Augustinus Bader

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. pmc Skin regeneration with conical and hair follicle structure of deep second-degree scalding injuries via combined expression of the EPO receptor and beta common receptor by local subcutaneous injection of nanosized rhEPO
    Augustinus Bader
    Department of Applied Stem Cell Biology and Cell Techniques, Centre for Biotechnology and Biomedicine, University of Leipzig, Deutscher Platz 5, Leipzig, Germany
    Int J Nanomedicine 7:1227-37. 2012
  2. doi request reprint Proteomic analysis to display the effect of low doses of erythropoietin on rat liver regeneration
    Augustinus Bader
    Department of Cell Technologies and Applied Stem Cell Biology, Biomedical Biotechnological Center, University Leipzig, Leipzig, Germany
    Life Sci 89:827-33. 2011
  3. pmc Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs
    Tina T Chowdhury
    School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK
    Arthritis Res Ther 12:R82. 2010
  4. doi request reprint Interactive role of trauma cytokines and erythropoietin and their therapeutic potential for acute and chronic wounds
    Augustinus Bader
    University of Leipzig, Centre for Biotechnology and Biomedicine, Department of Applied Stem Cell Biology and Cell Techniques, Leipzig, Germany
    Rejuvenation Res 14:57-66. 2011
  5. doi request reprint Erythropoietin enhances cell proliferation and survival of human fetal neuronal progenitors in normoxia
    Sanja Pavlica
    Department of Cell Technologies and Applied Stem Cell Biology, Biomedical Biotechnological Centre, University of Leipzig, Leipzig, Germany
    Brain Res 1452:18-28. 2012
  6. doi request reprint Matrix-associated implantation of predifferentiated mesenchymal stem cells versus articular chondrocytes: in vivo results of cartilage repair after 1 year
    Bastian Marquass
    Department of Trauma and Reconstructive Surgery, University of Leipzig, Leipzig, Germany
    Am J Sports Med 39:1401-12. 2011
  7. doi request reprint Biotransformation of diazepam in a clinically relevant flat membrane bioreactor model using primary porcine hepatocytes
    Michael Maringka
    Centre for Biotechnology and Biomedicine, Department of Cell Techniques and Applied Stem Cell Biology, University of Leipzig, Deutscher Platz 5, D 04103 Leipzig, Germany
    Fundam Clin Pharmacol 25:343-53. 2011
  8. doi request reprint Cryopreservation of primary porcine liver cells in an organotypical sandwich model in a clinically relevant flat membrane bioreactor
    Shibashish Giri
    Department of Cell Technologies and Applied Stem Cell Biology, Biomedical Biotechnological Center, University of Leipzig, Deutscher Platz 5, 04103, Leipzig, Germany
    Biotechnol Lett 32:765-71. 2010
  9. doi request reprint Effect of native and NH3 plasma-functionalized polymeric membranes on the gene expression profiles of primary hepatocytes
    Sanja Pavlica
    Centre for Biotechnology and Biomedicine, BBZ, University of Leipzig, Germany
    J Tissue Eng Regen Med 6:486-96. 2012
  10. doi request reprint Tuning liver stiffness against tumours: an in vitro study using entrapped cells in tumour-like microcapsules
    Aldo Leal-Egana
    Department of Cell Technology and Applied Stem Cell Biology, Biotechnology and Biomedicine Centre BBZ, University of Leipzig, Deutscher Platz 5, 04103, Leipzig, Germany
    J Mech Behav Biomed Mater 9:113-21. 2012

Collaborators

Detail Information

Publications37

  1. pmc Skin regeneration with conical and hair follicle structure of deep second-degree scalding injuries via combined expression of the EPO receptor and beta common receptor by local subcutaneous injection of nanosized rhEPO
    Augustinus Bader
    Department of Applied Stem Cell Biology and Cell Techniques, Centre for Biotechnology and Biomedicine, University of Leipzig, Deutscher Platz 5, Leipzig, Germany
    Int J Nanomedicine 7:1227-37. 2012
    ..However, proof of coexpression of these heterogenic receptors in regenerating skin after burns is still lacking...
