S E Baldus

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi p21/waf1/cip1 in gastric cancer: associations with histopathological subtypes, lymphonodal metastasis, prognosis and p53 status
    S E Baldus
    Institute of Pathology, University of Cologne, Germany
    Scand J Gastroenterol 36:975-80. 2001
  2. ncbi Comparative evaluation of the prognostic value of MUC1, MUC2, sialyl-Lewis(a) and sialyl-Lewis(x) antigens in colorectal adenocarcinoma
    S E Baldus
    Institute of Pathology, Medical Faculty, University of Cologne, Cologne, Germany
    Histopathology 40:440-9. 2002
  3. ncbi Immunoreactivity of monoclonal antibody BW835 represents a marker of progression and prognosis in early gastric cancer
    S E Baldus
    Institute of Pathology, University of Cologne, Germany
    Oncology 61:147-55. 2001
  4. ncbi Correlation of MUC5AC immunoreactivity with histopathological subtypes and prognosis of gastric carcinoma
    Stephan E Baldus
    Institute of Pathology and Center of Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
    Ann Surg Oncol 9:887-93. 2002
  5. ncbi [Clinical, pathological and molecular prognostic factors in colorectal carcinomas]
    S E Baldus
    Institut fur Pathologie, Universitat zu Koln, Cologne
    Pathologe 24:49-60. 2003
  6. ncbi MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis
    Stephan E Baldus
    Institute of Pathology, University of Cologne, Cologne, Germany
    Clin Cancer Res 10:2790-6. 2004
  7. ncbi Epitope-dependent differential immunoreactivities of anti-MUC1 monoclonal antibodies in human carcinomas
    S E Baldus
    Institute of Pathology, Medical Faculty, University of Cologne, D 50924 Cologne, Germany
    Int J Oncol 18:507-12. 2001
  8. ncbi [Adenocarcinoma of the stomach with heterotopic ossification. Case report and discussion of the pathogenesis]
    S E Baldus
    Zentrum für Pathologie, Universitat zu Koln, Joseph Stelzmann Strasse 9, 50931 Koln
    Pathologe 23:156-60. 2002
  9. ncbi Expression of MUC1, MUC2 and oligosaccharide epitopes in breast cancer: prognostic significance of a sialylated MUC1 epitope
    Stephan E Baldus
    Institute of Pathology, University of Cologne, D 50931 Cologne, Germany
    Int J Oncol 27:1289-97. 2005
  10. ncbi MUC1 and the MUCs: a family of human mucins with impact in cancer biology
    Stephan E Baldus
    Institute of Pathology and Center of Biochemistry, University of Cologne, Cologne, Germany
    Crit Rev Clin Lab Sci 41:189-231. 2004

Collaborators

Detail Information

Publications94

  1. ncbi p21/waf1/cip1 in gastric cancer: associations with histopathological subtypes, lymphonodal metastasis, prognosis and p53 status
    S E Baldus
    Institute of Pathology, University of Cologne, Germany
    Scand J Gastroenterol 36:975-80. 2001
    ..In the present study, we investigated the role of p21 and p53 in the biology of gastric cancer, focusing on its influence on progression and prognosis (n = 195)...
  2. ncbi Comparative evaluation of the prognostic value of MUC1, MUC2, sialyl-Lewis(a) and sialyl-Lewis(x) antigens in colorectal adenocarcinoma
    S E Baldus
    Institute of Pathology, Medical Faculty, University of Cologne, Cologne, Germany
    Histopathology 40:440-9. 2002
    ....
  3. ncbi Immunoreactivity of monoclonal antibody BW835 represents a marker of progression and prognosis in early gastric cancer
    S E Baldus
    Institute of Pathology, University of Cologne, Germany
    Oncology 61:147-55. 2001
    ..These results indicate that TF and MUC1-TF immunoreactivity defines a 'high-risk' subgroup of stage I patients in gastric cancer...
  4. ncbi Correlation of MUC5AC immunoreactivity with histopathological subtypes and prognosis of gastric carcinoma
    Stephan E Baldus
    Institute of Pathology and Center of Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
    Ann Surg Oncol 9:887-93. 2002
    ..MUC5AC represents a mucin peptide core expressed in normal gastric epithelia. Its presence in gastric carcinomas was previously described as a characteristic of gastric differentiation...
  5. ncbi [Clinical, pathological and molecular prognostic factors in colorectal carcinomas]
    S E Baldus
    Institut fur Pathologie, Universitat zu Koln, Cologne
    Pathologe 24:49-60. 2003
    ..In the future, so-called response predictors will presumably gain a certain relevance in the context of neoadjuvant (radiotherapy) chemotherapy. The present review summarizes these results and discusses the future clinical relevance...
  6. ncbi MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis
    Stephan E Baldus
    Institute of Pathology, University of Cologne, Cologne, Germany
    Clin Cancer Res 10:2790-6. 2004
    ..We tried to elucidate the coexpression of both molecules in colorectal cancer to demonstrate possible correlations with clinical, pathological, and prognostic data...
