Hans Jurgen Bandelt

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. pmc Distilling artificial recombinants from large sets of complete mtDNA genomes
    Qing Peng Kong
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
    PLoS ONE 3:e3016. 2008
  2. ncbi request reprint Phylogeography of the human mitochondrial haplogroup L3e: a snapshot of African prehistory and Atlantic slave trade
    H J Bandelt
    Fachbereich Mathematik, Universitat Hamburg, Germany
    Ann Hum Genet 65:549-63. 2001
  3. pmc Contamination and sample mix-up can best explain some patterns of mtDNA instabilities in buccal cells and oral squamous cell carcinoma
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
    BMC Cancer 9:113. 2009
  4. doi request reprint Median network analysis of defectively sequenced entire mitochondrial genomes from early and contemporary disease studies
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, Hamburg, Germany
    J Hum Genet 54:174-81. 2009
  5. doi request reprint Perfectly misleading distances from ternary characters
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, Hamburg, Germany
    Syst Biol 57:540-3. 2008
  6. ncbi request reprint Consistent treatment of length variants in the human mtDNA control region: a reappraisal
    H J Bandelt
    Department of Mathematics, University of Hamburg, Bundesstrasse 55, 20146, Hamburg, Germany
    Int J Legal Med 122:11-21. 2008
  7. ncbi request reprint High penetrance of sequencing errors and interpretative shortcomings in mtDNA sequence analysis of LHON patients
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
    Biochem Biophys Res Commun 352:283-91. 2007
  8. ncbi request reprint What is a 'novel' mtDNA mutation--and does 'novelty' really matter?
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, Bundesstr 55, 20146, Hamburg, Germany, and Centro Nacional de Genotipado, Hospital Clinico Universitario, Galicia, Spain
    J Hum Genet 51:1073-82. 2006
  9. ncbi request reprint Translating DNA data tables into quasi-median networks for parsimony analysis and error detection
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
    Mol Phylogenet Evol 42:256-71. 2007
  10. ncbi request reprint Quality assessment of DNA sequence data: autopsy of a mis-sequenced mtDNA population sample
    H J Bandelt
    Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
    Ann Hum Genet 70:314-26. 2006

