Beatrice Bachmeier

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Immunohistochemical pattern of cytokeratins and MMPs in human keratinocyte cell lines of different biological behaviour
    Beatrice E Bachmeier
    Department of Legal Medicine, Ludwig Maximilians University, Munich, Germany
    Int J Oncol 20:495-9. 2002
  2. ncbi Novel aspects for the application of Curcumin in chemoprevention of various cancers
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig Maximilians University Munich, Munchen, Germany
    Front Biosci (Schol Ed) 2:697-717. 2010
  3. ncbi Analysis of tissue distribution of TNF-alpha, TNF-alpha-receptors, and the activating TNF-alpha-converting enzyme suggests activation of the TNF-alpha system in the aging intervertebral disc
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, University of Munich, Nussbaumstr 10, D 80336 Munich, Germany
    Ann N Y Acad Sci 1096:44-54. 2007
  4. ncbi Reference profile correlation reveals estrogen-like trancriptional activity of Curcumin
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig Maximilians University, Munich, Germany
    Cell Physiol Biochem 26:471-82. 2010
  5. ncbi The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice
    Beatrice Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Surgical Hospital, Ludwig Maximilians University Munich, Germany
    Cell Physiol Biochem 19:137-52. 2007
  6. ncbi Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Surgical Hospital, Ludwig Maximilians University Munich, Munich, Germany
    Mol Cancer 8:129. 2009
  7. ncbi Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig Maximilians University Munich, D 80336 MUnchen, Germany
    Carcinogenesis 29:779-89. 2008
  8. ncbi Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells
    Beatrice Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 6:e20550. 2011
  9. ncbi Enhanced expression and activation of major matrix metalloproteinases in distinct topographic areas of invasive breast carcinomas
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig-Maximilians-University, Germany
    Int J Oncol 26:1203-7. 2005
  10. ncbi Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc
    Christoph Weiler
    Institute of Pathology, Ludwig Maximilians University, Thalkirchnerstrasse 36, 80337 Munich, Germany
    Eur Spine J 19:1761-70. 2010