  2. doi request reprint Proteomic analysis to display the effect of low doses of erythropoietin on rat liver regeneration
    Augustinus Bader
    Department of Cell Technologies and Applied Stem Cell Biology, Biomedical Biotechnological Center, University Leipzig, Leipzig, Germany
    Life Sci 89:827-33. 2011
    ..Systemic administration of high doses of this cytokine is a clinical concern due to risk of thrombosis. Herein, we applied EPO in low dosages and investigated whether it can stimulate liver regeneration after liver resection...
  3. pmc Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs
    Tina T Chowdhury
    School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK
    Arthritis Res Ther 12:R82. 2010
    ..The present study examined the effect of collagen fragments on anabolic and catabolic activities by chondrocyte/agarose constructs subjected to dynamic compression...
  4. doi request reprint Interactive role of trauma cytokines and erythropoietin and their therapeutic potential for acute and chronic wounds
    Augustinus Bader
    University of Leipzig, Centre for Biotechnology and Biomedicine, Department of Applied Stem Cell Biology and Cell Techniques, Leipzig, Germany
    Rejuvenation Res 14:57-66. 2011
    ..In trauma, EPO ceases its inhibitory role and reverts to a clinically relevant boosting function. EPO may be an important therapeutic tool for the topical treatment of acute and chronic wounds...
  5. doi request reprint Erythropoietin enhances cell proliferation and survival of human fetal neuronal progenitors in normoxia
    Sanja Pavlica
    Department of Cell Technologies and Applied Stem Cell Biology, Biomedical Biotechnological Centre, University of Leipzig, Leipzig, Germany
    Brain Res 1452:18-28. 2012
    ..Moreover, as EPO signaling is hypoxia-inducible, our findings may also indicate the beneficial effect of EPO to mimic hypoxia, while bypassing its negative effects, to culture human fetal midbrain-derived progenitor cells...
  6. doi request reprint Matrix-associated implantation of predifferentiated mesenchymal stem cells versus articular chondrocytes: in vivo results of cartilage repair after 1 year
    Bastian Marquass
    Department of Trauma and Reconstructive Surgery, University of Leipzig, Leipzig, Germany
    Am J Sports Med 39:1401-12. 2011
    ..This raises the need for a longer term follow-up study and comparison with a clinically established method...
  7. doi request reprint Biotransformation of diazepam in a clinically relevant flat membrane bioreactor model using primary porcine hepatocytes
    Michael Maringka
    Centre for Biotechnology and Biomedicine, Department of Cell Techniques and Applied Stem Cell Biology, University of Leipzig, Deutscher Platz 5, D 04103 Leipzig, Germany
    Fundam Clin Pharmacol 25:343-53. 2011
    ..Our results suggest that this plasma exposure bioreactor may offer a useful approach in clinical use of extracorporeal BAL, as well as for drug metabolite investigation into toxicological research...
  8. doi request reprint Cryopreservation of primary porcine liver cells in an organotypical sandwich model in a clinically relevant flat membrane bioreactor
    Shibashish Giri
    Department of Cell Technologies and Applied Stem Cell Biology, Biomedical Biotechnological Center, University of Leipzig, Deutscher Platz 5, 04103, Leipzig, Germany
    Biotechnol Lett 32:765-71. 2010
    ..This study showed that cryopreserved cells can recover liver-specific functions. This result has the potential to dramatically expand the clinical application of bioartificial liver supports...
  9. doi request reprint Effect of native and NH3 plasma-functionalized polymeric membranes on the gene expression profiles of primary hepatocytes
    Sanja Pavlica
    Centre for Biotechnology and Biomedicine, BBZ, University of Leipzig, Germany
    J Tissue Eng Regen Med 6:486-96. 2012
    ..Both membranes sustained liver functions at the molecular level, demonstrating their suitability for the reconstruction of liver and as a toxicogenomic tool to predict the liver response to novel drugs...
  10. doi request reprint Tuning liver stiffness against tumours: an in vitro study using entrapped cells in tumour-like microcapsules
    Aldo Leal-Egana
    Department of Cell Technology and Applied Stem Cell Biology, Biotechnology and Biomedicine Centre BBZ, University of Leipzig, Deutscher Platz 5, 04103, Leipzig, Germany
    J Mech Behav Biomed Mater 9:113-21. 2012
    ....
