Detail Information
Publications
Mechanism of PP2A-mediated IKK beta dephosphorylation: a systems biological approachJohannes Witt
Institute for System Dynamics, Universitat Stuttgart, Pfaffenwaldring 9, 70569 Stuttgart, Germany
BMC Syst Biol 3:71. 2009....
Tyrosine phosphatase inhibition triggers sustained canonical serine-dependent NFkappaB activation via Src-dependent blockade of PP2ASandra Barisic
Institute of Cell Biology and Immunology, University of Stuttgart, Germany
Biochem Pharmacol 80:439-47. 2010..Additionally to the known survival pathways triggered by Src, Src-mediated canonical and persistent NFkappaB activation may fortify its tumorigenic effects...
Modeling time delay in the NFκB signaling pathway following low dose IL-1 stimulationJohannes Witt
Institute for System Dynamics, University of Stuttgart, Pfaffenwaldring 9, 70569 Stuttgart, Germany
EURASIP J Bioinform Syst Biol 2011:3. 2011..The extension is shown to be consistent with the original model and contains very sensitive processes which may serve as potential intervention targets...
Phosphorylation of Ser 402 impedes phosphatase activity of slingshot 1Sandra Barisic
Institute for Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
EMBO Rep 12:527-33. 2011..We thus identify a universal mechanism by which PKD controls SSH1 phosphatase activity...