  7. ncbi Epitope-dependent differential immunoreactivities of anti-MUC1 monoclonal antibodies in human carcinomas
    S E Baldus
    Institute of Pathology, Medical Faculty, University of Cologne, D 50924 Cologne, Germany
    Int J Oncol 18:507-12. 2001
    ..In conclusion, future immunohistochemical, immunoserological and therapeutic studies involving MUC1 antigen should prefer well-characterized and highly reactive mabs detecting defined peptide epitopes...
  8. ncbi [Adenocarcinoma of the stomach with heterotopic ossification. Case report and discussion of the pathogenesis]
    S E Baldus
    Zentrum für Pathologie, Universitat zu Koln, Joseph Stelzmann Strasse 9, 50931 Koln
    Pathologe 23:156-60. 2002
    ..Various speculations regarding the pathogenesis of heterotopic ossifications in gastrointestinal adenocarcinomas are discussed...
  9. ncbi Expression of MUC1, MUC2 and oligosaccharide epitopes in breast cancer: prognostic significance of a sialylated MUC1 epitope
    Stephan E Baldus
    Institute of Pathology, University of Cologne, D 50931 Cologne, Germany
    Int J Oncol 27:1289-97. 2005
    ..Our data suggest that only the presence of a sialylated short-chain MUC1 glycoform is associated with a better prognosis, whereas the other molecules under study are not correlated with the course of disease and survival probability...
  10. ncbi MUC1 and the MUCs: a family of human mucins with impact in cancer biology
    Stephan E Baldus
    Institute of Pathology and Center of Biochemistry, University of Cologne, Cologne, Germany
    Crit Rev Clin Lab Sci 41:189-231. 2004
    ....
  11. ncbi Immunoreactivity of Thomsen-Friedenreich (TF) antigen in human neoplasms: the importance of carrier-specific glycotope expression on MUC1
    S E Baldus
    Institute of Pathology, University of Cologne, Germany
    Histol Histopathol 14:1153-8. 1999
    ..The marker qualities of both antigens, TF and MUC1, are combined in the binding specificity of BW835, and hence this antibody may have a high impact for the immunodetection of these tumor-associated antigens...
  12. ncbi [Regression of oesophageal carcinomas after neoadjuvant radiochemotherapy: criteria of the histopathological evaluation]
    S E Baldus
    Institut fur Pathologie, Universitat zu Koln, Joseph Stelzmann Strasse 9, 50931 Koln
    Pathologe 25:421-7. 2004
    ..These results underline the importance of an exact examination and histomorphological evaluation of the response for the assessment of survival probability after neoadjuvant radiochemotherapy of oesophageal carcinomas...
  13. ncbi Increased galectin-3 expression in gastric cancer: correlations with histopathological subtypes, galactosylated antigens and tumor cell proliferation
    S E Baldus
    Institute of Pathology, University of Cologne, Germany
    Tumour Biol 21:258-66. 2000
    ..On the other hand, nuclear galectin-3 immunoreactivity did not correlate with the incidence of Ki-67-positive tumor cells. A prognostic value of galectin-3 regarding patient survival could not be established...
  14. ncbi Immunoreactivity of Lewis blood group and mucin peptide core antigens: correlations with grade of dysplasia and malignant transformation in the colorectal adenoma-carcinoma sequence
    S E Baldus
    Institute of Pathology, University of Cologne, Germany
    Histol Histopathol 17:191-8. 2002
    ..In conclusion, these results demonstrate that Le(y) and MUC1 immunoreactivity correlate with malignant transformation in the colorectum, whereas MUC2 represents a marker for low-grade dysplasia and the subtype of mucinous carcinomas...
  15. ncbi Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer
    H Alakus
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Histol Histopathol 23:917-23. 2008
    ....
  16. ncbi Expression of mucin-associated carbohydrate core antigens in esophageal squamous cell carcinomas
    U Flucke
    Institute of Pathology and Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Anticancer Res 21:2189-93. 2001
    ..In conclusion, it is suggested that mucin-associated carbohydrate core antigens are involved in the biology and clinical course of esophageal squamous carcinomas...
  17. ncbi Immunoreactivity of cytokeratins (CK7, CK20) and mucin peptide core antigens (MUC1, MUC2, MUC5AC) in adenocarcinomas, normal and metaplastic tissues of the distal oesophagus, oesophago-gastric junction and proximal stomach
    U Flucke
    Institute of Pathology, University of Cologne, Cologne, Germany
    Histopathology 43:127-34. 2003
    ..The immunohistochemical data suggest a similar histogenesis of these tumours...
  18. ncbi Expression of MMP-2 is associated with progression and lymph node metastasis of gastric carcinoma
    S P Mönig
    Department of Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    Histopathology 39:597-602. 2001
    ..The aim of this study was to investigate correlations between matrix metalloproteinase 2 (MMP-2) immunoreactivity and currently used classification systems and possible relationships between lymph node metastasis and MMP-2 expression...
