Ralf Baron

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. ncbi request reprint painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain
    Rainer Freynhagen
    Klinik fur Anasthesiologie, Universitatsklinikum Dusseldorf, Dusseldorf, Germany
    Curr Med Res Opin 22:1911-20. 2006
  2. doi request reprint Assessment and diagnosis of neuropathic pain
    Ralf Baron
    Department of Neurological Pain Research and Therapy, Department of Neurology, Christian Albrechts University, Kiel, Germany
    Curr Opin Support Palliat Care 2:1-8. 2008
  3. doi request reprint Subgrouping of patients with neuropathic pain according to pain-related sensory abnormalities: a first step to a stratified treatment approach
    Ralf Baron
    Sektion Neurologische Schmerzforschung und Therapie, Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Kiel, Germany
    Lancet Neurol 11:999-1005. 2012
  4. pmc Novel SCARB2 mutation in action myoclonus-renal failure syndrome and evaluation of SCARB2 mutations in isolated AMRF features
    Franziska Hopfner
    Institute of Human Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    BMC Neurol 11:134. 2011
  5. pmc Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain: the report of an expert panel
    Alessandro P Burlina
    Neurological Unit, St Bassiano Hospital, Bassano del Grappa, Italy
    BMC Neurol 11:61. 2011
  6. doi request reprint Efficacy and safety of 5% lidocaine (lignocaine) medicated plaster in comparison with pregabalin in patients with postherpetic neuralgia and diabetic polyneuropathy: interim analysis from an open-label, two-stage adaptive, randomized, controlled trial
    Ralf Baron
    Division of Neurological Pain Research and Therapy, Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    Clin Drug Investig 29:231-41. 2009
  7. doi request reprint Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment
    Ralf Baron
    Sektion für Neurologische Schmerzforschung und therapie, Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    Lancet Neurol 9:807-19. 2010
  8. doi request reprint Efficacy and safety of combination therapy with 5% lidocaine medicated plaster and pregabalin in post-herpetic neuralgia and diabetic polyneuropathy
    Ralf Baron
    Division of Neurological Pain Research and Therapy, Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    Curr Med Res Opin 25:1677-87. 2009
  9. doi request reprint 5% lidocaine medicated plaster versus pregabalin in post-herpetic neuralgia and diabetic polyneuropathy: an open-label, non-inferiority two-stage RCT study
    Ralf Baron
    Division of Neurological Pain Research and Therapy, Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    Curr Med Res Opin 25:1663-76. 2009
  10. ncbi request reprint [Complex regional pain syndrome. Sympathetic reflex dystrophy and causalgia]
    R Baron
    Universitätsklinik für Neurologie, Christian Albrects Universität, Kiel
    Schmerz 17:213-26. 2003

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain
    Rainer Freynhagen
    Klinik fur Anasthesiologie, Universitatsklinikum Dusseldorf, Dusseldorf, Germany
    Curr Med Res Opin 22:1911-20. 2006
    ....
  2. doi request reprint Assessment and diagnosis of neuropathic pain
    Ralf Baron
    Department of Neurological Pain Research and Therapy, Department of Neurology, Christian Albrechts University, Kiel, Germany
    Curr Opin Support Palliat Care 2:1-8. 2008
    ..There is now recognition from clinical investigations that neuropathic pain is not a monolithic entity, but instead presents as a composite of pain and other sensory symptoms...
  3. doi request reprint Subgrouping of patients with neuropathic pain according to pain-related sensory abnormalities: a first step to a stratified treatment approach
    Ralf Baron
    Sektion Neurologische Schmerzforschung und Therapie, Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Kiel, Germany
    Lancet Neurol 11:999-1005. 2012
    ..Subgrouping patients on the basis of individual sensory profiles could reduce this heterogeneity and improve trial design...
  4. pmc Novel SCARB2 mutation in action myoclonus-renal failure syndrome and evaluation of SCARB2 mutations in isolated AMRF features
    Franziska Hopfner
    Institute of Human Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    BMC Neurol 11:134. 2011
    ..To test the hypothesis whether isolated appearance of individual AMRF syndrome features could be related to heterozygote SCARB2 mutations, we screened for SCARB2 mutations in unrelated patients showing isolated AMRF features...
  5. pmc Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain: the report of an expert panel
    Alessandro P Burlina
    Neurological Unit, St Bassiano Hospital, Bassano del Grappa, Italy
    BMC Neurol 11:61. 2011
    ..Patients with Fabry disease often remain undiagnosed until severe complications involving the kidney, heart, peripheral nerves and/or brain have arisen...
  6. doi request reprint Efficacy and safety of 5% lidocaine (lignocaine) medicated plaster in comparison with pregabalin in patients with postherpetic neuralgia and diabetic polyneuropathy: interim analysis from an open-label, two-stage adaptive, randomized, controlled trial
    Ralf Baron
    Division of Neurological Pain Research and Therapy, Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    Clin Drug Investig 29:231-41. 2009
    ..This study aimed to compare 5% lidocaine medicated plaster treatment with pregabalin in patients with PHN and patients with DPN...
