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, D 04103 Leipzig, Germany
    Psychiatry Res 140:63-72. 2005
    ..Our data provide evidence for imbalanced monoaminergic neurotransmitter modulation in OCD. Further studies with more selective DAT and SERT radiotracers are needed...
  15. ncbi request reprint Concordant pre- and postsynaptic deficits of dopaminergic neurotransmission in neurologic Wilson disease
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Germany
    AJNR Am J Neuroradiol 24:234-8. 2003
    ..The present study was initiated to intra-individually determine the integrity of these compartments in patients with WD...
  16. doi request reprint Partial-Volume Effect Correction Improves Quantitative Analysis of 18F-Florbetaben β-Amyloid PET Scans
    Michael Rullmann
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Nucl Med 57:198-203. 2016
    ..This study investigated whether partial-volume effect correction (PVEC), adjusting for this atrophy bias, improves the accuracy of (18)F-florbetaben Aβ PET...
  17. doi request reprint Decreased cerebral α4β2* nicotinic acetylcholine receptor availability in patients with mild cognitive impairment and Alzheimer's disease assessed with positron emission tomography
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 38:515-25. 2011
    ....
  18. ncbi request reprint Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders
    Swen Hesse
    Department of Nuclear Medicine, University Hospital, University of Leipzig, Leipzig, Germany
    Neurosci Biobehav Rev 28:547-63. 2004
    ..We furthermore elucidate the potential of SERT imaging techniques in estimating the effect of selective serotonin reuptake-inhibitors...
  19. doi request reprint Reduced alpha4beta2*-nicotinic acetylcholine receptor binding and its relationship to mild cognitive and depressive symptoms in Parkinson disease
    Philipp M Meyer
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Arch Gen Psychiatry 66:866-77. 2009
    ..Cognitive or depressive disorders are frequently noted in patients with Parkinson disease (PD) and may be related to altered signaling through alpha4beta2*-nicotinic acetylcholine receptors (alpha4beta2*-nAChRs)...
  20. ncbi request reprint Is correction for age necessary in neuroimaging studies of the central serotonin transporter?
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Germany
    Eur J Nucl Med Mol Imaging 30:427-30. 2003
    ..From these results we conclude that age-related changes in SERT density need to be considered in future clinical studies...
  21. doi request reprint Critical Comparison of Different Biomarkers for Alzheimer's Disease in a Clinical Setting
    David Weise
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    J Alzheimers Dis 48:425-32. 2015
    ..Biomarkers of neuronal injury and amyloid pathology play a pivotal role in the diagnosis of Alzheimer's disease (AD). The degree of AD biomarker congruence is still unclear in clinical practice...
  22. doi request reprint Alzheimer's Disease FDG PET Imaging Pattern in an Amyloid-Negative Mild Cognitive Impairment Subject
    Solveig Tiepolt
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Alzheimers Dis 47:539-43. 2015
    ..Further studies are required to determine frequency and relevance of cases with neurodegeneration-first biomarker constellations to improve our understanding on pathogenesis and diagnosis of AD. ..
  23. doi request reprint Dissociation of amyloid biomarkers in PET and CSF in Alzheimer's disease: a case report
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1A and Clinic for Cognitive Neurology, University of Leipzig, Liebigstr 16 04103, Leipzig, Germany
    BMC Neurol 15:152. 2015
    ....
  24. doi request reprint First-in-human PET quantification study of cerebral α4β2* nicotinic acetylcholine receptors using the novel specific radioligand (-)-[(18)F]Flubatine
    Osama Sabri
    Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany Integrated Research and Treatment Centre IFB Adiposity Diseases, University of Leipzig, Philipp Rosenthal Straße 27, 04103 Leipzig, Germany Electronic address
    Neuroimage 118:199-208. 2015
    ....
  25. doi request reprint Lean body mass correction of standardized uptake value in simultaneous whole-body positron emission tomography and magnetic resonance imaging
    Thies H Jochimsen
    Department of Nuclear Medicine, Leipzig University Hospital Liebigstr 18, D 04103 Leipzig, Germany
    Phys Med Biol 60:4651-64. 2015
    ..The reduced dependency is comparable to that obtained by CT and predictive equations. Therefore, it is more comparable across patients. The technique does not impose an overhead in measurement time and is straightforward to implement...
  26. pmc PET/MR in children. Initial clinical experience in paediatric oncology using an integrated PET/MR scanner
    Franz Wolfgang Hirsch
    Department of Paediatric Radiology, University of Leipzig, Liebigstr 20a, 04103, Leipzig, Germany
    Pediatr Radiol 43:860-75. 2013
    ..In our initial experience, PET/MR has turned out to be an unexpectedly stable and reliable hybrid imaging modality, which generates a complementary diagnostic study of great additional value. ..
  27. doi request reprint Meta-analysis based SVM classification enables accurate detection of Alzheimer's disease across different clinical centers using FDG-PET and MRI
    Juergen Dukart
    Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
    Psychiatry Res 212:230-6. 2013
    ..Furthermore, combining imaging information from MRI and FDG-PET might substantially improve the accuracy of AD diagnosis...