  19. ncbi Is the urokinase-type plasminogen activator system a reliable prognostic factor in gastric cancer?
    T Luebke
    Department of Surgery, University of Cologne, Cologne, Germany
    Int J Biol Markers 21:162-9. 2006
    ..The aim of this prospective study was to evaluate the clinical and prognostic impact of immunohistochemically assessed uPA and PAI-1 in patients with gastric cancer...
  20. ncbi Coexpression of MUC1 mucin peptide core and the Thomsen-Friedenreich antigen in colorectal neoplasms
    S E Baldus
    Institute of Pathology, University of Cologne, Germany
    Cancer 82:1019-27. 1998
    ..Moreover, there is no information available regarding the carrier protein(s) of this antigen...
  21. ncbi Lesser curvature lymph node metastases with esophageal squamous cell carcinoma: implications for gastroplasty
    W Schroder
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    World J Surg 25:1125-8. 2001
    ..Therefore preservation of the lesser curvature and the left gastric artery for gastroplasty reduces the radicality regarding lymph node metastases...
  22. ncbi Histopathological subtypes and prognosis of gastric cancer are correlated with the expression of mucin-associated sialylated antigens: Sialosyl-Lewis(a), Sialosyl-Lewis(x) and sialosyl-Tn
    S E Baldus
    Institute of Pathology, University of Cologne, Germany
    Tumour Biol 19:445-53. 1998
    ..In the subgroup of diffuse-type cancers as defined according to Laurén's classification, the expression of all three antigens indicated a worsening of the prognosis...
  23. ncbi High rate of lymph-node metastasis in submucosal esophageal squamous-cell carcinomas and adenocarcinomas
    E Bollschweiler
    Dept. of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Endoscopy 38:149-56. 2006
    ..Submucosal infiltration is a contraindication for endoscopic mucosectomy. Limited surgical procedures without adequate lymphadenectomy do not appear to be appropriate in the treatment of patients with submucosal esophageal carcinomas...
  24. ncbi Histological grading in gastric cancer by Goseki classification: correlation with histopathological subtypes and prognosis
    S Monig
    Department of Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    Anticancer Res 21:617-20. 2001
    ..The aim of the study was to compare the Goseki classification with the currently used classification systems and to define the prognostic significance of the Goseki classification system...
  25. ncbi Splenectomy in proximal gastric cancer: frequency of lymph node metastasis to the splenic hilus
    S P Mönig
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    J Surg Oncol 76:89-92. 2001
    ..The purpose of this study was to investigate the frequency of lymph node metastasis to the splenic hilus and metastasis to the spleen in proximal gastric carcinomas...
  26. ncbi GNAS1 T393C polymorphism is associated with histopathological response to neoadjuvant radiochemotherapy in esophageal cancer
    H Alakus
    Department of General, Visceral and Cancer Surgery, Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany
    Pharmacogenomics J 9:202-7. 2009
    ..The results support the role of the T393C polymorphism as a predictive molecular marker for tumor response to cisplatin/5-FU-based radiochemotherapy in esophageal cancer...
  27. ncbi Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors
    D Vallbohmer
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Oncol Rep 20:779-83. 2008
    ..Since our data are merely hypothesis-generating, serosal penetration should be evaluated in large prospective databases...
  28. ncbi HIF-1alpha protein expression is associated with the environmental inflammatory reaction in Barrett's metaplasia
    F C Ling
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Dis Esophagus 22:694-9. 2009
    ..All were significantly increased in metaplasia compared to SE without further change in tumor development. HIF-1alpha protein expression appears to be associated with inflammatory processes in the development of BM...
  29. ncbi Histomorphologic tumor regression and lymph node metastases determine prognosis following neoadjuvant radiochemotherapy for esophageal cancer: implications for response classification
    Paul M Schneider
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Ann Surg 242:684-92. 2005
    ..We sought to quantitatively and objectively evaluate histomorphologic tumor regression and establish a relevant prognostic regression classification system for esophageal cancer patients receiving neoadjuvant radiochemotherapy...
  30. ncbi Staging of esophageal carcinoma: length of tumor and number of involved regional lymph nodes. Are these independent prognostic factors?
    Elfriede Bollschweiler
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    J Surg Oncol 94:355-63. 2006
    ..The aim of this study was to analyze the prognostic relevance of tumor length as well as number of involved regional lymph nodes (LNM) in patients with esophageal carcinoma...
  31. ncbi Extracapsular lymph node involvement differs between squamous cell and adenocarcinoma of the esophagus
    Ralf Metzger
    Department of General, Visceral, and Cancer Surgery, University of Cologne, Germany
    Ann Surg Oncol 16:447-53. 2009
    ..005) higher in patients with pN1 AC (median = 5) compared with pN1 SCC (median = 3). We conclude that extracapsular LNI is an independent negative prognostic factor which occurs more frequently in esophageal AC than SCC...