  7. doi request reprint Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment
    Ralf Baron
    Sektion für Neurologische Schmerzforschung und therapie, Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    Lancet Neurol 9:807-19. 2010
    ..A better understanding of neuropathic pain and, in particular, of the translation of pathophysiological mechanisms into sensory signs will lead to a more effective and specific mechanism-based treatment approach...
  8. doi request reprint Efficacy and safety of combination therapy with 5% lidocaine medicated plaster and pregabalin in post-herpetic neuralgia and diabetic polyneuropathy
    Ralf Baron
    Division of Neurological Pain Research and Therapy, Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    Curr Med Res Opin 25:1677-87. 2009
    ....
  9. doi request reprint 5% lidocaine medicated plaster versus pregabalin in post-herpetic neuralgia and diabetic polyneuropathy: an open-label, non-inferiority two-stage RCT study
    Ralf Baron
    Division of Neurological Pain Research and Therapy, Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    Curr Med Res Opin 25:1663-76. 2009
    ..To compare efficacy and safety of 5% lidocaine medicated plaster with pregabalin in patients with post-herpetic neuralgia (PHN) or painful diabetic polyneuropathy (DPN)...
  10. ncbi request reprint [Complex regional pain syndrome. Sympathetic reflex dystrophy and causalgia]
    R Baron
    Universitätsklinik für Neurologie, Christian Albrects Universität, Kiel
    Schmerz 17:213-26. 2003
    ..After reduced spontaneous pain,physiotherapy should be increased stepwise...
  11. doi request reprint A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: Differences in demographic data and sensory symptoms
    Ralf Baron
    Sektion Neurologische Schmerzforschung und Therapie, Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstr 10, 24105 Kiel, Germany
    Pain 146:34-40. 2009
    ..Patient-Reported Outcomes can be used to obtain a precise sensory characterization of each patient...
  12. ncbi request reprint [How neuropathic is sciatica? The mixed pain concept]
    R Baron
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel
    Orthopade 33:568-75. 2004
    ..Therefore, the combination of these analgesic compounds with NSAID could be useful in patients with sciatic pain who do not respond to NSAID...
  13. ncbi request reprint Post-herpetic neuralgia case study: optimizing pain control
    R Baron
    Neurological Clinic, Christian Albrechts Universitat zu Kiel, Kiel, Germany
    Eur J Neurol 11:3-11. 2004
    ..This review article features a case study of a patient with PHN to illustrate current diagnostic and treatment approaches...
  14. ncbi request reprint [Diagnosis of neuropathic pain]
    R Baron
    Sektion Neurologische Schmerzforschung und Therapie, Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel
    Dtsch Med Wochenschr 132:2139-44. 2007
    ..These medications exert specific molecular pharmacological effects against the pathophysiological mechanisms of neuropathic pain...
  15. ncbi request reprint Mechanisms of disease: neuropathic pain--a clinical perspective
    Ralf Baron
    Department of Neurological Pain Research and Therapy, Christian Albrechts Universitat Kiel, Germany
    Nat Clin Pract Neurol 2:95-106. 2006
    ..This review discusses the conceptual framework of the novel mechanism-based classification, encouraging the reader to see neuropathic pain as a clinical entity rather than a compilation of single disease states...
  16. ncbi request reprint Prevention and treatment of postherpetic neuralgia
    Ralf Baron
    Division of Neurological Pain Research and Therapy, Department of Neurology, Universitatsklinikum Schleswig Holstein, 24105 Kiel, Germany
    Lancet 367:186-8. 2006
  17. doi request reprint Efficacy and safety of pregabalin in patients with diabetic peripheral neuropathy or postherpetic neuralgia: Open-label, non-comparative, flexible-dose study
    Ralf Baron
    Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital of Schleswig Holstein, Campus Kiel, Schittenhelmstr 10, D 24105 Kiel, Germany
    Eur J Pain 12:850-8. 2008
    ..The PGIC and CGIC and the specific pain and sleep scores, but not the anxiety score were generally well correlated but not synonymous...
  18. ncbi request reprint Complex regional pain syndromes--how do we escape the diagnostic trap?
    Ralf Baron
    Department of Neurological Pain Research and Therapy, Neurological Clinic, Christian Albrechts Universitat zu Kiel, 24105 Kiel, Germany
    Lancet 364:1739-41. 2004
  19. doi request reprint The efficacy and safety of pregabalin in the treatment of neuropathic pain associated with chronic lumbosacral radiculopathy
    Ralf Baron
    Division of Neurological Pain Research and Therapy, Department of Neurology, Christian Albrechts University, Kiel, Germany
    Pain 150:420-7. 2010
    ..Considering the results of all phases of the study, it is difficult to draw definitive conclusions from it, suggesting a need for further work to understand the clinical potential of pregabalin treatment for lumbosacral radiculopathy...