  11. doi request reprint Rat embryonic liver cell expansion and differentiation on NH3 plasma-grafted PEEK-WC-PU membranes
    Sanja Pavlica
    Department of Cell Technologies and Applied Stem Cell Biology, Biomedical Biotechnological Center, Medical Faculty, University Leipzig, Deutscher Platz 5, Leipzig 04103, Germany
    Biomaterials 30:6514-21. 2009
    ..Thus, membranes are able to sustain in vitro the same in vivo liver functions and to allow the expansion of progenitor cells...
  12. doi request reprint Telomerase activity and hepatic functions of rat embryonic liver progenitor cell in nanoscaffold-coated model bioreactor
    Shibashish Giri
    Department of Cell Technologies and Applied Stem Cell Biology, Biomedical Biotechnological Center BBZ, Deutscher Platz 5, 04103, Leipzig, Germany
    Mol Cell Biochem 336:137-49. 2010
    ....
  13. doi request reprint Multilineage differentiation potential of human dermal skin-derived fibroblasts
    Katrin Lorenz
    Department of Cell Techniques and Applied Stem Cell Biology, Biotechnological Biomedical Center, University of Leipzig, Leipzig, Germany
    Exp Dermatol 17:925-32. 2008
    ..In summary, these data indicate that dermal fibroblasts with multilineage differentiation potential are present in human dermis and they might play a key role in cutaneous wound healing...
  14. ncbi request reprint Paracetamol treatment increases telomerase activity in rat embryonic liver cells
    Augustinus Bader
    Biotechnological Biomedical Center, Department of Cell Techniques and Stem Cell Biology, University of Leipzig, Deutscher Platz 5, 04103 Leipzig, Germany
    Pharmacol Rep 63:1435-41. 2011
    ..Our findings should encourage further studies to investigate a link between telomerase activity and toxicity, implying a role of impaired telomerase activity in human pathology...
  15. pmc Determination of pore size distribution at the cell-hydrogel interface
    Aldo Leal-Egana
    Department of Cell Technology and Applied Stem Cell Biology, Biotechnology and Biomedicine Centre, University of Leipzig, Deutscher Platz 5, 04103, Leipzig, Germany
    J Nanobiotechnology 9:24. 2011
    ..However, the majority of the methods for the assessment of the porosity in biomaterials are not suitable to give quantitative information about the textural properties of these nano-interfaces...
  16. doi request reprint Three dimensional cultures of rat liver cells using a natural self-assembling nanoscaffold in a clinically relevant bioreactor for bioartificial liver construction
    Shibashish Giri
    Department of Cell Techniques and Applied Stem Cell Biology, Centre for Biotechnology and Biomedicine, University of Leipzig, Leipzig, Germany
    J Cell Physiol 227:313-27. 2012
    ..This present study demonstrates an optimized 3D signaling/scaffolding in a preclinical BAL model, as well as preclinical drug screening for better drug development...
  17. doi request reprint Repair of chronic osteochondral defects using predifferentiated mesenchymal stem cells in an ovine model
    Matthias Zscharnack
    Department of Cell Techniques and Applied Stem Cell Biology, Center of Biotechnology and Biomedicine, University of Leipzig, Deutscher Platz 5, D 04103 Leipzig, Germany
    Am J Sports Med 38:1857-69. 2010
    ..However, there is a lack of studies in large-animal models examining the benefits of chondrogenic predifferentiation in vitro for repair of chronic osteochondral defects...
  18. ncbi request reprint Analysis of extracellular matrix production in artificial cartilage constructs by histology, immunocytochemistry, mass spectrometry, and NMR spectroscopy
    Ronny Schulz
    Department of Cell Techniques and Applied Stem Cell Biology, Center of Biotechnology and Biomedicine, University of Leipzig, Deutscher Platz 5, D 04103 Leipzig, Germany
    J Nanosci Nanotechnol 6:2368-81. 2006
    ..Therefore, MALDI-TOF mass spectrometry and 13C solid-state NMR are useful experimental techniques that can assist the quantitative evaluation and quality control of artificially engineered tissues...