  32. ncbi Quantitative c-erbB-2 but not c-erbB-1 mRNA expression is a promising marker to predict minor histopathologic response to neoadjuvant radiochemotherapy in oesophageal cancer
    F Miyazono
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Br J Cancer 91:666-72. 2004
    ..This test could be used to prevent expensive, non effective and potentially harmful therapies in approximately one-fourth of our patients, and leads to a more individualised type of combined modality treatment...
  33. ncbi Frequency of nodal metastases to the upper mediastinum in Barrett's cancer
    W Schroder
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Ann Surg Oncol 9:807-11. 2002
    ..In Barrett's cancer, the frequency of lymph node metastases to the middle and upper mediastinum has rarely been analyzed because it requires a complete mediastinal lymphadenectomy...
  34. ncbi Reduced incidence of nodal micrometastasis after major response to neoadjuvant chemoradiation in locally advanced esophageal cancer
    Klaus L Prenzel
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Ann Surg Oncol 14:954-9. 2007
    ..The influence on nodal micrometastasis has not yet been evaluated...
  35. ncbi Preoperative lymph-node staging in gastrointestinal cancer--correlation between size and tumor stage
    S P Mönig
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Onkologie 25:342-4. 2002
    ..These results emphasize that a reliable pathological staging of gastro-intestinal cancer must be based on a standardized systematic lymphadenectomy because lymph-node sampling based on lymph-node size is not sufficient...
  36. ncbi Feasibility of sentinel node concept in gastric carcinoma: clinicopathological analysis of gastric cancer with solitary lymph node metastases
    S P Moenig
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    Anticancer Res 25:1349-52. 2005
    ..The feasibility and diagnostic reliability of sentinel lymph node biopsy of gastric carcinoma are still unclear and controversial...
  37. ncbi Comparative analysis of four histopathological classification systems to discriminate benign and malignant behaviour in gastrointestinal stromal tumors
    D Vallbohmer
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Anticancer Res 28:367-72. 2008
    ..The prognostic value of the four most common histopathological classification systems in gastrointestinal stromal tumors (GISTs) was evaluated retrospectively...
  38. ncbi MUC1 (EMA) expressing plasma cells in bone marrow infiltrated by plasma cell myeloma
    S E Baldus
    Institute of Pathology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Histol Histopathol 22:889-93. 2007
    ..However, its strong expression in a certain percentage of cases of plasma cell myeloma may be of therapeutic impact, since new therapeutic strategies include the enrichment of MUC1-specific T cells or MUC1 vaccination...
  39. ncbi Forssman disaccharide is the specific ligand of a galectin from the sponge Geodia cydonium but does not mediate its binding to nuclear protein np56
    F G Hanisch
    Institute of Immunobiology, University of Cologne, Germany
    Glycobiology 6:321-36. 1996
    ..Thus, GCA resembles galectin-3 in its binding characteristics but is likewise related to galectin-1 by sequence homology of its primary structure and by the molecular mass of its subunits...
  40. ncbi Identification and topology of variant sequences within individual repeat domains of the human epithelial tumor mucin MUC1
    K Engelmann
    Institute of Biochemistry II, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, 50931 Cologne, Germany
    J Biol Chem 276:27764-9. 2001
    ..The largely constant topology of variant repeats is interpreted by the assumption that the variable number of tandem repeats domain has evolved as a recent expansion of sequence variable super-repeats...
  41. ncbi High cyclooxygenase-2 expression following neoadjuvant radiochemotherapy is associated with minor histopathologic response and poor prognosis in esophageal cancer
    Huan Xi
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Clin Cancer Res 11:8341-7. 2005
    ..01). CONCLUSION: High COX-2 protein expression following neoadjuvant radiochemotherapy in resection specimens is significantly associated with minor histopathologic response to neoadjuvant therapy and very poor prognosis...
  42. ncbi Overexpression of survivin mRNA is associated with a favorable prognosis following neoadjuvant radiochemotherapy in esophageal cancer
    Ute Warnecke-Eberz
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph-Stelzmann-Strasse 9, 50931 Cologne, Germany
    Oncol Rep 13:1241-6. 2005
    ..However, overexpression of survivin mRNA in pretreatment biopsies (T/N ratio >1) was associated with superior survival probabilities...
  43. ncbi Histological grading in gastric cancer by Ming classification: correlation with histopathological subtypes, metastasis, and prognosis
    Thomas Luebke
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph-Stelzmann-Strasse 9, Cologne 50931, Germany
    World J Surg 29:1422-7; discussion 1428. 2005
    ..The 3-year survival rates were lower in the infiltrative tumor type than in the expansive tumor type according to Ming. However, the Ming classification is not an independent prognostic factor...
  44. ncbi Skip metastasis in nonsmall cell lung carcinoma: predictive markers and isolated tumor cells in N1 lymph nodes
    Klaus L Prenzel
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Cancer 100:1909-17. 2004
    ..In patients with pN2 skip metastases, micrometastases to N1 lymph nodes, which only mimic skip metastases, have not been investigated...