  20. doi request reprint [Types of topical treatment for peripheral neuropathic pain : Mechanism of action and indications]
    R Baron
    Sektion Neurologische Schmerzforschung und Therapie, Klinik fur Neurologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Haus 41, Arnold Heller Str 3, 24105, Kiel, Deutschland
    Schmerz 24:317-25. 2010
    ..Pharmacological interactions with systematically acting substances are also virtually absent; thus, topically applied substances are especially appropriate for add-on therapy in addition to systemic pain medication...
  21. ncbi request reprint Afferent large fiber polyneuropathy predicts the development of postherpetic neuralgia
    R Baron
    Klinik fur Neurologie, Christian Albrechts Universitat zu Kiel, Germany
    Pain 73:231-8. 1997
    ..e., impairment of afferent A beta-fiber function, may be used as a predictor of PHN...
  22. ncbi request reprint Optimal treatment of phantom limb pain in the elderly
    R Baron
    Klinik fur Neurologie, Christian Albrechts Universitat zu Kiel, Germany
    Drugs Aging 12:361-76. 1998
    ..Patients with severe pain should be referred to a pain specialist to ensure optimal and timely interventional pain management...
  23. ncbi request reprint Brain processing of capsaicin-induced secondary hyperalgesia: a functional MRI study
    R Baron
    Department of Neurology, University of California at San Francisco, USA
    Neurology 53:548-57. 1999
    ..To investigate, using functional MRI (fMRI), the neural network that is activated by the pain component of capsaicin-induced secondary mechanical hyperalgesia...
  24. ncbi request reprint Peripheral neuropathic pain: from mechanisms to symptoms
    R Baron
    Klinik fur Neurologie, Christian Albrechts Universitat Kiel, Germany
    Clin J Pain 16:S12-20. 2000
    ..The treatment of neuropathic pain is currently unsatisfactory. In the future, drugs will be developed that address specifically the relevant combination of mechanisms...
  25. ncbi request reprint Activation of the somatosensory cortex during Abeta-fiber mediated hyperalgesia. A MSI study
    R Baron
    Department of Neurology, University of California, San Francisco, USA
    Brain Res 871:75-82. 2000
    ..To investigate the neural activation in the primary somatosensory cortex (SI) that is induced by capsaicin-evoked secondary Abeta-fiber-mediated hyperalgesia with magnetic source imaging (MSI) in healthy humans...
  26. ncbi request reprint [Neuropathic pain. The long path from mechanisms to mechanism-based treatment]
    R Baron
    Klinik fur Neurologie, Christian Albrechts Universitat zu Kiel
    Anaesthesist 49:373-86. 2000
    ..Drug therapies that are available today include NSAIDS, opioids, tricyclic antidepressants, anticonvulsives (carbamazepine, gabapentin), GABA-agonists, Capsaicin and NMDA-antagonists...
  27. ncbi request reprint Complex regional pain syndromes
    R Baron
    Klinik fur Neurologie, Christian Albrechts Universitat Kiel, Niemannsweg 147, Kiel 24105, Germany
    Curr Pain Headache Rep 5:114-23. 2001
    ..Interdisciplinary treatment includes physical, pharmacologic, and invasive interventional therapy, as well as stimulation techniques...
  28. ncbi request reprint Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case-control study
    R Baron
    Klinik für Neurologie Christian Albrechts Universität Kiel, Kiel, Germany
    Lancet 359:1655-60. 2002
    ..We aimed to establish the effect of physiological sympathetic cutaneous vasoconstrictor activity on pain and hyperalgesia in patients with complex regional pain syndromes...
  29. ncbi request reprint Reflex sympathetic dystrophy and causalgia
    Ralf Baron
    Universitatsklinikum Schleswig Holstein, Campus Kiel, Klinik fur Neurologie, Schittenhelmstrasse 10, D 24105 Kiel, Germany
    Suppl Clin Neurophysiol 57:24-38. 2004
  30. ncbi request reprint [Complex regional pain syndrome. Reflex sympathetic dystrophy and causalgia]
    R Baron
    Universitätsklinik für Neurologie, Kiel
    Nervenarzt 73:305-18; quiz 319. 2002
    ..After reduced spontaneous pain, physiotherapy should be increased stepwise...
  31. doi request reprint Effect of local and intravenous lidocaine on ongoing activity in injured afferent nerve fibers
    Irina Kirillova
    Physiologisches Institut, Christian Albrechts Universitat zu Kiel, Kiel, Germany
    Pain 152:1562-71. 2011
    ..The results support the hypothesis that decrease of neuropathic pain following local or systemic application of a local anesthetic is related to decrease of ectopic ongoing activity in injured afferent nerve fibers...
  32. ncbi request reprint Postherpetic neuralgia: topical lidocaine is effective in nociceptor-deprived skin
    Gunnar Wasner
    Dept of Neurological Pain Research and Therapy, Neurological Clinic, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
    J Neurol 252:677-86. 2005
    ..The aim of the present investigation was to classify patients according to their predominant peripheral nociceptor function and to compare these data with the results of a controlled study using dermal lidocaine patch...