  19. ncbi request reprint A simple non-destructive method for the fixation and immunostaining of cultured cells encapsulated in alginate
    Aldo Leal-Egana
    Department of Cell Technology and Applied Stem Cell Biology Biotechnology and Biomedicine Centre, BBZ, University of Leipzig, Deutscher Platz 5, 04103, Leipzig, Federal Republic of Germany
    Biotechnol Appl Biochem 44:143-50. 2006
    ..These results demonstrate that this simple method is suitable for the non-destructive analysis of protein expression by cells encapsulated in alginate...
  20. pmc Nanostructured self-assembling peptides as a defined extracellular matrix for long-term functional maintenance of primary hepatocytes in a bioartificial liver modular device
    Shibashish Giri
    Department of Cell Techniques and Applied Stem Cell Biology, Center for Biotechnology and Biomedicine BBZ, University of Leipzig, Leipzig, Germany
    Int J Nanomedicine 8:1525-39. 2013
    ....
  21. doi request reprint Thrombopoietin is a growth factor for rat hepatic progenitors
    Eva Schmelzer
    Department of Cell Culture and Stem Cell Biology, Biomedical Biotechnical Center, University of Leipzig, Leipzig, Germany
    Eur J Gastroenterol Hepatol 20:209-16. 2008
    ..Therefore, the influence of TPO on the proliferation of fetal hepatic progenitors in vitro compared with that of adult hepatocytes was analyzed. The expression of the TPO receptor, c-mpl, was investigated in fetal and adult liver...
  22. ncbi request reprint New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures
    Rolf Gebhardt
    Institute of Biochemistry, University of Leipzig, Leipzig, Germany
    Drug Metab Rev 35:145-213. 2003
    ..Representative results with test substances and recommendations for application of these in vitro systems, as well as standard operation procedures are given...
  23. ncbi request reprint Development and characterization of a small-scale bioreactor based on a bioartificial hepatic culture model for predictive pharmacological in vitro screenings
    Stephanie Schmitmeier
    Biotechnological Biomedical Center, Cell Techniques and Applied Stem Cell Biology, University of Leipzig, Deutscher Platz 5, 04103 Leipzig, Germany
    Biotechnol Bioeng 95:1198-206. 2006
    ..This in vitro model could serve as a tool to predict the liver response to newly developed drugs...
  24. ncbi request reprint Cartilage tissue engineering and bioreactor systems for the cultivation and stimulation of chondrocytes
    Ronny Maik Schulz
    Department of Cell Techniques and Applied Stem Cell Biology, Center of Biotechnology and Biomedicine, University of Leipzig, Leipzig, Germany
    Eur Biophys J 36:539-68. 2007
    ....
  25. doi request reprint Development and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructs
    Ronny M Schulz
    Department of Cell Techniques and Applied Stem Cell Biology, Center of Biotechnology and Biomedicine, University of Leipzig, Germany
    Biotechnol Bioeng 101:714-28. 2008
    ..Experimental data on mechanotransduction and long-term studies on the beneficial effects of combined perfusion and different mechanical loading patterns on chondrocyte seeded scaffolds will be published separately...
  26. doi request reprint Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach
    Augustinus Bader
    Centre for Biotechnology and Biomedicine, Department of Applied Stem Cell Biology and Cell Techniques, University of Leipzig, Leipzig, Germany
    J Cell Mol Med 14:1877-89. 2010
    ..This tissue-engineered approach and ongoing research in airway transplantation is reviewed and presented here...
  27. doi request reprint Hepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages
    Shibashish Giri
    Biomedical Biotechnological Center, Department of Cell Technologies, Leipzig, Germany
    Expert Opin Drug Metab Toxicol 6:895-917. 2010
    ..Although there are many reasons underlying drug-induced hepatotoxicity, one of the most important is hepatotoxicity induced by drug metabolites...
  28. doi request reprint The influence of oxygen supply on metabolism of neural cells cultured on a gas-permeable PTFE foil
    Corinna Mauth
    Dept of Cell Techniques and Stem Cell Biology, Biotechnological Biomedical Center, University of Leipzig, Leipzig 04103, Germany
    Biotechnol Prog 26:1724-32. 2010
    ....