  45. ncbi Topographical distribution of lymph node metastasis in adenocarcinoma of the gastroesophageal junction
    Stefan P Monig
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Hepatogastroenterology 49:419-22. 2002
    ..The current discussion concerning the extent of resection in patients with adenocarcinoma of the gastroesophageal junction is focused beside the luminal extent of resection primarily on the value of lymphadenectomy...
  46. ncbi Analysis of microsatellite instability in colorectal carcinoma by microfluidic-based chip electrophoresis
    M Odenthal
    Institute of Pathology, University Hospital of Cologne, Germany
    J Clin Pathol 62:850-2. 2009
    ..In conclusion, microfluidic chip technology is a simple and reliable approach for MSI detection that allows label-free and very fast analysis of microsatellite amplicons...
  47. ncbi [Combined laparoscopic/endoscopic treatment of gastric stroma tumors]
    H Schafer
    Klinik und Poliklinik für Viszeral und Gefässchirurgie der Universität zu Köln
    Zentralbl Chir 131:206-9. 2006
    ..Local resection will be carried out if technically possible. We describe the technique of laparoscopic wedge resection combined with intraoperative gastroscopy in order to achieve complete tumor resection...
  48. ncbi [Submucosal infiltration and local recurrence in pT1 low-risk rectal cancer treated by transanal endoscopic microsurgery]
    H Schafer
    Klinik und Poliklinik für Visceral und Gefässchirurgie, Universitat zu Koln
    Chirurg 76:379-84. 2005
    ..The association between submucosal infiltration and tumor recurrence was analyzed by long-term follow-up of patients with pT1 "low risk" rectal carcinoma...
  49. ncbi Soft tissue reactions of different biodegradable polylactide implants
    A Prokop
    Department of Trauma and Reconstructive Surgery, University Hospital, Cologne, Joseph Stelzmann Strasse 9, D 50924 Cologne, Germany
    Biomaterials 25:259-67. 2004
    ..Due to the slow degradation process of biodegradable polylactide implants, there is no clinically relevant inflammation of either joint or lymph nodes. The addition of 10% beta-TCP did not result in any significant enhancement...
  50. ncbi The overexpression of c-met as a prognostic indicator for gastric carcinoma compared to p53 and p21 nuclear accumulation
    Uta Drebber
    Institute of Pathology, University of Cologne, Cologne, Germany
    Oncol Rep 19:1477-83. 2008
    ..P21 proved to be a significant prognostic factor in the multivariate analysis. Our data suggest that the overexpression of c-met and p21 may represent independent prognostic factors in gastric carcinoma...
  51. ncbi Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases
    Ute Warnecke-Eberz
    Department of Visceral and Vascular Surgery, Laboratory for Molecular Oncology, University of Cologne, Kerpener Strasse 62, Cologne, Germany
    Oncol Rep 20:619-24. 2008
    ..8%). Down-regulation occurs already in the early stage of NSCLC and is either directly involved in the lymphatic progression in NSCLC or represents a surrogate marker...
  52. ncbi Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis
    Karin Hartmann
    Department of Dermatology, University of Cologne, Cologne, Germany
    Gastroenterology 129:1042-6. 2005
    ..Our studies identify a new regulatory region in the KIT molecule and strongly suggest that patients with extracellular KIT mutations respond to tyrosine kinase inhibitors...
  53. ncbi Expression of Bcl-2 and Bcl-xL in cutaneous and bone marrow lesions of mastocytosis
    Karin Hartmann
    Department of Dermatology, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Am J Pathol 163:819-26. 2003
    ..Thus, overexpression of bcl-2 and bcl-xL leading to prolonged survival of mast cells may contribute to the pathogenesis of mastocytosis. Our findings may help to develop new strategies for the treatment of this disease...
  54. ncbi Localization of isolated lymph node metastases in esophageal cancer--does it influence the sentinel node concept?
    Wolfgang Schroder
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Hepatogastroenterology 54:1116-20. 2007
    ..This study analyses the localization of single lymph node metastases in esophageal cancer and discusses the possible theoretical impact on SNL navigation...
  55. ncbi Lymph node staging of esophageal squamous cell carcinoma in patients with and without neoadjuvant radiochemotherapy: histomorphologic analysis
    Wolfgang Schroder
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    World J Surg 26:584-7. 2002
    ..Therefore, evaluation of the nodal status in patients with squamous cell carcinoma of the esophagus is entirely based on pathohistologic analysis after a well defined lymphadenectomy...
  56. ncbi Presence of Epstein-Barr virus in esophageal cancer is restricted to tumor infiltrating lymphocytes
    Sabine Awerkiew
    Institut fur Virologie, Fürst Pückler Str 56, 50935 Cologne, Germany
    Med Microbiol Immunol 194:187-91. 2005
    ..The present data provide no evidence for the persistence of EBV in the tumor cells of esophageal cancer. In contrast to a previous report from Taiwan, EBV is unlikely to play a role in esophageal carcinogenesis...