  33. ncbi request reprint No adrenergic sensitization of afferent neurons in painful sensory polyneuropathy
    Jörn Schattschneider
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstr 10, 24105 Kiel, Germany
    J Neurol 253:280-6. 2006
    ....
  34. doi request reprint Influence of deep brain stimulation and levodopa on sensory signs in Parkinson's disease
    Janne Gierthmühlen
    Department of Neurology, Division of Neurological Pain Research and Therapy, Universitatsklinikum Schleswig Holstein, Kiel, Germany
    Mov Disord 25:1195-202. 2010
    ....
  35. pmc Fibromyalgia and neuropathic pain--differences and similarities. A comparison of 3057 patients with diabetic painful neuropathy and fibromyalgia
    Jana Koroschetz
    Sektion Neurologische Schmerzforschung und Therapie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Arnold Heller Str, 3, Haus 41, 24105 Kiel, Germany
    BMC Neurol 11:55. 2011
    ..The aims were (1) to compare epidemiological features and co-morbidities and (2) to identify similarities and differences of sensory symptoms in both entities...
  36. pmc Axial low back pain: one painful area--many perceptions and mechanisms
    Matti Förster
    Sektion Neurologische Schmerzforschung und Therapie, Klinik für Neurologie Universitätsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    PLoS ONE 8:e68273. 2013
    ..Standardized phenotyping of pain symptoms with easy tools may help to develop an individualized therapy leading to a higher success rate in pharmacotherapy of axial low back pain. ..
  37. ncbi request reprint Modulation of sensitized C-fibers by adrenergic stimulation in human neuropathic pain
    Jörn Schattschneider
    Sektion für Neurologische Schmerzforschung, Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstr 10, 24103 Kiel, Germany
    Eur J Pain 12:517-24. 2008
    ..The aim of the present study was to investigate if in patients with nerve entrapment nociceptive afferents can be modulated by adrenergic stimulation...
  38. doi request reprint Detection of a characteristic painful neuropathy in Fabry disease: a pilot study
    Rainer Maag
    Division of Neurological Pain Research and Therapy, Christian Albrechts Universitat Kiel, Kiel, Germany
    Pain Med 9:1217-23. 2008
    ..Early detection of this likely underdiagnosed disease is an important approach because a causal therapy is available...
  39. ncbi request reprint Mechanisms of adrenosensitivity in capsaicin induced hyperalgesia
    Jörn Schattschneider
    Sektion Neurologische Schmerzforschung und Therapie, Klinik für Neurologie des Universitätsklinikums Schleswig Holstein, Campus Kiel, Schittenhelmstr 10, 24103, Kiel, Germany
    Eur J Pain 11:756-63. 2007
    ....
  40. doi request reprint Topical high-concentration (40%) menthol-somatosensory profile of a human surrogate pain model
    Andreas Binder
    Division of Neurological Pain Research and Therapy, Christian Albrechts Universitat Kiel, Kiel, Germany
    J Pain 12:764-73. 2011
    ..The data suggest that topical 40% menthol application is a useful model for studies of cold hyperalgesia and pinprick hyperalgesia in humans...
  41. ncbi request reprint Effect of sympathetic muscle vasoconstrictor activity on capsaicin-induced muscle pain
    Gunnar Wasner
    Klinik fur Neurologie, Christian Albrechts Universitat Kiel, Niemannsweg 147, 24105 Kiel, Germany
    Muscle Nerve 26:113-21. 2002
    ....
  42. doi request reprint A cross-sectional survey of 3035 patients with fibromyalgia: subgroups of patients with typical comorbidities and sensory symptom profiles
    Stefanie E Rehm
    Sektion Neurologische Schmerzforschung und Therapie, Klinik fur Neurologie, Christian Albrechts Universitat Kiel, Arnold Heller Strasse 3, Haus 41, 24105 Kiel, Germany
    Rheumatology (Oxford) 49:1146-52. 2010
    ..Patients with FM are heterogeneous. They present with a variety of pain qualities, sensory abnormalities and additional comorbidities. The aim was to identify clinically distinguishable subgroups of patients...
  43. doi request reprint Cutaneous afferent C-fibers regenerating along the distal nerve stump after crush lesion show two types of cold sensitivity
    Lydia Grossmann
    Physiologisches Institut, Christian Albrechts Universitat zu Kiel, Olshausenstrasse 40, 24098 Kiel, Germany
    Eur J Pain 13:682-90. 2009
    ..Thus regenerating cutaneous C-fibers show two types of cold sensitivity similar to those observed in intact skin: fibers of one group are predominantly sensitive to cooling, whereas the others are polymodal...
  44. doi request reprint Enhancement of ectopic discharge in regenerating A- and C-fibers by inflammatory mediators
    Lydia Grossmann
    Physiologisches Institut, Christian Albrechts Universitat zu Kiel, 24098 Kiel, Germany
    J Neurophysiol 101:2762-74. 2009
    ..The results suggest that inflammatory mediators may be critical to enhance ectopic excitability of regenerating afferent nerve fibers. These peripheral mechanisms may be important triggering and maintaining neuropathic pain...