  29. pmc Detection of nanolevel drug metabolites in an organotypic culture of primary human hepatocytes and porcine hepatocytes with special reference to a two-compartment model
    Ali Acikgöz
    Center for Biotechnology and Biomedicine, Cell Techniques and Applied Stem Cell Biology, Universitat Leipzig, Germany
    Int J Nanomedicine 7:5859-72. 2012
    ..Preclinical drug screening assessment tests that use this two-compartment strategy may facilitate safer registration of new drug candidates...
  30. doi request reprint Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes
    Ali Acikgöz
    Center for Biotechnology and Biomedicine, Cell Techniques and Applied Stem Cell Biology, Universitat Leipzig, Deutscher Platz 5, D 04103 Leipzig, Germany
    Toxicol Appl Pharmacol 234:179-91. 2009
    ....
  31. doi request reprint Determination of the decay rate constant for hepatocytes immobilized in alginate microcapsules
    Aldo Leal-Egana
    Department of Cell Technology and Applied Stem Cell Biology, Biotechnology and Biomedicine Centre BBZ, University of Leipzig, Leipzig, Germany
    J Microencapsul 27:86-93. 2010
    ..According to the author's knowledge, this is the first report of a systematic study and determination of the K(d) value for immobilized hepatocytes, incorporating a wide range of cell concentrations within the alginate matrix...
  32. doi request reprint Improved preclinical safety assessment using micro-BAL devices: the potential impact on human discovery and drug attrition
    Shibashish Giri
    Centre for Biotechnology and Biomedicine, Department of Cell Techniques and Applied Stem Cell Biology, University of Leipzig, Deutscher Platz 5, D 04103 Leipzig, Germany
    Drug Discov Today 16:382-97. 2011
    ....
  33. doi request reprint Porcine endogenous retrovirus released by a bioartificial liver infects primary human cells
    Jan Henning Frühauf
    Department of Cell Techniques and Applied Stem Cell Biology, Biomedical Biotechnological Center BBZ, Leipzig, Germany
    Liver Int 29:1553-61. 2009
    ..There is no evidence of in vivo productive infection in humans because PERV is inactivated by human serum. However, PERV can infect human cell lines and human primary cells in vitro and inhibit human immune functions...
  34. ncbi request reprint Quantum dots for human mesenchymal stem cells labeling. A size-dependent autophagy activation
    Oleksandr Seleverstov
    Center for Biotechnology and Biomedicine BBZ, University of Leipzig, D 04103 Leipzig, Germany
    Nano Lett 6:2826-32. 2006
    ..An asymmetrical intracellular uptake of red (605 nm) and green (525 nm) quantum dots was observed. We describe for the first time a size-dependent activation of autophagy, caused by nanoparticles...
  35. doi request reprint Analysis of stem cell lipids by offline HPTLC-MALDI-TOF MS
    Beate Fuchs
    Faculty of Medicine, Institute of Medical Physics and Biophysics, University of Leipzig, Härtelstrasse 16 18, 04107, Leipzig, Germany
    Anal Bioanal Chem 392:849-60. 2008
    ..Additionally, MS images of the developed TLC plates will be shown and potential applications, new methods of data analysis as well as problems discussed...
  36. doi request reprint Enrichment of human beta 1 bri/alpha 6 bri/CD71 dim keratinocytes after culture in defined media
    Katrin Lorenz
    University of Leipzig, Biotechnological Biomedical Center, Department of Cell Techniques and Applied Stem Cell Biology, Leipzig, Germany
    Cells Tissues Organs 189:382-90. 2009
    ..In conclusion, these findings implicate new applications in keratinocyte stem cell research and regenerative medicine...
  37. ncbi request reprint Evaluation of liver support systems for preclinical testing by animal trials
    Oleksandr Seleverstov
    Center for Biotechnology and Biomedicine BBZ, University of Leipzig, Leipzig, Germany
    Artif Organs 30:815-21. 2006
    ..A standardization of evaluation methods between testing groups would also be beneficial to the field of liver support...