  57. ncbi Artificial neural network for prediction of lymph node metastases in gastric cancer: a phase II diagnostic study
    Elfriede H Bollschweiler
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Ann Surg Oncol 11:506-11. 2004
    ..The aim of this study was to evaluate artificial neural networks (ANN) for predicting LNM in patients with gastric cancer and to compare the predictive power with that of MCP...
  58. ncbi Transmembrane and secreted MUC1 probes show trafficking-dependent changes in O-glycan core profiles
    Katja Engelmann
    Center of Biochemistry Medical Facility, University of Cologne, Joseph Stelzmann Str 52, 50931 Koln, Germany
    Glycobiology 15:1111-24. 2005
    ..In conclusion, glycan core profiles reflected the subcellular trafficking pathways of the secretory or membranous probes and the modifying activities of the resident glycosyltransferases...
  59. ncbi Response evaluation by endoscopy, rebiopsy, and endoscopic ultrasound does not accurately predict histopathologic regression after neoadjuvant chemoradiation for esophageal cancer
    Paul M Schneider
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Ann Surg 248:902-8. 2008
    ....
  60. ncbi Rapid immunohistochemical detection of tumor cells in gastric carcinoma
    Stefan P Monig
    Department of Visceral and Vascular Surgery, University of Cologne, 50924 Cologne, Germany
    Oncol Rep 16:1143-7. 2006
    ..Intraoperative rapid immunostaining can be a simple and useful technique to detect LNM...
  61. ncbi Failure in downregulation of intratumoral survivin expression following neoadjuvant chemoradiation in esophageal cancer
    Daniel Vallbohmer
    Department of Visceral and Vascular Surgery, University of Cologne, Kerpenerstrasse 62, 50937 Cologne, Germany
    Pharmacogenomics 9:681-90. 2008
    ..We aimed to examine the association of survivin protein expression, an inhibitor of apoptosis, with histopathologic response to neoadjuvant chemoradiation and prognosis in patients with esophageal cancer...
  62. ncbi Lymph node revealing solution in gastric carcinoma does not provide upstaging of the N-status
    Thomas Luebke
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph-Stelzmann Strasse 9, 50931 Cologne, Germany
    Oncol Rep 13:361-5. 2005
    ..Immunohistochemical techniques aid in identifying micrometastatic disease in lymph nodes missed in routine H&E staining in order to define the pN(i) status according to the TNM classification...
  63. ncbi Loss of IL-6 receptor expression in cervical carcinoma cells inhibits autocrine IL-6 stimulation: abrogation of constitutive monocyte chemoattractant protein-1 production
    S Hess
    Institute of Virology, University of Cologne, Cologne, Germany
    J Immunol 165:1939-48. 2000
    ..Both mechanisms might help the tumor to escape the immune system...
  64. ncbi Selectins (CD62L, CD62P) and megakaryocytic glycoproteins (CD41a, CD42b) mediate megakaryocyte-fibroblast interactions in human bone marrow
    C Wickenhauser
    Institute of Pathology, University of Cologne, Joseph Stelzmann Str 9, D 50934, Cologne, Germany
    Leuk Res 24:1013-21. 2000
    ....
  65. ncbi Lymph node size and metastatic infiltration in non-small cell lung cancer
    Klaus L Prenzel
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Chest 123:463-7. 2003
    ..Lymph nodes > 1 cm in size are regarded as metastatic nodes. The surgical approach and potential application of neoadjuvant therapy regimens are dependent on this evaluation...
  66. ncbi Modulation of MUC1 and blood group antigen expression in gastric adenocarcinoma cells by cytokines
    Georg P M Grohmann
    Institute of Pathology, University of Cologne, Joseph-Stelzmann-Street 9, D-50931 Cologne, Germany
    Cytokine 23:86-93. 2003
    ..These data provide evidence that TNF-alpha can raise the expression of important mucin peptide as well as mucin-associated carbohydrate antigens and thereby potentially influence the progression of gastric carcinomas...
  67. ncbi Clinical significance of nm23 gene expression in gastric cancer
    Stefan P Monig
    Department of Visceral and Vascular Surgery, University of Cologne, Kerpener Str 62, 50937 Cologne, Germany
    Anticancer Res 27:3029-33. 2007
    ..The expression of the putative metastasis-suppressor gene nm23 in gastric carcinoma is controversial. The aim of this study was the analysis of nm23 expression in a large series of gastric cancer patients...
  68. ncbi COX-2 mRNA expression is significantly increased in acid-exposed compared to nonexposed squamous epithelium in gastroesophageal reflux disease
    Georg Lurje
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    J Gastrointest Surg 11:1105-11. 2007
    ..The objectives of this study were to further analyze COX-2 mRNA expression in patients with GERD compared to Barrett's esophagus (BE) and Barrett's cancer (BC)...