  28. doi request reprint In Vivo Correlation of Glucose Metabolism, Cell Density and Microcirculatory Parameters in Patients with Head and Neck Cancer: Initial Results Using Simultaneous PET/MRI
    Matthias Gawlitza
    Department of Diagnostic and Interventional Radiology, University Hospital of Leipzig, Liebigstraße 20, 04103 Leipzig, Germany
    PLoS ONE 10:e0134749. 2015
    ....
  29. doi request reprint Physical and organizational provision for installation, regulatory requirements and implementation of a simultaneous hybrid PET/MR-imaging system in an integrated research and clinical setting
    Bernhard Sattler
    Department of Nuclear Medicine, University Hospital Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany
    MAGMA 26:159-71. 2013
    ....
  30. pmc Simultaneous PET/MRI in stroke: a case series
    Peter Werner
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Cereb Blood Flow Metab 35:1421-5. 2015
    ..By offering highly complementary information, [(15)O]H2O-PET/MRI might help to identify critically hypoperfused tissue resulting in an improved patient stratification in thrombolysis trials. ..
  31. doi request reprint Integrated PET/MRI for planning navigated biopsies in pediatric brain tumors
    Matthias Preuss
    Department of Neurosurgery, Pediatric Neurosurgery, University Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany
    Childs Nerv Syst 30:1399-403. 2014
    ..An integrated PET/MRI scanner has been used in selected cases of pediatric brain tumor patients to obtain additional metabolic information about lesions for preoperative biopsy planning and navigation...
  32. ncbi request reprint [18F]Fluoroazomycinarabinofuranoside (18FAZA) and [18F]Fluoromisonidazole (18FMISO): a comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors
    Dietlind Sorger
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Nucl Med Biol 30:317-26. 2003
    ..This advantage of a faster reduction of unspecific binding, in light of similar or marginally lower tumor uptake, warrants further investigation of (18)FAZA as a marker of regional hypoxia in tumors...
  33. ncbi request reprint Different mechanisms for changes in glucose uptake of the right and left ventricular myocardium in pulmonary hypertension
    Regine Kluge
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Nucl Med 46:25-31. 2005
    ..The aim of this study was to measure the metabolic rates of glucose uptake for the RV and LV myocardium in patients in relationship to parameters of RV and LV function...
  34. doi request reprint Effect of progenitor cells on myocardial perfusion and metabolism in patients after recanalization of a chronically occluded coronary artery
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Nucl Med 49:557-63. 2008
    ....
  35. ncbi request reprint Small-animal imaging of tumour proliferation with PET
    Henryk Barthel
    Molecular Therapy and PET Oncology, Imperial College London, Hammersmith Hospital, UK
    Lancet Oncol 5:100. 2004
  36. pmc Combined evaluation of FDG-PET and MRI improves detection and differentiation of dementia
    Juergen Dukart
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    PLoS ONE 6:e18111. 2011
    ....
  37. doi request reprint Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: phase 3 study
    Osama Sabri
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany Electronic address
    Alzheimers Dement 11:964-74. 2015
    ..Evaluation of brain β-amyloid by positron emission tomography (PET) imaging can assist in the diagnosis of Alzheimer disease (AD) and other dementias...
  38. doi request reprint The role of positron emission tomography imaging in understanding Alzheimer's disease
    Henryk Barthel
    Department of Nuclear Medicine, Leipzig University, Liebigstr 11, 04103 Leipzig, Germany
    Expert Rev Neurother 15:395-406. 2015
    ..As such, PET imaging at different disease stages (asymptomatic, prodromal and dementia stages) is on its way to becoming a valuable routine clinical biomarker and a drug testing and research tool in AD. ..
  39. ncbi request reprint Correlation between automated writing movements and striatal dopaminergic innervation in patients with Wilson's disease
    Wieland Hermann
    Department of Neurology, University of Leipzig, Liebigstr 22a, 04107 Leipzig, Germany
    J Neurol 249:1082-7. 2002
    ..Furthermore analysis of automated handwriting movements could be useful for therapy monitoring and evaluation of striatal dopaminergic innervation...
  40. ncbi request reprint Effect of drug-induced cytotoxicity on glucose uptake in Hodgkin's lymphoma cells
    Ursula Banning
    Division of Pediatric Hematology and Oncology, Clinic and Policlinic for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Eur J Haematol 77:102-8. 2006
    ..However, drug-mediated downregulation of glucose uptake in viable Hodgkin's lymphoma cells might limit the use of FDG-PET...
  41. doi request reprint Permanent middle cerebral artery occlusion in sheep: a novel large animal model of focal cerebral ischemia
    Johannes Boltze
    Fraunhofer Institute of Cell Therapy and Immunology, Leipzig, Germany
    J Cereb Blood Flow Metab 28:1951-64. 2008
    ..This model could be used as an alternative to existing large animal models, especially for longitudinal analyses of the safety and therapeutic impact of novel therapies in the field of translational stroke research...