  45. ncbi request reprint Topical menthol--a human model for cold pain by activation and sensitization of C nociceptors
    Gunnar Wasner
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Niemannsweg 147, D 24105 Kiel, Germany
    Brain 127:1159-71. 2004
    ..In conclusion, topical menthol is a human model for cold pain by exposing for the first time the mechanism of sensitized peripheral cold C nociceptors that may also be involved in neuropathic pain...
  46. ncbi request reprint Behavioral and sensory changes after direct ischemia-reperfusion injury in rats
    Janne Ludwig
    Division of Neurological Pain Research and Therapy, Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 10, Kiel, Germany
    Eur J Pain 11:677-84. 2007
    ..Using Wistar rats, our data do not support the idea that an ischemia-reperfusion injury can play a major role in the development of CRPS...
  47. doi request reprint Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus
    Miroslav Misha Backonja
    Department of Neurology, University of Wisconsin Madison, Madison, WI, USA
    Pain 154:1807-19. 2013
    ..When appropriate standards, as discussed here, are applied, QST can provide important and unique information about the functional status of somatosensory system, which would be complementary to already existing clinical methods. ..
  48. doi request reprint A case of pain, motor impairment, and swelling of the arm after acute herpes zoster infection
    Matti Förster
    Klinik fur Neurologie, Sektion für Neurologische Schmerzforschung und therapie, Universitatsklinik Schleswig Holstein, Campus Kiel, Kiel, Germany
    Pain 153:2478-81. 2012
    ..Here, we present a patient suffering from CRPS II following PHN of one upper extremity. This case demonstrates that both etiology and part of the body affected by a neuropathy influence the pain phenotype...
  49. ncbi request reprint Assessment of pain and somatosensory function in Fabry disease: early diagnosis
    Rainer Maag
    Division of Neurological Pain Research and Therapy, Department of Neurology, University of Kiel, Schittenhelmstrasse 10, Kiel, Germany
    Clin Ther 30:S52-3. 2008
  50. ncbi request reprint Pseudoradicular and radicular low-back pain--a disease continuum rather than different entities? Answers from quantitative sensory testing
    Rainer Freynhagen
    Department of Anesthesiology, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    Pain 135:65-74. 2008
    ..The spatial incongruence of pain and sensory loss in pseudoradicular pain, however, may also indicate that the two are not causally related...
  51. ncbi request reprint Idiopathic restless legs syndrome: abnormalities in central somatosensory processing
    Jörn Schattschneider
    Dept of Neurology, University Hospital Schleswig Holstein, Campus Kiel, Niemannsweg 147, 24105 Kiel, Germany
    J Neurol 251:977-82. 2004
    ....
  52. ncbi request reprint Complex regional pain syndromes: the influence of cutaneous and deep somatic sympathetic innervation on pain
    Jörn Schattschneider
    Klinik fur Neurologie, Sektion für Schmerzforschung und therapie, Univeritätsklinikum Schleswig Holstein, Campus Kiel, Germany
    Clin J Pain 22:240-4. 2006
    ....
  53. doi request reprint Sensory signs in complex regional pain syndrome and peripheral nerve injury
    Janne Gierthmühlen
    Division of Neurological Pain Research and Therapy, Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    Pain 153:765-74. 2012
    ..These sensory profiles should help prioritize approaches for translation between animal and human research...
  54. ncbi request reprint Pain in oxaliplatin-induced neuropathy--sensitisation in the peripheral and central nociceptive system
    Andreas Binder
    Division of Neurological Pain Research and Therapy, Christian Albrechts Universitat Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
    Eur J Cancer 43:2658-63. 2007
    ..This study aimed to determine the somatosensory characteristics and pain types in patients with acute oxaliplatin-induced neuropathy and to relate this profile to the hereby detected underlying pathophysiological mechanisms...
  55. ncbi request reprint Docetaxel-induced nail changes--a neurogenic mechanism: a case report
    Gunnar Wasner
    Klinik fur Neurologie, Universitätsklinikum der Christian Albrechts Universität zu Kiel, Germany
    J Neurooncol 58:167-74. 2002
    ..In accordance with this hypothesis, a cyclooxygenase-2 inhibitor improved nail alterations of the non-paretic limbs...
  56. doi request reprint Post-herpetic neuralgia: 5% lidocaine medicated plaster, pregabalin, or a combination of both? A randomized, open, clinical effectiveness study
    Stefanie Rehm
    Universitatsklinikum Schleswig Holstein, Kiel, Germany
    Curr Med Res Opin 26:1607-19. 2010
    ..To compare efficacy and safety of 5% lidocaine medicated plaster with pregabalin in patients with post-herpetic neuralgia (PHN), and to assess the benefits of combining both drugs in patients not responding to either single agent...
  57. ncbi request reprint Mechanistic and clinical aspects of complex regional pain syndrome (CRPS)
    Ralf Baron
    Klinik fur Neurologie, Christian Albrechts Universitat Kiel, Niemannsweg 147, 24105 Kiel, Germany
    Novartis Found Symp 261:220-33; discussion 233-8, 256-61. 2004
    ..Transcutaneous electrical stimulation of nociceptive C-fibre provoked protein extravasation into the interstitial fluid (microdialysis) only in CRPS patients and not in controls...