  69. ncbi Increased human telomerase reverse transcriptase (hTERT) mRNA expression but not telomerase activity is related to survival in curatively resected non-small cell lung cancer
    Ralf Metzger
    Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Joseph Stelzmann Strasse 9, D 50931 Cologne, Germany
    Anticancer Res 29:1157-62. 2009
    ..The purpose of this study was to evaluate the significance of human telomerase reverse transcriptase (hTERT) mRNA expression and telomerase activity as prognostic markers in non-small cell lung cancer (NSCLC)...
  70. ncbi Neoadjuvant chemoradiotherapy for esophageal cancer: impact on extracapsular lymph node involvement
    Ralf Metzger
    Department of General, Visceral and Cancer Surgery, Center for Integrated Oncology, University Hospital of Cologne, Kerpener Strasse 62, Cologne, Germany
    World J Gastroenterol 16:1986-92. 2010
    ..To assess the effects of neoadjuvant chemoradiotherapy (CRT) on the presence of extracapsular lymph node involvement (LNI) and its prognostic value in patients with resected esophageal cancer...
  71. ncbi [18F]-Fluorodeoxyglucose-positron emission tomography for the assessment of histopathologic response and prognosis after completion of neoadjuvant chemoradiation in esophageal cancer
    Daniel Vallbohmer
    General, Visceral, and Cancer Surgery, University of Cologne, Germany
    Ann Surg 250:888-94. 2009
    ....
  72. ncbi Extracapsular lymph node spread: a new prognostic factor in gastric cancer
    Hakan Alakus
    Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
    Cancer 116:309-15. 2010
    ..The aim of the current study was to examine the prognostic value of extracapsular lymph node involvement in gastric cancer and to find correlations with clinicopathological parameters...
  73. ncbi PCR-screening of human esophageal and bronchial cancers reveals absence of adenoviral DNA sequences
    Ylva Mende
    Institute of Genetics, University of Cologne, Weyertal 121, , Germany
    Virus Res 104:81-5. 2004
    ....
  74. ncbi Differential c-erbB-1 and c-erbB-2 mRNA expression in cancer of the pancreas compared with cancer of the papilla of Vater
    Klaus L Prenzel
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Str 9, 50931 Cologne, Germany
    World J Gastroenterol 12:437-42. 2006
    ....
  75. ncbi Increased EpCAM expression in malignant insulinoma: potential clinical implications
    Andreas Raffel
    Department of General, Institute of Pathology, University Hospital of the Heinrich Heine University Düsseldorf, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Eur J Endocrinol 162:391-8. 2010
    ..We tested whether EpCAM overexpression is reactivated in insulinomas, endocrine tumors arising in the pancreas...
  76. ncbi Up-regulation of survivin mRNA might be a marker for non-invasive detection of non-small cell lung cancer rather than for prognosis
    Ute Warnecke-Eberz
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Anticancer Res 28:1525-9. 2008
    ..To evaluate the prognostic importance of the apoptosis inhibitor survivin for non-small cell lung cancer (NSCLC), a study was performed in 64 patients with R0 resections for NSCLC and histopathological stages I-IIIA...
  77. ncbi Differences between biopsy- or specimen-related Laurén and World Health Organization classification in gastric cancer
    Uta Flucke
    Department of Visceral and VascularSurgery, University of Cologne, Joseph-Stelzmann Str. 9, 50931 Cologne, Germany
    World J Surg 26:137-40. 2002
    ..Since this may have consequences for the surgical strategy, the extent of surgical resection, rebiopsies, and reconfirmation of an intestinal type should be performed at least in those cases with any doubts of this classification...
  78. ncbi Mutations in the mitochondrial DNA D-Loop region occur frequently in adenocarcinoma in Barrett's esophagus
    Futoshi Miyazono
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph-Stelzmann-Strasse 9, 50931 Cologne, Germany
    Oncogene 21:3780-3. 2002
    ..Since mutations were identified in tumor-associated dysplastic Barrett's epithelium, they also might become a marker for the malignant potential of Barrett's epithelium...
  79. ncbi Methylenetetrahydrofolate reductase C677T polymorphism and risk of adenocarcinoma of the upper gastrointestinal tract
    Mario Sarbia
    Institute of Pathology, Technical University, Munich, Germany
    Scand J Gastroenterol 40:109-11. 2005
  80. ncbi Differential expression proteomics of human colorectal cancer based on a syngeneic cellular model for the progression of adenoma to carcinoma
    Udo Roth
    Center for Molecular Medicine Cologne CMMC, University of Cologne, 50931 Koln, Germany
    Proteomics 10:194-202. 2010
    ....
  81. ncbi High specificity of quantitative excision repair cross-complementing 1 messenger RNA expression for prediction of minor histopathological response to neoadjuvant radiochemotherapy in esophageal cancer
    Ute Warnecke-Eberz
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Clin Cancer Res 10:3794-9. 2004
    ....