Detail Information

Publications23

  1. pmc Distilling artificial recombinants from large sets of complete mtDNA genomes
    Qing Peng Kong
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
    PLoS ONE 3:e3016. 2008
    ....
  2. ncbi request reprint Phylogeography of the human mitochondrial haplogroup L3e: a snapshot of African prehistory and Atlantic slave trade
    H J Bandelt
    Fachbereich Mathematik, Universitat Hamburg, Germany
    Ann Hum Genet 65:549-63. 2001
    ..Enforced migration of African slaves to the Americas translocated L3e mitochondria, the descendants of which in Brazil and the Caribbean still reflect their different regional African ancestries...
  3. pmc Contamination and sample mix-up can best explain some patterns of mtDNA instabilities in buccal cells and oral squamous cell carcinoma
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
    BMC Cancer 9:113. 2009
    ..We demonstrate here that the phylogenetic linkage of whole arrays of mtDNA mutations provides strong evidence of artificial recombination in previous studies on buccal cells and oral squamous cell carcinoma...
  4. doi request reprint Median network analysis of defectively sequenced entire mitochondrial genomes from early and contemporary disease studies
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, Hamburg, Germany
    J Hum Genet 54:174-81. 2009
    ..Our study provides a paradigm for an a posteriori evaluation of sequence quality and for detection of potential problems with inferring a pathogenic status of a particular mutation...
  5. doi request reprint Perfectly misleading distances from ternary characters
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, Hamburg, Germany
    Syst Biol 57:540-3. 2008
    ..In the present note we will answer this question by showing that three character states suffice to construct such misleading sequences--even if we insist that they conform to an ultrametric (i.e., fit a molecular clock)...
  6. ncbi request reprint Consistent treatment of length variants in the human mtDNA control region: a reappraisal
    H J Bandelt
    Department of Mathematics, University of Hamburg, Bundesstrasse 55, 20146, Hamburg, Germany
    Int J Legal Med 122:11-21. 2008
    ..To remedy the situation, we propose a phylogenetic approach for multiple alignment and resulting notation...
  7. ncbi request reprint High penetrance of sequencing errors and interpretative shortcomings in mtDNA sequence analysis of LHON patients
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
    Biochem Biophys Res Commun 352:283-91. 2007
    ..Here, we re-analyse four problematic LHON studies and propose guidelines by which some of the pitfalls could be avoided...
  8. ncbi request reprint What is a 'novel' mtDNA mutation--and does 'novelty' really matter?
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, Bundesstr 55, 20146, Hamburg, Germany, and Centro Nacional de Genotipado, Hospital Clinico Universitario, Galicia, Spain
    J Hum Genet 51:1073-82. 2006
    ....
  9. ncbi request reprint Translating DNA data tables into quasi-median networks for parsimony analysis and error detection
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
    Mol Phylogenet Evol 42:256-71. 2007
    ..A pertinent example drawn from human mtDNA illustrates these points...
  10. ncbi request reprint Quality assessment of DNA sequence data: autopsy of a mis-sequenced mtDNA population sample
    H J Bandelt
    Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
    Ann Hum Genet 70:314-26. 2006
    ..Since no complete correction of these data has appeared to date, this example of mis-sequencing necessitates circumstantial evidence that is bullet-proof...
  11. ncbi request reprint Mosaics of ancient mitochondrial DNA: positive indicators of nonauthenticity
    Hans Jurgen Bandelt
    Fachbereich Mathematik, Universitat Hamburg, Hamburg, Germany
    Eur J Hum Genet 13:1106-12. 2005
    ..To reject or question authenticity of particular sequencing results a posteriori, one can follow similar strategies of focused database comparisons that have proven to be effective and successful in the case of flawed modern mtDNA data...
  12. ncbi request reprint Low "penetrance" of phylogenetic knowledge in mitochondrial disease studies
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, Germany
    Biochem Biophys Res Commun 333:122-30. 2005
    ..To further validate our phylogenetic deductions, we completely sequenced two mtDNAs from healthy subjects that nearly match the mtDNAs of two patients, whose sequences gave problematic results...
  13. ncbi request reprint Artificial recombination in forensic mtDNA population databases
    H J Bandelt
    Fachbereich Mathematik, Universitat Hamburg, Bundesstrasse 55, 20146 Hamburg, Germany
    Int J Legal Med 118:267-73. 2004
    ..Therefore, we suggest that this approach should be applied to data prior to publication in order to uncover such errors in time...
  14. ncbi request reprint Identification of Native American founder mtDNAs through the analysis of complete mtDNA sequences: some caveats
    H J Bandelt
    Fachbereich Mathematik, Universitat Hamburg, Hamburg, Germany
    Ann Hum Genet 67:512-24. 2003
    ....
  15. pmc A critical reassessment of the role of mitochondria in tumorigenesis
    Antonio Salas
    Unidade de Xenetica, Instituto de Medicina Legal, Facultade de Medicina, Universidad de Santiago de Compostela, Galicia, Spain
    PLoS Med 2:e296. 2005
    ....
  16. pmc High mitochondrial DNA stability in B-cell chronic lymphocytic leukemia
    Maria Cerezo
    Unidade de Xenetica, Instituto de Medicina Legal, and Departamento de Anatomía Patolóxica y Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, Santiago de Compostela, Galicia, Spain
    PLoS ONE 4:e7902. 2009
    ..Chronic Lymphocytic Leukemia (CLL) leads to progressive accumulation of lymphocytes in the blood, bone marrow, and lymphatic tissues. Previous findings have suggested that the mtDNA could play an important role in CLL...
  17. ncbi request reprint A practical guide to mitochondrial DNA error prevention in clinical, forensic, and population genetics
    Antonio Salas
    Unidade de Xenetica, Instituto de Medicina Legal, Facultade de Medicina, 15782 Universidade de Santiago de Compostela, Centro Nacional de Xenotipado CeGen, Hospital Clinico Universitario, 15706 Galicia, Spain
    Biochem Biophys Res Commun 335:891-9. 2005
    ..A fictitious case study of a European mtDNA data set (albeit composed from the literature) then demonstrates the steps one has to go through in order to assess the quality of sequencing and documentation...
  18. doi request reprint The brave new era of human genetic testing
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
    Bioessays 30:1246-51. 2008
    ..The flow of money generated by such concerns looks likely to erode traditional research operations and small-scale projects, which risk becoming pebbles on the 'big science' landscape...
  19. pmc The fingerprint of phantom mutations in mitochondrial DNA data
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg
    Am J Hum Genet 71:1150-60. 2002
    ..The filtering procedure is illustrated with two mtDNA data sets that were severely affected by phantom mutations...
  20. doi request reprint Haplogrouping mitochondrial DNA sequences in Legal Medicine/Forensic Genetics
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, 20146, Hamburg, Germany
    Int J Legal Med 126:901-16. 2012
    ..Furthermore, we re-examine a few articles in forensic journals providing mtDNA population data where appropriate haplogrouping following PhyloTree immediately highlights several kinds of sequence errors...
  21. doi request reprint Exaggerated status of "novel" and "pathogenic" mtDNA sequence variants due to inadequate database searches
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, Hamburg, Germany
    Hum Mutat 30:191-6. 2009
    ..Further, we reassess the recent rediscovery of m.15287T>C by listing all known occurrences and, where possible, providing the haplogroup context, shedding new light on the potential pathogenicity status of m.15287T>C...
  22. doi request reprint The case for the continuing use of the revised Cambridge Reference Sequence (rCRS) and the standardization of notation in human mitochondrial DNA studies
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, Hamburg, Germany
    J Hum Genet 59:66-77. 2014
    ..It is therefore neither necessary nor sensible to change the present reference sequence, the rCRS, in any way. The proposed switch to RSRS would inevitably lead to notational chaos, mistakes and misinterpretations...
  23. doi request reprint Current next generation sequencing technology may not meet forensic standards
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
    Forensic Sci Int Genet 6:143-5. 2012
    ..Before one can really set out to access to entire mtDNA genome data with relative ease for forensic purposes, one needs careful calibration studies under strict forensic conditions-or might have to wait for another generation...