  58. doi request reprint Topical 5% lidocaine (lignocaine) medicated plaster treatment for post-herpetic neuralgia: results of a double-blind, placebo-controlled, multinational efficacy and safety trial
    Andreas Binder
    Division of Neurological Pain Research and Therapy, Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    Clin Drug Investig 29:393-408. 2009
    ..The aim of this study was to evaluate the analgesic efficacy and safety of topical analgesic treatment (5% lidocaine [lignocaine] medicated plaster) compared with placebo plaster in patients with PHN...
  59. ncbi request reprint Complex regional pain syndrome is a disease of the central nervous system
    Wilfrid Jänig
    Physiologisches Institut, Christian Albrechts Universitat zu Kiel, Germany
    Clin Auton Res 12:150-64. 2002
    ..This changed view will bring about a diagnostic reclassification and redefinition of CRPS and will have bearings on the therapeutic approaches. Finally it will shift the focus of research efforts...
  60. pmc Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients
    Andreas Binder
    Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    PLoS ONE 6:e17387. 2011
    ....
  61. ncbi request reprint Screening of neuropathic pain components in patients with chronic back pain associated with nerve root compression: a prospective observational pilot study (MIPORT)
    Rainer Freynhagen
    Department of Anesthesiology, Heinrich Heine University, Universitatsklinikum Dusseldorf, Germany
    Curr Med Res Opin 22:529-37. 2006
    ..We also aimed to assess the usefulness of handheld computers (PDAs) in data collection...
  62. doi request reprint Disease mechanisms in neuropathic itch
    Andreas Binder
    Division of Neurological Pain Research and Therapy, Department of Neurology, Christian Albrechts University of Kiel, Kiel, Germany
    Nat Clin Pract Neurol 4:329-37. 2008
    ..Finally, we propose appropriate treatment strategies for neuropathic itch, in view of the fact that this condition has different mechanisms of itch generation to other types of itch and consequently requires different therapies...
  63. pmc Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease
    Janne Ludwig
    Division of Neurological Pain Research and Therapy, University of Kiel, Kiel, Germany
    J Neurol Neurosurg Psychiatry 78:742-5. 2007
    ..Since less pharmacotherapy is needed after STN stimulation, reduced levodopa intake results in relative improvement of autonomic function in deep brain stimulated PD patients...
  64. pmc Sensory symptom profiles and co-morbidities in painful radiculopathy
    Friederike Mahn
    Sektion Neurologische Schmerzforschung und Therapie, Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    PLoS ONE 6:e18018. 2011
    ..These differences in pathogenesis might explain why medications effective in DPN and PHN failed to demonstrate efficacy in RAD...
  65. ncbi request reprint [Stepped analgesic approach to herpes zoster pain]
    J Ludwig
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Kiel
    MMW Fortschr Med 148:41-3. 2006
  66. doi request reprint A case of neuropathic brachioradial pruritus caused by cervical disc herniation
    Andreas Binder
    Department of Neurological Pain Research and Therapy, Christian Albrechts University of Kiel, Kiel, Germany
    Nat Clin Pract Neurol 4:338-42. 2008
    ..No dermatological diseases, trauma to the affected extremity or the spine, or familial pruritus were reported...
  67. doi request reprint Mechano- and thermosensitivity of injured muscle afferents
    Irina Kirillova
    Physiologisches Institut, Christian Albrechts Universitat zu Kiel, Olshausenstrasse 40, 24098 Kiel, Germany
    J Neurophysiol 105:2058-73. 2011
    ..Comparing the functional properties of injured muscle A- and C-afferents with those of injured cutaneous A- and C-afferents shows that both populations of injured afferent neurons behave differently in several aspects...
  68. doi request reprint Axonal thermosensitivity and mechanosensitivity of cutaneous afferent neurons
    Alina Teliban
    Physiologisches Institut, Christian Albrechts Universitat zu Kiel, Kiel, Germany
    Eur J Neurosci 33:110-8. 2011
    ..Mechanosensitivity is restricted to the afferent endings in the skin...
  69. doi request reprint Evaluation of symptom heterogeneity in neuropathic pain using assessments of sensory functions
    Kathrin Arning
    Division of Neurological Pain Research and Therapy, Department of Neurology, Christian Albrechts Universitat Kiel, Germany
    Neurotherapeutics 6:738-48. 2009
    ..Second, in clinical practice it becomes possible to establish an individualized therapy--that is, to identify the particular patients who require a specific treatment option...
  70. ncbi request reprint Neuropathic pain: translational research and impact for patient care
    Rainer Maag
    Division of Neurological Pain Research and Therapy, Department of Neurology, Christian Albrechts University Kiel, Schittenhelmstr 10, 24105 Kiel, Germany
    Curr Pain Headache Rep 10:191-8. 2006
    ....