  82. ncbi Variable 18F-fluorodeoxyglucose uptake in gastric cancer is associated with different levels of GLUT-1 expression
    Hakan Alakus
    Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Cologne, Germany
    Nucl Med Commun 31:532-8. 2010
    ..To clarify this observation, FDG uptake in gastric carcinoma was analyzed by focusing on histopathology and on the expression of the glucose transporter (GLUT-1) in the primary tumor...
  83. ncbi Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater
    Klaus L Prenzel
    Department of Visceral and Vascular Surgery, University of Cologne, 50931 Cologne, Germany
    Oncol Rep 15:1397-401. 2006
    ..In conclusion, SPARC mRNA overexpression is significantly more frequent in CP than CPV and adds further evidence that CP and CPV are biologically different tumor entities...
  84. ncbi Significant down-regulation of the plasminogen activator inhibitor 1 mRNA in pancreatic cancer
    Ute Warnecke-Eberz
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Pancreas 36:173-7. 2008
    ..Expression profiles were compared with paired uninvolved normal tissues to define a possible differential role of these genes in tumorigenesis of both tumor types...
  85. ncbi Down-regulation of Gadd45 expression is associated with tumor differentiation in non-small cell lung cancer
    Hiroshi Higashi
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Anticancer Res 26:2143-7. 2006
    ..The purpose of this study was to determine the gene expression patterns and clinical relevance of Gadd45 in tumor specimens of non-small cell lung cancer (NSCLC) patients...
  86. ncbi Smad4 deficiency in cervical carcinoma cells
    Stephan E Baldus
    Institute of Pathology, University of Cologne, D 50931 Cologne, Germany
    Oncogene 24:810-9. 2005
    ..Altogether, our results strongly suggest that Smad4 gene alterations are involved in cervical carcinogenesis...
  87. ncbi HIF-1alpha mRNA is not associated with histopathological regression following neoadjuvant chemoradiation in esophageal cancer
    Frederike C Ling
    Department of Visceral and Vascular Surgery, University of Cologne, 50931 Cologne, Germany
    Anticancer Res 26:4505-9. 2006
    ..CONCLUSION: HIF-1alpha mRNA expression is differentially upregulated in esophageal squamous cell carcinoma compared to adenocarcinomas, but does not predict tumor regression or prognosis...
  88. ncbi Quantification of MET and hepatocyte growth factor/scatter factor expression in colorectal adenomas, carcinomas and non-neoplastic epithelia by quantitative laser scanning microscopy
    Stephan E Baldus
    Institute of Pathology, University of Duesseldorf, D 40225 Duesseldorf, Germany
    Int J Oncol 31:199-204. 2007
    ..The presumed role of MET-HGF interactions in large bowel carcinogenesis may therefore be a result of or depend upon other regulatory factors involved in MET-mediated signalling pathways...
  89. ncbi Altered apoptosis and cell cycling of mast cells in bone marrow lesions of patients with systemic mastocytosis
    Stephan E Baldus
    Haematologica 89:1525-7. 2004
    ..An altered rate of apoptosis and cell cycling may contribute to accumulation of mast cells in mastocytosis...
  90. ncbi Sequence-variant repeats of MUC1 show higher conformational flexibility, are less densely O-glycosylated and induce differential B lymphocyte responses
    Silvia von Mensdorff-Pouilly
    Department of Obstetrics and Gynaecology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, Netherlands
    Glycobiology 15:735-46. 2005
    ..In contrast, the IgG response in patients with adenocarcinoma shifted to higher frequencies of preferential DTR peptide binding...
  91. ncbi Downregulation of TS, DPD, ERCC1, GST-Pi, EGFR, and HER2 gene expression after neoadjuvant three-modality treatment in patients with esophageal cancer
    Sylke Schneider
    Department of Molecular Biology and Biochemistry and Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    J Am Coll Surg 200:336-44. 2005
    ..01). CONCLUSIONS: The expression levels of a set of genes that are possible determinants of 5-FU/cisplatin/radiation therapy antitumor activity are significantly downregulated by neoadjuvant radiochemotherapy in esophageal cancer...
  92. ncbi Loss of Smad4 correlates with loss of the invasion suppressor E-cadherin in advanced colorectal carcinomas
    Anke Reinacher-Schick
    Department of Internal Medicine, IMBL, University of Bochum, Bochum, Germany
    J Pathol 202:412-20. 2004
    ....
  93. ncbi Protein expression profiling in high-risk breast cancer patients treated with high-dose or conventional dose-dense chemotherapy
    Raihanatou Diallo Danebrock
    Institute of Pathology and Department of Obstetrics and Gynecology, Heinrich Heine University of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Clin Cancer Res 13:488-97. 2007
    ....
  94. ncbi High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF
    Andreas Claudius Hoffmann
    Department of Biochemistry and Molecular Biology and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    Neoplasia 10:674-9. 2008
    ..In this study, we investigated the prognostic values of HIF1a, bFGF, VEGF, and PDGFA gene expressions as well as their interrelationships...