Research Topics
| Hans Jurgen BandeltSummaryAffiliation: University of Hamburg Country: Germany Publications
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Detail Information
Publications
Phylogeography of the human mitochondrial haplogroup L3e: a snapshot of African prehistory and Atlantic slave tradeH J Bandelt
Fachbereich Mathematik, Universitat Hamburg, Germany
Ann Hum Genet 65:549-63. 2001..Enforced migration of African slaves to the Americas translocated L3e mitochondria, the descendants of which in Brazil and the Caribbean still reflect their different regional African ancestries...
Contamination and sample mix-up can best explain some patterns of mtDNA instabilities in buccal cells and oral squamous cell carcinomaHans Jurgen Bandelt
Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
BMC Cancer 9:113. 2009..We demonstrate here that the phylogenetic linkage of whole arrays of mtDNA mutations provides strong evidence of artificial recombination in previous studies on buccal cells and oral squamous cell carcinoma...
Median network analysis of defectively sequenced entire mitochondrial genomes from early and contemporary disease studiesHans Jurgen Bandelt
Department of Mathematics, University of Hamburg, Hamburg, Germany
J Hum Genet 54:174-81. 2009..Our study provides a paradigm for an a posteriori evaluation of sequence quality and for detection of potential problems with inferring a pathogenic status of a particular mutation...- Perfectly misleading distances from ternary charactersHans Jurgen Bandelt
Department of Mathematics, University of Hamburg, Hamburg, Germany
Syst Biol 57:540-3. 2008..In the present note we will answer this question by showing that three character states suffice to construct such misleading sequences--even if we insist that they conform to an ultrametric (i.e., fit a molecular clock)... - Consistent treatment of length variants in the human mtDNA control region: a reappraisalH J Bandelt
Department of Mathematics, University of Hamburg, Bundesstrasse 55, 20146, Hamburg, Germany
Int J Legal Med 122:11-21. 2008..To remedy the situation, we propose a phylogenetic approach for multiple alignment and resulting notation... - High penetrance of sequencing errors and interpretative shortcomings in mtDNA sequence analysis of LHON patientsHans Jurgen Bandelt
Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
Biochem Biophys Res Commun 352:283-91. 2007..Here, we re-analyse four problematic LHON studies and propose guidelines by which some of the pitfalls could be avoided... - What is a 'novel' mtDNA mutation--and does 'novelty' really matter?Hans Jurgen Bandelt
Department of Mathematics, University of Hamburg, Bundesstr 55, 20146, Hamburg, Germany, and Centro Nacional de Genotipado, Hospital Clinico Universitario, Galicia, Spain
J Hum Genet 51:1073-82. 2006.... - Translating DNA data tables into quasi-median networks for parsimony analysis and error detectionHans Jurgen Bandelt
Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
Mol Phylogenet Evol 42:256-71. 2007..A pertinent example drawn from human mtDNA illustrates these points... - Quality assessment of DNA sequence data: autopsy of a mis-sequenced mtDNA population sampleH J Bandelt
Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
Ann Hum Genet 70:314-26. 2006..Since no complete correction of these data has appeared to date, this example of mis-sequencing necessitates circumstantial evidence that is bullet-proof... - Mosaics of ancient mitochondrial DNA: positive indicators of nonauthenticityHans Jurgen Bandelt
Fachbereich Mathematik, Universitat Hamburg, Hamburg, Germany
Eur J Hum Genet 13:1106-12. 2005..To reject or question authenticity of particular sequencing results a posteriori, one can follow similar strategies of focused database comparisons that have proven to be effective and successful in the case of flawed modern mtDNA data... - Low "penetrance" of phylogenetic knowledge in mitochondrial disease studiesHans Jurgen Bandelt
Department of Mathematics, University of Hamburg, Germany
Biochem Biophys Res Commun 333:122-30. 2005..To further validate our phylogenetic deductions, we completely sequenced two mtDNAs from healthy subjects that nearly match the mtDNAs of two patients, whose sequences gave problematic results... - Artificial recombination in forensic mtDNA population databasesH J Bandelt
Fachbereich Mathematik, Universitat Hamburg, Bundesstrasse 55, 20146 Hamburg, Germany
Int J Legal Med 118:267-73. 2004..Therefore, we suggest that this approach should be applied to data prior to publication in order to uncover such errors in time... - Identification of Native American founder mtDNAs through the analysis of complete mtDNA sequences: some caveatsH J Bandelt
Fachbereich Mathematik, Universitat Hamburg, Hamburg, Germany
Ann Hum Genet 67:512-24. 2003.... 
A critical reassessment of the role of mitochondria in tumorigenesisAntonio Salas
Unidade de Xenetica, Instituto de Medicina Legal, Facultade de Medicina, Universidad de Santiago de Compostela, Galicia, Spain
PLoS Med 2:e296. 2005....- A practical guide to mitochondrial DNA error prevention in clinical, forensic, and population geneticsAntonio Salas
Unidade de Xenetica, Instituto de Medicina Legal, Facultade de Medicina, 15782 Universidade de Santiago de Compostela, Centro Nacional de Xenotipado CeGen, Hospital Clinico Universitario, 15706 Galicia, Spain
Biochem Biophys Res Commun 335:891-9. 2005..A fictitious case study of a European mtDNA data set (albeit composed from the literature) then demonstrates the steps one has to go through in order to assess the quality of sequencing and documentation... - High mitochondrial DNA stability in B-cell chronic lymphocytic leukemiaMaria Cerezo
Unidade de Xenetica, Instituto de Medicina Legal, and Departamento de Anatomía Patolóxica y Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, Santiago de Compostela, Galicia, Spain
PLoS ONE 4:e7902. 2009..Chronic Lymphocytic Leukemia (CLL) leads to progressive accumulation of lymphocytes in the blood, bone marrow, and lymphatic tissues. Previous findings have suggested that the mtDNA could play an important role in CLL... - The brave new era of human genetic testingHans Jurgen Bandelt
Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
Bioessays 30:1246-51. 2008..The flow of money generated by such concerns looks likely to erode traditional research operations and small-scale projects, which risk becoming pebbles on the 'big science' landscape... - The fingerprint of phantom mutations in mitochondrial DNA dataHans Jurgen Bandelt
Department of Mathematics, University of Hamburg
Am J Hum Genet 71:1150-60. 2002..The filtering procedure is illustrated with two mtDNA data sets that were severely affected by phantom mutations... - Exaggerated status of "novel" and "pathogenic" mtDNA sequence variants due to inadequate database searchesHans Jurgen Bandelt
Department of Mathematics, University of Hamburg, Hamburg, Germany
Hum Mutat 30:191-6. 2009..Further, we reassess the recent rediscovery of m.15287T>C by listing all known occurrences and, where possible, providing the haplogroup context, shedding new light on the potential pathogenicity status of m.15287T>C... - Haplogrouping mitochondrial DNA sequences in Legal Medicine/Forensic GeneticsHans Jurgen Bandelt
Department of Mathematics, University of Hamburg, 20146, Hamburg, Germany
Int J Legal Med 126:901-16. 2012..Furthermore, we re-examine a few articles in forensic journals providing mtDNA population data where appropriate haplogrouping following PhyloTree immediately highlights several kinds of sequence errors... - Current next generation sequencing technology may not meet forensic standardsHans Jurgen Bandelt
Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
Forensic Sci Int Genet 6:143-5. 2012..Before one can really set out to access to entire mtDNA genome data with relative ease for forensic purposes, one needs careful calibration studies under strict forensic conditions-or might have to wait for another generation...