Detail Information

Publications20

  1. ncbi Immunohistochemical pattern of cytokeratins and MMPs in human keratinocyte cell lines of different biological behaviour
    Beatrice E Bachmeier
    Department of Legal Medicine, Ludwig Maximilians University, Munich, Germany
    Int J Oncol 20:495-9. 2002
    ..In addition, we provide circumstantial evidence that the expression of several major MMPs is associated with changes in the maturation pattern as evidenced by expression of CKs...
  2. ncbi Novel aspects for the application of Curcumin in chemoprevention of various cancers
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig Maximilians University Munich, Munchen, Germany
    Front Biosci (Schol Ed) 2:697-717. 2010
    ..Despite our increasing knowledge on this interesting substance there still remain many unknown effects that deserve intense investigation...
  3. ncbi Analysis of tissue distribution of TNF-alpha, TNF-alpha-receptors, and the activating TNF-alpha-converting enzyme suggests activation of the TNF-alpha system in the aging intervertebral disc
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, University of Munich, Nussbaumstr 10, D 80336 Munich, Germany
    Ann N Y Acad Sci 1096:44-54. 2007
    ..In consequence, TNF-alpha seems to be activated (by the converting enzyme TACE) and biologically active through its receptors in human lumbar disc tissue...
  4. ncbi Reference profile correlation reveals estrogen-like trancriptional activity of Curcumin
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig Maximilians University, Munich, Germany
    Cell Physiol Biochem 26:471-82. 2010
    ..However, it is still unclear whether these compounds elicit estrogen dependent transcription of genes at physiological concentrations...
  5. ncbi The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice
    Beatrice Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Surgical Hospital, Ludwig Maximilians University Munich, Germany
    Cell Physiol Biochem 19:137-52. 2007
    ..Dietary chemoprevention of metastases appears therefore feasible...
  6. ncbi Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Surgical Hospital, Ludwig Maximilians University Munich, Munich, Germany
    Mol Cancer 8:129. 2009
    ..These features render the drug a promising candidate for tumor therapy especially for cancers known for their high rates concerning therapy resistance like melanoma...
  7. ncbi Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig Maximilians University Munich, D 80336 MUnchen, Germany
    Carcinogenesis 29:779-89. 2008
    ..We therefore suggest that the decrease of CXCL1 and -2 mediated by Curcumin is involved in the inhibition of metastasis...
  8. ncbi Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells
    Beatrice Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 6:e20550. 2011
    ..Taken together our in vitro and in vivo results correlate well showing for the first time that artesunate induces resistance in highly metastatic breast tumors...
  9. ncbi Enhanced expression and activation of major matrix metalloproteinases in distinct topographic areas of invasive breast carcinomas
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig-Maximilians-University, Germany
    Int J Oncol 26:1203-7. 2005
    ..Our study provides considerable evidence that expression and activation of major MMPs is dependent on tumor cell density. This has a major impact on the biological behavior of tumor cells such as invasion and metastasis...
  10. ncbi Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc
    Christoph Weiler
    Institute of Pathology, Ludwig Maximilians University, Thalkirchnerstrasse 36, 80337 Munich, Germany
    Eur Spine J 19:1761-70. 2010
    ..The presence of these cells is associated with distinct features of (early) age-related disc degeneration, particularly with granular matrix changes...
  11. ncbi Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig Maximilians University Munchen, Munich, Germany
    Eur Spine J 18:1573-86. 2009
    ..Control of the proteolytic activity of MMP-3 may, therefore, come into the focus when aiming to develop new treatment options for early disc degeneration...
  12. ncbi Transcriptional control of cell density dependent regulation of matrix metalloproteinase and TIMP expression in breast cancer cell lines
    Beatrice E Bachmeier
    Dept of Clinical Chemistry and Clinical Biochemistry, Surgical Hospital, Ludwig Maximilians University, Nussbaumstr 20, D 80336 MUnchen, Germany
    Thromb Haemost 93:761-9. 2005
    ..Overexpression of MMPs in sparse cultures could help explain early dissemination of potentially metastatic cells...
  13. ncbi Cell density-dependent regulation of matrix metalloproteinase and TIMP expression in differently tumorigenic breast cancer cell lines
    Beatrice E Bachmeier
    Department Clinical Chemistry and Clinical Biochemistry, Hospital of Surgery, Ludwig Maximilians University, Nussbaumstr 20, D 80336 MUnchen, Germany
    Exp Cell Res 305:83-98. 2005
    ..Our data provide clear evidence that cell density regulates major MMPs and TIMPs which are controlled by AP-1 activity so that ultimately a major regulation pathway for the control of the invasive potential of tumor cells is presented...
  14. ncbi Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls
    Christoph Weiler
    Institute of Pathology, Ludwig Maximilians University Munich, Germany
    Spine (Phila Pa 1976) 30:44-53; discussion 54. 2005
    ..Immunohistochemical study of tumor necrosis factor alpha expression in autopsy and surgical specimens of human lumbar intervertebral discs...
  15. ncbi Molecular analysis of TGF-(beta)s and their receptors in human keratinocyte cell lines of different biological behaviour
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig Maximilians University, Munich, Germany
    Int J Mol Med 10:371-6. 2002
    ..This suggests a dysregulation of cytokine control on the level of TGF-beta expression, which may be responsible for the biological behaviour...
  16. ncbi Lineage infidelity and expression of melanocytic markers in human breast cancer
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig Maximilians University, Munich, Germany
    Int J Oncol 33:1011-5. 2008
    ....
  17. ncbi Expression of fibronectin and TGF-beta1 mRNA and protein suggest altered regulation of extracellular matrix in degenerated disc tissue
    Andreas G Nerlich
    Institute of Pathology, Academic Hospital Munchen Bogenhausen, Englschalkingerstrasse 77, 81925, Munich, Germany
    Eur Spine J 14:17-26. 2005
    ..This may offer new approaches to interfere with disc matrix alterations...
  18. ncbi Maillard products as biomarkers in cancer
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig Maximilians University Munich, D 80336 Munich, Germany
    Ann N Y Acad Sci 1126:283-7. 2008
    ..We conclude that CML formation is a general tumor cell-associated process...
  19. ncbi Matrix metalloproteinases in cancer: comparison of known and novel aspects of their inhibition as a therapeutic approach
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Biochemistry, Surgical Clinic, Ludwig-Maximilians-University Munich, Nussbaumstr. 20, D-80336 Munich, Germany
    Expert Rev Anticancer Ther 5:149-63. 2005
    ..Additionally, these substances have little or no toxic side effects and good bioavailability, and therefore their continuing analysis provides intriguing insight into tumor pathophysiology and possibly new therapeutic options...
  20. ncbi Immunomorphological analysis of RAGE receptor expression and NF-kappaB activation in tissue samples from normal and degenerated intervertebral discs of various ages
    Andreas G Nerlich
    Department of Pathology, Academic Hospital Munich Bogenhausen, Englschalkingerstr 77, D 81925 Munich, Germany
    Ann N Y Acad Sci 1096:239-48. 2007
    ..Oxidative stress (as monitored by CML modifications) may lead to RAGE activation and NF-kappaB translocation...