  71. ncbi request reprint The motor system shows adaptive changes in complex regional pain syndrome
    Christian Maihofner
    Department of Neurology, Institute for Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    Brain 130:2671-87. 2007
    ..In summary, the results of this study suggest that substantial adaptive changes within the central nervous system may contribute to motor symptoms in CRPS...
  72. doi request reprint Complex regional pain syndrome type I: neuropathic or not?
    Dennis Naleschinski
    Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 3, Haus 41, 24105, Kiel, Germany
    Curr Pain Headache Rep 14:196-202. 2010
    ..We analyzed the strength of the scientific evidence that supports the neuropathic nature of complex regional pain syndromes...
  73. ncbi request reprint Complex regional pain syndrome: mystery explained?
    Wilfrid Jänig
    Department of Physiology, Christian Albrechts University of Kiel, Kiel, Germany
    Lancet Neurol 2:687-97. 2003
    ..The most important question for future research is what causes CRPS? In this article, we suggest a change to the focus of research efforts and treatment. We also suggest there be diagnostic reclassification and redefinition of CRPS...
  74. doi request reprint Role of sympathetic nervous system in activity-induced cerebral perfusion
    Janne Gierthmühlen
    Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital of Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 3, Haus 41, Kiel, Germany
    J Neurol 257:1798-805. 2010
    ....
  75. ncbi request reprint Harlequin syndrome--one face of many etiologies
    Gunnar Wasner
    Prince of Wales Medical Research Institute, University of New South Wales, Randwick, Sydney, NSW, Australia
    Nat Clin Pract Neurol 1:54-9. 2005
    ..8 x 1.2 x 1.2 cm (volume 1.1 ml) had been discovered 2 years previously, within the left lobe of an otherwise uncomplicated goiter that had been successfully managed for 20 years. Otherwise, the patient was healthy...
  76. ncbi request reprint The pathophysiology of parkinsonian tremor: a review
    G Deuschl
    Department of Neurology, Christian Albrechts Universitat Kiel
    J Neurol 247:V33-48. 2000
    ..Assuming the oscillator within the basal ganglia pathway, the mechanism of stereotactic surgery might be a desynchronization of the activity of the basal ganglia-thalamo-cortical or the cerebello-thalamo-cortical pathway...
  77. ncbi request reprint Vascular abnormalities in reflex sympathetic dystrophy (CRPS I): mechanisms and diagnostic value
    G Wasner
    , , Kiel, Niemannsweg 147, 24105 Kiel, Germany
    Brain 124:587-99. 2001
    ..Vascular abnormalities are dynamic. The maximal skin temperature difference that occurs during the thermoregulatory cycle distinguishes CRPS I from other extremity pain syndromes with high sensitivity and specificity...
  78. ncbi request reprint Histamine-induced itch converts into pain in neuropathic hyperalgesia
    R Baron
    , , Niemannsweg 147, Kiel, Germany
    Neuroreport 12:3475-8. 2001
    ..In neuropathies irritable nociceptors may express histamine receptors or induce central sensitization to histaminergic stimuli so that itch converts into pain...
  79. ncbi request reprint [The symptom sympathetic maintained pain]
    J Schattschneider
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel
    Schmerz 17:317-24. 2003
    ....
  80. doi request reprint Somatosensory processing in a German family with PINK1 mutations: its potential role in Parkinson disease
    J Gierthmühlen
    Universitatsklinikum Schleswig Holstein, Campus Kiel, Department of Neurology, Division of Neurological Pain Research and Therapy, Kiel, Germany
    J Neurol Neurosurg Psychiatry 80:571-4. 2009
    ..It is unclear whether sensory symptoms in Parkinson disease (PD) are of primary or of secondary origin attributable to motor symptoms such as rigidity and bradykinesia...
  81. ncbi request reprint Complex regional pain syndrome--diagnostic, mechanisms, CNS involvement and therapy
    G Wasner
    Klinik fur Neurologie, Universitatsklinikum Kiel, 24105 Kiel, Germany
    Spinal Cord 41:61-75. 2003
    ..An early diagnosis and an interdisciplinary approach are important for optimal and successful treatment...
  82. doi request reprint Somatosensory function in asymptomatic Parkin-mutation carriers
    J Gierthmühlen
    Division of Neurological Pain Research and Therapy, Department of Neurology, University of Kiel, Kiel, Germany
    Eur J Neurol 17:513-7. 2010
    ..The aim of our study was to investigate asymptomatic Parkin-mutation carriers to elucidate whether putative somatosensory abnormalities precede motor symptoms therewith helping to determine the origin of somatosensory signs...
  83. ncbi request reprint [Recent trends in understanding and therapy of complex regional pain syndromes]
    G Wasner
    Klinik fur Neurologie, Universitatsklinikum Kiel
    Anaesthesist 52:883-95. 2003
    ..An early and interdisciplinary approach is the basis for an optimal and successful treatment...
  84. pmc Platelet-leukocyte interaction and platelet activation in migraine: a link to ischemic stroke?
    J A Zeller
    Department of Neurology, Christian Albrechts University Kiel, Kiel, Germany
    J Neurol Neurosurg Psychiatry 75:984-7. 2004
    ..We aimed to determine whether platelet-leukocyte aggregation is increased in migraine patients outside an acute attack...
  85. ncbi request reprint Endothelial dysfunction in cold type complex regional pain syndrome
    J Schattschneider
    Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Neurology 67:673-5. 2006
    ..No significant differences were found after application of sodium nitroprusside. The results demonstrate impaired endothelial function in chronic CRPS I...
  86. ncbi request reprint [Neuropathic pain]
    J Ludwig
    Sektion Neurologische Schmerzforschung und Therapie, Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstr 10, D 24105 Kiel
    MMW Fortschr Med 147:76-8. 2005
    ..Arises after an injury to nociceptive systems. Examples of the most common causes are polyneuropathies, acute zoster neuralgia, and postherpetic neuralgia. The differential diagnosis and management are discussed...
  87. ncbi request reprint [Pain prevention allows patients with chronic pruritus to itch from central sensitivity for itching]
    G Wasner
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel
    Schmerz 19:324-7. 2005
  88. doi request reprint Cytokine expression in serum and cerebrospinal fluid in non-inflammatory polyneuropathies
    J Ludwig
    Division of Neurological Pain Research and Therapy, Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Neurol Neurosurg Psychiatry 79:1268-73. 2008
    ..Pro-inflammatory cytokines have been shown to induce or increase inflammatory or neuropathic pain...
  89. ncbi request reprint Platelet activation and platelet-leucocyte interaction in patients with migraine. Subtype differences and influence of triptans
    J A Zeller
    Department of Neurology, Christian Albrechts University Kiel, Kiel, Germany
    Cephalalgia 25:536-41. 2005
    ..This mechanism may account for the triptan-induced increases in headache frequency. The involvement of proinflammatory platelet-leucocyte cross-talk suggests a possible therapeutic strategy using anti-inflammatory drugs...
  90. ncbi request reprint Interaction between histamine-induced itch and experimental muscle pain
    G Wasner
    Klinik fur Neurologie, Christian Albrechts Universitat Kiel, Kiel, Germany
    Eur J Pain 8:179-85. 2004
    ..A bi-directional interaction between cutaneous histamine-sensitive afferents and nociceptive muscle afferents via central mechanisms is suggested...
  91. ncbi request reprint Skin temperature side differences--a diagnostic tool for CRPS?
    Gunnar Wasner
    Klinik fur Neurologie, Universitätsklinikum Kiel der Christian Albrechts Universität, Niemannsweg 147, 24105 Kiel, Germany
    Pain 98:19-26. 2002
    ..Taking this into consideration, skin temperature differences in the distal limbs are capable of reliably distinguishing CRPS I from other extremity pain syndromes with high sensitivity and specificity...
  92. ncbi request reprint Postganglionic cholinergic dysautonomia with incomplete recovery: a clinical, neurophysiological and immunological case study
    R Baron
    , , Germany
    J Neurol 243:18-24. 1996
    ..Whatever autoimmunological mechanism might be involved, the postulated antibodies act highly specifically on unknown structures of the cholinergic postganglionic autonomic neurons...
  93. ncbi request reprint National Institutes of Health Workshop: reflex sympathetic dystrophy/complex regional pain syndromes--state-of-the-science
    Ralf Baron
    Department of Neurology, University of Kiel, Germany
    Anesth Analg 95:1812-6. 2002
  94. pmc Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli
    Hee Kee Kim
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Pain 129:93-101. 2007
    ....
  95. ncbi request reprint [Pregabalin--clinical evidence and experiences]
    Ralf Baron
    Krankenpfl J 43:204-5. 2005
  96. ncbi request reprint Peripheral burning cold pain
    Gunnar Wasner
    Pain 120:325; discussion 325-6. 2006
  97. ncbi request reprint Is CRPS I a neuropathic pain syndrome?
    Wilfrid Jänig
    Pain 120:227-9. 2006
  98. ncbi request reprint [Reducing pain by new forms of therapy]
    Ralf Baron
    Krankenpfl J 42:224-5. 2004
  99. ncbi request reprint Efficacy of lidocaine patch 5% in the treatment of focal peripheral neuropathic pain syndromes: a randomized, double-blind, placebo-controlled study
    Torsten Meier
    Department of Anesthesiology, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Pain 106:151-8. 2003
    ..4 in the present study compared reasonably well with other studies of PHN, such as topically applied capsaicin (NNT: 5.3-infinity) or systemic treatment with gabapentin (NNT: 3.2-5.0)...
  100. ncbi request reprint [Neuropathic pain. Basic principles for successful therapy]
    Thomas R Tolle
    Neurologische Klinik, TU Munchen
    MMW Fortschr Med 144:41-4. 2002
  101. ncbi request reprint Translation of symptoms and signs into mechanisms in neuropathic pain
    Troels S Jensen
    Department of Neurology, Aarhus University, DK 8000 Aarhus C, Denmark
    Pain 102:1-8. 2003